scholarly journals A classification model for lncRNA and mRNA based on k-mers and a convolutional neural network

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Jianghui Wen ◽  
Yeshu Liu ◽  
Yu Shi ◽  
Haoran Huang ◽  
Bing Deng ◽  
...  

Abstract Background Long-chain non-coding RNA (lncRNA) is closely related to many biological activities. Since its sequence structure is similar to that of messenger RNA (mRNA), it is difficult to distinguish between the two based only on sequence biometrics. Therefore, it is particularly important to construct a model that can effectively identify lncRNA and mRNA. Results First, the difference in the k-mer frequency distribution between lncRNA and mRNA sequences is considered in this paper, and they are transformed into the k-mer frequency matrix. Moreover, k-mers with more species are screened by relative entropy. The classification model of the lncRNA and mRNA sequences is then proposed by inputting the k-mer frequency matrix and training the convolutional neural network. Finally, the optimal k-mer combination of the classification model is determined and compared with other machine learning methods in humans, mice and chickens. The results indicate that the proposed model has the highest classification accuracy. Furthermore, the recognition ability of this model is verified to a single sequence. Conclusion We established a classification model for lncRNA and mRNA based on k-mers and the convolutional neural network. The classification accuracy of the model with 1-mers, 2-mers and 3-mers was the highest, with an accuracy of 0.9872 in humans, 0.8797 in mice and 0.9963 in chickens, which is better than those of the random forest, logistic regression, decision tree and support vector machine.

Author(s):  
Wanli Wang ◽  
Botao Zhang ◽  
Kaiqi Wu ◽  
Sergey A Chepinskiy ◽  
Anton A Zhilenkov ◽  
...  

In this paper, a hybrid method based on deep learning is proposed to visually classify terrains encountered by mobile robots. Considering the limited computing resource on mobile robots and the requirement for high classification accuracy, the proposed hybrid method combines a convolutional neural network with a support vector machine to keep a high classification accuracy while improve work efficiency. The key idea is that the convolutional neural network is used to finish a multi-class classification and simultaneously the support vector machine is used to make a two-class classification. The two-class classification performed by the support vector machine is aimed at one kind of terrain that users are mostly concerned with. Results of the two classifications will be consolidated to get the final classification result. The convolutional neural network used in this method is modified for the on-board usage of mobile robots. In order to enhance efficiency, the convolutional neural network has a simple architecture. The convolutional neural network and the support vector machine are trained and tested by using RGB images of six kinds of common terrains. Experimental results demonstrate that this method can help robots classify terrains accurately and efficiently. Therefore, the proposed method has a significant potential for being applied to the on-board usage of mobile robots.


2019 ◽  
Vol 8 (4) ◽  
pp. 160 ◽  
Author(s):  
Bingxin Liu ◽  
Ying Li ◽  
Guannan Li ◽  
Anling Liu

Spectral characteristics play an important role in the classification of oil film, but the presence of too many bands can lead to information redundancy and reduced classification accuracy. In this study, a classification model that combines spectral indices-based band selection (SIs) and one-dimensional convolutional neural networks was proposed to realize automatic oil films classification using hyperspectral remote sensing images. Additionally, for comparison, the minimum Redundancy Maximum Relevance (mRMR) was tested for reducing the number of bands. The support vector machine (SVM), random forest (RF), and Hu’s convolutional neural networks (CNN) were trained and tested. The results show that the accuracy of classifications through the one dimensional convolutional neural network (1D CNN) models surpassed the accuracy of other machine learning algorithms such as SVM and RF. The model of SIs+1D CNN could produce a relatively higher accuracy oil film distribution map within less time than other models.


2021 ◽  
Vol 11 (1) ◽  
pp. 15-24
Author(s):  
Dequan Guo ◽  
Gexiang Zhang ◽  
Hui Peng ◽  
Jianying Yuan ◽  
Prithwineel Paul ◽  
...  

In recent years, diseases of cardiovascular and cerebrovascular have attracted much attention due to main causes in death in human beings. To reduce mortality, there are lots of efforts which are focused on early diagnosis and prevention. It is an important reference index for cardiovascular diseases through the endovascular membrane in carotid artery by medical ultrasound images. The paper proposes a method which finds the region of interest (ROI) by convolutional neural network, segments and measures intima-media membrane mainly using support vector machine (SVM). Essentially, the task of detecting the membrane is one target detection problem. This paper adopts the strategy, named Yon Only Look Once (YOLO), a new detection algorithm, and follows the convolution neural network algorithm based on end-to-end training. Firstly, sufficient samples are extracted according to certain characteristics in the special region. It can be trained by the SVM classification model. Then the ROI is processed and all the pixels are classified into boundary points and non-boundary points through the classification model. Thirdly, the boundary points are selected to obtain the accurate boundary and calculate the intima-media thickness (IMT). In experiments, two hundred ultrasound images are tested, and the results verify that our algorithm is consistent with the results by ground truth (GT). The detection speed of the algorithm in this paper is in real time, and it has high generalization characteristics. The algorithm computes the intima-media thickness in ultrasound images accurately and quickly with 95% consistence to ground truth.


