scholarly journals Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio Can be Useful Markers for Distinguishing Uterine Adenomyosis and Leiomyoma

2018 ◽  
Vol 24 (3) ◽  
pp. 147 ◽  
Author(s):  
Yusuf Madendag ◽  
Erdem Sahin ◽  
Emine Aydin ◽  
Ilknur Col Madendag ◽  
Gokhan Acmaz ◽  
...  
Keyword(s):  
Neutrophil Count ◽  
Pelvic Mass ◽  
Abnormal Uterine Bleeding ◽  
Study Groups ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Inflammation Markers ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Uterine Adenomyosis

<p><strong>Objectıve:</strong> Both pelvic masses and preoperative diagnosis of them have still continued as an important investigation subject. It is important to discriminate the diagnoses of leiomyoma and adenomyosis before operation especially among infertile patients. Neoplasm can alter systemic or local immune response in their originating area. We aim to investigate using new inflammation markers, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio, whether they are useful to discriminate between adenomyosis and leiomyoma.</p><p><strong>Study Design:</strong> We reviewed a database of all patients that had complaint from abnormal uterine bleeding resistant to medical treatment or detected pelvic mass in perimenopausal period and underwent hysterectomy in our department between January 2011 and July 2016 for study groups. However, a total of 124 patients (44 adenomyosis and 80 leiomyoma) were evaluated because of exclusion criteria and matched with 72 women who were healthy and had normal uterus and ovaries as a control group.</p><p><strong>Results:</strong> Neutrophil and platelet count, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio levels were significantly higher in adenomyosis group than in control group (p=0.039, p=0.046, p=0.001 and p=0.046 respectively). Neutrophil count and neutrophil to lymphocyte ratio levels were significantly higher in adenomyosis group than in leiomyoma group (p=0.039 and p=0.001, respectively).</p><p><strong>Conclusıon:</strong> As a result, high neutrophil count and neutrophil to lymphocyte ratio levels may be useful marker to discriminate between adenomyosis and leiomyoma. Therefore, the examinations, which are more invasive and more expensive such as magnetic resonance imaging, may be less need by the agency of combined use of those inflammation markers and ultrasound in preoperative period.</p>

scholarly journals Evaluation of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and C-Reactive Protein in Tension-Type Headache Patients

2021 ◽  
Author(s):  
Hasan Hüseyin Özdemir ◽  
Ahmet Dönder
Keyword(s):  
Systemic Inflammation ◽  
Tension Type Headache ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
C Reactive Protein ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Significant Difference ◽  
Type Headache

Abstract Objectives A tension headache is the most common type of headache, and its causes are multifactorial. A relationship has been shown between migraine headaches and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP). In this study, we investigated the NLR, PLR, and serum CRP levels in frequent episodic tension-type headache (FETTH) and chronic tension-type headache (CTTH) patients. Materials and Methods This retrospective study included 64 patients with FETTH, 80 patients with CTTH, and 60 healthy controls who were followed up in the neurology clinic. Hematological parameters were compared between the patient and control groups. Results In CTTH patients, platelets, NLR, PLR, and CRP values were statistically higher than in FETTH patients and patients in the control group. In FETTH patients, the PLR value was higher than in patients in the control group, but there was no statistically significant difference in NLR and CRP values between FETTH patients and patients in the control group. Also, there was no correlation between these values and age and gender. Conclusion Increase platelet count might have an effect on tension-type headache pathophysiology. Systemic inflammation parameters were shown to be significantly higher in CTTH patients. More comprehensive studies are needed to evaluate the effect of systemic inflammation on the chronicity of tension headaches.

scholarly journals Predictive Values of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Other Prognostic Factors in Pediatric Patients With Bell’s Palsy

2020 ◽  
pp. 014556132092209 ◽  
Author(s):  
Dong Hyun Kim ◽  
Jae Hwan Oh ◽  
Junsuk Kim ◽  
Chang Hyun Cho ◽  
Ju Hyoung Lee
Keyword(s):  
Prognostic Factors ◽  
Pediatric Patients ◽  
Bell’S Palsy ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Low Grade ◽  
High Grade ◽  
Bell's Palsy ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio

