An Investigation into the Response of Palatally Displaced Canines to the Removal of Deciduous Canines and an Assessment of Factors Contributing to Favourable Eruption

1993 ◽  
Vol 20 (3) ◽  
pp. 215-223 ◽  
Author(s):  
Susan M. Power ◽  
Mary B. E. Short
Keyword(s):  
Standard Deviation ◽  
Discriminant Analysis ◽  
Clinical Features ◽  
Prognostic Indicators ◽  
Successful Outcome ◽  
Tooth Width ◽  
Maximum Period

The effect of the removal of deciduous canines on palatally displaced maxillary canines was assessed and factors contributing to a successful outcome were analysed. Thirty-nine consecutive patients of mean age 11·2 years (standard deviation 1·43), with 47 palatalfy displaced canines were included in the study. The cases were examined clinically and radiographically for a maximum period of 2 years following deciduous canine removal. Twenty-nine (62 per cent) of the 47 ectopic canines achieved a normal eruptive position and nine (19 per cent) showed some improvement in eruptive position. The outcome of the removal of the deciduous canine depended on the position of the permanent canine. Horizontal overlap of the nearest incisor was found to be the most significant factor. If this exceeded half the tooth width, success was unlikely. The presence of crowding was found to affect adversely the favourable eruption of the canine. Discriminant analysis was carried out to try to identify clinical features which could act as prognostic indicators for the outcome of deciduous canine removal.

scholarly journals Acute period of polytrauma in children in the light of discriminant analysis

2021 ◽  
Vol 10 (2) ◽  
pp. 145-156
Author(s):  
Vladislav B. Bakovsky ◽  
Sergey I. Golovkin ◽  
Tatyana V. Kukharova ◽  
Vladimir A. Utkin ◽  
Elena N. Chalaya ◽  
...  
Keyword(s):  
Discriminant Analysis ◽  
Injury Severity ◽  
Successful Outcome ◽  
White Blood Count ◽  
Patient Response ◽  
Acute Period ◽  
Internal Bleeding ◽  
Patient Withdrawal ◽  
Vector Orientation ◽  
Individual Patient Response

Introduction. The treatment of polytrauma in children requires identifying the signs that characterize the severity of the acute period and quantifying the priorities of the parameters. Collectively, these reflect the direction of drift of the leading pathophysiological manifestations at each stage of the patient withdrawal program from a state of severe shock. Purpose. This study uses discriminant analysis to clarify the tactics of children with polytrauma in the first days of overcoming its consequences. It is based on the pathogenetically sound idea that each of the observed parameters role, together in the form of a vector, reflects injury severity and the childs prognosis. Materials and methods. This analysis included 45 children (34 boys and 11 girls) with polytrauma aged from 2.5 to 17 years and hospitalized in Kemerovos intensive care unit. Two groups were analyzed: the survivors and those who were deceased. Both were dominated by severe traumatic brain injury (PMT). The injury severity score (ISS) scale was used for clinical assessment of injury severity. Results. Combined with objectively obtained data on the structure of polytrauma in the direction of drift, a successful outcome is defined as a whole. It borders on the day to day priorities, potassium, PH, white blood count, and hematocrit. Also, the vector orientation pattern was observed to increase organ failure. This progressive decline occurred despite timely surgical intervention to stop internal bleeding, very active efforts to compensate for hypovolemia, acidosis, and the use of adequate means of detoxification. The deterioration in the child's condition manifests itself by increased potassium losses against the background of almost no reaction from leukocytes. Conclusions. The application of discriminant analysis enables the better revelation of the peculiarities of a polytraumas multidimensional dynamics in children in the first few days of resuscitation. It also permits the numerical expression of the priorities of individual parameters that describe their state, and by the severity and individual patient response in real-time to optimize treatment.

scholarly journals Long non-coding RNA SNHG15 in various cancers: a meta and bioinformatic analysis

