Solitary fibrous tumor of the pleura with Doege–Potter syndrome: Second recurrence in a 93-year-old female

Solitary fibrous tumors are rare mesenchymal tumors most commonly arising from the pleura. When associated with paraneoplastic syndrome of hypoglycemia caused by the secretion of a high-molecular-weight form of insulin-like growth factor II, it is referred to as the Doege–Potter syndrome. Surgery with complete tumor resection is the only curative treatment. We present here the case of a 93-year-old female diagnosed with a Doege–Potter syndrome who underwent three repetitive surgical resections of recurrent solitary fibrous tumor.

Download Full-text

Solitary fibrous tumor of the pleura with Doege-Potter syndrome.

Advances in Thoracic Diseases ◽

10.15342/atd.2021.470 ◽

2021 ◽

Vol 2021 ◽

Author(s):

Sara Waguaf ◽

Souheil Boubia ◽

Najat Id El Haj ◽

Abdellah Fatene ◽

Mohamed Ridai

Keyword(s):

Solitary Fibrous Tumor ◽

Tumor Resection ◽

Curative Treatment ◽

Rare Tumor ◽

Complete Tumor Resection ◽

Fibrous Tumor ◽

Complete Tumor

Solitary fibrous tumor of pleura (SFTP) is a rare tumor. Complete tumor resection is the curative treatment and the key to preventing recurrence. We present here the case of a 65-year-old female diagnosed with a Doege-Potter syndrome who underwent resection of pleural solitary fibrous tumor.

Download Full-text

Solitary fibrous tumor of the pleura as a rare cause of severe hypoglycemia: Doege-Potter syndrome

Perspectives in Surgery ◽

10.33699/pis.2020.99.2.95-98 ◽

2020 ◽

Vol 99 (2) ◽

pp. 95-98

Keyword(s):

Case Report ◽

Growth Factor ◽

Solitary Fibrous Tumor ◽

Tumor Resection ◽

Insulin Like Growth Factor ◽

En Bloc ◽

Solitary Fibrous Tumors ◽

Factor Ii ◽

Fibrous Tumor ◽

Recurrent Hypoglycemia

Introduction: Doege-Potter syndrome is a rare syndrome characterized by hypo-insulinemic hypoglycemia. It is caused by excessive ectopic secretion of insulin-like growth factor II from a solitary fibrous tumors of intrapleural or extrapleural origin. Laboratory tests reveal low levels of C-peptide and insulin, on the contrary insulin-like growth factor II level is elevated, which is characteristic for Doege-Potter syndrome. Majority of solitary fibrous tumors present no symptomatology, recurrent hypoglycemia is relatively rare, but it may be the only clinical manifestation. The therapy is surgical, consisting of radical en-bloc tumor resection. Case report: Authors present a case report of a patient with recurrent hypoglycemia caused solely by solitary fibrous tumor. Hypoglycemia resolved immediately after surgical resection and there were no recurrences. Conclusion: Doege-Potter syndrome should be considered as the differential diagnosis in a patient with suspicion on thoracic malignancy if accompanied by features suggestive of hypoglycemia. Prolonged follow up is strongly advised because of the risk of disease recurrence, even in patients with benign solitary fibrous tumors of the pleura (SFTP).

Download Full-text

A Rare Case of a Solitary Fibrous Tumor of the Spermatic Cord

Case Reports in Pathology ◽

10.1155/2021/9956305 ◽

2021 ◽

Vol 2021 ◽

pp. 1-3

Author(s):

Moyosore Awobajo ◽

Stefanie Hettwer ◽

Sarah Hackman

Keyword(s):

Solitary Fibrous Tumor ◽

Spermatic Cord ◽

Rare Case ◽

Surgical Excision ◽

Mesenchymal Tumors ◽

Solitary Fibrous Tumors ◽

Important Differential Diagnosis ◽

History Of ◽

Scrotal Swelling ◽

Fibrous Tumor

Solitary fibrous tumors (SFTs) are rare mesenchymal tumors, originally identified in the pleura. Even though they have subsequently been described in several extrapleural sites, the incidence of SFTs in the spermatic cord is particularly rare. Here, we report a case of a 27-year-old male that presented with a 3-year history of left scrotal swelling. Computed tomography (CT) and ultrasound demonstrated multiple solid, hypoechoic well-circumscribed masses that were separate from the testis. Surgical excision of the mass led to pathologic diagnosis of a solitary fibrous tumor involving the spermatic cord. Solitary fibrous tumors, although rare, are an important differential diagnosis for urogenital tumors.

