scholarly journals Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Sudhakar Chintharlapalli ◽  
Sabitha Papineni ◽  
Ping Lei ◽  
Satya Pathi ◽  
Stephen Safe
Keyword(s):  
Colon Cancer ◽  
Transcription Factors ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Betulinic Acid ◽  
Colon Cancer Cell ◽  
Sp Transcription Factors

scholarly journals Aspirin Inhibits Colon Cancer Cell and Tumor Growth and Downregulates Specificity Protein (Sp) Transcription Factors

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e48208 ◽  
Author(s):  
Satya Pathi ◽  
Indira Jutooru ◽  
Gayathri Chadalapaka ◽  
Vijayalekshmi Nair ◽  
Syng-Ook Lee ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Transcription Factors ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Specificity Protein ◽  
Sp Transcription Factors

scholarly journals Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth

2010 ◽  
Vol 316 (13) ◽  
pp. 2174-2188 ◽  
Author(s):  
Indira Jutooru ◽  
Gayathri Chadalapaka ◽  
Sandeep Sreevalsan ◽  
Ping Lei ◽  
Rola Barhoumi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Transcription Factors ◽  
Tumor Growth ◽  
Arsenic Trioxide ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Specificity Protein ◽  
Sp Transcription Factors

scholarly journals Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors

2013 ◽  
Vol 34 (12) ◽  
pp. 2870-2879 ◽  
Author(s):  
V. Nair ◽  
S. Pathi ◽  
I. Jutooru ◽  
S. Sreevalsan ◽  
R. Basha ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Transcription Factors ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Sp Transcription Factors

scholarly journals Tian Xian Liquid (TXL) induces apoptosis in HT-29 colon cancer cell in vitro and inhibits tumor growth in vivo

2010 ◽  
Vol 5 (1) ◽  
pp. 25 ◽  
Author(s):  
Qing Liu ◽  
Yao Tong ◽  
Stephen Sze ◽  
Wing Liu ◽  
Lam Lam ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Ht 29

scholarly journals Trolox induces inhibition of cell proliferation and apoptosis in human colon cancer cells

2015 ◽  
Vol 10 (4) ◽  
pp. 931 ◽  
Author(s):  
Li-Guang Yang ◽  
Xiang-An Tian ◽  
Xiao-Yan Li ◽  
Jian-Guo Huang ◽  
Nai-Qing Liu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines

<p class="Abstract">In the present study, the effect of trolox on human colon cancer cell lines was investigated. The results revealed that trolox treatment caused inhibition of cell growth in T84 and HCT-15 colon cancer cell lines in a dose-dependent manner. The inhibition was significant at 50 µM of trolox after 48 hours in both cell lines. Trolox treatment promoted expression of p38 and inhibited expression of survivin and Akt. It also induced cleavage of PARP and caspase-3 and ultimately induced apoptosis in T84 and HCT-15 cells. The tumor growth was inhibited significantly in the xenotransplanted mice on treatment with trolox compared to the control group. Since trolox treatment exhibits inhibitory effect on the proliferation of colon cancer cells and inhibits tumor growth in vivo therefore, can be of therapeutic importance for the treatment of colon cancer.</p><p> </p>

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