scholarly journals Beauvericin K, a New Antifungal Beauvericin Analogue from a Marine-derived Fusarium sp

2016 ◽  
Vol 11 (12) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Xiuli Xu ◽  
Shujiang Zhao ◽  
Ying Yu ◽  
Zhengkun Chen ◽  
Huihui Shen ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Spectroscopic Analysis ◽  
2D Nmr ◽  
Chemical Investigation ◽  
Significant Activity ◽  
Fusarium Sp ◽  
Nmr Methods

Chemical investigation of a Chinese collection of a marine-derived fungus, Fusarium sp., led to the characterization of beauvericin K, a new analogue of beauvericin. The structure of the new compound was elucidated by detailed spectroscopic analysis, including 1D and 2D NMR methods, and HRMS. Beauvericin K showed significant activity against the yeast Candida albicans with an IC50 value of 6.25 μg/mL.

Antifungal and allelopathic activities of sesquiterpenes from Solidago canadensis

2021 ◽  
Vol 25 ◽  
Author(s):  
Na Liu ◽  
Meina Song ◽  
Yulin Sun ◽  
Fengying Yang ◽  
Haina Yu ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Seed Germination ◽  
Invasive Plant ◽  
2D Nmr ◽  
Solidago Canadensis ◽  
Significant Activity ◽  
Inhibitory Effects ◽  
Ic50 Values ◽  
Allelopathic Effects

: One new eudesmane sesquiterpene (1) and one new chromolaevane sesquiterpene (2), along with 19 known compounds, have been isolated from the invasive plant Solidago canadensis. Their structures were established by spectroscopic means including 1D/2D-NMR and HR-ESIMS analyses. Compounds 10 and 12, in combination with fluconazole, showed significant activity in an in vitro synergistic antifungal assay against Candida albicans, with FIC values of <0.15625 and <0.28125, respectively. Meanwhile, the allelopathic effects of these sesquiterpenes on Arabidopsis seed germination were also tested. Compounds 5, 7, 17 and 18 retarded the seed germination of Arabidopsis with IC50 values ranging from 9.1 to 41 μg/mL, while other compounds showed no obvious inhibitory effects.

Glucosides from the Fresh Flowers of Juglans regia L. and Their Biological Evaluation

2019 ◽  
Vol 17 (1) ◽  
pp. 31-35
Author(s):  
Haibo Wang ◽  
Xikui Liu
Keyword(s):  
Spectroscopic Analysis ◽  
Juglans Regia ◽  
2D Nmr ◽  
Antibacterial Activities ◽  
Biological Evaluation ◽  
Chemical Investigation ◽  
Etoac Extract

The chemical investigation of the EtOAc extract of the fresh flowers of Juglans regia L. resulted in a new &#945;-tetralonyl glucoside (1) and two known glucosides (2-3). The structure of the new compound was determined by extensive 1D and 2D NMR spectroscopic analysis and HRESIMS. The biological evaluation of the obtained glucosides showed that compound 1 and 3 displayed good antioxidant and antibacterial activities. These two compounds were identified as the main functional molecules in the fresh flowers of Juglans regia L.

Acylated flavonol diglucosides from Ammania auriculata

2015 ◽  
Vol 70 (1-2) ◽  
pp. 39-43 ◽  
Author(s):  
Mahmoud Nawwar ◽  
Nahla Ayoub ◽  
Mohamed El-Raey ◽  
Soumaya Zaghloul ◽  
Amani Hashem ◽  
...  
Keyword(s):  
Spectroscopic Analysis ◽  
2D Nmr ◽  
Chemical Investigation ◽  
Conventional Methods

Abstract Chemical investigation of the extract of the whole Ammania auriculata plant resulted in the identification of 13 polyphenols, including the hitherto unknown flavonoids, kaempferol 3-O-β-(6″-galloylglucopyranoside)-7-O-β-glucopyranoside, and its quercetin analogue. The structures of all isolates were elucidated by conventional methods, spectroscopic analysis, including 1D and 2D NMR, and by HRESI-MS as well.

