scholarly journals Increased risk of second primary tumours in patients with oesophageal squamous cell carcinoma: A nationwide study in a Western population

2020 ◽  
pp. 205064062097712
Author(s):  
Steffi EM van de Ven ◽  
Janne M Falger ◽  
Rob HA Verhoeven ◽  
Robert J Baatenburg de Jong ◽  
Manon CW Spaander ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Digestive Tract ◽  
Squamous Cell ◽  
Primary Tumour ◽  
Second Primary ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Increased Risk ◽  
Second Primary Tumours ◽  
Multiple Primary

Background Patients with primary oesophageal squamous cell carcinoma are at risk of developing multiple primary tumours in the upper aero digestive tract. To date, most studies are performed in the Asian population. We aimed to evaluate the risk of multiple primary tumours in the upper aero digestive tract and stomach in patients with oesophageal squamous cell carcinoma in a Western population. Methods We performed a nationwide, retrospective cohort study in collaboration with the Netherlands Cancer Registry. Patients with primary oesophageal squamous cell carcinoma, diagnosed between 2000–2016, were included. Primary endpoints were synchronous and metachronous multiple primary tumour risk. Results The cohort consisted of 9058 patients, diagnosed with oesophageal squamous cell carcinoma (male: 57.3%, median age 67 years). In 476 patients (5.3%), 545 multiple primary tumours have been diagnosed. Most of them were located in the head and neck region (49.5%). Among all multiple primary tumours, 329 (60.4%) were diagnosed synchronously (<6 months after oesophageal squamous cell carcinoma diagnosis) and 216 (39.6%) metachronously (≥6 months). Patients with oesophageal squamous cell carcinoma had a significantly increased risk of both synchronous (standardised incidence ratio 10.95, 99% confidence interval 9.40–12.53) and metachronous multiple primary tumours (standardised incidence ratio 4.36, 99% confidence interval 3.56–5.10), compared to the general population. The median interval to metachronous second primary tumour diagnosis was 3.0 years (interquartile range 1.8–5.9). Conclusion Approximately one in 20 patients with primary oesophageal squamous cell carcinoma have a second primary tumour in the upper aero digestive tract or stomach, either at the time of oesophageal squamous cell carcinoma diagnosis or at a later stage. As second primary tumours occur at an increased risk compared to the general population, prospective studies are necessary to investigate the yield and survival benefit of screening for second primary tumours in patients with oesophageal squamous cell carcinoma.

Second primary tumours after squamous cell carcinoma of the oral cavity

2021 ◽  
Author(s):  
Maria T. Brands ◽  
Gaby Campschroer ◽  
Matthias A.W. Merkx ◽  
André L.M. Verbeek ◽  
Boukje A.C. van Dijk ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Second Primary ◽  
Second Primary Tumours

scholarly journals Lesion human leukocyte antigen-E is associated with favourable prognosis for patients with oesophageal squamous cell carcinoma

2021 ◽  
Vol 49 (10) ◽  
pp. 030006052110472
Author(s):  
Yong-Fu Xu ◽  
Xue-Feng Du ◽  
Zhen-Yu Li ◽  
Zhe-Ping Fang ◽  
Fa-Biao Zhang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Leukocyte Antigen ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Tumour ◽  
Human Leukocyte ◽  
Clinicopathological Characteristics ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Leukocyte Antigen ◽  
Node Metastasis

Objective To investigate the clinical significance of human leukocyte antigen (HLA)-E levels in oesophageal squamous cell carcinoma (ESCC). Methods The levels of HLA-E immunostaining in ESCC lesions and 47 corresponding adjacent normal tissues were measured using immunohistochemistry. The correlation between the levels of immunostaining and clinical parameters was analysed. Results This study analysed 110 paraffin-embedded primary tumour lesions and 47 case–controlled paracancerous tissues that were surgically resected from 110 patients with ESCC. Positive immunostaining for HLA-E was observed in 88.2% (97 of 110) of ESCC lesions and 29.8% (14 of 47) of normal oesophageal tissues. There was no correlation between HLA-E immunostaining in ESCC lesions and clinicopathological characteristics such as lymph node metastasis, tumour–node–metastasis stage and differentiation grade. Kaplan–Meier survival analysis revealed a significantly better prognosis in patients with higher levels of HLA-E immunostaining than in those with lower levels of HLA-E immunostaining; overall survival was 28.6 months (95% confidence interval [CI], 23.2, 34.0) versus 15.3 months (95% CI, 11.5, 19.1), respectively. Furthermore, multivariate analysis showed that the HLA-E level was an independent prognostic factor in patients with ESCC. Conclusion A higher level of HLA-E immunostaining was associated with favourable survival in patients with ESCC.