Background and Objectives: Bell’s palsy (BP) is the most frequent cause of unilateral facial paralysis, and inflammation is believed to play an important role in pathogenesis. Due to its rarity, however, no consensus has been reached regarding optimum treatment or factors affecting prognosis. In the present study, treatment outcomes and prognostic factors of BP were investigated in pediatric patients who underwent steroid therapy. The goal was to investigate the relationship between BP and inflammation using multiple inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and red cell distribution width (RDW). Materials and Methods: In all, 54 patients diagnosed with BP and 39 healthy randomly selected controls were enrolled in this retrospective study. Demographic characteristics and complete blood cell count test results were compared. In addition, prognostic factors were sought by dividing the 54 patients with BP into 2 groups according to the House-Brackmann grading system: low grade BP (grades II and III) and high grade BP (grades IV and V). Serum samples were analyzed retrospectively on initial presentation and 6 months after the symptom begins. Meaningful hematological parameters include NLR, PLR, MPV, and RDW. Results: The NLR values in the BP group were significantly higher than in the control group. The NLR value in the 2 groups of patients with BP differed significantly. The mean PLR value in the BP group was higher than in the control group; however, there were no significant differences between the low-grade and high-grade BP groups nor were there any statically significant differences in the other characteristics. Conclusion: The NLR and PLR values are readily accessible parameters that may be useful prognostic markers in pediatric patients with BP. Further studies are required to confirm these results and their utility in predicting prognosis and treating pediatric patients with BP.

The value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) parameters in analysis with fetal malnutrition neonates

2019 ◽  
Vol 47 (7) ◽  
pp. 775-779 ◽  
Author(s):  
Emrah Can ◽  
Ceren Can
Keyword(s):  
Sensitivity And Specificity ◽  
Characteristic Curve ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Platelet To Lymphocyte Ratio ◽  
Cross Sectional ◽  
Lymphocyte Ratio ◽  
Appropriate For Gestational Age ◽  
Fetal Malnutrition ◽  
Pregnancy Weight

Abstract Objective To assess the association between fetal malnutrition (FM) and the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) in singleton term appropriate for gestational age (AGA) neonates. Methods This cross-sectional observational study was performed with 4340 singleton, term AGA neonates without perinatal disease over a two-year period. Results A total of 4320 neonates were evaluated in this study. Those diagnosed with fetal malnutrition, 284 (6%) neonates, were compared with 150 healthy term AGA neonates. Gestational week, birth weight, birth height, head circumference, maternal age, last pregnancy weight, and status of income of the FM group were found to be lower when compared to the control group (P = 0.011). Low last pregnancy weight (P = 0.017) and low level of income (P = 0.042) were found to be factors that affect the presence of FM. The NLR and PLR were found to be significantly higher in the FM group compared with term AGA healthy controls. In correlation analyses, there was a negative correlation between the NLR and PLR with fetal nutritional status (P = 0.011 and P < 0.001, respectively). When the NLR level was taken as 4.51, the sensitivity and specificity of the test for FM were calculated as 81.2% and 80.8%, respectively [area under the receiver-operating characteristic curve (AUROC): 0.81]; when the PLR level was taken as 155.4, the sensitivity and specificity of the test for FM were calculated as 87.0% and 85.4%, respectively (AUROC: 0.94). Conclusion Cord-blood NLR and PLR negatively correlate with term FM AGA neonates.

scholarly journals Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, Mean Platelet Volume and Red Cell Distribution Width Measures in Bells Palsy

2017 ◽  
Vol 5 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Caner Sahin ◽  
Ceyhun Varım
Keyword(s):  
Absolute Neutrophil Count ◽  
Neutrophil Count ◽  
Control Group ◽  
Red Cell ◽  
Cell Distribution ◽  
Platelet Volume ◽  
Platelet To Lymphocyte Ratio ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
The Mean