Chemical constituents of two Ecuadorian medicinal plants, Tagetes terniflora Kunth and Croton rivinifolius Kunth

2021 ◽  
Author(s):  
Alírica I Suárez ◽  
Vladimir Morocho ◽  
Vladimir Luna ◽  
Katty Castillo ◽  
Chabaco Armijos
Keyword(s):  
Medicinal Plants ◽  
Spectroscopic Analysis ◽  
Chemical Constituents ◽  
Two Dimensional ◽  
Phytochemical Study ◽  
Isolation And Characterization ◽  
Organic Extracts ◽  
Medicinal Properties ◽  
Nmr Methods

Phytochemical study of two medicinal plants from Ecuador, Tagetes terniflora Kunth, and Croton rivinifolius Kunth, led to the isolation and characterization of the major constituents present in the organic extracts obtained from these plants: 5-(4-acetoxy-1-butynil)-2,2’-bi-thiophene (1), 5-methyl-2,2’:5’,2”- terthiophene (2), patuletin (3) from Tagetes terniflora, and isocorydine (4), sweroside (5), tiliroside (6) from Croton rivinifolius. The structures of these compounds were established by spectroscopic analysis including two-dimensional NMR methods, MS, and comparison with published spectral data. They are recognized as secondary metabolites that represent the chemotaxonomy of Tagetes and Croton genera and could be responsible for the recognized medicinal properties attributed to these species. This paper deals with the first report that shows the presence of these compounds in these plants.

Characterization of the capsular antigen of Streptococcus pneumoniae serotype 35B

1995 ◽  
Vol 73 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Linda M. Beynon ◽  
James C. Richards ◽  
Malcolm B. Perry ◽  
Peter J. Kniskern
Keyword(s):  
2D Nmr ◽  
Mass Spectrometric ◽  
High Molecular Weight Polymer ◽  
Molecular Weight Polymer ◽  
Capsular Antigen ◽  
Phosphate Diester ◽  
Structure Formula ◽  
Chemical Techniques ◽  
Nmr Methods

The specific capsular antigen of Streptococcuspneumoniae serotype 35B was shown by a combination of 2D NMR methods and mass spectrometric and classical carbohydrate chemical techniques to be a high molecular weight polymer containing D-galactose, D-glucose, 2-acetamido-2-deoxy-D-galactose, and ribitol (2:1:1:1). The pentasaccharide repeating unit is polymerized through phosphate diester linkages to give the structure,[Formula: see text]Seventy percent of the β-D-Galf residues glycosidically linked to the ribitol units carry an O-acetyl substituent. Keywords: Streptococcuspneumoniae, capsular antigen, polysaccharide structure.

scholarly journals Sesquiterpene Lactones, Acyl Phenyl Propanoids and Other Constituents from Schkuhria pinnata var. wislizeni. Antioxidant Evaluation

2019 ◽  
Vol 53 (3) ◽  
Author(s):  
Alejandra León ◽  
Blanca M. Reyes ◽  
María Isabel Chávez ◽  
Rubén A. Toscano ◽  
Guillermo Delgado
Keyword(s):  
Antioxidant Activity ◽  
Spectroscopic Analysis ◽  
Sesquiterpene Lactones ◽  
Diels Alder ◽  
Chemical Investigation ◽  
Biological Assays ◽  
Aerial Parts ◽  
Antioxidant Evaluation ◽  
Alder Adduct

Chemical investigation of aerial parts of Schkuhria pinnata var wislizeni (Asteraceae) allowed the characterization of the sesquiterpene lactones 1, 2 and 5, the flavonoids 3 and 4, and the acyl phenyl propanoids 10 and 11. Structure 2, named dischkuhriolin, was confirmed as a Diels Alder adduct of 1 as dienophile and a guaianolide as diene. Spectroscopic analysis of 5 and its diacetyl derivative allowed the structural correction of compounds previously reported from Schkuhria. 2, 10 and 11 are new natural compounds. Biological assays indicated that the mixture 10 + 11 showed antioxidant activity expressed as inhibition of AAPH-induced damage in rat pancreatic homogenate.

scholarly journals Novel Substituted Thiophenes and Sulf-Polyacetylene Ester from Echinops ritro L.

