Tumor Markers, Liver Function Tests and Symptoms in 115 Patients with Isolated Colorectal Liver Metastases

1989 ◽  
Vol 4 (1) ◽  
pp. 18-26 ◽  
Author(s):  
M. Lorenz ◽  
R.P. Baum ◽  
G. Oremek ◽  
R. Inglis ◽  
M. Reimann-Kirkowa ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Tumor Antigens ◽  
Preoperative Staging ◽  
Liver Function Tests ◽  
Ca 125 ◽  
Control Group ◽  
Biliary Disease ◽  
Function Tests

Development of the hybridoma technique has made the identification of several new tumor antigens possible. Although it was hoped that they would be more tumor-specific, none of these markers are found exclusively in tumor or in serum of tumor patients. Compared with carcinoembryionic antigen (CEA) and liver function tests, the roles of these markers (CA 19-9, CA 125, CA 15-3) were prospectively evaluated in 115 patients with colorectal liver metastases. Patients were classified according to tumor volume (T1 <25%, T2 25-75%, T3 >75%), and the extension of infiltration (solitary/multiple/diffuse; unilateral, bilateral). Patients with benign liver or biliary disease served as a control group (n=63). Overall sensitivity was 87% for *1 , 50% for *2 and 38% for *3 , with a significant correlation with tumor size. CEA serum levels were elevated in 88% of all patients. CA 19-9 was less sensitive: positive in 59%. Because of some complementary elevations, the combined use of CEA, CA 19-9 and CA 125 raised sensitivity to 94%. CA 19-9 and LDH could be useful for confirmation because of their higher specificity; however, the specificity of CEA rose to 93% on using a cut-off of 10 ng/ml instead of 3 ng/ml. The results indicate that CEA and CA 19-9 as well as liver function tests are helpful for preoperative staging in conjunction with imaging procedures before liver resection or regional chemotherapy.

scholarly journals The Role of CEA and Liver Function Tests in the Detection of Hepatic Metastases From Colo-Rectal Cancer

HPB Surgery ◽  
1990 ◽  
Vol 3 (1) ◽  
pp. 29-37 ◽  
Author(s):  
G. Bonfanti ◽  
Luigia Bombelli ◽  
F. Bozzetti ◽  
R. Doci ◽  
L. Gennari ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Liver Function ◽  
Liver Metastases ◽  
Predictive Value ◽  
Imaging Technique ◽  
Hepatic Metastases ◽  
Liver Function Tests ◽  
Good Prediction ◽  
Gamma Glutamyl Transpeptidase ◽  
Function Tests

Carcinoembryonic antigen and some liver function tests (alkaline phosphatase, gamma-glutamyl-transpeptidase, lactic dehydrogenase and cholinesterase) were evaluated in patients with primary colorectal cancer in order to define their role in the pre-operative detection of liver metastases.The records of 278 consecutive patients admitted to the Istituto Nazionale Tumori of Milan between January 1982 and December 1983 who were suffering from primary invasive colo-rectal cancer and who underwent laparotomy were retrospectively analyzed.At laparotomy, liver metastases were found in 38 pts (13.7%). Considering single tests, CEA was the most sensitive (71%); no single test was found to be reliably predictive, when the result was abnormal. On the contrary, the normal value of each test was associated with a good prediction.When we considered all the five tests together in the single patient their predictive value, when abnormal, proved to be quite good only if four or five results were abnormal. On the other hand, liver metastases in the presence of all normal tests were found only in two patients, so giving a negative predictive value of about 97%.So we conclude that, in the lack of an infallable imaging technique for liver evaluation, in the presence of all normal tests any other investigation on the liver could be avoided. However, when liver tests are pathologic, some other imaging technique should be performed in order to supply the surgeon with information about the extent and the spread of the metastases.