2019 ◽  
Author(s):  
Marcelo Vilela Vizoni ◽  
Aparecido Nilceu Marana

This paper presents a new method for person authentication that relies on the fusion of two biometric authentication methods based, respectively, on ocular deep features and facial deep features. In our work, the deep features are extracted from the regions of interest by using a very deep CNN (Convolutional Neural Network). Another interesting aspect of our work is that, instead of using directly the deep features as input for the authentication methods, we use the difference between the probe and gallery deep features. So, our method adopts a pairwise strategy. Support Vector Machine classifiers are trained separately for each approach. The fusion of the ocular and the facial based methods are carried out in the score level. The proposed method was assessed with a facial database taken under uncontrolled environment and reached good results. Besides, the fusion strategy proposed in this work showed better results than the results obtained by each individual method.


2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Ankita Tyagi ◽  
Ritika Mehra

AbstractAutomatic heart disease detection from human heartbeats is a challenging and intellectual assignment in signal processing because periodically monitoring of the heart beat arrhythmia for patient is an essential task to reduce the death rate due to cardiovascular disease (CVD). In this paper, the focus of research is to design hybrid Convolutional Neural Network (CNN) architecture by making use of Grasshopper Optimization Algorithm (GOA) to classify different types of heart diseases from the ECG signal or human heartbeats. Convolutional Neural Network (CNN) as an artificial intelligence approach is widely used in computer vision-based medical data analysis. However, the traditional CNN cannot be used for classification of heart diseases from the ECG signal because lots of noise or irrelevant data is mixed with signal. So this study utilizes the pre-processing and selection of feature for proper heart diseases classification, where Discrete Wavelet Transform (DWT) is used for the noise reduction as well as segmentation of ECG signal and Grasshopper Optimization Algorithm (GOA) is used for selection of R-peaks features from the extracted feature sets in terms of R-peaks and R-R intervals that help to attain better classification accuracy. For training as well as testing of projected Heartbeats Classification Model (HCM), the Standard MIT-BIH arrhythmia database is utilized with hybrid Convolutional Neural Network (CNN) architecture. The assortment of proper R-peaks and R-R intervals is a major factor and because of the deficiency of apposite pre-processing phases like noise removal, signal decomposition, smoothing and filtering, the uniqueness of extracted feature is less. The experimental outcomes show that the planned HCM is effective for detecting irregular human heartbeats via R-peaks and R-R intervals. When the proposed Heartbeats Classification Model (HCM) was verified on the database, model achieved higher efficiency than other state-of-the-art techniques for 16 heartbeat disease categories and the average classification accuracy is 99.58% with fast and robust responses where the correctly classified heartbeats are 86,005 and misclassified beats is only 108 with 0.42% error rate.


Author(s):  
Ghazal Shamsipour ◽  
Saied Pirasteh

Recognition of the human interaction on the unconstrained videos taken from cameras and remote sensing platforms like a drone is a challenging problem. This study presents a method to resolve issues of motion blur, poor quality of videos, occlusions, the difference in body structure or size, and high computation or memory requirement. This study contributes to the improvement of recognition of human interaction during disasters such as an earthquake and flood utilizing drone videos for rescue and emergency management. We used Support Vector Machine (SVM) to classify the high-level and stationary features obtained from Convolutional Neural Network (CNN) in key-frames from videos. We extracted conceptual features by employing CNN to recognize objects from first and last images from a video. The proposed method demonstrated the context of a scene, which is significant in determining the behaviour of human in the videos. In this method, we do not require person detection, tracking, and many instances of images. The proposed method was tested for the University of Central Florida (UCF Sports Action), Olympic Sports videos. These videos were taken from the ground platform. Besides, camera drone video was captured from Southwest Jiaotong University (SWJTU) Sports Centre and incorporated to test the developed method in this study. This study accomplished an acceptable performance with an accuracy of 90.42%, which has indicated improvement of more than 4.92% as compared to the existing methods.


2020 ◽  
Vol 36 (5) ◽  
pp. 743-749
Author(s):  
Xingwang Li ◽  
Xiaofei Fan ◽  
Lili Zhao ◽  
Sheng Huang ◽  
Yi He ◽  
...  

