scholarly journals Differential Contribution of the Medial and the Lateral Side of the Joint to Symptoms in Knee Osteoarthritis: A Radiographic and Laboratory Analysis in the Nagahama Study

Cartilage ◽  
2021 ◽  
pp. 194760352110258
Author(s):  
Kazuya Nigoro ◽  
Hiromu Ito ◽  
Tomotoshi Kawata ◽  
Shinichiro Ishie ◽  
Yugo Morita ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Clinical Outcomes ◽  
Knee Pain ◽  
High Sensitivity ◽  
Analysis Of Covariance ◽  
Radiographic Evaluation ◽  
Radiographic Feature ◽  
Lateral Side ◽  
Cross Sectional ◽  
Medial Side

Objective: This cross-sectional study aimed to explore the differences of the medial and lateral sides of the knee joint and precise radiographic abnormalities in contribution to the knee pain and clinical outcomes. Design: Participants 60 years or older who underwent radiographic evaluation were included. Knee radiography was assessed using grading systems of the Osteoarthritis Research Society International (OARSI) atlas. The Japanese Knee Osteoarthritis Measure (JKOM) was evaluated as clinical outcomes. Serum high-sensitivity C-reactive protein (hsCRP) was used to evaluate systemic inflammation. We divided the participants into normal, medial-, lateral-, and medial & lateral-OA types and compared their JKOM using an analysis of covariance. Furthermore, we analyzed the relationship between the knee pain and stiffness of JKOM and the grading of each radiographic feature using a multiple regression model. Results: Lateral- and medial & lateral-OA groups had a significantly worse symptoms in the total and the pain score, especially in movement subscales, in JKOM score. Lateral-OA groups had higher hsCRP than medial-OA group. Multivariate analysis showed that medial joint space narrowing (JSN), and lateral femoral and tibial osteophytes significantly affected knee pain (adjusted odds ratios: 1.73, 1.28, and 1.55, respectively). The radiographic changes are associated with pain more in JSN in the medial side and osteophytes in the lateral side. Conclusion: Lateral- and medial & lateral-OA groups showed worth symptom. In addition, medial JSN and lateral osteophytes have potent effects on the knee pain.

scholarly journals Reliability of a Proposed Ultrasonographic Grading Scale for Severity of Primary Knee Osteoarthritis

2016 ◽  
Vol 9 ◽  
pp. CMAMD.S38141 ◽  
Author(s):  
Mohamed Mortada ◽  
Ayman Zeid ◽  
Mirvat Abd El-hamid Al-Toukhy ◽  
Nillie Ezzeldin ◽  
M. Elgawish
Keyword(s):  
Knee Osteoarthritis ◽  
Knee Pain ◽  
High Sensitivity ◽  
Conventional Radiography ◽  
Cross Sectional ◽  
American College Of Rheumatology ◽  
Acr Criteria ◽  
Grading Scale ◽  
Joint Examination ◽  
Ultrasonographic Assessment

Objectives The objective of this study was to examine the concordance of a grading scale (0–4) of medial femoral osteophytes in knee joint detected by ultrasound (US) compared with the corresponding grades (0–4) of Kellgren–Lawrence (K&L) scale of conventional radiography and clinical joint examination. Patients and Methods A cross-sectional observational study included 160 patients with knee pain who fulfilled the American College of Rheumatology (ACR) criteria for knee osteoarthritis (KOA) and 20 patients with knee pain who have not fulfilled the ACR criteria for KOA. All patients were subjected to clinical assessment (Western Ontario and McMaster Universities Index of Osteoarthritis and global visual analog scale) and radiological assessment in the form of X-ray grading according to K&L grading scale and ultrasonographic assessment of medial femoral osteophytes according to a scale that was proposed by the first author and consisted of five grades (0–4), where grade 0 denoted no osteoarthritis and grade 4 denoted the most advanced grade of KOA. Grade 2 was divided into two subgrades A and B with grade 2B considered as a more advanced stage than grade 2A. Results The proposed US grading scale had high sensitivity and specificity in detecting the different grades of KOA compared with K&L grading scale (a total sensitivity of 94.6% and a total specificity of 93.3%). Intra- and interreader reliability of US was excellent (kappa >0.93 and >0.85, respectively). Conclusions US can reliably detect the severity of KOA. Good agreement was found between the proposed US grading scale and K&L grading scale. The proposed US grading scale is simple and reliable.

scholarly journals Digital Radiographic Assessment of Knee Joint Space with its Clinical Significances

