Initial Screening Transferrin Saturation Values, Serum Ferritin Concentrations, and HFE Genotypes in Native Americans and Whites in the Hemochromatosis and Iron Overload Screening (HEIRS) Study.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3712-3712
Author(s):  
James C. Barton ◽  
Ronald T. Acton ◽  
Laura Lovato ◽  
Mark R. Speechley ◽  
Christine E. McLaren ◽  
...  
Keyword(s):  
Native American ◽  
Native Americans ◽  
Iron Overload ◽  
Allele Frequency ◽  
White Women ◽  
Transferrin Saturation ◽  
White Men ◽  
Initial Screening ◽  
Native American Women ◽  
Men And Women

Abstract There are few reports of transferrin saturation (TfSat) and serum ferritin (SF) phenotypes and HFE C282Y and H63D genotypes in native Americans. We compared initial screening data of 645 native American and 43,453 white HEIRS Study participants who reported a single race/ethnicity and who did not report a previous diagnosis of hemochromatosis or iron overload. Each underwent TfSat and SF measurements without regard to fasting, and HFE C282Y and H63D genotyping. Elevated measurements were defined as: TfSat >50% (men), >45% (women); and SF >300 ng/mL (men), >200 ng/mL (women). Mean TfSat was lower in native American men than in white men (31% vs. 32%, respectively; p = 0.0337), and lower in native American women than in white women (25% vs. 27%, respectively; p <0.0001). Mean SF was similar in native American and white men (153 μg/L vs. 151 μg/L; p = 0.8256); mean SF was lower in native American women than in white women (55 μg/L vs. 63 μg/L, respectively; p = 0.0015). The respective percentages of native American men and women with elevated TfSat or elevated SF were similar to those of white men and women. The respective mean TfSat and SF values of native American and white participants with genotype HFE wt/wt were similar. The C282Y allele frequency was 0.0340 in native Americans and 0.0683 in whites (p <0.0001). The H63D allele frequency was 0.1150 in native Americans and 0.1532 in whites (p = 0.0001). We conclude that the screening TfSat and SF phenotypes of native Americans do not differ greatly from those of whites. The respective allele frequencies of HFE C282Y and H63D are significantly lower in native Americans than in whites.

Initial Screening Transferrin Saturations, Serum Ferritin Concentrations, and HFE Genotypes in Whites and Blacks in the Hemochromatosis and Iron Overload Screening (HEIRS) Study.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3202-3202
Author(s):  
James C. Barton ◽  
Ronald T. Acton ◽  
Fitzroy W. Dawkins ◽  
Paul C. Adams ◽  
Laura Lovato ◽  
...  
Keyword(s):  
Black Women ◽  
Iron Overload ◽  
Allele Frequency ◽  
Black Men ◽  
Serum Ferritin ◽  
White Women ◽  
Transferrin Saturation ◽  
White Men ◽  
P Value ◽  
Initial Screening

Abstract We compared initial screening data of 44,149 whites (17,043 men; 27,106 women) and 26,947 blacks (9,788 men; 17,159 women) who reported no previous diagnosis of hemochromatosis or iron overload from a primary care-based sample of ~100,000 adults ≥25 years recruited from 5 Field Centers. Each underwent transferrin saturation (TfSat) and serum ferritin (SF) measurements without regard to fasting, and HFE C282Y and H63D genotyping. We observed these mean TfSat and SF values and percentages of participants with elevated biochemical measurements (TfSat >50% and SF >300 ng/mL, men; TfSat >45% and SF >200 ng/mL, women): Participants Mean % TfSat (95% CI) Elevated TfSat, % Participants Mean SF, ng/mL (95% CI) Elevated SF, % Participants White men 32.4 (32.3, 32.6) 7.05 150.9 (149.1, 152.8) 19.49 Black men 29.3 (29.1, 29.5) 4.03 178.4 (175.5, 181.3) 25.95 p Value <0.0001 <0.0001 <0.0001 <0.0001 White women 27.5 (27.3, 27.6) 6.62 63.0 (62.3, 63.7) 8.74 Black women 23.3 (23.1, 23.4) 3.04 68.3 (67.2, 69.4) 15.43 p Value <0.0001 <0.0001 <0.0001 <0.0001 In participants grouped by decade, mean TfSat was greater in white men than in black men, and in white women than in black women (all p<0.0001). Mean SF was greater in black men than in white men in all decades except 25–34 years, and in black women than in white women in decades ≥45 years. SF increased with age to ~45 years in white men and ~50 years in black men, and then decreased. In white women, SF rose with age until ~62 years and less rapidly to age ≥80. In black women, SF rose with age until ~62 years and then decreased. C282Y allele frequency was 0.0700 (95% CI: 0.0683, 0.0717) in whites and 0.0119 (0.0110, 0.0129) in blacks. H63D allele frequency was 0.1532 (0.1509, 0.1556) in whites and 0.0299 (0.0284, 0.0313) in blacks. Frequencies of genotypes with C282Y or H63D were greater in whites than in blacks (all p<0.0001). The prevalence of elevated TfSat and SF plus genotype C282Y/C282Y was 0.003 in whites and 0.00004 in blacks (p<0.0001). The prevalence of elevated TfSat and SF plus genotype C282Y/C282Y, C282Y/H63D, or H63D/H63D was 0.006 in whites and 0.0003 in blacks (p<0.0001). We conclude that: 1) the prevalence of elevated TfSat is higher in whites and the prevalence of elevated SF is higher in blacks; 2) SF levels increase with age; 3) HFE C282Y and H63D alleles occur more frequently in whites than in blacks; and 4) the prevalence of elevated TfSat and SF plus genotypes with two common HFE mutations is greater in whites than in blacks.

