Lymphoma for GPs across the cancer continuum

2022 ◽  
pp. 175573802110661
Author(s):  
Samuel W D Merriel
Keyword(s):  
Early Diagnosis ◽  
World Health Organisation ◽  
World Health ◽  
Cancer Type ◽  
Care Needs ◽  
Adolescents And Adults ◽  
History Of ◽  
The Uk

Lymphomas are a diverse and relatively common cancer type in the UK. Early diagnosis of lymphoma is vital for improving patient outcomes. The majority of patients diagnosed with lymphoma have a life expectancy of more than 5 years. Lymphoma treatments can have long-term health consequences, and patients with a history of lymphoma have a higher risk of subsequently developing other cancers. More robust evidence for the early diagnosis of lymphoma in primary care has been published in recent years, and the classification of lymphoma has recently been updated by the World Health Organisation. This article focuses on the diagnosis of lymphoma in adolescents and adults and the on-going care needs of patients who are being treated for lymphoma or have survived a diagnosis of lymphoma. Further information about lymphoma and other cancers in children can be found in the InnovAiT article by Dr Jennifer Kelly published in 2017.

scholarly journals A Lip Lump: An Unexpected Histological Diagnosis of a Lip Schwannoma

2017 ◽  
Vol 2017 ◽  
pp. 1-2 ◽  
Author(s):  
Thomas Haigh ◽  
John Raad Glore ◽  
David Gouldesbrough ◽  
Winson Wong
Keyword(s):  
Surgical Excision ◽  
World Health Organisation ◽  
World Health ◽  
Clinical Impression ◽  
Upper Lip ◽  
Benign Schwannoma ◽  
History Of ◽  
Benign Tumours ◽  
The Right

Schwannomas are benign nerve sheath tumours arising from Schwann cells. They comprise 1% of all benign tumours. In the 2016 World Health Organisation Classification of Central Nervous System, they are classified as a tumour of the cranial and paraspinal nerves, Schwannoma 9560/0. A 23-year-old Caucasian lady presented with a seven-month history of a painless right upper lip lump. Examination revealed a small cystic 0.5 cm diameter lesion within the right upper lip. The clinical impression was that of a mucocele. Excision of the lip lesion was performed under local anaesthetic. Histological examination of the excised lesion demonstrated a circumscribed nodule consisting of spindle cells mixed with vascular spaces containing red blood cells and fibrin. Immunohistochemistry for S100 was strongly positive. The findings were consistent with that of a small benign schwannoma. The current consensus is for surgical excision of a conservative nature with no need for margins. If recurrence does occur one needs to consider whether complete enucleation was achieved or whether malignant transformation has occurred.

scholarly journals Understanding Leisure Centre-Based Physical Activity after Physical Activity Referral: Evidence from Scheme Participants and Completers in Northumberland UK

2021 ◽  
Vol 18 (6) ◽  
pp. 2957
Author(s):  
Jordan Bell ◽  
Lis Neubeck ◽  
Kai Jin ◽  
Paul Kelly ◽  
Coral L. Hanson
Keyword(s):  
Physical Activity ◽  
Administrative Data ◽  
World Health Organisation ◽  
Ordinal Regression ◽  
World Health ◽  
Activity Levels ◽  
The World ◽  
The Uk

Physical activity referral schemes (PARS) are a popular physical activity (PA) intervention in the UK. Little is known about the type, intensity and duration of PA undertaken during and post PARS. We calculated weekly leisure centre-based moderate/vigorous PA for PARS participants (n = 448) and PARS completers (n = 746) in Northumberland, UK, between March 2019–February 2020 using administrative data. We categorised activity levels (<30 min/week, 30–149 min/week and ≥150 min/week) and used ordinal regression to examine predictors for activity category achieved. PARS participants took part in a median of 57.0 min (IQR 26.0–90.0) and PARS completers a median of 68.0 min (IQR 42.0–100.0) moderate/vigorous leisure centre-based PA per week. Being a PARS completer (OR: 2.14, 95% CI: 1.61–2.82) was a positive predictor of achieving a higher level of physical activity category compared to PARS participants. Female PARS participants were less likely (OR: 0.65, 95% CI: 0.43–0.97) to achieve ≥30 min of moderate/vigorous LCPA per week compared to male PARS participants. PARS participants achieved 38.0% and PARS completers 45.3% of the World Health Organisation recommended ≥150 min of moderate/vigorous weekly PA through leisure centre use. Strategies integrated within PARS to promote PA outside of leisure centre-based activity may help participants achieve PA guidelines.

scholarly journals Towards a hydrological classification of European soils: preliminary test of its predictive power for the base flow index using river discharge data

2007 ◽  
Vol 11 (4) ◽  
pp. 1501-1513 ◽  
Author(s):  
M. K. Schneider ◽  
F. Brunner ◽  
J. M. Hollis ◽  
C. Stamm
Keyword(s):  
Water Movement ◽  
Base Flow ◽  
Regression Coefficients ◽  
Northern Europe ◽  
Flow Index ◽  
Discharge Data ◽  
Base Flow Index ◽  
The Uk

