scholarly journals Pulmonary hypertension in chronic lung disease and hypoxia

2019 ◽  
Vol 53 (1) ◽  
pp. 1801914 ◽  
Author(s):  
Steven D. Nathan ◽  
Joan A. Barbera ◽  
Sean P. Gaine ◽  
Sergio Harari ◽  
Fernando J. Martinez ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Current State ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Oxygen Requirements ◽  
Impaired Quality

Pulmonary hypertension (PH) frequently complicates the course of patients with various forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is invariably associated with reduced functional ability, impaired quality of life, greater oxygen requirements and an increased risk of mortality. The aetiology of CLD-PH is complex and multifactorial, with differences in the pathogenic sequelae between the diverse forms of CLD. Haemodynamic evaluation of PH severity should be contextualised within the extent of the underlying lung disease, which is best gauged through a combination of physiological and imaging assessment. Who, when, if and how to screen for PH will be addressed in this article, as will the current state of knowledge with regard to the role of treatment with pulmonary vasoactive agents. Although such therapy cannot be endorsed given the current state of findings, future studies in this area are strongly encouraged.

scholarly journals Is Psoriatic Arthritis Associated With Higher Risk of Mortality?

2021 ◽  
pp. jrheum.210963
Author(s):  
Ying-Ying Leung
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Psoriatic Arthritis ◽  
Cardiovascular Events ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Systemic Inflammatory Disease ◽  
Impaired Quality

Psoriatic arthritis (PsA) is a systemic inflammatory disease affecting domains beyond the musculoskeletal system, and may lead to disability and impaired quality of life. It is associated with comorbidities such as hypertension, diabetes mellitus, obesity, metabolic syndrome, and increased risk of cardiovascular events.

scholarly journals Music and dance in chronic lung disease

Breathe ◽  
2019 ◽  
Vol 15 (2) ◽  
pp. 116-120 ◽  
Author(s):  
Keir Philip ◽  
Adam Lewis ◽  
Nicholas S. Hopkinson
Keyword(s):  
Chronic Disease ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Personalised Medicine ◽  
Evidence Base ◽  
Self Management ◽  
Music Making ◽  
Arts In Health

Arts in Health interventions show potential to improve the quality of life of people with chronic lung disease. Listening to music, making music, and dance have accepted and established roles in the lives of people without chronic disease. However, their potential utility in chronic disease management is infrequently considered by medical professionals. The aim of this review is to examine the use of music and dance in the treatment and self-management of chronic lung disease. Although the evidence base is currently limited, existing research suggests a range of biopsychosocial benefits. As personalised medicine and social prescribing become more prominent, further research is required to establish the role of arts interventions in chronic lung disease.

Treating Preterm Infants at Risk for Chronic Lung Disease with Dexamethasone Leads to an Impaired Quality of General Movements

Neonatology ◽  
2002 ◽  
Vol 82 (3) ◽  
pp. 155-158 ◽  
Author(s):  
Arend F. Bos ◽  
Jasmin Dibiasi ◽  
Ansje H. Tiessen ◽  
Klasien A. Bergman
Keyword(s):  
At Risk ◽  
Lung Disease ◽  
Preterm Infants ◽  
Chronic Lung Disease ◽  
General Movements ◽  
Impaired Quality

scholarly journals The Role of Macrolides in Childhood Non-Cystic Fibrosis-Related Bronchiectasis

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
R. Masekela ◽  
R. J. Green
Keyword(s):  
Quality Of Life ◽  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Lung Disease ◽  
Mucociliary Clearance ◽  
Improve Quality ◽  
Immunomodulatory Properties ◽  
Impaired Quality

Non-cystic fibrosis-related bronchiectasis is a chronic inflammatory lung disease, which is regarded as an “orphan” lung disease, with little research devoted to the study of this condition. Bronchiectasis results in impaired quality of life and mortality if left untreated. The tools available in the armamentarium for the management of bronchiectasis entail antibiotic therapy traditionally used to treat exacerbations, stratagems to improve mucociliary clearance, and avoidance of toxins. Macrolides have been known for the last two decades to have not only anti-bacterial effects but immunomodulatory properties as well. In cystic fibrosis, the use of macrolides is well documented in subjects colonized withPseudomonas aeruginosa, to improve quality of life and lung function. There is currently emerging evidence to suggest the benefit of macrolides in subjects not colonized withPseudomonas aeruginosa. This beneficial effect has been less explored in the context of bronchiectasis from other causes. The purpose of this paper is to review the current literature on the use of macrolides in non-cystic fibrosis related bronchiectasis in paediatrics.

scholarly journals Current State of the Autoimmune Thyroiditis Problem

2019 ◽  
pp. 4-13
Author(s):  
V. A. Rozhko
Keyword(s):  
Thyroid Gland ◽  
Autoimmune Thyroiditis ◽  
Convincing Evidence ◽  
Current State ◽  
Number Of Patients ◽  
Increased Risk ◽  
Study Results ◽  
The Republic