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Caizhi Chen ◽  
Yeqian Feng ◽  
Jingjing Wang ◽  
Ye Liang ◽  
Wen Zou
Keyword(s):  
Publication Bias ◽  
Clinical Features ◽  
Tumour Progression ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Host Gene ◽  
The Cancer Genome Atlas ◽  
Prognostic Indicators ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract Background The snoRNA host gene SNHG15 produces a long non-coding RNA (lncRNA) with a short half-life and has been reported to be dysregulated in multiple cancers and has recently been found to be correlated with tumour progression. Therefore, this meta-analysis was performed to evaluate the generalised prognostic role of small nucleolar RNA host gene 15 (SNHG15) in malignancies, based on variable data from different studies. Methods Four public databases were used to identify eligible studies. The association between prognostic indicators and clinical features was extracted and pooled to estimate the hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs). Publication bias was measured using Begg’s test and Egger’s test, and the stability of pooled results were measured using sensitivity analysis. Additionally, an online database based on The Cancer Genome Atlas (TCGA) was screened to further validate our results. Ultimately, we predicted the molecular regulation of SNHG15 based on the public databases. Results In total, 11 studies including 1087 patients were ultimately enrolled in our meta-analysis. We found that SNHG15 overexpression was associated with worse overall survival (OS) and disease-free survival (DFS), and this was validated in the Gene Expression Profiling Interactive Analysis (GEPIA) cohort. Moreover, increased SNHG15 expression suggested advanced TNM stage and LNM, but was not associated with age, gender, or tumour size. No publication bias or instability of the results was observed. SNHG15 was significantly upregulated in seven cancers and elevated expression of SNHG15 indicated shorter OS and DFS in five malignancies based on the validation using the GEPIA cohort. Further functional prediction indicated that SNHG15 may participate in some cancer-related pathways. Conclusions Upregulation of lncRNA SNHG15 was notably associated with worse prognosis and clinical features, suggesting that SNHG15 might serve as a novel prognostic factor in various cancers.

scholarly journals Hantavirus Pulmonary Syndrome: Report of Four Alberta Cases

1995 ◽  
Vol 6 (4) ◽  
pp. 184-190 ◽  
Author(s):  
Ameeta E Singh ◽  
Denise H Werker ◽  
Lesia R Boychuk ◽  
Lilly J Miedzinski
Keyword(s):  
Intensive Care ◽  
Clinical Features ◽  
Peromyscus Maniculatus ◽  
Hantavirus Pulmonary Syndrome ◽  
Successful Outcome ◽  
Open Label ◽  
Rodent Host ◽  
Fourth Case ◽  
Open Label Trial ◽  
Syndrome Report

Four Alberta cases of hantavirus pulmonary syndrome are reported. Three cases required intensive care, with one experiencing a fulminant course resulting in death. A fourth case with milder illness was identified after epidemiological investigations. Ribavirin was used in one patient who experienced a successful outcome. A recent open label trial has not supported the efficacy of this drug. The epidemiology ofPeromyscus maniculatus, the primary rodent host, and the clinical features of this syndrome are summarized.

scholarly journals Novel insights into fecal incontinence in men

2017 ◽  
Vol 312 (1) ◽  
pp. G46-G51 ◽  
Author(s):  
Yoav Mazor ◽  
Michael Jones ◽  
Alison Andrews ◽  
John E. Kellow ◽  
Allison Malcolm
Keyword(s):  
Sex Differences ◽  
Fecal Incontinence ◽  
Clinical Features ◽  
Successful Outcome ◽  
Biofeedback Therapy ◽  
Tertiary Referral ◽  
Future Studies ◽  
Tertiary Referral Center ◽  
Rectal Pressure