scholarly journals Incidence of second and higher order smoking-related primary cancers following lung cancer: a population-based cohort study

Thorax ◽  
2019 ◽  
Vol 74 (5) ◽  
pp. 466-472 ◽  
Author(s):  
Matthew E Barclay ◽  
Georgios Lyratzopoulos ◽  
Fiona M Walter ◽  
Sarah Jefferies ◽  
Michael D Peake ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Second Primary ◽  
Primary Cancer ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Second Primary Cancer ◽  
Rate Ratios ◽  
First Diagnosis

BackgroundLung cancer 5-year survival has doubled over 15 years. Although the risk of second primary cancer is recognised, quantification over time is lacking. We describe the incidence of second and higher order smoking-related primary cancers in lung cancer survivors, identifying high-incidence groups and how incidence changes over time from first diagnosis.MethodsData on smoking-related primary cancers (lung, laryngeal, head and neck, oesophageal squamous cell carcinoma and bladder) diagnosed in England between 2000 and 2014 were obtained from Public Health England National Cancer Registration and Analysis Service. We calculated absolute incidence rates and standardised incidence rate ratios, both overall and for various subgroups of second primary cancer for up to 10 years from the initial diagnosis of lung cancer, using Poisson regression.ResultsElevated incidence of smoking-related second primary cancer persists for at least 10 years from first lung cancer diagnosis with those aged 50 and 79 at first diagnosis at particularly high risk. The most frequent type of second malignancy was lung cancer although the highest standardised incidence rate ratios were for oesophageal squamous cell carcinoma (2.4) and laryngeal cancers (2.8) and consistently higher in women than in men. Over the last decade, the incidence of second primary lung cancer has doubled.ConclusionLung cancer survivors have increased the incidence of subsequent lung, laryngeal, head and neck and oesophageal squamous cell carcinoma for at least a decade from the first diagnosis. Consideration should be given to increasing routine follow-up from 5 years to 10 years for those at highest risk, alongside surveillance for other smoking-related cancers.

scholarly journals Dietary patterns and risk of oesophageal squamous cell carcinoma: a case–control study

2010 ◽  
Vol 13 (7) ◽  
pp. 1107-1112 ◽  
Author(s):  
Bahareh Hajizadeh ◽  
Bahram Rashidkhani ◽  
Anahita H Rad ◽  
Seyed M Moasheri ◽  
Hojjatollah Saboori
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dietary Patterns ◽  
Case Control Study ◽  
Case Control ◽  
Processed Meat ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Increased Risk ◽  
Control Study

AbstractObjectiveWe conducted a hospital-based, case–control study to examine the association between dietary patterns and the risk of oesophageal squamous cell carcinoma in Iran.DesignA total of forty-seven patients with oesophageal squamous cell carcinoma and ninety-six controls underwent face-to-face interviews. Factor analysis was used to detect dietary patterns. Multivariate logistic regression was used to estimate OR and 95 % CI.ResultsWe defined two major dietary patterns in this population: ‘healthy diet’ (high in vegetables, nuts, fruits, low-fat dairy and fish) and ‘western diet’ (high in solid oil, sugar, sweets, tea, eggs, pickles and processed meat). Both healthy and western pattern scores were divided into two categories (based on medians). Higher healthy pattern scores were significantly associated with decreased risk of oesophageal squamous cell carcinoma (high: second median v. low: first median, OR = 0·17, 95 % CI 0·19, 0·98). An increased risk of oesophageal squamous cell carcinoma was observed with the western pattern (high: second median v. low: first median, OR = 10·13, 95 % CI 8·45, 43·68).ConclusionsThe results of the present study suggested that diet might be associated with oesophageal carcinoma.