Race Difference in Auditory Sensitivity

1964 ◽  
Vol 7 (4) ◽  
pp. 389-393 ◽  
Author(s):  
David C. Shepherd ◽  
Robert Goldstein ◽  
Benjamin Rosenblüt
Keyword(s):  
White Women ◽  
White Men ◽  
Sensitivity Study ◽  
Auditory Sensitivity ◽  
Race Difference ◽  
Men And Women ◽  
Auditory Thresholds ◽  
Békésy Audiometry ◽  
Method Of Adjustment ◽  
Better Than

Two separate studies investigated race and sex differences in normal auditory sensitivity. Study I measured thresholds at 500, 1000, and 2000 cps of 23 white men, 26 white women, 21 negro men, and 24 negro women using the method of limits. In Study II thresholds of 10 white men, 10 white women, 10 negro men, and 10 negro women were measured at 1000 cps using four different stimulus conditions and the method of adjustment by means of Bekesy audiometry. Results indicated that the white men and women in Study I heard significantly better than their negro counterparts at 1000 and 2000 cps. There were no significant differences between the average thresholds measured at 1000 cps of the white and negro men in Study II. White women produced better auditory thresholds with three stimulus conditions and significantly more sensitive thresholds with the slow pulsed stimulus than did the negro women in Study II.

Representing Native American Women in Early Colonial American Writings: Álvar Núñez Cabeza de Vaca, Juan Ortiz and John Smith

Sederi ◽  
2009 ◽  
pp. 25-45
Author(s):  
Mª Carmen Gomez Galisteo
Keyword(s):  
Native American ◽  
Native Americans ◽  
Gender Roles ◽  
Contact Period ◽  
Native American Women ◽  
American Women ◽  
Early Colonial ◽  
Hernando De Soto ◽  
Female Roles ◽  
Cabeza De Vaca

Most observers of Native Americans during the contact period between Europe and the Americas represented Native American women as monstrous beings posing potential threats to the Europeans’ physical integrity. However, the most well known portrait of Native American women is John Smith’s description of Pocahontas, the Native American princess who, the legend goes, saved Smith from being executed. Transformed into a children’s tale, further popularized by the Disney movie, as well as being the object of innumerable historical studies questioning or asserting the veracity of Smith’s claims, the fact remains that the Smith-Pocahontas story is at the very core of North American culture. Nevertheless, far from being original, John Smith’s story had a precedent in the story of Spaniard Juan Ortiz, a member of the ill-fated Narváez expedition to Florida in 1527. Ortiz, who got lost in America and spent the rest of his life there, was also rescued by a Native American princess from being sacrificed in the course of a Native American ritual, as recounted by the Gentleman of Elvas, member of the Hernando de Soto expedition. Yet another vision of Native American women is that offered by Álvar Núñez Cabeza de Vaca, another participant of the Narváez expedition who, during almost a decade in the Americas fulfilled a number of roles among the Native Americans, including some that were regarded as female roles. These female roles provided him with an opportunity to avert captivity as well as a better understanding of gender roles within Native American civilization. This essay explores the description of Native American women posed by John Smith, Juan Ortiz and Álvar Núñez Cabeza de Vaca so as to illustrate different images of Native American women during the early contact period as conveyed by these works.

