Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and other hematological parameters in psoriasis patients

Abstract Background Psoriasis is a chronic immune‐mediated skin disorder. Systemic inflammation plays an important role in the pathogenesis of psoriasis. Methods A total of 477 patients with psoriasis vulgaris (PsV, n = 347), generalized pustular psoriasis (GPP, n = 37), erythrodermic psoriasis (PsE, n = 45), arthritic psoriasis (PsA, n = 25) and mixed psoriasis (n = 23), and 954 healthy control subjects were included in the study. Demographic, clinical, and laboratory information were collected and compared between subgroups. Results Compared with the healthy control group, patients with psoriasis had higher total white blood cell (WBC), neutrophil, platelet counts, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR), but lower hemoglobin (Hb) levels, lymphocyte and red blood cell (RBC) counts. NLR values in the PsV group were significantly lower than those in the GPP, PsE, and PsA groups, with GPP group being the highest. PLR values in the PsV group were significantly lower than those in the GPP, PsE, and PsA groups. There was no significant correlation between the psoriasis area severity index (PASI) score and either the NLR or PLR in the PsV group. Conclusions Elevated NLR and PLR were associated with psoriasis and differed between subtypes, suggesting that they could be used as markers of systemic inflammation in psoriasis patients.

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Evaluation of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and C-Reactive Protein in Tension-Type Headache Patients

Journal of Neurosciences in Rural Practice ◽

10.1055/s-0041-1730124 ◽

2021 ◽

Author(s):

Hasan Hüseyin Özdemir ◽

Ahmet Dönder

Keyword(s):

Systemic Inflammation ◽

Tension Type Headache ◽

Neutrophil To Lymphocyte Ratio ◽

Control Group ◽

C Reactive Protein ◽

Platelet To Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Reactive Protein ◽

Significant Difference ◽

Type Headache

Abstract Objectives A tension headache is the most common type of headache, and its causes are multifactorial. A relationship has been shown between migraine headaches and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP). In this study, we investigated the NLR, PLR, and serum CRP levels in frequent episodic tension-type headache (FETTH) and chronic tension-type headache (CTTH) patients. Materials and Methods This retrospective study included 64 patients with FETTH, 80 patients with CTTH, and 60 healthy controls who were followed up in the neurology clinic. Hematological parameters were compared between the patient and control groups. Results In CTTH patients, platelets, NLR, PLR, and CRP values were statistically higher than in FETTH patients and patients in the control group. In FETTH patients, the PLR value was higher than in patients in the control group, but there was no statistically significant difference in NLR and CRP values between FETTH patients and patients in the control group. Also, there was no correlation between these values and age and gender. Conclusion Increase platelet count might have an effect on tension-type headache pathophysiology. Systemic inflammation parameters were shown to be significantly higher in CTTH patients. More comprehensive studies are needed to evaluate the effect of systemic inflammation on the chronicity of tension headaches.

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The value of hemoglobin-to-red blood cell distribution width ratio (Hb/RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for the diagnosis of nasopharyngeal cancer

10.21203/rs.2.22048/v1 ◽

2020 ◽

Author(s):

Zhongyuan Lin Lin ◽

Xuan Zhang ◽

Songshan Zhu ◽

Yu Luo ◽

Yanyun Chen ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Nasopharyngeal Cancer ◽

