ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI3K and MAPK signaling pathways in gastric cancer

Abstract Background and aim: Gastric cancer) GC) is one of the most common cancer with high mortality worldwide. The human Wharton's jelly stem cells (hWJSCs) can inhibit several cancer cells through several molecular pathways. Therefore, the present study aimed to investigate anticancer effects of hWJSCs conditioned medium (hWJSC-CM) and cell-free lysate (hWJSC-CL) against of GC cell line AGS and underlying signaling pathways. Methods: In this study, we evaluated the effects of hWJSC-CM and hWJSC-CL on viability, proliferation, migration, invasion, apoptosis, and MAPK and NF‑κB signaling pathways in AGS cells. Moreover, mRNA expression of genes involved in apoptosis (BAX, BCL2, SMAC, and SURVIVIN), as well as expression of proteins involved in NF-κB and MAPK signaling pathways were evaluated. Results: The obtained results showed that the hWJSC-CM and hWJSC-CL decreased viability, migration, and invasion of GC cell line AGS in a concentration and time dependent manner. We observed that the hWJSC-CM and hWJSC-CL induced apoptosis pathway through regulation of apoptosis involved genes mRNA expression. In addition, the hWJSC-CM and hWJSC-CL suppressed NF-κB signaling pathways as well as promoted MAPK signaling pathways. Conclusions: In general, our study suggested that the hWJSC-CM and hWJSC-CL inhibits proliferation and viability of GC cell line AGS through induction of apoptosis, as well as modification of NF-κB and MAPK signaling pathways.

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ABA plays essential roles in regulating root growth by interacting with auxin and MAPK signaling pathways and cell-cycle machinery in rice seedlings

Plant Growth Regulation ◽

10.1007/s10725-014-0017-7 ◽

2014 ◽

Vol 75 (2) ◽

pp. 535-547 ◽

Cited By ~ 11

Author(s):

Feng Yun Zhao ◽

Feng Xiang Cai ◽

Hua Jian Gao ◽

Shi Yong Zhang ◽

Kai Wang ◽

...

Keyword(s):

Cell Cycle ◽

Root Growth ◽

Signaling Pathways ◽

Mapk Signaling ◽

Rice Seedlings ◽

Cell Cycle Machinery ◽

Mapk Signaling Pathways

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Long non-coding RNA-mediated regulation of signaling pathways in gastric cancer

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2017-1139 ◽

2018 ◽

Vol 56 (11) ◽

pp. 1828-1837 ◽

Cited By ~ 12

Author(s):

Wei Zong ◽

Shaoqing Ju ◽

Rongrong Jing ◽

Ming Cui

Keyword(s):

Gastric Cancer ◽

Signaling Pathways ◽

Surgical Resection ◽

High Frequency ◽

Tumor Recurrence ◽

Mapk Signaling ◽

Non Coding Rna ◽

Non Coding Rnas ◽

Long Non Coding Rna ◽

Mapk Signaling Pathways

Abstract Gastric cancer (GC) is one of the most common cancers globally. Because of the high frequency of tumor recurrence, or metastasis, after surgical resection, the prognosis of patients with GC is poor. Therefore, exploring the mechanisms underlying GC is of great importance. Recently, accumulating evidence has begun to show that dysregulated long non-coding RNAs (lncRNAs) participate in the progression of GC via several typical signaling pathways, such as the AKT and MAPK signaling pathways. Moreover, the interactions between lncRNAs and microRNAs appear to represent a novel mechanism in the pathogenesis of GC. This review provides a synopsis of the latest research relating to lncRNAs and associated signaling pathways in GC.

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