HighlightsThis study revealed the feasibility of to classify pepper seed varieties using multispectral imaging combined with one-dimensional convolutional neural network (1D-CNN).Convolutional neural networks were adopted to develop models for prediction of seed varieties, and the performance was compared with KNN and SVM.In this experiment, the classification effect of the SVM classification model is the best, but the 1D-CNN classification model is relatively easy to implement.Abstract. When non-seed materials are mixed in seeds or seed varieties of low value are mixed in high value varieties, it will cause losses to growers or businesses. Thus, the successful discrimination of seed varieties is critical for improvement of seed ralue. In recent years, convolutional neural networks (CNNs) have been used in classification of seed varieties. The feasibility of using multispectral imaging combined with one-dimensional convolutional neural network (1D-CNN) to classify pepper seed varieties was studied. The total number of three varieties of samples was 1472, and the average spectral curve between 365nm and 970nm of the three varieties was studied. The data were analyzed using full bands of the spectrum or the feature bands selected by successive projection algorithm (SPA). SPA extracted 9 feature bands from 19 bands (430, 450, 470, 490, 515, 570, 660, 780, and 880 nm). The classification accuracy of the three classification models developed with full band using K nearest neighbors (KNN), support vector machine (SVM), and 1D-CNN were 85.81%, 97.70%, and 90.50%, respectively. With full bands, SVM and 1D-CNN performed significantly better than KNN, and SVM performed slightly better than 1D-CNN. With feature bands, the testing accuracies of SVM and 1D-CNN were 97.30% and 92.6%, respectively. Although the classification accuracy of 1D-CNN was not the highest, the ease of operation made it the most feasible method for pepper seed variety prediction. Keywords: Multispectral imaging, One-dimensional convolutional neural network, Pepper seed, Variety classification.


2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yunjun Xu

A sports training video classification model based on deep learning is studied for targeting low classification accuracy caused by the randomness of objective movement in sports training video. The camera calibration technology is used to restore the position of the target in the real three-dimensional space. After the camera calibration in the video, the sports training video is preprocessed. The input video segment is divided into equal length segments to obtain the subvideo segment. The motion vector field, brightness feature, color feature, and texture feature of the subvideo segment are extracted, and the extracted features are input into the AlexNet convolutional neural network. ReLU is used as the activation function in this convolutional neural network. Local response normalization is used to suppress and enhance the output of neurons to highlight the performance of useful information, so that the output classification results are more accurate. Event matching method is used to match the convolutional neural network output to complete the sports training video classification. The experimental results of the proposed study show that the model can effectively solve the problems of target moving randomness. The classification accuracy of sports training video is more than 99%, and the classification speed is faster which is shown from the results of the experiments.


2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Miao Wu ◽  
Chuanbo Yan ◽  
Huiqiang Liu ◽  
Qian Liu ◽  
Yi Yin

Cervical cancer (CC) is one of the most common gynecologic malignancies in the world. The incidence and mortality keep high in some remote and poor medical condition regions in China. In order to improve the current situation and promote the pathologists’ diagnostic accuracy of CC in such regions, we tried to propose an intelligent and efficient classification model for CC based on convolutional neural network (CNN) with relatively simple architecture compared with others. The model was trained and tested by two groups of image datasets, respectively, which were original image group with a volume of 3012 datasets and augmented image group with a volume of 108432 datasets. Each group has a number of fixed-size RGB images (227*227) of keratinizing squamous, non-keratinizing squamous, and basaloid squamous. The method of three-folder cross-validation was applied to the model. And the classification accuracy of the models, overall, 93.33% for original image group and 89.48% for augmented image group. The improvement of 3.85% has been achieved by using augmented images as input data for the model. The results got from paired-samples ttest indicated that two models’ classification accuracy has a significant difference (P<0.05). The developed scheme we proposed was useful for classifying CCs from cytological images and the model can be served as a pathologist assistance to improve the doctor’s diagnostic level of CC, which has a great meaning and huge potential application in poor medical condition areas in China.


2021 ◽  
Vol 2066 (1) ◽  
pp. 012091
Author(s):  
Xiaojing Fan ◽  
A Runa ◽  
Zhili Pei ◽  
Mingyang Jiang

Abstract This paper studies the text classification based on deep learning. Aiming at the problem of over fitting and training time consuming of CNN text classification model, a SDCNN model is constructed based on sparse dropout convolutional neural network. Experimental results show that, compared with CNN, SDCNN further improves the classification performance of the model, and its classification accuracy and precision can reach 98.96% and 85.61%, respectively, indicating that SDCNN has more advantages in text classification problems.


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