Neutrophil To Lymphocyte Ratio ◽

Control Group ◽

Cell Distribution ◽

Platelet To Lymphocyte Ratio ◽

Distribution Width ◽

Lymphocyte Ratio ◽

Red Blood Cell Distribution

Abstract Background: The clinical significance of hemoglobin-to-red blood cell distribution width (Hb/RDW) for the diagnosis of nasopharyngeal cancer (NPC) has not been reported yet. This study aimed to evaluate the value of preoperative Hb/RDW, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for the diagnosis of NPC.Methods: A total of 180 NPC patients (NPC group) and 149 healthy subjects (control group) were recruited to assess the value of Hb/RDW, NLR, and PLR for the diagnosis of NPC. Results: It was noted that NLR and PLR were significantly higher in the NPC group than those in the control group (P<0.001), however, Hb/RDW was lower in the NPC group compared with that in the control group (P<0.001). NLR was also remarkably different between patients of stageⅠ+Ⅱ and those of stage Ⅲ+Ⅳ (P=0.043), and that was different in patients with lymph node metastases or not(P=0.030). Besides, PLR was signiﬁcantly different in patients with serosal invasion or not (P=0.031).Compared with Hb/RDW alone (sensitivity, 66.67%; specificity, 85.23%), the sensitivity (67.78%, 72.78%) and specificity (89.62%, 90.6%) of Hb/RDW with NLR and PLR were both increased. Furthermore, Hb/RDW combined with NLR (area under the receiver operating characteristic curve (ROC) (AUC), 0.824; 95% confidence interval (CI):0.779-0.864, P=0.0080) or PLR (AUC:0.851, 95%CI:0.808-0.888, P=0.0002) had a greater AUC value for the diagnosis of NPC compared with Hb/RDW alone (AUC: 0.781, 95% CI: 0.732-0.824).Conclusion: Hb/RDW can be used as a valuable indicator for the diagnosis of NPC. Preoperative Hb/RDW combined with NLR or PLR had higher value for the diagnosis of NPC.

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The Diagnostic Value of Eosinophil Count And Platelet-To-Lymphocyte Ratio In Eosinophilic Gastroenteritis

10.21203/rs.3.rs-1042591/v1 ◽

2021 ◽

Author(s):

Qiong Lin ◽

Renmin Zhou ◽

Hao Wujuan ◽

Zhumeng Ni ◽

Xiaozhong Li

Keyword(s):

Blood Cell ◽

Roc Curve ◽

Diagnostic Value ◽

Eosinophilic Gastroenteritis ◽

Control Group ◽

Platelet To Lymphocyte Ratio ◽

Roc Curve Analysis ◽

Record System ◽

Lymphocyte Ratio ◽

The Difference

Abstract Objective: To evaluate the diagnostic value of eosinophil (EO) count and platelet-to-lymphocyte ratio (PLR) in eosinophilic gastroenteritis (EGE). Methods: In total, 91 patients with EGE and 83 age–sex matched patients without EGE were selected as study subjects during January 2018 to December 2020. Data on blood cell count, and serum, C-reactive protein (CRP), and albumin levels were obtained from the Wuxi children's hospital electronic medical record system; the neutrophil-to-lymphocyte ratio (NLR), PLR, and CRP-to-albumin ratio (CAR) in the peripheral blood were recorded. Independent sample t-test, non-parametric test, or χ2 test was used according the data type to compare the difference between two groups, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic value for EGE. Results: The EO counts and PLR were significantly higher in the EGE group than those in the control group, whereas differences in the white blood cell, lymphocyte, neutrophil, and platelet counts, and the CRP level, NLR, and CAR were not significant. After treatment(Corticosteroids, 1mg/kg.d, lasting for 2 weeks）, the EO counts and PLR in the EGE group decreased gradually and the difference was significant. The diagnostic value of EO counts and PLR was determined with an area under the ROC curve as 0.756 and 0.616, sensitivity was 75.00% and 34.29%, and specificity was 74.29% and 92.31%, respectively. Conclusions EO and PLR represent potential predictive markers for diagnosing EGE.

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Blood Cell Count Derived Inflammation Indexes in Patients with Idiopathic Pulmonary Fibrosis

Lung ◽

10.1007/s00408-020-00386-7 ◽

2020 ◽

Vol 198 (5) ◽

pp. 821-827

Author(s):

Angelo Zinellu ◽

Panagiotis Paliogiannis ◽

Elisabetta Sotgiu ◽

Sabrina Mellino ◽

Arduino A. Mangoni ◽

...

Keyword(s):

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Blood Cell ◽

Cell Count ◽

Systemic Inflammation ◽

Smoking Status ◽

Neutrophil To Lymphocyte Ratio ◽

Blood Cell Count ◽

Lymphocyte Ratio ◽

Aggregate Index

Abstract Purpose Inflammation and immunity play a pivotal but yet unclear role in idiopathic pulmonary fibrosis (IPF), a chronic disorder characterized by progressive damage of lung parenchyma and severe loss of lung function despite optimal treatment. However, the pathophysiological and predictive role of combined blood cell count indexes of inflammation in IPF is uncertain. Methods Seventy-three patients with IPF and 62 healthy subjects matched for age, gender and smoking status were included in this cross-sectional study. Results We found significant differences in neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI) between IPF patients and healthy controls. In logistic regression, all combined blood inflammation indexes, barring PLR, were independently associated with the presence of IPF after adjusting for age, gender, body mass index and smoking status. Furthermore, significant associations between FVC% and NLR, LMR, SIRI and AISI, and between DLCO% and NLR, dNLR, LMR, SIRI and AISI, were observed. Conclusions In conclusion, our data indicate significant alterations of combined blood cell count indexes of inflammation in IPF.