Man-Made Medicine and Women's Health: The Biopolitics of Sex/Gender and Race/Ethnicity

1994 ◽  
Vol 24 (2) ◽  
pp. 265-283 ◽  
Author(s):  
Nancy Krieger ◽  
Elizabeth Fee
Keyword(s):  
Social Class ◽  
Native Americans ◽  
White Men ◽  
The United States ◽  
Vital Statistics ◽  
Men And Women ◽  
Class Differences ◽  
Biological Variables ◽  
Race Ethnicity ◽  
19Th And 20Th Century

National vital statistics in the United States present data in terms of race, sex, and age, treated as biological variables. Some races are clearly of more interest than others: data are usually available for whites and blacks, and increasingly for Hispanics, but seldom for Native Americans or Asians and Pacific Islanders. These data indicate that white men and women generally have the best health and that men and women, within each racial/ethnic group, have different patterns of disease. Obviously, the health status of men and women differs for conditions related to reproduction, but it differs for many nonreproductive conditions as well. In national health data, patterns of disease by race and sex are emphasized while social class differences are ignored. This article discusses how race and sex became such all-important, self-evident categories in 19th and 20th century biomedical thought and practice. It examines the consequences of these categories for knowledge about health and for the provision of health care. It then presents alternative approaches to understanding the relationship between race/ethnicity, gender, and health, with reference to the neglected category of social class.

The Earnings of Women and Ethnic Minorities, 1959–1979

ILR Review ◽  
1988 ◽  
Vol 41 (4) ◽  
pp. 530-546 ◽  
Author(s):  
Leonard A. Carlson ◽  
Caroline Swartz
Keyword(s):  
Asian Indian ◽  
White Women ◽  
Census Data ◽  
White Men ◽  
Racial Groups ◽  
Japanese Men ◽  
Men And Women ◽  
Earnings Gap ◽  
Minority Men ◽  
Annual Earnings

Using 1980 Census data, the authors present estimates of annual earnings equations for twelve ethnic and racial groups, by gender, for 1979, and compare their results with an earlier study's estimates for 1959 and 1969. All minority men and women except Asian Indian and Japanese men earned less than white men in the years for which data were available. The earnings gap for most groups of men and women, however, declined over those years, and the portion of that gap that might be assignable to discrimination (the unexplained “residual”) also declined. A notable exception was white women, whose mean earnings relative to white men's changed little between 1969 and 1979, even when corrected for differences in productive characteristics.

scholarly journals Identity and the Legislative Decision Making Process: A Case Study of the Maryland State Legislature

2011 ◽  
Vol 34 (1) ◽  
pp. 45-68 ◽  
Author(s):  
Nadia Brown
Keyword(s):  
Decision Making ◽  
Black Women ◽  
African American Women ◽  
Black Men ◽  
White Women ◽  
White Men ◽  
State Legislature ◽  
Men And Women ◽  
Women Legislators ◽  
Men I

Both politicians and the mass public believe that identity influences political behavior yet, political scientists have failed to fully detail how identity is salient for all political actors not just minorities and women legislators. To what extent do racial, gendered, and race/gendered identities affect the legislation decision process? To test this proposition, I examine how race and gender based identities shape the legislative decisions of Black women in comparison to White men, White women, and Black men. I find that Black men and women legislators interviewed believe that racial identity is relevant in their decision making processes, while White men and women members of the Maryland state legislature had difficulty deciding whether their identities mattered and had even more trouble articulating how or why they did. African American women legislators in Maryland articulate or describe an intersectional identity as a meaningful and significant component of their work as representatives. More specifically, Black women legislators use their identity to interpret legislation differently due to their race/gender identities.