Fisher Discrimination of Metabolic Changes in Rats Treated with Aspirin and Ibuprofen

Pharmacology ◽  
2017 ◽  
Vol 100 (3-4) ◽  
pp. 194-200 ◽  
Author(s):  
Jing Zhang ◽  
Huanchun Song ◽  
Shuying Jiang ◽  
Zhibin Chen ◽  
Shuhua Tong ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Gas Chromatography Mass Spectrometry ◽  
Control Group ◽  
Intragastric Administration ◽  
Acetoacetic Acid ◽  
Toxic Reaction ◽  
Function Tests ◽  
Metabolomic Data ◽  
Aspirin Group

Background: Aspirin and ibuprofen are the most frequently prescribed non-steroidal anti-inflammatory drugs in the world. However, both are associated with a variety of toxicities. We applied serum metabonomics and Fisher discrimination for the early diagnosis of its toxic reaction in order to help diagnose these toxicities. Methods: A total of 45 rats were randomly divided into Control group, Aspirin group, and Ibuprofen groups. The experiment groups were given intragastric aspirin (15 mg/kg) or ibuprofen (15 mg/kg) for 3 weeks. Liver function tests were performed and blood metabonomics were analyzed by gas chromatography-mass spectrometry. Results: The most important compounds altered were trihydroxybutyric acid and l-alanine in the aspirin group, and acetoacetic acid, l-alanine, and trihydroxybutyric acid in the ibuprofen group. With respect to metabolic profiles, all 3 groups were completely distinct from one another. Fisher discrimination showed that 91.1% of the original grouped cases were correctly classified by the third week. However, only 55.6% of liver function tests were able to classify grouped cases correctly. Conclusion: Trihydroxybutyric acid, l-alanine, and acetoacetic acid were the most significant indicators of altered serum metabolites following intragastric administration of aspirin and ibuprofen in rates. These metabolomic data may be used for classification of aspirin and ibuprofen toxicity.

scholarly journals SYNERGISTIC ANTIOXIDANT ACTION OF MURRAYA KOENIGII AND PLUMERIA RUBRA EXTRACTS ENHANCE HEPATOPROTECTIVE EFFICACY AGAINST METHOTREXATE INDUCED LIVER INJURY

2017 ◽  
Vol 9 (10) ◽  
pp. 152
Author(s):  
Engineer A. S. ◽  
Pal S. ◽  
Desai K. R. ◽  
Highland H. N.
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Control Group ◽  
Liver Protein ◽  
Murraya Koenigii ◽  
Dual Formulation ◽  
Significant Recovery ◽  
Function Tests ◽  
Group I ◽  
Plumeria Rubra

Objective: The present study was focussed on evaluating the hepatoprotective capacity of a combination of leaf extracts of Murraya koenigii and Plumeria rubra on drug-induced toxicity in mice liver.Methods: Hydromethanolic and aqueous extracts were prepared from the leaves of Murraya koenigii and Plumeria rubra. A combination of these extracts was tested as a dual formulation (DF). The extracts were evaluated for their antioxidant activity and phytochemical content. Healthy adult male mice were treated in five groups, for 30 d: Control (Group I-Untreated), Group II (Methotrexate at 10 mg/kg Body weight, intraperitoneally), Group III (Methotrexate+Silymarin), Group IV (Methotrexate+hydromethanolic extract of DF-250 mg/kg b.w., orally), Group V (Methotrexate+aqueous extract of the DF-250 mg/kg b.w. orally). After treatment, the animals were necropsied. Blood was collected for serum parameters such as alanine transaminase (ALT), Aspartate transaminase (AST) and γ glutamyl transpeptidase (GGT). Further liver function tests like Alkaline phosphatase (ALP), Phosphorylase as well as Oxidative stress parameters like Lipid peroxidation (LPO), Superoxide dismutase (SOD), Catalase (CAT), along with the liver protein and cholesterol content were analyzed.Results: Administration of both the DF extracts significantly ameliorated the methotrexate-induced toxic effects on all the aforementioned biochemical parameters. The hydromethanolic extract showed significant recovery in the liver function tests like ALT (p<0.05) and AST (p<0.001). Antioxidant stress enzymes like SOD (p<0.001) and Catalase (p<0.001) also showed significant recovery after administration of both the extracts. The other parameters assayed also followed the same trend. Although both the extracts showed remarkable hepatoprotection, the hydromethanolic extract was found to be significantly more potent than the aqueous extract.Conclusion: The present study concludes that the Dual formulation of the extracts of Murraya koenigii and Plumeria rubra could be an effective hepatoprotective agent due to the synergistic action of the phytoconstituents of both the plants.