The review provides up-to-date data on pathogenetic mechanisms, opportunities of diagnosis, and organizational and medical measures concerning autoimmune thyroiditis (AIT). AIT is a polyetiological disease which is mainly caused by environmental factors, genetic predisposition and disorder in immune regulation. Primary AIT incidence in the Republic of Belarus in 2017 is 58 cases per 100,000 population in the overall structure of the thyroid gland pathology, the AIT accounts for up to 40 %. The upward trend in the number of autoimmune diseases of the thyroid gland, including that in ecologically unfavorable regions, is explained not only by the true increase in the number of patients with AIT, the consequences of stress, but also by the overdiagnosis. There is contradictory data on the correlation of the level of iodine sufficiency of the population with the AIT development; there is no convincing evidence of the role of radiation factors in increasing the risk of AIT. The review analyzes the correlation of AIT with an imbalance in a number of microelements involved in the synthesis of thyroid hormones and affecting the iodine exchange. The article presents the study results that determined the nature of immune disorders in AIT and hypothyroidism in such forms as disorders of lymphocyte subpopulations, proinflammatory and anti-inflammatory cytokines, changes in the apoptosis mechanisms, which were proposed for use as predictors of the severity of thyroid immune inflammation and hypothyroidism. The criteria for selecting patients with an increased risk of developing AIT complications remain unclear, that necessitates the development and implementation of additional organizational and medical measures for following-up of such patients and assessing their quality of life.

scholarly journals Biochemical and Bioimpedance Correlation with Quality of Life and Illness Perception in Hemodialysis Patients

2019 ◽  
Vol 70 (2) ◽  
pp. 679-684
Author(s):  
Mihaela-Dora Donciu ◽  
Laura Florea ◽  
Luanda-Irina Mititiuc ◽  
Elena-Rodica Popescu ◽  
Roxana Chirita
Keyword(s):  
Quality Of Life ◽  
Illness Perception ◽  
Psychometric Evaluation ◽  
Hemodialysis Patients ◽  
Cross Sectional ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Sectional Analysis ◽  
Impaired Quality

In hemodialysis patients malnutrition-inflammation syndrome, evaluated by biochemical laboratory analysis and through bioimpedance spectroscopy, was associated to impaired quality of life and with an increased risk of mortality. The present study goal was to investigate, in a cross-sectional analysis, performed in 122 hemodialysis patients, the association between biochemical parameters and bioimpedance-derived measurements the association of undernutrition with quality of life and illness perception. The results showed that our cohort perceived an impaired quality of life and illness perception and that these psychometric evaluation was associated with malnutrition markers.

Biopsychosocial Patterning of Multimorbidity and Its Consequences

2018 ◽  
pp. 220-236
Author(s):  
Elliot Friedman ◽  
Beth LeBreton ◽  
Lindsay Fuzzell ◽  
Elizabeth Wehrpsann
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Functional Outcomes ◽  
The United States ◽  
Chronic Medical Conditions ◽  
Quality Of Life Research ◽  
Increased Risk ◽  
Over Time

By many estimates the majority of adults over age 65 have two or more chronic medical conditions (multimorbidity) and are consequently at increased risk of adverse functional outcomes. Nonetheless, many older adults with multimorbidity are able to maintain high levels of function and retain good quality of life. Research presented here is designed to understand the influences that help ensure better functional outcomes in these older adults. This chapter presents findings that draw on data from the Midlife in the United States study. The independent and interactive contributions of diverse factors to multimorbidity and changes in multimorbidity over time are reviewed. The degree that multimorbidity increases risk of cognitive impairment and disability is examined. The role of inflammation as a mediator is considered. Multimorbidity is increasingly the norm for older adults, so better understanding of factors contributing to variability in multimorbidity-related outcomes can lead to improved quality of life.

scholarly journals Early and Late Postoperative Seizures in Meningioma Patients and Prediction by a Recent Scoring System

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 450
Author(s):  
Peter Baumgarten ◽  
Mana Sarlak ◽  
Daniel Monden ◽  
Andrea Spyrantis ◽  
Simon Bernatz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Tumor Volume ◽  
Total Risk ◽  
Increased Risk ◽  
Independent Risk Factors ◽  
Temporal Location ◽  
Meningioma Surgery ◽  
Impaired Quality

Seizures are among the most common symptoms of meningioma. This retrospective study sought to identify risk factors for early and late seizures in meningioma patients and to evaluate a modified STAMPE2 score. In 556 patients who underwent meningioma surgery, we correlated different risk factors with the occurrence of postoperative seizures. A modified STAMPE2 score was applied. Risk factors for preoperative seizures were edema (p = 0.039) and temporal location (p = 0.038). For postoperative seizures preoperative tumor size (p < 0.001), sensomotory deficit (p = 0.004) and sphenoid wing location (p = 0.032) were independent risk factors. In terms of postoperative status epilepticus; sphenoid wing location (p = 0.022), tumor volume (p = 0.045) and preoperative seizures (p < 0.001) were independent risk factors. Postoperative seizures lead to a KPS deterioration and thus an impaired quality of life (p < 0.001). Late seizures occurred in 43% of patients with postoperative seizures. The small sub-cohort of patients (2.7%) with a STAMPE2 score of more than six points had a significantly increased risk for seizures (p < 0.001, total risk 70%). We concluded that besides distinct risk factors, high scores of the modified STAMPE2 score could estimate the risk of postoperative seizures. However, it seems not transferable to our cohort

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