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The value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in salivary gland tumors.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e17592 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e17592-e17592

Author(s):

Idris Yucel ◽

Ozgur Kemal ◽

Yasemin Kemal ◽

Ayse Bel ◽

Ugur Yildirim ◽

...

Keyword(s):

Salivary Gland ◽

Malignant Tumors ◽

Hematological Parameters ◽

Salivary Gland Tumor ◽

Salivary Gland Tumors ◽

Neutrophil To Lymphocyte Ratio ◽

Platelet To Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Inflammatory Parameters ◽

Tumor Group

e17592 Background: Salivary gland tumors are rare, comprising only 6 to 8 percent of head and neck neoplasms. Most of them are benign and commonly occur in the parotid gland. In the last decade elevated hematological inflammatory parameters like neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were identified as predictive and prognostic factors in various malignancies. The aim of this study was to evaluate the differences of preoperative of NLR and PLR levels in benign and malignant causes of salivary gland tumors. Methods: This retrospective study was made of a total of 133 patients with salivary gland tumors (age range: 17-89 years; 68 male and 65 female) who were treated between January 2006 and May 2016. Preoperative counts and levels of hematological parameters were obtained from the recorded computerized database in benign and malignant tumors. Results: NLR and PLR levels were significantly higher in the malignant salivary gland tumor group than the benign group( NLR: 0.66±1.3 vs 0.59±0.31 p=0.001, PLR: 160.3±85.7 vs 124.6±44.1 p=0.014). Conclusions: The results of the current study revealed the potential predicitve role of NLR and PLR in patients with salivary gland tumors. These cheap and easily available blood count parameters could be useful biomarkers in the future; but further investigations are needed to confirm our findings. [Table: see text]

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Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio Can be Useful Markers for Distinguishing Uterine Adenomyosis and Leiomyoma

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2017.716 ◽

2018 ◽

Vol 24 (3) ◽

pp. 147 ◽

Cited By ~ 1

Author(s):

Yusuf Madendag ◽

Erdem Sahin ◽

Emine Aydin ◽

Ilknur Col Madendag ◽

Gokhan Acmaz ◽

...

Keyword(s):

Neutrophil Count ◽

Pelvic Mass ◽

Abnormal Uterine Bleeding ◽

Study Groups ◽

Neutrophil To Lymphocyte Ratio ◽

Control Group ◽

Inflammation Markers ◽

Platelet To Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Uterine Adenomyosis

Objectıve: Both pelvic masses and preoperative diagnosis of them have still continued as an important investigation subject. It is important to discriminate the diagnoses of leiomyoma and adenomyosis before operation especially among infertile patients. Neoplasm can alter systemic or local immune response in their originating area. We aim to investigate using new inflammation markers, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio, whether they are useful to discriminate between adenomyosis and leiomyoma.Study Design: We reviewed a database of all patients that had complaint from abnormal uterine bleeding resistant to medical treatment or detected pelvic mass in perimenopausal period and underwent hysterectomy in our department between January 2011 and July 2016 for study groups. However, a total of 124 patients (44 adenomyosis and 80 leiomyoma) were evaluated because of exclusion criteria and matched with 72 women who were healthy and had normal uterus and ovaries as a control group.Results: Neutrophil and platelet count, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio levels were significantly higher in adenomyosis group than in control group (p=0.039, p=0.046, p=0.001 and p=0.046 respectively). Neutrophil count and neutrophil to lymphocyte ratio levels were significantly higher in adenomyosis group than in leiomyoma group (p=0.039 and p=0.001, respectively).Conclusıon: As a result, high neutrophil count and neutrophil to lymphocyte ratio levels may be useful marker to discriminate between adenomyosis and leiomyoma. Therefore, the examinations, which are more invasive and more expensive such as magnetic resonance imaging, may be less need by the agency of combined use of those inflammation markers and ultrasound in preoperative period.