Download Full-text

Doege–Potter Syndrome and Hypoglycemia associated with Solitary Fibrous Tumor of the Pleura: Two Case Reports

Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine ◽

10.1177/1179548420964759 ◽

2020 ◽

Vol 14 ◽

pp. 117954842096475

Author(s):

Liliana Fernández-Trujillo ◽

Jhon E Bolaños ◽

Carolina Álvarez ◽

Julián Giraldo ◽

Mauricio Velásquez ◽

...

Keyword(s):

Growth Factor ◽

Solitary Fibrous Tumor ◽

Incidental Finding ◽

Case Reports ◽

Tumor Resection ◽

Insulin Like Growth Factor ◽

Solitary Fibrous Tumors ◽

Mesenchymal Neoplasms ◽

Single Mass ◽

Fibrous Tumor

Solitary fibrous tumors of the pleura (SFTP) are rare mesenchymal neoplasms that originate from mesenchymal growth in the pleura, tend to be single tumors, usually have an indolent course and show nonspecific symptoms. SFTP can be often diagnosed from an incidental finding of a single mass in the thorax and should be confirmed by biopsy and immunohistochemistry. A minority of cases may present Doege–Potter syndrome (DPS, episodes of refractory hypoglycemia) associated with production of insulin-like growth factor 2 (IGF-2). Both SFTP and DPS are rare occurrences with less than 2000 cases reported worldwide. The curative treatment is tumor resection. Two cases of patients with DPS caused by SFTP are presented below.

Download Full-text

Solitary Fibrous Tumor of the Orbit With Epithelioid Features

Archives of Pathology & Laboratory Medicine ◽

10.5858/2006-130-1039-sftoto ◽

2006 ◽

Vol 130 (7) ◽

pp. 1039-1041 ◽

Cited By ~ 1

Author(s):

Irfan Warraich ◽

Dale M. Dunn ◽

Jeffrey W. Oliver

Keyword(s):

Differential Diagnosis ◽

Mitotic Activity ◽

Solitary Fibrous Tumor ◽

Spindle Cell ◽

Fibrous Histiocytoma ◽

Mesenchymal Tumors ◽

Nuclear Atypia ◽

Solitary Fibrous Tumors ◽

Fibrous Tumor ◽

Extrapleural Solitary Fibrous Tumor

Abstract Extrapleural solitary fibrous tumors have often been confused with other mesenchymal tumors, such as hemangiopericytoma, fibrous histiocytoma, fibrous meningioma, and leiomyoma, because of morphologic similarity and underrecognition, especially if some unusual features are present. Recently, epithelioid solitary fibrous tumor has been reported in the mediastinum. We report a case of solitary fibrous tumor of the orbit with biphasic architecture, including spindle cell and epithelioid components. Both components demonstrated immunohistochemical features of a solitary fibrous tumor. A background of scattered vessels was present. No evidence of significant nuclear atypia or mitotic activity was noted. In this report, we discuss the differential diagnosis of solitary fibrous tumor with unusual epithelioid features. Extrapleural solitary fibrous tumor should be included in the differential diagnosis of tumors of the orbit with a spindle cell appearance even in the presence of some epithelioid morphology.

Download Full-text

Solitary fibrous tumor of the mesentery: a case report and review of the literature

Journal of International Medical Research ◽

10.1177/0300060520950111 ◽

2020 ◽

Vol 48 (10) ◽

pp. 030006052095011

Author(s):

Jing-Ni Liu ◽

Zhao Liu ◽

Peng-Yu Ji ◽

Hong Zhang ◽

Shun-Lin Guo

Keyword(s):

Abdominal Pain ◽

Solitary Fibrous Tumor ◽

Clinical Course ◽

Review Of The Literature ◽

Mesenchymal Tumors ◽

Solitary Fibrous Tumors ◽

Fibrous Tumor ◽

Left Abdomen ◽

Irregular Mass

Solitary fibrous tumors are rare mesenchymal tumors that typically arise from the pleura and rarely originate from the mesentery. We herein report a case involving a 66-year-old patient who presented with a mass on the left abdomen. This mass had been incidentally noticed 10 years earlier. The patient sometimes experienced abdominal pain. Physical examination revealed an irregular mass, which was resected. A biopsy of the mass revealed that it was a solitary fibrous tumor originating from the mesentery of the small intestine. The patient was discharged 1 week after surgery and had an uneventful clinical course throughout the 4-month postoperative follow-up.