Molecules ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 805 ◽  
Author(s):  
Liang-Bo Li ◽  
Guang-Da Xiao ◽  
Wei Xiang ◽  
Xing Yang ◽  
Ke-Xin Cao ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Candida Albicans ◽  
Spectroscopic Analysis ◽  
Inhibitory Concentration ◽  
2D Nmr ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Whole Plant

Three new substituted bithiophenes (1–3), and one new sulf-polyacetylene ester, ritroyne A (16) were isolated from the whole plant of Echinops ritro together with twelve known substituted thiophenes. The structures were elucidated on the basis of extensive spectroscopic analysis including 1D and 2D NMR as well as MS. Furthermore, the absolute configuration of ritroyne A (16) was established by computational methods. In bioscreening experiments, four compounds (2, 4, 12, 14) showed similar antibacterial activity against Staphylococcus aureus ATCC 2592 with levofloxacin (8 µg/mL). Five compounds (2, 4, 9, 12, 14) exhibited antibacterial activities against Escherichia coli ATCC 25922, with minimum inhibitory concentration (MIC) values of 32–64 µg/mL. Three compounds (2, 4, 12) exhibited antifungal activities against Candida albicans ATCC 2002 with MIC values of 32–64 µg/mL. However, compound 16 did not exhibit antimicrobial activities against three microorganisms.

Chemical constituents of the leaves of Campylospermum elongatum

2017 ◽  
Vol 72 (1-2) ◽  
pp. 71-75 ◽  
Author(s):  
Savio S. Elo-Manga ◽  
Anastasie E. Tih ◽  
Raphael T. Ghogomu ◽  
Alain Blond ◽  
Bernard Bodo
Keyword(s):  
Spectroscopic Data ◽  
Spectroscopic Analysis ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Flavone Glycoside ◽  
First Report

AbstractThe leaves ofCampylospermum elongatumhave furnished the cyano-glycoside (lithospermoside), nine isomeric biflavonoid derivatives among which five are I3–II6linked (robustaflavone; 4′-O-methyl robustaflavone; 4′,4″′-di-O-methyl robustaflavone; 7,4′,4″-tri-O-methyl robustaflavone; 4′,7″-di-O-methyl robustaflavone) and four I3–II8linked (amentoflavone; 7-O-methyl amentoflavone; 7,7″-di-O-methyl amentoflavone; 7, 4′,7″-tri-O-methyl amentoflavone) and a flavone glycoside, 4″-O-methyl-7-O-β-d-galactosylapigenin. All structures were established from a complete spectroscopic analysis (MS, IR, 1D, and 2D NMR, including HSQC, HMBC, and NOESY) as well as by comparing the obtained spectroscopic data with literature. This is the first report on the characterization of 4′-O-methyl-7-O-β-d-galactosylapigenin from the genuscampylospermumand thus has important chemotaxonomic implications.

Characterization of Chemical Impurities in Glutaraldehyde

1975 ◽  
Vol 33 ◽  
pp. 620-621
Author(s):  
B. J. Grenon ◽  
A. J. Tousimis
Keyword(s):  
Glutaric Acid ◽  
Spectroscopic Analysis ◽  
Aldol Condensation ◽  
Condensation Product ◽  
Amorphous Solid ◽  
Water Soluble ◽  
Impurity Component ◽  
Chemical Impurities ◽  
Soluble Liquid

Ever since the introduction of glutaraldehyde as a fixative in electron microscopy of biological specimens, the identification of impurities and consequently their effects on biologic ultrastructure have been under investigation. Several reports postulate that the impurities of glutaraldehyde, used as a fixative, are glutaric acid, glutaraldehyde polymer, acrolein and glutaraldoxime.Analysis of commercially available biological or technical grade glutaraldehyde revealed two major impurity components, none of which has been reported. The first compound is a colorless, water-soluble liquid with a boiling point of 42°C at 16 mm. Utilizing Nuclear Magnetic Resonance (NMR) spectroscopic analysis, this compound has been identified to be — dihydro-2-ethoxy 2H-pyran. This impurity component of the glutaraldehyde biological or technical grades has an UV absorption peak at 235nm. The second compound is a white amorphous solid which is insoluble in water and has a melting point of 80-82°C. Initial chemical analysis indicates that this compound is an aldol condensation product(s) of glutaraldehyde.

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