scholarly journals Platelet Antiaggregating Activity and Chemical Constituents of Salvia x Jamensis J. Compton

2008 ◽  
Vol 3 (6) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Angela Bisio ◽  
Giovanni Romussi ◽  
Eleonora Russo ◽  
Nunziatina De Tommasi ◽  
Nicola Mascolo ◽  
...  
Keyword(s):  
Data Analysis ◽  
Platelet Aggregation ◽  
Ursolic Acid ◽  
Betulinic Acid ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
Isopimaric Acid ◽  
Phytochemical Study ◽  
Rat Platelets ◽  
Significant Concentration

A phytochemical study has been carried out on the surface exudate of Salvia x jamensis, which showed a significant platelet antiaggregating activity. The known compounds isopimaric acid (2), 14-α-hydroxy-isopimaric acid (3), 3β-hydroxy-isopimaric acid (4), 7,8β-dihydrosalviacoccin (5), betulinic acid (6), and ursolic acid (7) were isolated together with the new diterpene 1. The structure of 1 was determined as 15,16-epoxy-cleroda-3-en-7α,10β-dihydroxy-12,17;19,18-diolide on the basis of spectroscopic data analysis. Among all tested compounds, 2 showed a significant concentration-dependent antiaggregating activity when ADP (3 μM) was used as agonist on rat platelets. Conversely, 1 increased ADP–induced platelet aggregation.

scholarly journals Phytotoxic Activity of Salvia x jamensis

2009 ◽  
Vol 4 (12) ◽  
pp. 1934578X0900401
Author(s):  
Angela Bisio ◽  
Daniele Fraternale ◽  
Gianluca Damonte ◽  
Enrico Millo ◽  
Anna Paola Lanteri ◽  
...  
Keyword(s):  
Data Analysis ◽  
Avena Sativa ◽  
Betulinic Acid ◽  
Spectroscopic Data ◽  
Isopimaric Acid ◽  
Papaver Rhoeas ◽  
Phytotoxic Activity

A study has been carried out on the surface exudate of Salvia x jamensis, which showed a significant phytotoxic activity against Papaver rhoeas L. and Avena sativa L.. Bioguided separation of the exudate yielded active fractions from which 3β-hydroxy-isopimaric acid (1), hautriwaic acid (2), betulinic acid (3), 7,8β-dihydrosalviacoccin (4), isopimaric acid (5), 14α-hydroxy-isopimaric acid (7), 15,16-epoxy-7α,10β-dihydroxy-clerod-3,13(16),14-trien-17,12;18,19-diolide (8), cirsiliol (5,3′,4′-trihydroxy-6,7-dimethoxyflavone, 9) and two new neoclerodane diterpenes (6 and 10) were isolated. The structures of 6 and 10 were identified as 15,16-epoxy-10β-hydroxy-clerod-3,13(16),14-trien-17,12;18,19-diolide and 15,16-epoxy-7α,10-dihydroxy-clerod-2,13(16),14-trien-17,12;18,19-diolide respectively on the basis of spectroscopic data analysis. All compounds, but 7, 8 and 10, were active in inhibiting the germination of the tested species.

scholarly journals A New 28-Nor-oleanane Triterpene from Excoecaria agallocha

2018 ◽  
Vol 13 (1) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
De-Juan Mo ◽  
Jun Li ◽  
Min-Yi Li
Keyword(s):  
Data Analysis ◽  
Betulinic Acid ◽  
Spectroscopic Data ◽  
Excoecaria Agallocha

A new 28-nor-oleanane triterpene, 28- nor-olean-2α, 3β-dihydroxy-14,17-diene-16-one with a rare cyclohexa-2,5-dienone moiety, together with three known triterpenes, viz.β-amyrin (2), 3α- O - trans -coumaroyl-betulinic acid (3), 3-acetyl-aleuritolic acid (4), were isolated from the twigs of Excoecaria agallocha L.. Their structures were determined by extensive spectroscopic data analysis and comparison with previous literatures (known compounds).