Fecal incontinence (FI) in men is common, yet data on sex differences in clinical features, physiology, and treatment are scarce. Our aim was to provide insights into FI in males compared with females. Prospectively collected data from 73 men and 596 women with FI in a tertiary referral center were analyzed. Anorectal physiology, clinical characteristics, and outcome of instrumented biofeedback (BF) were recorded. Thirty-one men with FI proceeded to BF and were matched with 62 age-matched women with FI who underwent BF. Men with FI had higher resting, squeeze, and cough anal sphincter pressures ( P < 0.001) and were more able to hold a sustained squeeze compared with women ( P = 0.04). Men with FI had higher rectal pressure and less inadequate rectal pressure on strain and higher sensory thresholds ( P < 0.05). Men, but not women, with isolated soiling had higher anal resting and squeeze pressures compared with those with overt FI ( P < 0.05). Men were less likely to undergo BF when offered compared with women. Baseline symptom severity did not differ between the groups. In men, the absence of an organic cause for the FI and the presence of overt FI, but not isolated soiling, were correlated with improvement in patient satisfaction following BF. The outcomes of 50% reduction in FI episodes, physician assessment, symptoms, and quality of life scores after BF all significantly improved in men similarly to women. We conclude that men, compared with women, with FI have unique clinical features and physiology and are less likely to have investigations and treatment despite successful outcome with BF. Future studies to customize treatment in males and determine barriers to therapy are warranted. NEW & NOTEWORTHY Fecal incontinence in men is common, yet data on sex differences in clinical features, physiology, and treatment are scarce. We provide evidence that men, compared with women, with fecal incontinence have unique clinical features and physiology and are less likely to have investigations and treatment despite successful outcome with anorectal biofeedback therapy.

Color Based Classification for Berries of Japanese Blue Honeysuckle

2011 ◽  
Vol 7 (4) ◽  
Author(s):  
Longsheng Fu ◽  
Hiroshi Okamoto ◽  
Takashi Kataoka ◽  
Youichi Shibata
Keyword(s):  
Image Analysis ◽  
Standard Deviation ◽  
Discriminant Analysis ◽  
Success Rates ◽  
Fresh Market ◽  
Unique Form ◽  
Lonicera Caerulea ◽  
Lighting Conditions ◽  
Visual Characteristics ◽  
Blue Honeysuckle

Japanese blue honeysuckle (Lonicera caerulea L. var. emphyllocalyx Nakai) is a unique form of edible honeysuckle that has exceptionally tasty berries. Visual characteristics of the berry such as the color of the skin and the presence of defects are the most decisive factors in determining its quality. An image analysis based methodology for classifying the berries under uncontrolled outside lighting conditions was developed. A color sheet with hue value around 29° was determined as the background to support the berries whose hue values were found near 212°. With the thresholding level computed by Otsu’s algorithm in the red channel, berries were segmented from the background successfully. Three parameters, average and standard deviation of hue component and average of saturation component, were chosen as the best descriptions for each berry according to the Fisher’s least significant differences test. Three canonical functions and corresponding group centroids of each function obtained by discriminant analysis were able to classify the berries aimed for fresh market, processing, and waste at success rates of 95.1%, 85.1%, and 94.3%, respectively.

Patients With an Unclassified Genetic Variant in the BRCA1 or BRCA2 Genes Show Different Clinical Features From Those With a Mutation

2005 ◽  
Vol 23 (10) ◽  
pp. 2185-2190 ◽  
Author(s):  
Encarna B. Gómez-García ◽  
Ton Ambergen ◽  
Marinus J. Blok ◽  
Arthur van den Wijngaard
Keyword(s):  
Standard Deviation ◽  
Family History ◽  
Clinical Features ◽  
Predictive Models ◽  
Genetic Variant ◽  
Pathogenic Mutation ◽  
Unclassified Variant ◽  
The Family ◽  
Novel Variants ◽  
Combined Data

Purpose To obtain and compare the probabilities of finding a mutation in the BRCA1 or BRCA2 genes, the clinical features, and the family history among patients with an unclassified variant (UV) and those with a pathogenic mutation. Patients and Methods The study included 70 patients: 24 with a UV (BRCA1, n = 4; BRCA2, n = 19; both, n = 1), and 46 with a mutation (BRCA1, n = 32; BRCA2, n = 14). Two of the UVs were novel variants; the rest had been reported previously as UVs. Probabilities of finding a mutation were retrospectively obtained using BRCAPRO and Myriad II programs. Results The probability to detect a mutation was significantly lower in the group of patients with a UV than in those with a mutation (BRCAPRO [mean ± standard deviation], 0.297 ± 0.312 v 0.627 ± 0.315, P = .001; and Myriad II, 0.124 ± 0.090 v 0.283 ± 0.176, P = .001, respectively). Independent predictive factors of finding either a UV or a mutation were number of affected relatives (2.9 ± 1.4 v 4.0 ± 1.9; P = .039) and number of tumors among relatives (3.3 ± 1.4 v 4.4 ± 1.8; P = .031), respectively. Conclusion The combined data about the predictive models show significant differences between both groups. Individual probabilities can be regarded as a help to guide the clinical management of patients with a UV in those genes. However, a definitive conclusion about the pathogenicity of a UV can not be obtained from the clinical features alone, but only in combination with biochemical and epidemiologic data.

