Secondary Metabolites from the Fungus Emericella Nidulans
A new polyketide derivative koninginin H (1), has been isolated from the fungus Emericella nidulans, together with koninginin E (2), koninginin A (3), trichodermatide B (4), citrantifidiol (5), (4 S,5 R)-4-hydroxy-5-methylfuran-2-one (6), the glycerol derivatives gingerglycolipid B (7), (2 S)-bis[9 Z,12 Z]-1- O, 2- O-dilinoleoyl-3- O-[α-D-galactopyranosyl-(1″→6′)β-D-galactopyranosyl]glycerol (8), (2 S)-bis[9 Z,12 Z]-1- O, 2- O-dilinoleoyl-3- O-β-D-galactopyranosylglycerol (9), the cerebroside flavuside B (10), and the known sterols β-sitosterol glucoside and ergosta-5,7,22-trien-3-ol. Their structures were established by extensive NMR studies (1H NMR, 13C NMR, DEPT, 1H–1H COSY, HSQC, HMBC) and mass spectrometry. The antibacterial, antimalarial, antifungal and antileishmanial activities of compounds 1–10 were examined and the results indicated that compound 4 showed good antifungal activity against Cryptococcus neoformans with an IC50 value of 4.9 μg/mL.