scholarly journals Assessment and management of sexual dysfunction in the context of depression

2017 ◽  
Vol 8 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Pratap R. Chokka ◽  
Jeffrey R. Hankey

Sexual dysfunction (SD) is pervasive and underreported, and its effects on quality of life are underestimated. Due in part to its bidirectional relationship with depression, SD can be difficult to diagnose; it is also a common side effect of many antidepressants, leading to treatment noncompliance. While physicians often count on patients to spontaneously report SD, treatment is optimized when the clinician instead performs a thorough assessment of sexual functioning before and during drug therapy using a standardized questionnaire such as the Arizona Sexual Experiences Scale (ASEX). Separating the effects of the disorder from those of medications is challenging; we present a concise, evidence-based schematic to assist physicians in minimizing treatment-emergent sexual dysfunction (TESD) while treating depression. Vascular, hormonal, neurogenic, and pharmacological factors should be considered when a patient presents with SD. We also recommend that physicians obtain patient information about baseline and historical sexual functioning before prescribing a drug that may lead to SD and follow up accordingly. When the goal is to treat depression while attenuating the risk of sexual symptoms, physicians may wish to consider agomelatine, bupropion, desvenlafaxine, moclobemide, trazodone, vilazodone, and vortioxetine.

2010 ◽  
Vol 28 (31) ◽  
pp. 4687-4696 ◽  
Author(s):  
Yolanda Pardo ◽  
Ferran Guedea ◽  
Ferrán Aguiló ◽  
Pablo Fernández ◽  
Víctor Macías ◽  
...  

Purpose Earlier studies evaluating the effect on quality of life (QoL) of localized prostate cancer interventions included patients receiving adjuvant hormone therapy, which could have affected their outcomes. Our objective was to compare the QoL impact of the three most common primary treatments on patients who were not receiving adjuvant hormonal treatment. Patients and Methods This was a prospective study of 435 patients treated with radical prostatectomy, external-beam radiotherapy, or brachytherapy. QoL was assessed before and after treatment with the Short Form-36 and the Expanded Prostate Cancer Index Composite. Differences between groups were tested by analysis of variance. Distribution of outcome at 3 years was examined by stratifying according to baseline status. Generalized estimating equation models were constructed to assess the effect of treatment over time. Results Compared with the brachytherapy group, the prostatectomy group showed greater deterioration on urinary incontinence and sexual scores but better urinary irritative-obstructive results (−18.22, −13.19, and +6.38, respectively, at 3 years; P < .001). In patients with urinary irritative-obstructive symptoms at baseline, improvement was observed in 64% of those treated with nerve-sparing radical prostatectomy. Higher bowel worsening (−2.87, P = .04) was observed in the external radiotherapy group, with 20% of patients reporting bowel symptoms. Conclusion Radical prostatectomy caused urinary incontinence and sexual dysfunction but improved pre-existing urinary irritative-obstructive symptoms. External radiotherapy and brachytherapy caused urinary irritative-obstructive adverse effects and some sexual dysfunction. External radiotherapy also caused bowel adverse effects. Relevant differences between treatment groups persisted for up to 3 years of follow-up, although the difference in sexual adverse effects between brachytherapy and prostatectomy tended to decline over long-term follow-up. These results provide valuable information for clinical decision making.


2013 ◽  
Vol 31 (31) ◽  
pp. 3964-3970 ◽  
Author(s):  
Neeraj K. Arora ◽  
Roxanne E. Jensen ◽  
Nadiyah Sulayman ◽  
Ann S. Hamilton ◽  
Arnold L. Potosky

Purpose To investigate non-Hodgkin lymphoma (NHL) survivors' willingness to discuss health-related quality-of-life (HRQOL) problems with their follow-up care physician. Patients and Methods Willingness to discuss HRQOL problems (physical, daily, emotional, social, and sexual functioning) was examined among 374 NHL survivors, 2 to 5 years postdiagnosis. Survivors were asked if they would bring up HRQOL problems with their physician and indicate reasons why not. Logistic regression models examined the association of patient sociodemographics, clinical characteristics, follow-up care variables, and current HRQOL scores with willingness to discuss HRQOL problems. Results Overall, 94%, 82%, 76%, 43%, and 49% of survivors would initiate discussions of physical, daily, emotional, social, and sexual functioning, respectively. Survivors who indicated their physician “always” spent enough time with them or rated their care as “excellent” were more willing to discuss HRQOL problems (P < .05). Survivors reporting poorer physical health were less willing to discuss their daily functioning problems (P < .001). Men were more willing to discuss sexual problems than women (P < .001). One in three survivors cited “nothing can be done” as a reason for not discussing daily functioning problems, and at least one in four cited “this was not their doctor's job” and a preference to “talk to another clinician” as reasons for not discussing emotional, social, and sexual functioning. Conclusion NHL survivors' willingness to raise HRQOL problems with their physician varied by HRQOL domain. For some domains, even when survivors were experiencing problems, they may not discuss them. To deliver cancer care for the whole patient, interventions that facilitate survivor-clinician communication about survivors' HRQOL are needed.


