scholarly journals Metastasis of breast cancer to bladder

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Asma Hadhri ◽  
Rim Abidi ◽  
Najet Mahjoub ◽  
Alia Mousli ◽  
Khalil Mahjoubi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lobular Carcinoma ◽  
Bladder Wall ◽  
Hormonal Treatment ◽  
Left Breast ◽  
Case Presentation ◽  
History Of ◽  
Bladder Metastasis ◽  
One Year ◽  
Immunohistochemical Studies

Abstract Background Breast cancer is the leading cause of cancer death in women, and most breast cancer related deaths are due to metastasis. Urinary bladder metastasis from breast cancer is rarely reported in the literature. Case presentation We report a case of a 77-year-old female with history of left breast cancer, who presented a thickening of the bladder wall at pelvic ultrasound. Biopsy confirmed that the origin was lobular carcinoma of breast origin. The patient received chemotherapy, but the clinical course of the patient was very aggressive and she died one year later. Conclusion Bladder metastasis from breast cancer is rare, but the literature reveals an increase in such occurrence over the last few years. Pathologic diagnosis relies on immunohistochemical studies. Chemotherapy and hormonal treatment represent the standard therapy, with radiotherapy being used only to control bladder bleeding. The prognosis is usually poor.

scholarly journals Late urinary bladder metastasis from breast cancer

2019 ◽  
Vol 91 (1) ◽  
pp. 60-62 ◽  
Author(s):  
Aldo Franco De Rose ◽  
Federica Balzarini ◽  
Guglielmo Mantica ◽  
Carlo Toncini ◽  
Carlo Terrone
Keyword(s):  
Breast Cancer ◽  
Urinary Bladder ◽  
Bladder Wall ◽  
Unusual Site ◽  
Left Flank ◽  
History Of ◽  
Bladder Metastasis ◽  
Metastatic Involvement ◽  
Left Flank Pain ◽  
Rule Out

Introduction: Breast cancer (BrC) is the most common non-dermatologic cancer in women. It frequently metastasizes to lung, liver and bone, while the urinary bladder is considered as an unusual site for BrC metastases. Materials and methods: Four years after her first oncologic surgical approach, a known BrC patient complained of a left flank pain, dysuria and urgency. Computed tomography (CT scan) imaging showed an irregular thickening of the left bladder wall and bilateral hydronephrosis. Results: A bladder metastases from BrC was diagnosed based on a histological examination of a transurethral resection of the bladder (TURB-T) specimen. Conclusions: In patients with a history of BrC, urinary bladder screening is not needful. However, if low urinary symptoms persist, an evaluation of the bladder should be considered to rule out metastatic involvement.

Unusual Presentation of Breast Metastasis Mimicking Skin Abscess

2020 ◽  
Author(s):  
Armaghan Kazeminejad ◽  
Mohammad Jafar Ghahari ◽  
Ali Mirabi ◽  
Lotfollah Davoodi ◽  
Mohammad Tabarestani
Keyword(s):  
Breast Cancer ◽  
Clinical Presentation ◽  
Left Breast ◽  
Breast Metastasis ◽  
Common Site ◽  
Cutaneous Metastases ◽  
Invasive Ductal Breast Carcinoma ◽  
Erythrocyte Sedimentation ◽  
History Of ◽  
One Year

The primary malignant tumor that most commonly metastasizes to the skin in women is breast cancer and manifest variety forms of clinical presentation. Breast cancer has the ability to metastasize to any site such as the ovaries, lung, liver, bone, brain, gastrointestinal tract and skin. The skin is not a common site for metastatic spread. We would like to report a case of a 56 years old female patient with an infectious mass in her left inframammary fold with discharge. The patients had a one-year history of left breast pruritus and with a mass which increased in size over two months. There was axillary lymphadenopathy, tenderness, and erythema of breast skin around the mass in the physical examination and just elevated erythrocyte sedimentation rate in laboratory tests. The patient did not benefit from antimicrobial therapy. The histological examination revealed a tumor with sheets of malignant cells and many necrotic areas. The diagnosis was invasive ductal breast carcinoma, cutaneous metastases, and lymphatic embolization.

