Interim Assessment of Vitamin D Sufficiency in a Prospective Cohort of Late Postmenopausal Women

Objective: to assess vitamin D repletion in prospective cohort of late postmenopausal women and to establish the contribution of vitamin D deficiency and measures for its prevention to physical functioning of women. Material and methods. 107 postmenopausal Middle Urals region residents were recruited to a prospective cohort nested cross-sectional study. The data were obtained from 2016 to 2019. Results. According to the concentration level of 25(OH)D, an adequate level was detected in 24 patients (22.4%), insufficiency in 35 (32.7%), deficiency in 48 cases (44.8%). No significant seasonal differences in vitamin D levels were found. Patients significantly differed in age, according to the wrist dynamometry of dominant hand and according to results of tandem test. By the inclusion visit, 89 patients (83.1%) were not receiving vitamin D supplementation, 18 persons (16.8%) were compliant to cholecalciferol prophylactic doses consumption, had significantly higher values of 25(OH)D in the blood. Vitamin D deficiency and insufficiency in the group not receiving cholecalciferol were significantly more common than in the group who followed the recommendations. Conclusion. Deficiency and insufficiency of vitamin D are detected with high frequency in the residents of the Middle Urals in late postmenopause. Prophylactic administration of cholecalciferol did not achieve optimal concentration of vitamin D, but contributed to its higher values. Women who were optimally provided with vitamin D had significantly better physical functioning.

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Association Of Vitamin D Deficiency And Pelvic Organ Prolapse In Postmenopausal Women: A Cross-Sectional Study

10.21203/rs.3.rs-574096/v1 ◽

2021 ◽

Author(s):

Mateja Legan ◽

Matija Barbič ◽

Josko Osredkar ◽

Mija Blaganje

Keyword(s):

Vitamin D ◽

Pelvic Organ Prolapse ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

Test Group ◽

Pelvic Organ ◽

Cross Sectional ◽

Vaginal Deliveries ◽

Vitamin D Levels ◽

25 Oh Vitamin D

Abstract Background: Vitamin D is vital for skeletal integrity as well as optimal muscle work. High incidence and prevalence of vitamin D deficiency as well as pelvic organe prolapse are found in postmenopausal women, thus raising the question of whether the entities could be related.Methods: We compared 50 postmenopausal women with pelvic organ prolapse (POP) with 48 age- and weight-matched controls. The clinical assessment of the disorder was performed using the Pelvic Organ Prolapse Quantification system (POP-Q). A questionnaire was filled out by the participants and a blood sample was collected for 25-OH-vitamin D determination.Results: The two groups did not differ significantly in body mass index, but differed significantly in vitamin D blood level concentrations, those being lower in POP patients. A significantly higher prevalence of vitamin D deficiency (25-OH-vitamin D< 50 nmol/l) was found in the test group compared to controls. Higher parity/vaginal deliveries and less caesarean sections were found in patients than in controls. Conclusions: Vitamin D deficiency might be an important associated systemic factor associated to pelvic organ prolapse. The determination of vitamin D levels in postmenopausal women and replenishing its deficiency might also be of importance for the pelvic floor.

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Correlation of Vitamin D Serum Level of Mothers and Their Newborns

Modern Care Journal ◽

10.5812/modernc.115579 ◽

2021 ◽

Vol 18 (2) ◽

Author(s):

Hassan Boskabadi ◽

Elahe Heidari

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Levels ◽

Cross Sectional Study ◽

Vitamin D Supplementation ◽

High Rate ◽

Cross Sectional ◽

Maternal Vitamin ◽

Premature Newborns ◽

Vitamin D Levels

Background: The possibility of vitamin D deficiency is high among mothers and their premature newborns. Objectives: Due to the high rate of vitamin D deficiency in Iranian women, this study aimed to determine the association between the serum levels of vitamin D in the blood of premature newborns and their mothers in the Iranian population. Methods: This cross-sectional study was conducted on 324 mothers and their 324 newborns with gestational age less than 37 weeks, who were referred to Ghaem Hospital affiliated to Mashhad University of Medical Sciences, Mashhad, Iran, during 2016-2020. After clamping, 1.5 cc blood samples were obtained through the umbilical cord to determine the neonates’ vitamin D levels. Finally, the serum levels of vitamin D were measured, and the correlation between the levels of vitamin D of mothers and their newborns was calculated. Results: The mean vitamin D levels of newborns and mothers were 15.75 ± 11.18 and 20.16 ± 13.41 ng/mL, respectively. Moreover, there was a high correlation between the vitamin D levels of mothers and their newborns (r = 0.672; P < 0.001). Furthermore, a significant correlation was observed between the vitamin D levels of mothers, who used vitamin D supplementation during pregnancy and their neonates’ levels (r = 0.773; P < 0.001). Conclusions: The findings suggest a positive correlation between neonatal and maternal vitamin D levels. Moreover, it seems that maternal vitamin D levels can predict neonatal vitamin D deficiency.