2017 ◽  
Vol 25 (2) ◽  
pp. 123-127 ◽  
Author(s):  
Lisa H Glassman ◽  
Margaret-Anne Mackintosh ◽  
Alexander Talkovsky ◽  
Stephanie Y Wells ◽  
Kristen H Walter ◽  
...  

Introduction Quality of life (QOL) is significantly impaired among individuals with post-traumatic stress disorder (PTSD); however, few treatment outcome studies examine QOL following treatment. Furthermore, the use of videoconferencing to deliver evidence-based treatments for PTSD is increasing dramatically. Although videoconferencing has demonstrated non-inferiority to in-person treatment modalities for improving PTSD symptom severity, no studies to date have directly compared QOL outcomes of an evidence-based intervention delivered via videoconferencing to one delivered in-person. Methods This study presents a secondary data analysis of two randomized controlled trials comparing cognitive processing therapy (CPT) delivered via videoconferencing or a traditional in-person modality. The Men’s study delivered group CPT to 125 male veterans with PTSD, whereas the Women’s study delivered individuals CPT to 126 female civilians and veterans. Multigroup latent growth curve models were used to model changes in QOL Inventory (QOLI) scores over time. Results There was no effect of treatment modality on changes in QOLI scores over time (modality effect on slope estimate = 0.004 (–0.60, 0.61) and on quadratic estimate = 0.001 (–0.18, 0.20); all ps > 0.33). Model fit was the same for both genders (Δ χ2 (2) = 2.28, p = 0.32) and for the gender × treatment modality interaction (Δ χ2 (2) = 2.87, p = 0.24). QOLI scores improved at post-treatment and three-month follow-up assessments, but declined at the six-month follow-up assessment. Discussion This secondary analysis extends the findings of the parent studies by establishing the efficacy of the videoconferencing platform in improving QOL. Clinical implications of findings are discussed.