Case of second primary breast cancer in ectopic breast tissue and review of the literature

2021 ◽  
Vol 14 (4) ◽  
pp. e241361
Author(s):  
Jamin Kweku Addae ◽  
Thomas Genuit ◽  
Joseph Colletta ◽  
Kathy Schilling
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Breast Tissue ◽  
Delayed Diagnosis ◽  
Left Breast ◽  
Second Primary ◽  
Female Population ◽  
Accessory Breast ◽  
History Of ◽  
High Index Of Suspicion

Accessory breast tissue (ABT) is found in approximately 2%–6% of the female population and are subject to most of the physiological and pathological changes that occur in pectoral breast. Primary breast cancer occurring in ABT is a rare occurrence and a second primary breast cancer occurring in an accessory breast has never been reported. We report the case of a 60-year-old woman with a history of mastectomy for left breast cancer 5 years prior to presentation, who presented with an enlarging right axilla mass found to be a second primary breast cancer in an accessory tissue on biopsy. Many physicians are unfamiliar with the clinical presentation of accessory breast cancer due to the rarity of the condition and this ultimately results in delayed diagnosis and advanced disease at presentation. It is therefore prudent that physicians have a high index of suspicion when patients present with axillary masses.

scholarly journals Isolated Pulmonary Hydatid Cyst: A Rare Presentation in a Young Maasai Boy from Northern Tanzania

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Jay Lodhia ◽  
Ayesiga Herman ◽  
Rune Philemon ◽  
Adnan Sadiq ◽  
Deborah Mchaile ◽  
...  
Keyword(s):  
Rare Presentation ◽  
Case Presentation ◽  
The Public ◽  
Post Procedure ◽  
Northern Tanzania ◽  
Typical History ◽  
History Of ◽  
One Year ◽  
The Right ◽  
Pulmonary Hydatid Cyst

Introduction. Hydatidosis is a parasitic manifestation caused by Echinococcus granulosus. It is characterized by cystic lesions in the liver and lungs. Diagnosis is based on typical history and radiological measures. Case presentation. A four-year-old boy presented with a one-year history of dry cough and difficulty in breathing which was of gradual progression. Computed tomography of the chest revealed a large 11.7 cm×8.6 cm×11.0 cm cyst in the right hemithorax. The patient underwent thoracotomy and recovered well post procedure. Conclusion. This case report highlights that large hydatid cysts can be surgically removed with good outcome and the importance of realizing that the disease is a burden to the public health and is much neglected.

Adenomyoepithelioma of the Breast

2007 ◽  
Vol 93 (5) ◽  
pp. 493-495 ◽  
Author(s):  
Chun-Ying Huang ◽  
Shyr-Ming Sheen-Chen ◽  
Hock-Liew Eng ◽  
Sheung-Fat Ko
Keyword(s):  
Frozen Section ◽  
Color Doppler ◽  
Myoepithelial Cells ◽  
Left Breast ◽  
Full Description ◽  
Breast Lump ◽  
Supraclavicular Lymph Nodes ◽  
History Of ◽  
Immunohistochemical Studies ◽  
Uncommon Tumor

Adenomyoepithelioma of the breast is an uncommon tumor characterized by the presence of both epithelial and myoepithelial cells; its first full description was published in 1970 by Hamperl. A 45-year-old woman presented a left breast lump that had been palpable for 4 weeks. There was no family history of breast cancer. Neither axillary nor supraclavicular lymph nodes were palpable. Craniocaudal mammography showed a 1.6 cm, well-defined nodule with several punctate intranodular calcifications in the subareolar region of the left breast. Color Doppler sonogram showed an ovoid, well-defined, homogeneous hypoechoic subareolar nodule with prominent peripheral vessels in the 6 o'clock position of the left breast. Operation was arranged and intraoperative frozen section examination revealed proliferation of round, oval or tubular glandular elements with intervening islands and bands of polygonal myoepithelial cells. Adenomyoepithelioma of the breast was the impression. Wide excision with adequate removal of the tumor and preservation of the left breast contour was successfully achieved. The diagnosis of adenomyoepithelioma of the breast was confirmed by immunohistochemical studies.

scholarly journals Nodular Scleritis Revealing Metastasis of Breast Cancer: Diagnosis Not to Be Neglected