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Prevalence of vitamin D deficiency in various regions of the Russian Federation: results of the first stage of the multicenter cross-sectional randomized study

Osteoporosis and Bone Diseases ◽

10.14341/osteo12701 ◽

2021 ◽

Vol 23 (4) ◽

pp. 4-12

Author(s):

Ekaterina A. Pigarova ◽

Liudmila Y. Rozhinskaya ◽

Nino N. Katamadze ◽

Alexandra A. Povaliaeva ◽

Ekaterina A. Troshina

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Russian Federation ◽

Randomized Study ◽

Vitamin D Supplementation ◽

Vitamin D Status ◽

Anthropometric Parameters ◽

Cross Sectional ◽

Vitamin D Levels ◽

The Russian Federation

Background. A vitamin D deficiency is a global wide health problem. Inadequate vitamin D status leads to serious medical, social and economic consequences and requires timely diagnosis and adequate correction.Aim: to assess the incidence of vitamin D deficiency among the population living in regions of the Russian Federation located at latitudes from 45° to 70° and to study its relationship to various factors (demographic, socio-economic, geographical, etc.).Materials and methods. A multicenter, cross-sectional, randomized study of individuals of both sexes aged 18 to 50 years. The study of 25ОНD level in the blood serum was carried out by INVITRO LLC laboratories using chemilumescent analysis in two stages: in the period from March to May 2020 and from October to November 2020. The first stage of the study involved 500 volunteers (77% women, 23% men). Demographic and socioeconomic characteristics, factors associated with vitamin D levels, were assessed using a specially designed questionnaire.Results. In this article we present the results of the first stage. A countrywide high prevalence of vitamin D deficiency (56.4%) and insufficiency (27.9%) was revealed, that is, 84.3% of the population aged 18–50 years requires cholecalciferol supplementation. The lowest vitamin D status was found in St. Petersburg, Arkhangelsk, Kyzyl and Rostov-on-Don (over 90% of participants had inadequate levels). A decrease in the level of 25ОНD was observed to a greater extent in men than in women (p <0.05), as well as in young people aged 18–25 years (p <0.05). No major association of vitamin D status with anthropometric parameters, the number of days of disability, were not found. However, those who went to tanning beds or were in direct sunlight for at least 30 days a year had higher levels of 25ОНD, and those using sunscreens had lower levels.Conclusion. The data obtained confirms the widespread prevalence of vitamin D deficiency and insufficiency in the country (84.3% of participants), generally not related to the geographical latitude of residence, which indicates the need for vitamin D supplementation in a significant part of the population.

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Evaluating Vitamin D Status in Pre- and Postmenopausal Type 2 Diabetics and Its Association with Glucose Homeostasis

BioMed Research International ◽

10.1155/2018/9369282 ◽

2018 ◽

Vol 2018 ◽

pp. 1-12 ◽

Cited By ~ 13

Author(s):