Author(s):  
Hasanul Arifin ◽  
Alfansuri Kadri ◽  
Yuneldi Anwar

  A DESCRIPTION OF SEXUAL DYSFUNCTION, DISABILITY, AND QUALITY OF LIFE OF POST-STROKE PATIENTSABSTRACTIntroduction: Sexual function and disability are post-stroke complications that can affect the long-term quality of life. The problem is being neglected, thus cannot be intervened further. There are simple screenings that can be used to detect the disorder.Aim: To determine the characteristics  of sexual dysfunction, disability and quality of life, and also demographic profile of post stroke patients in Neurology Outpatient Clinic at General Hospital Haji Adam Malik, Medan.Method: A cross sectional descriptive study on poststroke patients in Neurology Outpatient Clinic of General Hospital Adam Malik, Medan between March and July 2018. Subjects were asked to fill three questionnaires; Changes in Sexual Functioning Questionnaire (CSFQ-14) to assess sexual dysfunction, Stroke-Specific Quality of Life (SS-QoL-12) to assess quality of life, and Barthel Index (BI) and modified Rankin Scale (mRS) to assess disability.Results: We identified 45 subjects and the mean of age was 60.27+10.12 years, mostly men (75.6%) and was suffered from ischemic stroke (95.6%). Majority of the subjects (93.3%) were reported of having sexual dysfunction, some have symptoms of disability (35.6%) and full dependence (44.5%). The quality of life was relatively better in male, especially in the physical domain.Discussion: In post stroke population, the prevalence of sexual dysfunction is 93.3%, mostly affected male patients. Majority of the subjects were independent and without significant disability. The quality of life was relatively better in male and the lowest value related to health was the power domain.Keywords: Disability, post-stroke, quality of life, sexual dysfunctionABSTRAKPendahuluan: Salah satu komplikasi pascastroke adalah gangguan fungsi dan disabilitas seksual yang dapat memengaruhi kualitas hidup jangka panjang. Namun hal ini masih terabaikan, hingga tidak dapat diintervensi lebih lanjut. Terdapat beberapa skrining sederhana yang dapat digunakan untuk mendeteksi gangguan tersebut.Tujuan: Untuk mengetahui gambaran disfungsi seksual, disabilitas, dan kualitas hidup pada penderita pascastroke di rawat jalan Neurologi RSUP Haji Adam Malik, Medan.Metode:  Penelitian  deskriptif  dengan  studi  potong  lintang  pada  pasien  pascastroke  di  Poliklinik  Neurologi RSUP Haji Adam Malik, Medan pada bulan Maret–Juli 2018. Subjek diminta mengisi 3 kuesioner, yaitu: Changes in Sexual Functioning Questionnaire (CSFQ-14) untuk menilai perubahan fungsi seksual, Stroke-Specific Quality of Life (SS-QoL-12) untuk menilai kualitas hidup, serta Indeks Barthel (IB) dan modified Rankin Scale (mRS) untuk  menilai disabilitas.Hasil: Didapatkan 45 subjek dengan rerata usia 60,27+10,12 tahun, terutama laki-laki (75,6%) dan menderita stroke iskemik (95,6%). Mayoritas subjek mengalami disfungsi seksual (93,3%), sebagian memiliki gejala disabilitas (35,6%) dan ketergantungan penuh (44,5%). Kualitas hidup relatif lebih baik pada laki-laki dan khususnya pada domain fisik.Diskusi: Didapatkan prevalensi disfungsi seksual sebanyak 93,3% pada pasien pascastroke, terutama laki-laki. Mayoritas subjek pada keadaan mandiri dan disabilitas yang tidak signifikan. Gambaran kualitas hidup secara keseluruhan relatif lebih baik pada laki-laki dengan nilai yang berhubungan dengan kesehatan yang relatif paling rendah adalah domain tenaga.Kata Kunci: Disabilitas, disfungsi seksual, kualitas hidup, pascastroke  


Author(s):  
SWOPNA PHUKAN ◽  
SAHELI DAS

Objective: The aim of the study is to assess the therapeutic efficacy of drugs used in acne vulgaris by measuring the severity of acne using the Global Acne Grading System score (GAGS) and Cardiff Acne Disability Index (CADI) questionnaire score pre and post-drug therapy. Methods: The present study was conducted in the Department of Dermatology after getting approval from the Institutional Ethics Committee (No MC/190/2007/Pt1/MAR-2019/PG/123) dated 10/04/2019. It was an observational study for a period of 1 y. 172 patients were enrolled in the study. Patients were divided into 4 grades depending on their clinical manifestation. The severity of acne vulgaris and the quality of life were measured using the GAGS scale and the CADI questionnaire, respectively at the first visit and at the follow-up visit in all the grades of acne vulgaris. A correlation was done between the GAGS and the CADI score at the follow-up visit in all grades of acne. Results: It was observed that the GAGS score and the CADI score was significantly improved at the F/U visit (p<0.05) as compared to baseline in all the 4 grades of acne. A correlation between GAGS score and QoL using CADI scale was done using Pearson Parametric Correlation Test. In none of the groups, the correlation was significant (p>0.05). Conclusion: We can conclude from our study that following treatment with drugs, the clinical severity of acne decreased and there was also a significant improvement in the quality of life of patients.


2015 ◽  
Vol 36 (5) ◽  
pp. 519-536 ◽  
Author(s):  
Susan M. McCurry ◽  
Rebecca G. Logsdon ◽  
Jennifer Mead ◽  
Kenneth C. Pike ◽  
David M. La Fazia ◽  
...  

Objectives: This article describes the translation and evaluation of STAR–Community Consultants program (STAR-C), an evidence-based dementia caregiver training program, within the Oregon Department of Human Services. Method: Staff from two regional Area Agencies on Aging (AAAs) were trained to implement all aspects of STAR-C, including screening, recruitment of caregiver/care-receiver dyads, and treatment delivery. Mailed assessments of caregiver depression, burden, and care-receiver mood, behavior, and quality of life were collected at pre-treatment, post-treatment, and 6-month follow-up. Results: One hundred fifty-one dyads entered the program; 96 completed the 8-week intervention. Significant positive post-treatment effects were obtained for caregiver depression, burden, and reactivity to behavior problems, and care-receiver depression and quality of life. At 6-month follow-up, improvements in caregiver reactivity and care-receiver depression were maintained. Caregivers reported high levels of satisfaction with the program. Discussion: STAR-C was successfully and effectively implemented by participating AAAs. Recommendations for replication, including training, recruitment, and assessment procedures are provided.