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Belghmaidi Sarah ◽  
Ghazza Ahmed ◽  
Boutgayout Saloua ◽  
Hajji Ibtissam ◽  
Moutaouakil Abdeljalil ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Breast Cancer Diagnosis ◽  
Left Breast ◽  
Histopathological Study ◽  
Ophthalmological Examination ◽  
Secondary Tumor ◽  
Systemic Corticosteroids ◽  
Anterior Scleritis ◽  
History Of

We report the case of ocular metastasis in a 48-year-old woman presenting left eye redness and pain. The patient was followed in another health institution for nodular scleritis and received systemic corticosteroids with moderate improvement. Medical history revealed that she was diagnosed three years ago with invasive ductal carcinoma of the left breast treated by tumorectomy with ganglion dissection. An ophthalmological examination found a hard scleral nodule with vascular architectural disorganization. A biopsy was performed, and the histopathological study revealed the presence of secondary tumor proliferation of poorly differentiated carcinoma of mammary cancer. This case report shows the fact that any unusual ocular presentation, even one simulating anterior scleritis, in a patient with a history of breast cancer should raise suspicion of metastasis.

scholarly journals Excision of metastatic breast cancer from sternum and reconstruction in two patients with solitary metastatic spread

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Saifullah Mohamed ◽  
Khurum Mazhar ◽  
Ahmed Osman ◽  
Akshay Patel ◽  
Lakshmi Srinivasan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Previous History ◽  
Metastatic Breast ◽  
Extent Of Resection ◽  
Left Breast ◽  
Term Survival ◽  
Metastatic Breast Carcinoma ◽  
History Of ◽  
Treated Breast

Abstract Metastatic breast carcinoma is a relatively common clinical entity. However, the prognosis of oligometastatic and polygometastatic disease differs considerably pertaining to five-year survival. Metastatic breast carcinoma to the sternum has been described as early as 1988. We describe two cases in our institution who presented with solitary sternal metastases with a previous history of treated breast cancer. In both cases, there had been a history of previous left breast cancer treated aggressively with surgical resection and adjuvant oncological therapy and maintenance hormonal therapy. Partial sternectomy or total sternectomy for solitary metastatic sternal deposits is well established with relatively low morbidity and mortality and improvement in quality of life and possible improvement in long-term survival. Furthermore, reconstructive options are inherently dependent on extent of resection performed. These techniques can incorporate the use of sternal plates in order to approximate defects and reinforce the sternum in the setting of partial sternectomy.

Association of use of bisphosphonates with risk of colorectal cancer.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 371-371
Author(s):  
G. Rennert ◽  
M. Pinchev ◽  
H. S. Rennert ◽  
S. B. Gruber
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Vegetable Consumption ◽  
Population Based ◽  
Relative Reduction ◽  
Sports Activity ◽  
Low Dose Aspirin ◽  
History Of ◽  
Post Menopausal ◽  
One Year

371 Background: Bisphosphonates are commonly used for the treatment of osteoporosis and of bone metastases due to breast cancer and were recently reported to be associated with reduced risk of breast cancer, but their association with risk of other cancers is unknown. Methods: The Molecular Epidemiology of Colorectal Cancer (MECC) study is a population-based case-control study in northern Israel of colorectal cancer cases and age/sex/clinic/ethnic-group matched controls. Use of bisphosphonates prior to diagnosis was assessed in a subset of 933 pairs of post-menopausal female cases and controls, enrolled in Clalit Health Services (CHS), using computerized pharmacy records. Results: The use of bisphosphonates for more than one year prior to diagnosis, but not for less than a year, was associated with a significantly reduced relative risk of colorectal cancer (odds ratio=0.50, 95% CI: 0.35-0.71). This association remained statistically significant after adjustment for, vegetable consumption, sports activity, family history of colorectal cancer, , BMI, use of low-dose aspirin, statins, vitamin D and post-menopausal hormones (OR=0.40, 0.24-0.64). Concomitant use of bisphosphonates and statins did not further reduce the risk. Conclusions: The use of oral bisphosphonates for more than 1 year was associated with a 60% relative reduction in the risk of colorectal cancer similar to the recently reported association of this drug class with reduction in breast cancer risk. No significant financial relationships to disclose.