Download Full-text

Osteosarcoma of the jaws: a literature review

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405616666200806173948 ◽

2020 ◽

Vol 16 ◽

Author(s):

Francesco Ricotta ◽

Massimo Bassi ◽

Nicola Tomasetti ◽

Angelo Campobassi ◽

Vincenzo Maiolo ◽

...

Keyword(s):

Treatment Guidelines ◽

State Of The Art ◽

Bone Erosion ◽

Tumor Resection ◽

Bone Destruction ◽

Cell Type ◽

Complete Tumor Resection ◽

Predominant Cell Type ◽

Bone Changes ◽

Complete Tumor

: Osteosarcoma of the jaws (OSJ) is a relatively rare disease, accounting for between 2% and 10% of all cases of osteosarcoma, it is morphologically and radiologically identical to the trunk and extremity variant, but distinct in several crucial aspects. : The lesion is characterized by sarcomatous cells which produces a variable amount of osteoid bone. It arises centrally within the bone and can be subdivided into osteoblastic, chondroblastic and fibroblastic subtype, depending on the predominant cell type. : Radiographically, these tumors display a spectrum of bone changes from well-demarcated borders to lytic bone destruction with indefinite margins and variable cortical bone erosion or, in some cases, images of sclerotic bone. Therapeutic options for OSJ include surgery, chemotherapy and radiotherapy, which are employed according to age of the patient, histological classification and localization of the tumor. Today there is no a general consensus in the treatment guidelines for the OSJ though surgery represents the key of the treatment. The main prognostic factor deeply influencing the patient's prognosis remains the complete tumor resection with negative surgical margins. : The aim of the present review is to describe the state of the art regarding diagnostic and surgical treatment aspects of the primary osteosarcoma of the jaws.

Download Full-text

Solitary fibrous tumor of the pleura with hypoglycemia associated with serum insulin-like growth factor II

Journal of Thoracic and Cardiovascular Surgery ◽

10.1016/j.jtcvs.2006.05.025 ◽

2006 ◽

Vol 132 (3) ◽

pp. 713-714 ◽

Cited By ~ 6

Author(s):

Ayako Hirai ◽

Ryoichi Nakanishi

Keyword(s):

Growth Factor ◽

Solitary Fibrous Tumor ◽

Serum Insulin ◽

Insulin Like Growth Factor ◽

Factor Ii ◽

Fibrous Tumor

Download Full-text

Malignant Solitary Fibrous Tumor of the Right Cerebellum: A Case Report

Case Reports in Neurology ◽

10.1159/000510844 ◽

2021 ◽

Vol 13 (1) ◽

pp. 259-266

Author(s):

Ye-Tao Zhu ◽

Yang Liu ◽

Li-Gang Chen ◽

Da-Ping Song

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Solitary Fibrous Tumor ◽

Immunohistochemical Staining ◽

Biological Behavior ◽

Resonance Imaging ◽

Solitary Fibrous Tumors ◽

The Central Nervous System ◽

Fibrous Tumor ◽

The Right

Solitary fibrous tumor is a very rare mesenchymal tumor that occurs mostly in the pleura, and there are few reported cases of a presence in the central nervous system, particularly in the cerebellum. In 2016, the WHO classified solitary fibrous tumors into grade I. In this article, we present a case of malignant solitary fibrous tumor recurring 8 years after surgery in a 63-year-old male. Magnetic resonance imaging showed low to intermediate mixed signal intensity on T1W1. Immunohistochemical staining positivity for Vimentin, CD99, CD34 and Bcl-2, it is consistent with the immunohistochemical characteristics of solitary fibrous tumor. We resected the patient’s tumor, and the patient was followed up for 3 months with no signs of recurrence. Solitary fibrous tumors are very rare in the central nervous system. Immunohistochemical staining positivity for CD34 and Bcl-2 is strongly expressed in most solitary fibrous tumor. Surgical resection is the preferred treatment. Due to the small number of cases, the biological behavior and prognosis of this tumor need to be further explored.

Download Full-text