10.2196/24271 ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. e24271
Author(s):  
Constantinos Bakogiannis ◽  
Anastasios Tsarouchas ◽  
Dimitrios Mouselimis ◽  
Charalampos Lazaridis ◽  
Efstratios K Theofillogianakos ◽  
...  

Background Heart failure (HF) remains a major public health challenge, while HF self-care is particularly challenging. Mobile health (mHealth)–based interventions taking advantage of smartphone technology have shown particular promise in increasing the quality of self-care among these patients, and in turn improving the outcomes of their disease. Objective The objective of this study was to co-develop with physicians, patients with HF, and their caregivers a patient-oriented mHealth app, perform usability assessment, and investigate its effect on the quality of life of patients with HF and rate of hospitalizations in a pilot study. Methods The development of an mHealth app (The Hellenic Educational Self-care and Support Heart Failure app [ThessHF app]) was evidence based, including features based on previous clinically tested mHealth interventions and selected by a panel of HF expert physicians and discussed with patients with HF. At the end of alpha development, the app was rated by mHealth experts with the Mobile Application Rating Scale (MARS). The beta version was tested by patients with HF, who rated its design and content by means of the Post-Study System Usability Questionnaire (PSSUQ). Subsequently, a prospective pilot study (THESS-HF [THe Effect of a Specialized Smartphone app on Heart Failure patients’ quality of self-care, quality of life and hospitalization rate]) was performed to investigate the effect of app use on patients with HF over a 3-month follow-up period. The primary endpoint was patients’ quality of life, which was measured with the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the 5-level EQ-5D version (EQ-5D-5L). The secondary endpoints were the European Heart Failure Self-care Behavior Scale (EHFScBS) score and the hospitalization rate. Results A systematic review of mHealth-based HF interventions and expert panel suggestions yielded 18 separate app features, most of which were incorporated into the ThessHF app. A total of 14 patients and 5 mHealth experts evaluated the app. The results demonstrated a very good user experience (overall PSSUQ score 2.37 [SD 0.63], where 1 is the best, and a median MARS score of 4.55/5). Finally, 30 patients (male: n=26, 87%) participated in the THESS-HF pilot study (mean age 68.7 [SD 12.4] years). A significant increase in the quality of self-care was noted according to the EHFScBS, which increased by 4.4% (SD 7.2%) (P=.002). The mean quality of life increased nonsignificantly after 3 months according to both KCCQ (mean increase 5.8 [SD 15] points, P=.054) and EQ-5D-5L (mean increase 5.6% [SD 15.6%], P=.06) scores. The hospitalization rate for the follow-up duration was 3%. Conclusions The need for telehealth services and remote self-care management in HF is of vital importance, especially in periods such as the COVID-19 pandemic. We developed a user-friendly mHealth app to promote remote self-care support in HF. In this pilot study, the use of the ThessHF app was associated with an increase in the quality of self-care. A future multicenter study will investigate the effect of the app use on long-term outcomes in patients with HF.


2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Jinmyoung Cho ◽  
Susanna Luk-Jones ◽  
Donald R Smith ◽  
Alan B Stevens

Abstract Background and Objectives Family caregiving interventions have been proven efficacious at reducing dementia caregiver’s stress and burden, yet translation of evidence-based interventions into community-based support service programs requires modification to the original intervention protocol. In collaboration with community partners, the REACH-TX program was developed based on the REACH II (Resources for Enhancing Alzheimer’s Caregiver Health) intervention. REACH-TX maintains the integrity of the multicomponent skill-based REACH II intervention but requires significantly fewer therapeutic contacts between the family caregiver and the dementia care specialist. This study presents an evaluation of REACH-TX implemented by the Alzheimer’s Association North Central Texas Chapter. Research Design and Methods REACH-TX was provided to 1,522 caregivers between November 2011 and December 2017. The number of therapeutic contacts scheduled for caregivers was determined by the Risk Appraisal Measure (RAM) and ranged from 1 to 23. The rate of follow-up data on outcome measures collected was 59.0% (n = 898). All five domains of the REACH II quality-of-life measure (burden, depression, social support, self-care, and problem behaviors) were assessed at baseline and at 6 months. Caregivers (n = 53) participating in the program more than once allowed us to investigate the long-term impact of the first exposure to REACH-TX and the value of repeating the program. Generalized linear models were used to assess changes in quality of life after adjusting for covariates. Results Caregivers who completed the program showed significant improvements from baseline to 6 months on all five domains of quality of life, as evidenced by the follow-up data. Furthermore, caregivers who enrolled a second time in REACH-TX showed significant improvement in burden and social support scores. Discussion and Implications This evaluation of REACH-TX suggests that REACH II evidence-based intervention can be translated into a valuable and sustainable community-based service for family caregivers. Additional translational research is needed to overcome the challenges of conducting standardized outcome assessments of caregiving services.