Evaluation of Risk Factors for Development of Anti-Tubercular Therapy Induced Hepatotoxicity: A Prospective Study

2020 ◽  
Vol 15 (3) ◽  
pp. 198-204
Author(s):  
Malladi V.S. Subbalaxmi ◽  
Radhika Soanker ◽  
Arivittur V. Lakshmi
Keyword(s):  
Risk Factors ◽  
Liver Function ◽  
Pulmonary Tuberculosis ◽  
Female Gender ◽  
Liver Function Tests ◽  
Study Patient ◽  
Control Group ◽  
Study Group ◽  
Cox Regression Analysis ◽  
Function Tests

Background: Incidence of Antitubercular Therapy (ATT)-induced hepatotoxicity is higher in India when compared to Western countries. As the occurrence of ATT-induced hepatotoxicity is unpredictable, serial intensive monitoring of hepatic function is now being recommended by the American Thoracic Society in individuals at high risk. This study was done to evaluate the risk factors for the development of ATT induced hepatotoxicity in India. Methodology: In this prospective, observational study, patient characteristics of microbiologically/ radiologically/ histopathologically confirmed tuberculosis were prospectively compiled. Serial liver function tests were done once a month in all patients. Patients who developed ATT-induced hepatotoxicity were considered as the study group and those who did not develop the event as a control group. The primary outcome measure was to estimate the hazard ratios associated with risk factors for the development of ATT induced hepatotoxicity. Cox Regression Analysis was done using SPSS 20. Results: : A total of 200 patients were enrolled in the study, of them, 14% developed ATT-induced hepatotoxicity and 86% did not develop the event. The baseline liver function tests in the study group and control group were within normal limits. Female gender, alcoholism, HIV co-infection and age >35 yrs were identified to have a higher risk for development of ATT-induced hepatotoxicity, while cases with pulmonary tuberculosis were found to be at lower risk of developing event. Conclusion: Intensive liver function monitoring needs to be done in patients with these risk factors, female gender, alcoholism, HIV co-infection, extra-pulmonary tuberculosis and age >35 yrs.

Escalating doses of hepatic arterial oxaliplatin in combination with docetaxel and capecitabine in patients with liver metastases from non-colorectal gastrointestinal malignancies

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 14110-14110
Author(s):  
S. De La Cruz ◽  
J. Rodriguez ◽  
J. De La Cámara ◽  
G. Nagore ◽  
S. Viteri ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Metastases ◽  
Dose Level ◽  
Hepatic Metastases ◽  
Liver Function Tests ◽  
Gastrointestinal Malignancies ◽  
Function Tests ◽  
Level 3 ◽  
Level 1 ◽  
Grade 3

14110 Background: Docetaxel (T), oxaliplatin (O) and capecitabine (C) are active agents in gastrointestinal (g.i.) tumors. Synergism has been reported in several preclinical studies. The purpose of this study was to assess the maximum tolerated dose of hepatic arterial oxaliplatin in combination with docetaxel and capecitabine in patients (pts) with hepatic metastases from non-colorectal g.i. tumors. Preliminary evidence of activity was also evaluated. Methods: Patients with liver metastases from gastric (n=3), pancreas (n=6), esophageal (n=2) and cholangiocarcinoma (n=1) were treated with fixed doses of docetaxel (60 mg/m2), capecitabine (650 mg/m2 bid on days 1–14) and escalating doses of hepatic intraarterial oxaliplatin. Oxaliplatin dose was escalated according to the following schedule: level 1, 100 mg/m2; level 2, 110 mg/m2; level 3, 120 mg/m2. The cycle was repeated every 3 weeks. A CT scan or MRI was performed to evaluate response. Liver function tests were performed the day after and before the hepatic arterial infusion. Results: The median number of cycles was 5. At first dose level, 1 pt showed grade 3 mucositis and capecitabine intolerance that required treatment discontinuation. Three pts were later included in the same level with no further toxicity. At dose level 3, grade 3 vomiting was recorded in 1 pt and subsequently this level is now being expanded. Liver function tests on day 2 were elevated over baseline in 10 pts (83%). Seven pts (58%) required morphine due to pain associated with intraarterial infusion. Among 11 evaluable pts, 10 (83%) PRs have been confirmed. Conclusions: Accrual is ongoing at dose level 3. Preliminary data on efficacy seems promising. No significant financial relationships to disclose.

