A New Azafluorenone from the Roots of Polyalthia cerasoides and its Biological Activity
2010 ◽
Vol 5
(12)
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pp. 1934578X1000501
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Keyword(s):
Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50 values in the range of 2.64-3.58 μg.mL−1 for A549, GLC4 and GLC4/Adr cells, but was not recognized by ABCC1/MRP1 protein. The compound also showed very strong inhibition of M. tuberculosis using a broth microdilution method, with an MIC value of 0.78 μg.mL−1, which was equal to that of ofloxacin, one of the four antibiotic drugs used as a positive control.
2016 ◽
Vol 7
(1)
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pp. 11
2008 ◽
Vol 63
(1-2)
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pp. 21-28
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2000 ◽
Vol 95
(1)
◽
pp. 127-129
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2006 ◽
Vol 50
(12)
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pp. 4027-4029
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2021 ◽
2000 ◽
Vol 44
(10)
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pp. 2752-2758
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