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Predictive Values of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Other Prognostic Factors in Pediatric Patients With Bell’s Palsy

Ear Nose & Throat Journal ◽

10.1177/0145561320922097 ◽

2020 ◽

pp. 014556132092209 ◽

Cited By ~ 1

Author(s):

Dong Hyun Kim ◽

Jae Hwan Oh ◽

Junsuk Kim ◽

Chang Hyun Cho ◽

Ju Hyoung Lee

Keyword(s):

Prognostic Factors ◽

Pediatric Patients ◽

Bell’S Palsy ◽

Neutrophil To Lymphocyte Ratio ◽

Control Group ◽

Low Grade ◽

High Grade ◽

Bell's Palsy ◽

Platelet To Lymphocyte Ratio ◽

Lymphocyte Ratio

Background and Objectives: Bell’s palsy (BP) is the most frequent cause of unilateral facial paralysis, and inflammation is believed to play an important role in pathogenesis. Due to its rarity, however, no consensus has been reached regarding optimum treatment or factors affecting prognosis. In the present study, treatment outcomes and prognostic factors of BP were investigated in pediatric patients who underwent steroid therapy. The goal was to investigate the relationship between BP and inflammation using multiple inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and red cell distribution width (RDW). Materials and Methods: In all, 54 patients diagnosed with BP and 39 healthy randomly selected controls were enrolled in this retrospective study. Demographic characteristics and complete blood cell count test results were compared. In addition, prognostic factors were sought by dividing the 54 patients with BP into 2 groups according to the House-Brackmann grading system: low grade BP (grades II and III) and high grade BP (grades IV and V). Serum samples were analyzed retrospectively on initial presentation and 6 months after the symptom begins. Meaningful hematological parameters include NLR, PLR, MPV, and RDW. Results: The NLR values in the BP group were significantly higher than in the control group. The NLR value in the 2 groups of patients with BP differed significantly. The mean PLR value in the BP group was higher than in the control group; however, there were no significant differences between the low-grade and high-grade BP groups nor were there any statically significant differences in the other characteristics. Conclusion: The NLR and PLR values are readily accessible parameters that may be useful prognostic markers in pediatric patients with BP. Further studies are required to confirm these results and their utility in predicting prognosis and treating pediatric patients with BP.

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The value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) parameters in analysis with fetal malnutrition neonates

Journal of Perinatal Medicine ◽

10.1515/jpm-2019-0016 ◽

2019 ◽

Vol 47 (7) ◽

pp. 775-779 ◽

Cited By ~ 1

Author(s):

Emrah Can ◽

Ceren Can

Keyword(s):

Sensitivity And Specificity ◽

Characteristic Curve ◽

Neutrophil To Lymphocyte Ratio ◽

Control Group ◽

Platelet To Lymphocyte Ratio ◽

Cross Sectional ◽

Lymphocyte Ratio ◽

Appropriate For Gestational Age ◽

Fetal Malnutrition ◽

Pregnancy Weight

Abstract Objective To assess the association between fetal malnutrition (FM) and the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) in singleton term appropriate for gestational age (AGA) neonates. Methods This cross-sectional observational study was performed with 4340 singleton, term AGA neonates without perinatal disease over a two-year period. Results A total of 4320 neonates were evaluated in this study. Those diagnosed with fetal malnutrition, 284 (6%) neonates, were compared with 150 healthy term AGA neonates. Gestational week, birth weight, birth height, head circumference, maternal age, last pregnancy weight, and status of income of the FM group were found to be lower when compared to the control group (P = 0.011). Low last pregnancy weight (P = 0.017) and low level of income (P = 0.042) were found to be factors that affect the presence of FM. The NLR and PLR were found to be significantly higher in the FM group compared with term AGA healthy controls. In correlation analyses, there was a negative correlation between the NLR and PLR with fetal nutritional status (P = 0.011 and P < 0.001, respectively). When the NLR level was taken as 4.51, the sensitivity and specificity of the test for FM were calculated as 81.2% and 80.8%, respectively [area under the receiver-operating characteristic curve (AUROC): 0.81]; when the PLR level was taken as 155.4, the sensitivity and specificity of the test for FM were calculated as 87.0% and 85.4%, respectively (AUROC: 0.94). Conclusion Cord-blood NLR and PLR negatively correlate with term FM AGA neonates.

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