Influence of the Parasite Viscum cruciatum Sieber on the Chemical Constituents of Crataegus monogyna Jacq

2001 ◽  
Vol 56 (11-12) ◽  
pp. 1091-1094
Author(s):  
Carmen Ahumada ◽  
Dolores García ◽  
Teresa Saenz ◽  
Alicia Gómez ◽  
Arturo Cert
Keyword(s):  
Plant Species ◽  
Ursolic Acid ◽  
Homologous Series ◽  
Chemical Constituents ◽  
Aliphatic Alcohols ◽  
Phytochemical Study ◽  
Crataegus Monogyna ◽  
Two Samples ◽  
Hexane Extracts

Abstract A phytochemical study of two plant species, Viscum cruciatum Sieber and Crataegus mono­gyna Jacq., was completed to investigate the influence of the parasite Viscum cruciatum on the host Crataegus monogyna. The study was carried out with two samples and consisted of hexane extracts of the Viscum cruciatum parasitizing on Crataegus monogyna and C. mono­gyna. In these samples ursolic acid, β-sitosterol and a triterpene fraction were found that contained mainly butyrospermol (3β-lanost 8 , 24-dien, 3-ol), 24-methylene-24-dihydrolanost-erol (24-methylene-5a-lanost-8-en-3β-ol), cycloartenol (9β, 19-cyclo-5α, 9β-lanost-24-en-3β-ol), β-amyrin (olean-12-en-3β-ol) and several aliphatic alcohols identified as the C18 to C30 members of the 1 -alkanol homologous series. β-Amyrin acetate was only isolated from Viscum cruciatum and was not found in Cratae­ gus monogyna.

scholarly journals FLAVONOIDS ISOLATED FROM THE FLOWERS OF CAMELLIA CHRYSANTHA

2019 ◽  
Vol 57 (3) ◽  
pp. 287
Author(s):  
Hong Van Thi Nguyen ◽  
Bach Cao Pham ◽  
Inh Thi Cam ◽  
Phuong Lan Doan ◽  
Thanh Tat Le ◽  
...  
Keyword(s):  
Data Analysis ◽  
Methyl Ether ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
Health Benefits ◽  
Small Tree ◽  
Evergreen Shrub ◽  
Chemical Structures ◽  
The Family ◽  
First Time

Camellia chrysantha (the golden camellia, golden tea) is a species of evergreen shrub or small tree belonging to the family Theaceae. The flowers and the leaves of this plant are used as tea and drank for its health benefits. The aim of this study was to investigate the chemical constituents of the flowers of Camellia chrysantha. Five flavonoids were isolated from the flowers of Camellia chrysantha (Theaceae), including (+)-catechin (1), (-)-epicatechin (2), quercetin (3), quercetin-3-O-methyl ether (4) and kaempferol (5). Their chemical structures were elucidated by spectroscopic data analysis and by comparison with those reported in the literature. Among five compounds, compounds 4 was isolated for the first time from this species.

Acute toxicity, antiedematogenic activity, and chemical constituents of Palicourea rigida Kunth

2016 ◽  
Vol 71 (3-4) ◽  
pp. 39-43
Author(s):  
Vanessa G. Alves ◽  
Elisa A. da Rosa ◽  
Laura L.M. de Arruda ◽  
Bruno A. Rocha ◽  
Ciomar A. Bersani Amado ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Crude Extract ◽  
Betulinic Acid ◽  
Leaf Extract ◽  
Chemical Constituents ◽  
Iridoid Glycosides ◽  
Hexane Fraction ◽  
Published Data ◽  
Phytochemical Study ◽  
Palicourea Rigida

Abstract The phytochemical study of the leaves, roots, and flowers of Palicourea rigida led to the isolation of the triterpenes betulinic acid (1) and lupeol (2), the diterpene phytol (3), and the iridoid glycosides sweroside (4) and secoxyloganin (5). These compounds were identified using NMR 1H and 13C and comparing the spectra with published data. We studied the antiedematogenic activity of crude extracts from the organs, and of different fractions, in mice and found that the n-hexane fraction of the leaf extract significantly inhibited the ear edema resulting from croton oil administration. The crude extract from leaves was not acutely toxic to the mice.