2020 ◽  
Vol 5 (1) ◽  
pp. 976-980
Author(s):  
Dil Islam `Mansur ◽  
Subindra Karki ◽  
Dilip Kumar Mehta ◽  
Pragya Shrestha ◽  
Sunima Maskey
Keyword(s):  
Knee Joint ◽  
Joint Space Width ◽  
Joint Space ◽  
Left Knee ◽  
Lateral Side ◽  
Cross Sectional ◽  
Mean Values ◽  
Medial Side ◽  
Digital Radiograph ◽  
The Right

Introduction: The knee joint space is seen on anteroposterior radiograph as a radiolucent area between lower end of femur and upper end of tibia which is an indirect way of evaluating the knee cartilage thickness.  Objective: This study was aimed to determine the knee joint space in the medial and lateral compartments of the knee joint using digital radiograph.  Methodology : This was cross-sectional study. It consisted of digital radiographs of knee joint of 320 individuals. The medial and lateral joint space width of each knee joint was measured using the scale in the computerized software.  Results: The mean values for medial and lateral joint space widths were found to be 6.11±1.57 mm and 7.92±1.66 mm of the right knee joint respectively and 5.99±1.47 mm and 8.18±1.69 mm of the left knee joint respectively. In males, mean values for joint space widths were 6.37±1.58 mm on medial side and 8.21±1.67 mm on lateral side of the right knee; and 6.24±1.56 mm on medial side and 8.33±1.64 mm on lateral side of the left knee. In Females, these values were 5.89±1.53 mm on medial side and 7.66±1.62 mm on lateral side of the right knee; and 5.79±1.37 mm on medial side and 8.06±1.72 mm on lateral side of the left knee.  Conclusions: It was concluded that the lateral joint space was greater than the medial joint space in both knees. The joint space widths were found to be reasonably constant with increasing age among studied population.

scholarly journals Association of bilateral flat feet with knee pain and disability in patients with knee osteoarthritis: A cross-sectional study

2017 ◽  
Vol 35 (11) ◽  
pp. 2490-2498 ◽  
Author(s):  
Hirotaka Iijima ◽  
Hiroshi Ohi ◽  
Takuya Isho ◽  
Tomoki Aoyama ◽  
Naoto Fukutani ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Flat Feet

scholarly journals The effect of rehabilitation protocol using mobile health in overweight and obese patients with knee osteoarthritis: a clinical trial

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Muhammad Tariq Rafiq ◽  
Mohamad Shariff Abdul Hamid ◽  
Eliza Hafiz
Keyword(s):  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Mobile Health ◽  
Functional Activity ◽  
Analysis Of Covariance ◽  
Secondary Outcome ◽  
Patient Specific ◽  
Control Group ◽  
Rehabilitation Protocol ◽  
To Receive

Abstract Objective The objective of this randomized controlled trial (RCT) was to investigate the effectiveness of the lower limb rehabilitation protocol (LLRP) combined with mobile health (mHealth) applications on knee pain, mobility, functional activity and activities of daily living (ADL) among knee osteoarthritis (OA) patients who were overweight and obese. Methods This study was a single-blind, RCT conducted at Teaching Bay of Rehmatul-Lil-Alameen Post Graduate Institute of Cardiology between February and November 2020. 114 knee OA patients who were overweight and obese were randomly divided by a computer-generated number into the rehabilitation group with mHealth (RGw-mHealth) to receive LLRP + instructions of daily care (IDC) combined with mHealth intervention, rehabilitation group without mHealth (RGwo-mHealth) to receive LLRP + IDC intervention and control group (CG) to receive IDC intervention. All three groups were also provided leaflets explaining about their intervention. The primary outcome measure was knee pain measured by the Western Ontario and McMaster Universities Osteoarthritis Index score. The secondary outcome measures were mobility measured by the Timed up and go (TUG) test, functional activity measured by the patient-specific functional scale (PSFS), and ADL measured by the Katz Index of independence in ADL scores. Results Among the 114 patients who were randomized (mean age, 53 years), 96 (84%) completed the trial. After 3-months of intervention, patients in all three groups had statistically significant knee pain reduction (RGw-mHealth: 2.54; RGwo-mHealth: 1.47; and CG: 0.37) within groups (P < 0.05). Furthermore, patients in the RGw-mHealth and RGwo-mHealth had statistically significant improvement in mobility, functional activity, and ADL within groups (P < 0.05), but no improvement was noted in the CG (p > 0.05). As indicated in the overall analysis of covariance, there were statistically significant differences in the mean knee pain, mobility, functional activity, and ADL changes between groups after 3-months (p < 0.001). The pairwise between-group comparisons (Bonferroni post hoc analysis) of the knee pain, mobility, functional activity, and ADL scores at 3-months revealed that patients in the RGw-mHealth had significantly higher mean change in the knee pain, TUG test, functional activity, and ADL scores compared to patients in the RGwo-mHealth or CG. Conclusion Reduction in knee pain, improvement in mobility, functional activity, and ADL were more among patients in the RGw-mHealth compared with the RGwo-mHealth or CG. Trial registration National Medical Research Registry: NMRR-20-1094-52911. Date of registration: 05–05-2020. URL: https://www.nmrr.gov.my.