Abstract. Predicting discharge in ungauged catchments or contaminant movement through soil requires knowledge of the distribution and spatial heterogeneity of hydrological soil properties. Because hydrological soil information is not available at a European scale, we reclassified the Soil Geographical Database of Europe (SGDBE) at 1:1 million in a hydrological manner by adopting the Hydrology Of Soil Types (HOST) system developed in the UK. The HOST classification describes dominant pathways of water movement through soil and was related to the base flow index (BFI) of a catchment (the long-term proportion of base flow on total stream flow). In the original UK study, a linear regression of the coverage of HOST classes in a catchment explained 79% of BFI variability. We found that a hydrological soil classification can be built based on the information present in the SGDBE. The reclassified SGDBE and the regression coefficients from the original UK study were used to predict BFIs for 103 catchments spread throughout Europe. The predicted BFI explained around 65% of the variability in measured BFI in catchments in Northern Europe, but the explained variance decreased from North to South. We therefore estimated new regression coefficients from the European discharge data and found that these were qualitatively similar to the original estimates from the UK. This suggests little variation across Europe in the hydrological effect of particular HOST classes, but decreasing influence of soil on BFI towards Southern Europe. Our preliminary study showed that pedological information is useful for characterising soil hydrology within Europe and the long-term discharge regime of catchments in Northern Europe. Based on these results, we draft a roadmap for a refined hydrological classification of European soils.

Founders without Limits

2021 ◽  
Author(s):  
Bobby V. Reddy
Keyword(s):  
Stock Exchange ◽  
High Growth ◽  
Global History ◽  
Public Markets ◽  
The Us ◽  
History Of ◽  
The Uk ◽  
Dual Class ◽  
Blue Chip

Big Tech has flourished on the US public markets in recent years with numerous blue-chip IPOs, from Google and Facebook, to new kids on the block such as Snap, Zoom, and Airbnb. A key trend is the burgeoning use of dual-class stock. Dual-class stock enables founders to divest of equity and generate finance for growth through an IPO, without losing the control they desire to pursue their long-term, market-disrupting visions. Bobby Reddy scrutinises the global history of dual-class stock, evaluates the conceptual and empirical evidence on dual-class stock, and assesses the approach of the London Stock Exchange and ongoing UK regulatory reforms to dual-class stock. A policy roadmap is presented that optimally supports the adoption of dual-class stock while still protecting against its potential abuses, which will more effectively attract high-growth, innovative companies to the UK equity markets, boost the economy, and unleash the true potential of 'founders without limits'.

scholarly journals Standardised, quantitative neutralisation responses to SARS-CoV-2 Variants of Concern by convalescent anti-sera from first wave infections of UK Health Care Workers and Patients

2021 ◽  
Author(s):  
Diego Cantoni ◽  
Martin Mayora-Neto ◽  
Angalee Nadesalingam ◽  
David A. Wells ◽  
George W. Carnell ◽  
...  
Keyword(s):  
Health Care Workers ◽  
Healthcare Workers ◽  
World Health Organisation ◽  
World Health ◽  
Care Centre ◽  
International Standard ◽  
Care Workers ◽  
The World ◽  
Antibody Titres ◽  
The Uk

One of the defining criteria of Variants of Concern (VOC) is their ability to evade pre-existing immunity, increased transmissibility, morbidity and/or mortality. Here we examine the capacity of convalescent plasma, from a well defined cohort of healthcare workers (HCW) and Patients infected during the first wave from a national critical care centre in the UK, to neutralise B.1.1.298 variant and three VOCs; B.1.1.7, B.1.351 and P.1. Furthermore, to enable lab to lab, country to country comparisons we utilised the World Health Organisation (WHO) International Standard for anti-SARS-CoV-2 Immunoglobulin to report neutralisation findings in International Units. These findings demonstrate a significant reduction in the ability of first wave convalescent plasma to neutralise the VOCs. In addition, Patients and HCWs with more severe COVID-19 were found to have higher antibody titres and to neutralise the VOCs more effectively than individuals with milder symptoms. Widespread use of the WHO International Standard by laboratories in different countries will allow for cross-laboratory comparisons, to benchmark and to establish thresholds of protection against SARS-CoV-2 and levels of immunity in different settings and countries.