Pleomorphic lobular carcinoma in situ: A distinct entity of controversial significance.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 177-177
Author(s):  
Marina De Brot ◽  
Shirin Muhsen ◽  
Victor P. Andrade ◽  
Starr Koslow Mautner ◽  
Melissa Murray ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Previous History ◽  
Prior History ◽  
Lobular Carcinoma In Situ ◽  
Pleomorphic Lobular Carcinoma ◽  
History Of

177 Background: Pleomorphic lobular carcinoma in situ (PLCIS) is an increasingly diagnosed variant of lobular carcinoma in situ. Histologically, it resembles ductal carcinoma in situ (DCIS), leading to controversy over proper management. Yet, the natural history of PLCIS is unknown. Here we describe our experience with PLCIS. Methods: Review of pathology reports (1995–2012) identified 233 cases of LCIS variants. Patients with synchronous ipsilateral DCIS or invasive cancer (IC) were excluded leaving 25 cases for review. Consensus review by 3 pathologists further excluded 7; leaving 18 cases, 12 of which were classified as PLCIS and 6 as LCIS with pleomorphic features (LCIS-PF). (Table) PLCIS was defined by cellular dyshesion, nuclear pleomorphism with a 2-3 fold size variation, conspicuous nucleoli, mitoses and abundant cytoplasm; lesions not meeting all parameters were classified as LCIS-PF. Loss of e-cadherin was confirmed; clinical data were obtained from medical records. Results: Mean patient age at diagnosis of PLCIS/LCIS-PF was 57 yrs (42-67 yrs). All cases presented with imaging abnormalities. A previous history of breast cancer was present in 7/18 (39%) pts (3/7, ipsilateral; 4/7, contralateral). Following PLCIS/LCIS-PF diagnosis, 6/18 (33%) pts underwent mastectomy and 12/18 had excision alone, with (n=3) or without chemoprevention (n=9). Margin status was negative in 4/12 pts; close in 3/12 pts and positive in 5/12 pts undergoing excision. At a median follow-up of 27 mos (2-148 mos), 2/12 pts treated with excision developed ipsilateral breast cancer (1 DCIS; 1 IC). Both had close margins at initial excision; median time to cancer, 54 mos. Conclusions: Pure PLCIS is an uncommon lesion. Synchronous malignancy or prior history of breast cancer are often present in patients with PLCIS, contributing to the difficulty in determining the actual risk conferred by this lesion and appropriate management. Efforts to systematically characterize LCIS variants and prospective documentation of outcomes are needed to clarify the significance of these lesions. [Table: see text]

scholarly journals A Rare Case of Acute Renal Failure Secondary to Rhabdomyolysis Probably Induced by Donepezil

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Osman Zikrullah Sahin ◽  
Teslime Ayaz ◽  
Suleyman Yuce ◽  
Fatih Sumer ◽  
Serap Baydur Sahin
Keyword(s):  
Emergency Department ◽  
Renal Failure ◽  
Creatine Kinase ◽  
Acute Renal Failure ◽  
Rare Case ◽  
Laboratory Studies ◽  
Case Presentation ◽  
History Of ◽  
One Year ◽  
Renal Function Tests

Introduction. Acute renal failure (ARF) develops in 33% of the patients with rhabdomyolysis. The main etiologic factors are alcoholism, trauma, exercise overexertion, and drugs. In this report we present a rare case of ARF secondary to probably donepezil-induced rhabdomyolysis.Case Presentation. An 84-year-old male patient was admitted to the emergency department with a complaint of generalized weakness and reduced consciousness for two days. He had a history of Alzheimer’s disease for one year and he had taken donepezil 5 mg daily for two months. The patient’s physical examination revealed apathy, loss of cooperation, and decreased muscle strength. Laboratory studies revealed the following: urea: 128 mg/dL; Creatinine 6.06 mg/dL; creatine kinase: 3613 mg/dL. Donepezil was discontinued and the patient’s renal function tests improved gradually.Conclusion. Rhabdomyolysis-induced acute renal failure may develop secondary to donepezil therapy.

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