scholarly journals A Rare Case of Triple Malignancy: Non Hodgkin Lymphoma, Carcinoma of Breast and Squamous Cell Carcinoma of Tongue in a Single Patient

2018 ◽  
Vol 9 (1) ◽  
pp. 75-78
Author(s):  
Md Ehteshamul Haque ◽  
Shahnaz Karim ◽  
Md Mahmudur Rahman Siddiqui ◽  
Mayesha Kareem ◽  
Amena Khatun
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Hodgkin Lymphoma ◽  
Squamous Cell ◽  
Primary Tumour ◽  
Medical College ◽  
Therapeutic Modalities ◽  
Non Hodgkin Lymphoma ◽  
Multiple Primary Malignancies ◽  
Increased Risk

We are reporting a case of having triple malignancy including Non Hodgkin Lymphoma (NHL), Carcinoma breast, Squamous cell carcinoma (SCC) of the tongue. Triple malignancy is a very rare occurrence. Cancer patient are at increased risk of developing a subsequent primary tumour. Prevalence of multiple primary malignancies is slowly increasing due to prolonged survival of cancer patients with advances in diagnostic and therapeutic modalities. The reasons may be environmental modifications, genetic predisposition or therapy-induced. People who have had non-Hodgkin lymphoma (NHL) can get any type of second cancer, but they have an increased risk of certain cancers, including carcinoma lung, skin, tongue, bladder, colon, kidney etc. Radiation therapy to the chest increases the risk of breast cancer.Anwer Khan Modern Medical College Journal Vol. 9, No. 1: Jan 2018, P 75-78

O156 Second Primary Tumours (SPTs) after a squamous cell carcinoma of the oral cavity or oropharynx

2007 ◽  
Vol 2 (1) ◽  
pp. 111
Author(s):  
I.S. van der Haring ◽  
M.S. Schaapveld ◽  
J.L.N. Roodenburg ◽  
G.H. de Bock
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Second Primary ◽  
Second Primary Tumours

scholarly journals Screening for synchronous esophageal second primary tumors in patients with head and neck cancer

2021 ◽  
Author(s):  
Steffi E M van de Ven ◽  
Wilmar de Graaf ◽  
Oisín Bugter ◽  
Manon C W Spaander ◽  
Suzan Nikkessen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Early Stage ◽  
Second Primary ◽  
Low Grade ◽  
Primary Tumors ◽  
Increased Risk ◽  
Second Primary Tumors

Summary Patients with head and neck squamous cell carcinoma (HNSCC) have an increased risk of developing esophageal second primary tumors (ESPTs). We aimed to determine the incidence, stage, and outcome of synchronous ESPTs in patients with HNSCC in a Western population. We performed a prospective, observational, and cohort study. Patients diagnosed with HNSCC in the oropharynx, hypopharynx, any other sub-location in combination with alcohol abuse, or patients with two synchronous HNSCCs, between February 2019 and February 2020 underwent screening esophagogastroduodenoscopy (EGD). ESPT was defined as presence of esophageal squamous cell carcinoma (ESCC) or high grade dysplasia (HGD). Eighty-five patients were included. A lesion suspected for ESPT was detected in 14 of 85 patients, which was pathologically confirmed in five patients (1 ESCC and 4 HGD). The radiotherapy field was extended to the esophagus in two of five patients, HGD was treated with endoscopic resection in three of five patients. None of the ESPTs were detected on MRI and/or CT-scan prior to EGD. Of the remaining nine patients, three had low grade dysplasia on histology whereas the other six patients had benign lesions. Incidence of synchronous ESPT was 5.9% in our cohort of HNSCC patients. All ESPTs were diagnosed at an early stage and treated with curative intent. We recommend that screening for synchronous ESPTs should be considered in a selected group of patients with HNSCC.

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