scholarly journals Chemical Constituents From the Bark of Garcinia oblongifolia

2020 ◽  
Vol 15 (8) ◽  
pp. 1934578X2094466
Author(s):  
Yutong Han ◽  
Xingyu Li ◽  
Chaonan Yuan ◽  
Ronghui Gu ◽  
Edward J. Kennelly ◽  
...  
Keyword(s):  
Data Analysis ◽  
Spectroscopic Data ◽  
Protocatechuic Acid ◽  
Methanol Extract ◽  
Chemical Constituents ◽  
Phytochemical Investigation

The phytochemical investigation of the methanol extract of bark of Garcinia oblongifolia yielded a new xanthone derivative 1,3,8-trihydroxy-6’,6’-dimethylpyrano (2’,3’:5,6) xanthone (5) along with 8 known compounds, including 1,2,5-trihydroxy-6-methoxyxanthone (1), 1,3,6,7-tetrahydroxy-2,5-bis (3-methylbut-2-enyl) xanthen-9-one (2), xanthone V1 (3), isojacareubin (4), methyl protocatechuate (6), isoxanthochymol (7), euxanthone (8), and protocatechuic acid (9). The structures of these compounds were verified based on extensive spectroscopic data analysis as well as comparison with the literature data.

Chemical constituents from Penianthus camerounensis Dekker (Menispermaceae)

2019 ◽  
Vol 74 (10) ◽  
pp. 703-708 ◽  
Author(s):  
Georges Bellier Tabekoueng ◽  
Carine Mvot Akak ◽  
Moses K. Langat ◽  
Anatole Guy Blaise Azebaze ◽  
Alain François Kamdem Waffo ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Chemical Analysis ◽  
Betulinic Acid ◽  
Chemical Constituents ◽  
2D Nmr ◽  
2D Nmr Spectroscopy ◽  
Phytochemical Study ◽  
Chemical Structures ◽  
First Time

AbstractThe phytochemical study of the roots, leaves and twigs of Penianthus camerounensis Dekker (Menispermaceae) has led to the isolation and the characterization of 20 compounds. A ceramide, camerounamide (1), and a furoclerodanediterpenoid, camerounin (2), have not been described previously, while the compounds xylopic acid (3), syringaresinol (4), iso-propylmethylcyclohexa-1,4-diol (5), 1-(28-hydroxyoctacosanoyl)glycerol (6), scoparone (7), friedelin (8), friedelanol (9) and betulinic acid (10) are being reported for the first time from the genus Penianthus alongside 10 known compounds (11–20). Chemical structures were determined using 1D- and 2D-NMR spectroscopy, MS and chemical analysis. Their chemotaxonomic importance is discussed.

scholarly journals Chemical Constituents from Fadogia homblei De Wild (Rubiaceae)

2013 ◽  
Vol 14 ◽  
pp. 116-124 ◽  
Author(s):  
Abdelhafeez M.A. Mohammed ◽  
Philip H. Coombes ◽  
Neil R. Crouch ◽  
Dulcie A. Mulholland
Keyword(s):  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Betulinic Acid ◽  
Chemical Constituents ◽  
First Report ◽  
Plant Source ◽  
Lupane Triterpenoids ◽  
Coumarin 7

The total of fourteen known compounds was isolated from the fruits, leaf and stem of Fadogia homblei De Wild. (Rubiaceae) and identified as: a coumarin, 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one (scopoletin) 1, two flavones; 3′,4′,5,7-tetrahydroxyflavone (luteolin) 2 and quercetin-3-O-β-D-galactoside 3, four lupane triterpenoids; lupeol 4, betulinic acid 5, 3β-dodecanoyllup-20(29)-en-28-al 6, lup-20(29)-en-3β-ylhexadecanoate 7, and two steroids; sitosterol 8, stigmasterol 9, a lignan 4,4′-dihydroxy-3,3′-dimethoxy-7,9′:7′,9-diepoxylignan ((-)-pinoresinol) 10, a phaeophytin A 11, an uracil 12, an oleanolic acid 13, and an ursolic acid 14. To our best knowledge, this is the first report for isolation of these compounds from this species. This finding is nevertheless significant as it is the first report of uracil from a plant source other than from various species of ferns.