AIM: The purpose of this study was to investigate the usefulness of the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) Mean Platelet Volume (MPV) and Red Cell Distribution Width (RDW) in the differential diagnosis and follow-up of patients with Bells Palsy.MATERIAL AND METHODS: Twenty-eight patients diagnosed with Bells Palsy and 28 control patients were included in the study. Serum samples were analysed retrospectively on the initial presentation and the seventh day of admission.RESULTS: On admission, the NLR was 1.7±1.2. The mean absolute neutrophil count was 6100 ± 900/mm^3 in Bells Palsy Group. NLR was 0.9 ± 0.2. The mean absolute neutrophil count was 4400 ± 1100/mm^3 in control group. Statistically, significant changes were not observed in NLR, PLR, MPV and RDW measurements in Bells Palsy group between House-Brackman Staging.CONCLUSION: Statistically significant changes in the neutrophil count and NLR were determined in the measurements between Bells Palsy and control group (p = 0.013, p = 0.016 respectively) on admission. A grade of the disease and NLR measurements had no statistically significant connection. RDW value was investigated for the first time in the literature for Bells Palsy patients.

scholarly journals The value of hemoglobin-to-red blood cell distribution width ratio (Hb/RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for the diagnosis of nasopharyngeal cancer

2020 ◽  
Author(s):  
Zhongyuan Lin Lin ◽  
Xuan Zhang ◽  
Songshan Zhu ◽  
Yu Luo ◽  
Yanyun Chen ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Nasopharyngeal Cancer ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Cell Distribution ◽  
Platelet To Lymphocyte Ratio ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Red Blood Cell Distribution

Abstract Background: The clinical significance of hemoglobin-to-red blood cell distribution width (Hb/RDW) for the diagnosis of nasopharyngeal cancer (NPC) has not been reported yet. This study aimed to evaluate the value of preoperative Hb/RDW, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for the diagnosis of NPC.Methods: A total of 180 NPC patients (NPC group) and 149 healthy subjects (control group) were recruited to assess the value of Hb/RDW, NLR, and PLR for the diagnosis of NPC. Results: It was noted that NLR and PLR were significantly higher in the NPC group than those in the control group (P<0.001), however, Hb/RDW was lower in the NPC group compared with that in the control group (P<0.001). NLR was also remarkably different between patients of stageⅠ+Ⅱ and those of stage Ⅲ+Ⅳ (P=0.043), and that was different in patients with lymph node metastases or not(P=0.030). Besides, PLR was significantly different in patients with serosal invasion or not (P=0.031).Compared with Hb/RDW alone (sensitivity, 66.67%; specificity, 85.23%), the sensitivity (67.78%, 72.78%) and specificity (89.62%, 90.6%) of Hb/RDW with NLR and PLR were both increased. Furthermore, Hb/RDW combined with NLR (area under the receiver operating characteristic curve (ROC) (AUC), 0.824; 95% confidence interval (CI):0.779-0.864, P=0.0080) or PLR (AUC:0.851, 95%CI:0.808-0.888, P=0.0002) had a greater AUC value for the diagnosis of NPC compared with Hb/RDW alone (AUC: 0.781, 95% CI: 0.732-0.824).Conclusion: Hb/RDW can be used as a valuable indicator for the diagnosis of NPC. Preoperative Hb/RDW combined with NLR or PLR had higher value for the diagnosis of NPC.

scholarly journals Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume in patients with idiopathic epiretinal membrane

2021 ◽  
Vol 13 ◽  
pp. 251584142110105
Author(s):  
Gokhan Demir ◽  
Husna Topcu ◽  
Semih Cakmak ◽  
Funda Ebru Aksoy ◽  
Mehmet Emin Sucu ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Epiretinal Membrane ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Platelet Volume ◽  
Platelet To Lymphocyte Ratio ◽  
Idiopathic Epiretinal Membrane ◽  
Lymphocyte Ratio ◽  
Control Subjects ◽  
The Mean