scholarly journals Prevalence of knee pain, radiographic osteoarthritis and arthroplasty in retired professional footballers compared with men in the general population: a cross-sectional study

2017 ◽  
Vol 52 (10) ◽  
pp. 678-683 ◽  
Author(s):  
Gwen Sascha Fernandes ◽  
Sanjay Mukund Parekh ◽  
Jonathan Moses ◽  
Colin Fuller ◽  
Brigitte Scammell ◽  
...  
Keyword(s):  
Risk Factors ◽  
General Population ◽  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Knee Injury ◽  
Comparison Group ◽  
Line Drawing ◽  
Marginal Model ◽  
Cross Sectional ◽  
Adjusted Risk

ObjectivesTo determine the prevalence of knee pain, radiographic knee osteoarthritis (RKOA), total knee replacement (TKR) and associated risk factors in male ex-professional footballers compared with men in the general population (comparison group).Methods1207 male ex-footballers and 4085 men in the general population in the UK were assessed by postal questionnaire. Current knee pain was defined as pain in or around the knees on most days of the previous month. Presence and severity of RKOA were assessed on standardised radiographs using the Nottingham Line Drawing Atlas (NLDA) in a subsample of 470 ex-footballers and 491 men in the comparison group. The adjusted risk ratio (aRR) and adjusted risk difference (aRD) with 95% CI in ex-footballers compared with the general population were calculated using the marginal model in Stata.ResultsEx-footballers were more likely than the comparison group to have current knee pain (aRR 1.91, 95% CI 1.77 to 2.06), RKOA (aRR 2.21, 95% CI 1.92 to 2.54) and TKR (aRR 3.61, 95% CI 2.90 to 4.50). Ex-footballers were also more likely to present with chondrocalcinosis (aRR 3.41, 95% CI 2.44 to 4.77). Prevalence of knee pain and RKOA were higher in ex-footballers at all ages. However, even after adjustment for significant knee injury and other risk factors, there was more than a doubling of risk of these outcomes in footballers.ConclusionsThe prevalence of all knee osteoarthritis outcomes (knee pain, RKOA and TKR) were two to three times higher in male ex-footballers compared with men in the general population group. Knee injury is the main attributable risk factor. Even after adjustment for recognised risk factors, knee osteoarthritis appear to be an occupational hazard of professional football.

scholarly journals Obesity with radiological changes or depression was associated with worse knee outcome in general population: a cluster analysis in the Nagahama study

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Kazuya Nigoro ◽  
◽  
Hiromu Ito ◽  
Tomotoshi Kawata ◽  
Kohei Nishitani ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
General Population ◽  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Radiographic Evaluation ◽  
Mineral Density ◽  
Factors Affecting ◽  
Radiological Changes ◽  
Hs Crp ◽  
Radiological Grade

Abstract Background In knee osteoarthritis (OA), pain is the most frequent and dominant symptom. However, which factors other than radiological changes contribute to the symptoms is unresolved. The aims of this study were to identify factors affecting knee pain from various variables with radiological changes taken into count and exploratively examine what subgroups or phenotype could be identified by cluster analysis using the identified knee pain factors. Methods Patients 60 years or older who underwent radiographic evaluation were included in this cross-sectional study, and those subjects who completed a questionnaire about knee symptoms without missing data were eligible for analysis. Multiple regression analysis was used to examine the associations between selected variables and The Japanese Knee Osteoarthritis Measure (JKOM) pain score. We grouped the subjects by cluster analysis using identified variables. Results Two thousand five hundred forty-two subjects were included in the full set of analyses. Age, body mass index (BMI), radiological grade, bone mineral density (BMD), and high-sensitivity C-reactive protein (hs-CRP) showed a statistically significant correlation with radiological showing the strongest value. For dichotomous variable, presence of depression showed a statistically significant result. We used BMI, radiological grade, BMD, hs-CRP, and presence of depression as a variable for cluster analysis and identified six subgroups: (1) minimal joint disease subgroup, (2) male and high BMD subgroup, (3) high CRP subgroup, (4) severe radiological OA subgroup, (5) depressive subgroup, and (6) moderate radiological OA with high BMI subgroup, showing the worst knee outcome. Conclusion This study identified the factors affecting knee pain other than radiological changes and identified six subgroups of knee outcome in the general population. The results showed that obesity with radiological changes or depression was associated with worse knee outcome.

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