Linda Ahenkorah Fondjo ◽

Samuel Asamoah Sakyi ◽

William K. B. A. Owiredu ◽

Edwin Ferguson Laing ◽

Eddie-Williams Owiredu ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

Glucose Control ◽

Fasting Blood Glucose ◽

Hypovitaminosis D ◽

Vitamin D Status ◽

Cross Sectional ◽

Vitamin D Levels

Background. Type 2 Diabetes Mellitus (T2DM) and menopause are associated with vitamin D status. Oestrogen decline during menopausal stages promotes hypovitaminosis D. However, the interplay between vitamin D, menopause, lifestyle, and T2DM cannot be overlooked. This study assessed vitamin D status among pre- and postmenopausal T2DM women and determined its association with glycemic control and influence of lifestyle habits on hypovitaminosis D.Methods. This cross-sectional study was conducted at the Komfo Anokye Teaching Hospital, Kumasi, Ghana. Structured questionnaires were administered to 192 T2DM women; blood samples were collected for estimation of 25(OH) D and insulin using ELISA. Fasting blood glucose (FBG), lipid profile, glycated haemoglobin (HbA1c), and calcium were measured. Statistical analyses were performed using Graphpad Prism 6.Results. The prevalence of vitamin D inadequacy was 92.2%. Hypovitaminosis D was more prevalent among the postmenopausal T2DM women (63.8% versus 58.2%). Hypovitaminosis D significantly associated with insulin [R2=0.01760,p=0.0008], HbA1c [R2=0.3709,p=<0.0001], and FBG [R2=0.3465,p=0.0001] in only the postmenopausal women.Conclusion. Vitamin D deficiency is prevalent in pre- and postmenopausal T2DM but higher among postmenopausal women. Adequate vitamin D levels in both groups were associated with improved glucose control while hypovitaminosis D in the postmenopausal women was related to poorer glucose control. Vitamin D screening should be incorporated into management plan for T2DM to serve as an early tool for prevention of vitamin D deficiency.

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Vitamin D deficiency in patients with tuberculosis and its correlation with glycemic status

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20195915 ◽

2019 ◽

Vol 8 (1) ◽

pp. 239

Author(s):

Ritu Karoli ◽

Shobhit Shakya ◽

Prem Shanker Singh

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Vitamin D Supplementation ◽

Glycemic Status ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Patients With Diabetes

Background: Comorbidity of diabetes and tuberculosis has serious health implications. Presence of diabetes at least three times increases the risk of tuberculosis which may be mediated by an abnormal innate immune response due to hyperglycaemia or low vitamin D levels.Aim of the study- Present study was carried out to investigate whether lower serum 25(OH) D might be associated with higher prevalence of pulmonary or extra pulmonary tuberculosis which might provide an evidence for a role of vitamin D in the comorbidity of these two diseases and does it have any correlation with glycemic status.Methods: In a hospital based cross sectional study, 264 patients with newly diagnosed tuberculosis were enrolled and according to glycemic status they were divided into three groups. They were assessed for vitamin D deficiency in addition to routine laboratory and biochemical parameters.Results: The patients with diabetes had significantly lower vitamin D levels. The prevalence of severe vitamin D deficiency was highest in patients who had diabetes with tuberculosis. There was negative correlation between vitamin D levels and Hba1C and extensiveness of pulmonary tuberculosisConclusions: Serum vitamin D levels were significantly lower in tuberculosis patients with pre-diabetes and type 2 diabetes compared with those, who had normal glycemic status. We suggest that there is a need to pay more attention to vitamin D status in this country and if there is coexisting diabetes or impaired glucose intolerance, emphasis on vitamin D supplementation can be of utmost importance.

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Mapping the Association between Vitamin D and Low Back Pain: A Systematic Review and MetaAnalysis of Observational Studies

January 2018 - Pain Physician ◽

10.36076/ppj/2017.7.611 ◽

2017 ◽

Vol 7 (20;7) ◽

pp. 611-640

Author(s):

Joshua Zadro

Keyword(s):