Efficiency of enterosorption in comprehensive therapy of viral hepatitis A in children

2020 ◽  
Vol 15 (5) ◽  
pp. 34-38
Author(s):  
R.Kh. Begaidarova ◽  
◽  
Yu.G. Starikov ◽  
G.K. Alshynbekova ◽  
A.E. Dyusembaeva ◽  
...  
Keyword(s):  
Liver Function ◽  
Viral Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Clinical Symptoms ◽  
Liver Function Tests ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Function Tests ◽  
Comprehensive Therapy

Objective. To evaluate therapeutic efficacy and safety of Enterosgel adsorbent and compare it with standard therapy in children with viral hepatitis Patients and methods. This open-label, prospective, randomized, controlled trial was conducted in the Regional Hospital for Infectious Diseases of Karaganda. We examined 98 children (mean age 10.56 ± 0.36 years) diagnosed with hepatitis A. The diagnosis was verified by identification of the marker reflecting active replication of hepatitis A virus (аnti-HAV IgM) using enzyme-linked immunosorbent assay. We evaluated the dynamics of clinical symptoms and liver function tests, including total bilirubin and its fractions, as well as levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The experimental group included 52 patients who received Enterosgel; the control group comprised 46 patients who received standard for hepatitis A therapy. Results. Enterosgel ensured more rapid resolution of clinical symptoms of acute hepatitis A and normalization of liver function tests compared to patients with the control group. This led to a shorter period of intoxication, vomiting, and jaundice, as well as to reduced ALT, and shorter in-hospital stay. Key words: hepatitis A, intoxication, jaundice, enterosorbent, Enterosgel

Diagnosis and significance of liver metastases in small cell carcinoma of the lung.

1984 ◽  
Vol 2 (7) ◽  
pp. 733-741 ◽  
Author(s):  
J L Mulshine ◽  
R W Makuch ◽  
A Johnston-Early ◽  
M J Matthews ◽  
D N Carney ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Biopsy ◽  
Liver Metastases ◽  
Hepatic Metastases ◽  
Liver Function Tests ◽  
Small Cell ◽  
Function Tests ◽  
Liver Scan ◽  
Prognostic Implications ◽  
Correct Discrimination

One hundred fifty-seven consecutive patients with small cell lung cancer seen at the National Cancer Institute over a four-year period underwent a series of pretherapy liver staging procedures to determine optimal means of detection and prognostic implications of hepatic metastases. Liver evaluation included physical examination, liver function tests, and liver scan (radionuclide or computerized tomography [CT]), as well as percutaneous and/or peritoneoscopy-directed liver biopsy when possible (74%). Liver metastases were detected in 26% of patients. Peritoneoscopy was the most sensitive method of liver evaluation and increased the detection of liver metastases when done in a sequential fashion after percutaneous liver biopsy from 18 to a total of 27 patients. Of the noninvasive procedures, radionuclide and CT liver scan were the most accurate concurring with liver biopsy in 87% of patients but permitting correct discrimination of stage in excess of 96% of patients. The accuracy of this noninvasive procedure was enhanced by an algorithm combining the results of radionuclide liver scan with liver function tests to detect patients with high or low likelihood of liver involvement. The survival and response of patients with liver metastases was significantly worse than those without such metastases with no three-year disease-free survivors among patients with liver metastases.

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