Sovereign Bodies: Native Nations, Native American Women, and the Politics of 2018

2020 ◽  
pp. 106591292091330
Author(s):  
Gabriel R. Sanchez ◽  
Raymond Foxworth ◽  
Laura E. Evans
Keyword(s):  
Native American ◽  
Native Americans ◽  
American Politics ◽  
Political Attitudes ◽  
The Political ◽  
Native American Women ◽  
Donald Trump ◽  
American Women ◽  
Racial Identities ◽  
Nationally Representative

What did Native American women and men voters think about Donald Trump on the eve of the 2018 election? This question has important implications for understanding the gendered political attitudes of peoples adversely targeted by Trump’s politics. To examine this issue, we analyze a path-breaking, nationally representative sample of six hundred Native American voters. We find that Native Americans’ attitudes about sexual harassment are central to their attitudes about politics and policy in the Trump era. This relationship suggests that Native American voters are an informed electorate influenced by the president’s words and actions. Our work demonstrates multiple ways that gender influenced Native American politics during an election where gender and racial identities were central. In so doing, our work illuminates how race, institutions, and vulnerability affect the political attitudes of Native American voters, one of the least studied groups in American politics.

Accelerated melanoma mortality rates among middle-aged white males with tumors of all thicknesses.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e21029-e21029
Author(s):  
Juliana Berk-Krauss ◽  
David Polsky ◽  
Jennifer Stein ◽  
Alan Geller
Keyword(s):  
White Women ◽  
Age Groups ◽  
White Men ◽  
Mortality Rates ◽  
Age Group ◽  
Middle Aged ◽  
Mortality Trends ◽  
Men And Women ◽  
And Gender ◽  
Melanoma Mortality

e21029 Background: Effective early detection of melanoma remains one of the most crucial strategies in improving patient prognosis, due to the inverse relationship between primary tumor thickness and survival time. However, recent studies have demonstrated the mortality burden of thin melanomas is at least as severe as that of thicker melanomas. Recognizing specific mortality trends among men and women by age and thickness is essential for establishing targeted melanoma screening efforts. Methods: We evaluated Surveillance, Epidemiology and End Results (SEER) data from 2009-2013. Melanoma thickness was divided into four standard categories: 0.01-1.00mm, 1.01-2.00mm, 2.01-4.00mm and > 4.01 mm. Melanoma mortalities were calculated among white men and women by age and thickness. We used a Bayesian analysis to calculate the probability of an individual dying from a melanoma of a given gender, age, and thickness. We then compared these probabilities between men and women. Results: Among white men, the largest increases in mortality rates occurred in the jump from the 45-49 to 50-54 age group at an increase of 68% for 0.01-1.00mm tumors, and from the 50-54 to 55-59 age group at an increase of 91% for 1.01-2.00mm tumors, 71% 2.01-4.00mm tumors and 80% for > 4.01mm tumors. In white women, mortality rates regardless of thickness increased at a slow incremental pace, across all age groups at an average overall rate of 36%. Mortality rates for white men with < 1mm and 1.01-2mm melanomas were comparable within the age groups less than 64 years, as was the case for white women with tumors of these thicknesses. The probability of a man dying was greater than of a woman for any age or thickness category. Conclusions: Melanoma mortality rate trends are nuanced and can vary significantly by age, thickness, and gender. In white men, mortality rates begin to accelerate sharply around the mid-50s age group. Screening efforts should therefore target detecting melanoma in middle-aged males in the in situ or earliest stage.

Free State Slavery: Bound Indian Labor and Slave Trafficking in California's Sacramento Valley, 1850–1864

2012 ◽  
Vol 81 (2) ◽  
pp. 155-192 ◽  
Author(s):  
Michael F. Magliari
Keyword(s):  
Native American ◽  
Native Americans ◽  
White Women ◽  
Work Force ◽  
Gold Rush ◽  
Alternative Source ◽  
Domestic Servants ◽  
Sacramento Valley ◽  
The Government ◽  
Rural Work

Although it outlawed chattel slavery, antebellum California permitted the virtual enslavement of Native Americans under the 1850 Act for the Government and Protection of Indians. Drawing data from a rare and valuable cache of Indian indenture records at the Colusa County courthouse and interpreting them through the lens of Henry Bailey's candid pioneer memoir, this article offers a detailed case study of bound Native American labor and Indian slave trafficking in Northern California's Sacramento Valley. While never comprising a majority of the state's rural work force, bound Indian laborers proved essential to California's rise as a major agricultural producer. Compensating for the dearth of white women and children in male-dominated Gold Rush society and providing a vital alternative source of labor in an expensive free wage market, captive Indian farm hands and domestic servants enabled pioneer farm operations and communities to flourish throughout the formative 1850s and 1860s.

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