Vitamin D ◽

Low Back Pain ◽

Back Pain ◽

Pain Intensity ◽

Vitamin D Deficiency ◽

Vitamin D Supplementation ◽

Low Back ◽

Cross Sectional ◽

Hydroxyvitamin D ◽

Vitamin D Levels

Background: Low back pain (LBP) is the highest contributor to disability worldwide, with current intervention strategies only providing small to moderate analgesic effects. The use of vitamin D supplementation for LBP has gained interest due to its proposed anti-inflammatory and neuromodulatory properties. However, it is still unclear whether vitamin D levels differ between those with and without LBP or if vitamin D levels are associated with pain intensity. Objectives: We aim to investigate the association between vitamin D levels and LBP and to determine if vitamin D levels correlate with pain intensity in individuals with LBP. Study Design: This study was conducted in accordance with the guidelines for performing a Metaanalysis and Systematic Review Of Observational Studies in Epidemiology (MOOSE). Methods: We performed electronic database searches combined keywords relating to vitamin D and LBP in MEDLINE, CINAHL, EMBASE, AMED, WEB OF SCIENCE, and SCOPUS from the earliest record to March 2017. Studies were included if they reported any quantitative measure of vitamin D, such as serum 25-hydroxyvitamin D [25(OH)D], with adequate data in patients with and without LBP or adequate data on pain intensity in patients with LBP. No restriction on the type or duration of LBP, nor the age and gender of patients was applied. Two reviewers independently performed the selection of studies, extracted data, and assessed the methodological quality of the included studies using a modified 15-item Downs and Black checklist. Results: After the removal of duplicates and the screening of titles and abstracts, 105 full texts were evaluated. There were 29 articles included in this systemic review (22 entered into a meta-analysis), including 19 cross-sectional studies, 9 case-control studies, and one single-arm surgical trial where the pre-operative data were used in our analyses. The pooled results from 19 studies showed that individuals with LBP were more likely to have vitamin D deficiency (pooled OR = 1.60, 95% CI: 1.20 - 2.12, P = 0.001, n = 19), severe deficiency (pooled OR = 2.08, 95% CI: 1.19 - 3.64, P = 0.010, n = 7), and lower serum concentrations of 25(OH)D (weighted MD = 3.86, 95% CI: 0.20 - 7.52, P = 0.039, n = 12) compared to those without LBP (where “n” is the number of studies). The association between vitamin D deficiency (pooled OR = 1.83, 95% CI: 1.26 - 2.66, P = 0.002, n = 9) or serum 25(OH)D (weighted MD = 7.64, 95% CI: 4.02 - 11.26, P < 0.001, n = 4) and LBP was stronger for women but failed to be statistically significant for men (pooled OR = 1.06, 95% CI: 0.62 - 1.81, P = 0.213, n = 3). In addition, there were strong associations between vitamin D deficiency and LBP in patients < 60 years old (particularly women). We found minimal evidence to support an association between vitamin D levels and pain intensity in patients with LBP. Limitations: We were unable to investigate whether vitamin D deficiency increases the risk of developing LBP as there were no longitudinal studies included in this review. Conclusion: Vitamin D deficiency is associated with LBP, with stronger associations observed in younger women and those with severe levels of deficiency. The association between vitamin D levels and pain intensity is inconsistent. These results may guide the implementation of future studies on vitamin D supplementation for LBP. PROSPERO Registration No: CRD42016046874. Key words: Vitamin D, low back pain, deficiency, pain intensity, serum 25-hydroxyvitamin D, supplementation, cross-sectional study, case-control study

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Vitamin D supplementation after the menopause

Therapeutic Advances in Endocrinology and Metabolism ◽

10.1177/2042018820931291 ◽

2020 ◽

Vol 11 ◽

pp. 204201882093129

Author(s):

Faustino R. Pérez-López ◽

Peter Chedraui ◽

Stefan Pilz

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Postmenopausal Women ◽

Vitamin D Supplementation ◽

Lifestyle Changes ◽

The Body ◽

Mineral Density ◽

The Metabolic Syndrome ◽

Vitamin D Levels

The purpose of this review was to assess recent evidence regarding the effects of low vitamin D levels on some highly prevalent clinical conditions of postmenopausal women. We reviewed and selected recent literature regarding menopause-related conditions associated with vitamin D deficiency and interventions to manage them. Low circulating 25-hydroxyvitamin D (25(OH)D) levels related to menopause are linked to diet, lifestyle, changes in body composition, insulin sensitivity, and reduced physical activity. Vitamin D supplementation increases serum 25(OH)D levels while normalizing parathyroid hormone and bone markers, and in women with serum 25(OH)D levels below 10 ng/ml supplementation may improve bone mineral density. Low vitamin D status has been associated with the metabolic syndrome, high triglyceride levels, and low high-density lipoprotein cholesterol levels. When compared with placebo, vitamin D supplementation may lower the risk of the metabolic syndrome, hypertriglyceridemia, and hyperglycemia. There is an inverse relationship between fat mass and serum 25(OH)D levels and, therefore, the dosage of supplementation should be adjusted according to the body mass index. Although vitamin D supplementation may improve glucose metabolism in prediabetic subjects, data regarding muscle strength are conflictive. There is evidence that vitamin D over-treatment, to reach extremely high circulating 25(OH)D levels, does not result in better clinical outcomes. The identification and treatment of vitamin D deficiency in postmenopausal women may improve their general health and health outcomes. Vitamin D supplementation should preferably be based on the use of either cholecalciferol or calcifediol.