scholarly journals Angioedema: Clinical and Etiological Aspects

2007 ◽  
Vol 2007 ◽  
pp. 1-6 ◽  
Author(s):  
Kanokvalai Kulthanan ◽  
Sukhum Jiamton ◽  
Kanonrat Boochangkool ◽  
Kowit Jongjarearnprasert
Keyword(s):  
Standard Deviation ◽  
Mucous Membrane ◽  
Clinical Features ◽  
University Hospital ◽  
Skin Involvement ◽  
Drug Induced ◽  
Common Cause ◽  
The Common ◽  
Systemic Symptoms ◽  
Idiopathic Angioedema

Angioedema is an abrupt swelling of the skin, mucous membrane, or both including respiratory and gastrointestinal tracts. This study aimed to report an experience of angioedema in a university hospital with respect to etiologies, clinical features, treatment, and outcome. One hundred and five patients were enrolled. About half had angioedema without urticaria. The common sites of involvement were periorbital area and lips. Forty five patients (49%) had systemic symptoms. The most common cause of angioedema was allergic angioedema. Nonsteroidal anti-inflammatory drug-induced angioedema and idiopathic angioedema were detected in 20% and 18%, respectively. Among patients with allergic angioedema, 41.7% were caused by food, 39.6% by drugs. Thirty seven patients (39%) had recurrent attacks of angioedema. Mean standard deviation (SD) number of attacks in patients with recurrent angioedema was 3.9 (2.7) (ranging from 2 to 10 times). Patients who had older age and multiple sites of skin involvement had tendency to have systemic symptoms.

scholarly journals Long non-coding RNA SNHG15 in various cancers: a meta and bioinformatic analysis

2020 ◽  
Author(s):  
Caizhi Chen ◽  
Yeqian Feng ◽  
Jingjing Wang ◽  
Ye Liang ◽  
Wen Zou
Keyword(s):  
Publication Bias ◽  
Clinical Features ◽  
Tumour Progression ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Host Gene ◽  
The Cancer Genome Atlas ◽  
Prognostic Indicators ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract Background: The snoRNA host gene SNHG15 produces a long non‐coding RNA (lncRNA) with a short half-life and has been reported to be dysregulated in multiple cancers and has recently been found to be correlated with tumour progression. Therefore, this meta-analysis was performed to evaluate the generalised prognostic role of small nucleolar RNA host gene 15 (SNHG15) in malignancies, based on variable data from different studies. Methods: Four public databases were used to identify eligible studies. The association between prognostic indicators and clinical features was extracted and pooled to estimate the hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs). Publication bias was measured using Begg’s test and Egger’s test, and the stability of pooled results were measured using sensitivity analysis. Additionally, an online database based on The Cancer Genome Atlas (TCGA) was screened to further validate our results. Ultimately, we predicted the molecular regulation of SNHG15 based on the public databases. Results: In total, 11 studies including 1,087 patients were ultimately enrolled in our meta-analysis. We found that SNHG15 overexpression was associated with worse overall survival (OS) and disease-free survival (DFS), and this was validated in the Gene Expression Profiling Interactive Analysis (GEPIA) cohort. Moreover, increased SNHG15 expression suggested advanced TNM stage and LNM, but was not associated with age, gender, or tumour size. No publication bias or instability of the results was observed. SNHG15 was significantly upregulated in seven cancers and elevated expression of SNHG15 indicated shorter OS and DFS in five malignancies based on the validation using the GEPIA cohort. Further functional prediction indicated that SNHG15 may participate in some cancer-related pathways. Conclusions: Upregulation of lncRNA SNHG15 was notably associated with worse prognosis and clinical features, suggesting that SNHG15 might serve as a novel prognostic factor in various cancers.

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