Investigation of malondialdehyde and some elements in young infertile males

2021 ◽  
pp. 5418-5422
Author(s):  
Khlowd Mohammed Jasem ◽  
Taha H. Alnasrawi ◽  
Haneen Haleem Shiblawi ◽  
Hameedah Hadi Abdul Wahid ◽  
Narjis Hadi Al-Saadi
Keyword(s):  
Trace Elements ◽  
Sperm Count ◽  
World Health Organisation ◽  
Toxic Chemicals ◽  
World Health ◽  
Psychosocial Effects ◽  
Radioactive Materials ◽  
The People ◽  
Zinc Levels

Infertility is an important medical issue that has serious medical and psychosocial effects on affected individuals. In 2003, the Iraqi community suffered from profanation acts because of conflicts in the country. Toxic chemicals and radioactive materials caused numerous injuries and deaths. The people who survived these horrific events eventually suffered either from cancer or infertility. The aim of this study was to determine the levels of malondialdehyde (MDA) and some trace elements in the seminal plasma of infertile males and determine their effects on sperm parameters. This study included 41 infertile males 18-40 years old. Levels of MDA, zinc, copper and magnesium were measured in their semen via spectrophotometry. According to the classification of the World Health Organisation, the patients were classified into three groups: normospermia, oligospermia and asthenspermia. Results showed significant differences in MDA and zinc levels among the three groups (p < 0.001). Moreover, results showed a mildly positive correlation between MDA levels and sperm count (r = 0.57). This study established that levels of MDA and some trace elements contribute to male infertility.

Roles and strategies of international humanitarian organisations in handling the Liberia Ebola outbreak

2019 ◽  
Author(s):  
Jia Bainga Kangbai ◽  
Ahmed Alameldeen
Keyword(s):  
Emergency Preparedness ◽  
Ebola Virus ◽  
Virus Disease ◽  
World Health Organisation ◽  
West African ◽  
World Health ◽  
Healthcare Personnel ◽  
African Countries ◽  
History Of ◽  
Public Health Emergency Preparedness

Abstract Background In Early August 2014, the World Health Organisation declared an Ebola Virus Disease (EVD) outbreak in the region of West Africa. The West African EVD outbreak was the largest, most severe, and complex in the nearly four-decade history of this disease. The management of EVD cases in Liberia was similar to the other affected West African countries. Methods We reviewed the method and strategies used by some of the international humanitarian organisations in handling the 2013-2016 Ebola outbreak in Liberia. This report is a collection of personal field experiences in Liberia as well as personal interviews of healthcare personnel working for some of these international organisations working on the Ebola emergency in Liberia. Findings Medecins Sans Frontieres (MSF) was the first humanitarian NGO to deploy medical staff to the field in Liberia during the 2013-2016 EVD outbreak. MSF staffs were already operating in Liberia even before the declaration of the outbreak in August 2014.Conclusions The slow response by the international humanitarian organisations to lend their support in bringing the EVD outbreak to and exhibited the fear the international community have for deadly infectious diseases more than armed conflicts.Recommendations We recommend regularly training in public health emergency preparedness for third world countries that are highly susceptible to health emergencies such as Ebola outbreak to help prepared them ahead of such outbreak.

11. The United Kingdom: Towards a Parting of the Ways

2020 ◽  
pp. 257-279
Author(s):  
Anand Menon ◽  
Luigi Scazzieri
Keyword(s):  
European Union ◽  
Public Opinion ◽  
Institutional Development ◽  
The European Union ◽  
Integration Process ◽  
The United Kingdom ◽  
History Of ◽  
Long Term Trends ◽  
The Uk

This chapter examines the history of the United Kingdom’s relationship with the European integration process. The chapter dissects the long-term trends in public opinion and the more contingent, short-term factors that led to the referendum vote to leave the European Union. The UK was a late joiner and therefore unable to shape the early institutional development of the EEC. British political parties and public opinion were always ambiguous about membership and increasingly Eurosceptic from the early 1990s. Yet the UK had a significant impact on the EU’s development, in the development of the single market programme and eastward enlargement. If Brexit goes through, Britain will nevertheless maintain relations with the EU in all policy areas from agriculture to energy and foreign policy. Europeanization will remain a useful theoretical tool to analyse EU–UK relations even if the UK leaves the Union.

scholarly journals Chelmsford Borough Council: A designated International Safe Community

1970 ◽  
pp. 230-234 ◽  
Author(s):  
Averil Price
Keyword(s):  
Local Authority ◽  
World Health Organisation ◽  
World Health ◽  
Community Safety ◽  
The World ◽  
Demonstration Site ◽  
Borough Council ◽  
Authority Area ◽  
The Uk ◽  
Safe Community

This article provides some background to the Safe Communities concept and sets out the criteria to be satisfied as an International Safe Community (ISC). It concludes with reflections about Chelmsford Borough Council’s responsibilities as a Demonstration Site within the UK, and how Council has contributed within an International Network.There are currently over 200 communities across the world that have been designated as International Safe Communities by the World Health Organisation (WHO), and in June 2010, the Chelmsford Borough Council became the first local authority area to achieve this recognition in the UK. International Safe Communities is a World Health Organisation initiative that recognises safety as a ‘universal concern and a responsibility for all’. 1 It is an approach to community safety that encourages greater cooperation and collaboration between a range of non-government organisations, the business sector and local and government agencies. In order to be designated as an ISC, communities are required to meet six criteria developed by the WHO Collaborating Centre on Community Safety. The ISC accreditation process provides support for communities and indicates a level of achievement by an organisation within the field of community safety.

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