Platelet Aggregation in Rats in Relation to Hyperuricaemia Induced by Dietary Single-Cell Protein and to Protein Deficiency

1978 ◽  
Vol 39 (02) ◽  
pp. 346-359 ◽  
Author(s):  
P D Winocour ◽  
M R Turner ◽  
T G Taylor ◽  
K A Munday
Keyword(s):  
Uric Acid ◽  
Platelet Count ◽  
Platelet Aggregation ◽  
Time Lag ◽  
Blood Platelet ◽  
Single Cell Protein ◽  
Cell Protein ◽  
Low Protein ◽  
Blood Platelet Count ◽  
Rat Platelets

SummaryA major limitation to single-cell protein (SCP) as a human food is its high nucleic acid content, the purine moiety of which is metabolised to uric acid. Rats given a Fusarium mould as a source of SCP in diets containing oxonate, a uricase inhibitor, showed elevated plasma and kidney uric acid concentrations after 21 d, which were related to the level of dietary mould. ADP-induced and thrombin-induced platelet aggregation was greater in the hyperuricaemic rats than in controls and a progressive increase in aggregation with increasing levels of dietary mould was observed. Furthermore a time-lag, exceeding the life-span of rat platelets, was observed between the development of hyperuricaemia and the increase in aggregation. A similar time-lag was observed between the lowering of the hyperuricaemia and the reduction of platelet aggregation when oxonate was removed from the diet.If human platelets react to uric acid in the same manner as rat platelets this might explain the link that has been suggested between hyperuricaemia and ischaemic heart disease. In that event diets high in nucleic acids might be contra-indicated in people at risk from ischaemic heart disease.In rats given a low protein diet (50 g casein/kg) for 21 d ADP-induced and thrombin-induced platelet aggregation and whole blood platelet count were reduced compared with control animals receiving 200 g casein/kg diet but not in rats given 90 or 130 g casein/kg diet. A study of the time course on this effect indicated that the reduction both in aggregation tendency and in whole blood platelet count occurred after 4 d of feeding the low protein diet. These values were further reduced with time.

Ticlopidine and Clopidogrel (SR 25990C) Selectively Neutralize ADP Inhibition of PGE1-Activated Platelet Adenylate Cyclase in Rats and Rabbits

1991 ◽  
Vol 65 (02) ◽  
pp. 186-190 ◽  
Author(s):  
G Defreyn ◽  
C Gachet ◽  
P Savi ◽  
F Driot ◽  
J P Cazenave ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Adenylate Cyclase ◽  
Direct Effect ◽  
Cyclic Nucleotide ◽  
Camp Accumulation ◽  
Rabbit Platelets ◽  
Camp Levels ◽  
Kinetics Of ◽  
Camp Elevation ◽  
Rat Platelets

SummaryTiclopidine and its potent analogue, clopidogrel, are powerful inhibitors of ADP-induced platelet aggregation. In order to improve the understanding of this ADP-selectivity, we studied the effect of these compounds on PGE1-stimulated adenylate cyclase and on the inhibition of this enzyme by ADP, epinephrine and thrombin. Neither drug changed the basal cAMP levels nor the kinetics of cAMP accumulation upon PGEj-stimulation in rat or rabbit platelets, which excludes any direct effect on adenylate cyclase or on cyclic nucleotide phosphodiesterase. However, the drop in cAMP levels observed after addition of ADP to PGEr stimulated control platelets was inhibited in platelets from treated animals. In contrast, the drop in cAMP levels produced by epinephrine was not prevented by either drug in rabbit platelets. In rat platelets, thrombin inhibited the PGEX-induced cAMP elevation but this effect seems to be entirely mediated by the released ADP. Under these conditions, it was not surprising to find that clopidogrel also potently inhibited that effect of thrombin on platelet adenylate cyclase. In conclusion, ticlopidine and clopidogrel selectively neutralize the ADP inhibition of PGEr activated platelet adenylate cyclase in rats and rabbits.

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