2000 ◽  
Vol 18 (9) ◽  
pp. 1942-1953 ◽  
Author(s):  
Carol M. Moinpour ◽  
Laura C. Lovato ◽  
Ian M. Thompson ◽  
John E. Ware ◽  
Patricia A. Ganz ◽  
...  

PURPOSE: To describe men who agreed to be randomized to the Prostate Cancer Prevention Trial (PCPT), a 7-year, double-blind placebo-controlled study of the efficacy of finasteride in preventing prostate cancer. METHODS: Comprehensive health-related quality-of-life data are presented for 18,882 randomized PCPT participants. RESULTS: PCPT participants are highly educated, middle to upper income, and primarily white (92%). Participants reported healthy lifestyles. The mean American Urological Association Symptom Index score was well below the maximum entry score of less than 19; existing urinary symptoms were generally not bothersome. The scores for two sexual functioning scales could range from 0 to 100, with higher scores reflecting worse sexual functioning. The mean score for the Sexual Problem Scale was 19.2 out of 100, and the mean Sexual Activities Scale was 44.1 out of 100. Scores for seven of the eight Medical Outcomes Study 36-item Short-Form Health Survey scales (higher scores are better) were 10 to 20 points higher than those reported by a general population sample and differed minimally by race but not by age. Previously reported associations between sexual dysfunction and hypertension, diabetes, and depression were also observed. Men who never smoked reported less sexual dysfunction than did those who either had quit or still smoked. CONCLUSION: Individuals who are likely to enroll in primary prevention trials have a high socioeconomic status, healthy lifestyle behaviors, and better health than the general population. These data help oncologists design chemoprevention trials with respect to the selection of health-related quality-of-life assessments and recruitment strategies.


2018 ◽  
Vol 33 (4) ◽  
pp. 762-772 ◽  
Author(s):  
Oana C Lindner ◽  
Martin G McCabe ◽  
Florien Boele ◽  
Andrew Mayes ◽  
Deborah Talmi ◽  
...  

Objective: The aim of this study is to perform a preliminary test of a practical, evidence-based model to enable discussions around quality of life–related concerns during cancer follow-up appointments. Design: Cross-sectional study measuring quality of life, illness perceptions, emotional distress, fatigue, and subjective cognitive complaints. Setting: Cancer outpatient follow-up clinics in four National Health Services in the United Kingdom. Participants: Working-age post-treatment cancer patients, treated with curative intent. Interventions: Not applicable. Main measures: European Organisation for the Research and Treatment of Cancer – Quality of Life Questionnaire – Core 30, Illness Perceptions Questionnaire – Revised, Hospital Anxiety and Depression Scale, Chalder Fatigue Scale, and Cognitive Failures Questionnaire. Results: Fifty-seven cancer patients, with a mean age of 36 years and on average 2.75 years post treatment, returned the completed questionnaires. Anxiety partially mediated the association between subjective cognitive complaints and illness identity (60%) and timeline (25%). Cognitive complaints mediated the relationships between quality of life and anxiety (45%), depression (30%), and fatigue (62%). Depression mediated the relationships between quality of life and illness identity (48%) and timeline (40%). Conclusion: Our study provides a preliminary test of an evidence-based model to help elicit quality of life–related concerns during cancer follow-up appointments. Illness perceptions are associated with quality of life through the mediation of other cancer-relevant factors. Discussing the type, origin, and expected duration of symptoms may elicit other concerns, such as emotional distress, fatigue, or cognitive complaints, which explained a significant amount of the relationship between illness perceptions and quality of life.


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