Purpose: To assess the role of inflammation in the pathogenesis of idiopathic epiretinal membrane (iERM) using the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) as indicators of inflammation and to compare these parameter levels between iERM and control subjects. Methods: We retrospectively analyzed the medical records of 36 patients who underwent vitrectomy-ERM peeling and 39 patients who had cataract surgery. We obtained blood samples from all individuals who participated in the study to investigate these parameters. Results: Seventy-five subjects were included in this study: 36 in the iERM group and 39 in the control group. The mean neutrophil and MPV levels were significantly higher in iERM subjects than in control subjects. The mean lymphocyte level was lower in the iERM group. The mean NLR, PLR, and MPV levels were higher in iERM subjects than in control subjects. Conclusion: The higher NLR, PLR, and MPV levels found in patients with iERM may indicate that subclinical systemic inflammation may associate with iERM.

scholarly journals The Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Acute Low Tone Sensorineural Hearing Loss

2020 ◽  
Vol 63 (12) ◽  
pp. 558-563
Author(s):  
Keon-Ho Kim ◽  
Byung Hun Kim ◽  
Seungyeol Lee ◽  
Jae Ho Chung ◽  
Hayoung Byun ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Prognostic Factors ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Recovery Group ◽  
Low Tone

Background and Objectives Acute low tone sensorineural hearing loss (ALHL), an acuteonset hearing loss limited to low tone, was thought to be a subtype of sudden sensorineural hearing loss (SSNHL) but also considered as new disease entity because it shows quite different symptoms, progress, and prognosis. More recently, however, it is thought that SSNHL results from chronic inflammation and thrombosis. Some studies have reported that neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were high in SSNHL patients, and that they were significant as prognostic factors. The aim of this study was to evaluate the significance of NLR and PLR in ALHL.Subjects and Method From January 2009 to June 2019, we retrospectively studied 58 patients who were diagnosed with ALHL. Characteristics of patients such as sex, age, symptoms and signs, the results of serologic test and pure tone audiometry were evaluated for recovery and for recurrence. Also, we selected 58 people with the same age as control group.Results A total of 167 patients were identified, of whom a half was diagnosed with ALHL and the other half with were the control group. Among the 58 patients, the mean age was 38.0±14.5 years old, and 10 (17.2%) patients were male and 48 (82.8%) patients were female. Among the patients, 35 (60.3%) were hospitalized and 23 (39.7%) were outpatients. For recovery, 38 (65.5%) patients fully recovered while 11 (19.0%) partially recovered, and 9 (15.5%) did not recover. Additionally, 16 (27.6%) patients recurred later with similar symptoms. Between the patient group and control group, there were significant differences in the total white blood cell count, neutrophil count, NLR and PLR (<i>p</i>=0.015, 0.001, 0.002, and 0.025), but there was no significant differences between the recovery group and non-recovery group in any laboratory findings. Also, NLR and PLR showed no significant differences between the recurred group and non-recurred group.Conclusion NLR and PLR in ALHL patients were relatively high compared to the control group, but there were no significant differences between the recovery group and non-recovery group. Furthermore, there was no correlation between NLR and PLR with recurrence. High NLR and PLR values in ALHL patients might reflect its inflammatory etiology, but there is lack evidence for them to serve as prognostic factors.

Investigation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus

2018 ◽  
Vol 132 (2) ◽  
pp. 129-132 ◽  
Author(s):  
B Ulusoy ◽  
K Bozdemir ◽  
M Akyol ◽  
H İ Mişe ◽  
A Kutluhan ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Statistical Significance ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Platelet To Lymphocyte Ratio ◽  
Distribution Width ◽  
Significance Level ◽  
Lymphocyte Ratio

AbstractObjective:This study aimed to evaluate patients with tinnitus in terms of mean platelet volume and platelet distribution width, and to explore neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio, recently reported in the literature as being possible inflammation markers.Methods:This study comprised 64 tinnitus patients and 64 age-matched healthy controls. Statistical significance level was accepted as p < 0.05.Results:Mean platelet volume (t = 3.245, p = 0.002) and platelet distribution width (Z = 3.945, p < 0.001) were significantly higher in the patient group than the control group.Conclusion:The results suggest that a prothrombotic condition might play a role in the pathophysiology of tinnitus.

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