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A study on vitamin D levels in preterm and term neonates and their mothers

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20200115 ◽

2020 ◽

Vol 7 (2) ◽

pp. 387

Author(s):

Deepa J. Thomas ◽

Habeeb U. Khan ◽

Saritha Paul ◽

Jaidev M. D. ◽

Pavan Hegde

Keyword(s):

Vitamin D ◽

Cord Blood ◽

Vitamin D Deficiency ◽

Tertiary Care ◽

Vitamin D Supplementation ◽

Care Hospital ◽

Cross Sectional ◽

Tropical Zone ◽

Maternal Vitamin ◽

Vitamin D Levels

Background: Vitamin D is a fat-soluble vitamin which has immunomodulatory and anti-inflammatory effects. Vitamin D deficiency is a worldwide problem and yet is one of the most under diagnosed and under treated nutritional deficiency. Despite India being in the tropical zone with plentiful sunlight, there is a wide prevalence of vitamin D deficiency.Methods: Cross sectional descriptive study done in a tertiary care hospital involving 30 mother baby dyads equally divided into term and preterm babies. Maternal vitamin D levels (before delivery) and cord blood vitamin D levels (after delivery) were estimated.Results: All the mothers had low vitamin D levels, 93% having deficiency and 7% having insufficiency. The maternal vitamin D levels correlated with cord blood vitamin D levels. There was significant correlation between maternal vitamin D levels and cord blood vitamin D levels with maternal age and parity. There was no correlation between maternal vitamin D levels with gestational age, sociodemographic profile or neonatal anthropometry.Conclusions: Vitamin D deficiency is widely prevalent even in well-nourished mothers. Vitamin D supplementation may be helpful in antenatal mothers. Larger studies are needed to study the prevalence of vitamin D deficiency in mothers and babies and look for effectiveness of supplementation.

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Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000662 ◽

2020 ◽

Vol 90 (3-4) ◽

pp. 346-352

Author(s):

Vincenzo Pilone ◽

Salvatore Tramontano ◽

Carmen Cutolo ◽

Federica Marchese ◽

Antonio Maria Pagano ◽

...

Keyword(s):

Bariatric Surgery ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Inverse Correlation ◽

Model Assessment ◽

Cross Sectional ◽

Serum Vitamin D ◽

Female Sex ◽

Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

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To Supplement or not to Supplement? The Rationale of Vitamin D Supplementation in Systemic Lupus Erythematosus

The Open Rheumatology Journal ◽

10.2174/1874312901812010226 ◽

2018 ◽

Vol 12 (1) ◽

pp. 226-247 ◽

Cited By ~ 1

Author(s):

Alessandra Nerviani ◽

Daniele Mauro ◽

Michele Gilio ◽

Rosa Daniela Grembiale ◽

Myles J. Lewis

Keyword(s):

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Lupus Erythematosus ◽

Clinical Manifestations ◽

Vitamin D Supplementation ◽

Current Evidence ◽

Systemic Lupus ◽

Vitamin D Receptors ◽

Vitamin D Levels

Background: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterised by abnormal activation of the immune system, chronic inflammation and organ damage. Lupus patients are more prone to be vitamin D deficient. However, current evidence is not conclusive with regards to the role played by vitamin D in SLE development, progression, and clinical manifestations. Objective: Here, we will summarise the current knowledge about vitamin D deficiency prevalence, risk factors, molecular effects, and potential pathogenic role in SLE. We will focus on the link between vitamin D deficiency and lupus clinical manifestations, and on the clinical trials assessing the effects of vitamin D supplementation in SLE. Method: A detailed literature search was performed exploiting the available databases, using “vitamin D and lupus/SLE” as keywords. The relevant interventional trials published over the last decade have been considered and the results are reported here. Conclusion: Several immune cells express vitamin D receptors. Thus, an immunomodulatory role for vitamin D in lupus is plausible. Numerous observational studies have investigated the relationship between vitamin D levels and clinical/serological manifestations of SLE with contrasting results. Negative correlations between vitamin D levels and disease activity, fatigue, renal and cardiovascular disease, and anti-dsDNA titres have been described but not conclusively accepted. In experimental models of lupus, vitamin D supplementation can improve the disease. Interventional trials have assessed the potential therapeutic value of vitamin D in SLE, but further larger studies are needed.

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