scholarly journals Linear and non-linear analysis of heart rate variability in HIV-positive patients on two different antiretroviral therapy regimens

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Anderson José Gonçalves ◽  
Marcus Vinícius Almeida Braga ◽  
Pedro Henrique Santana ◽  
Luiz Antônio Pertilli Rodrigues Resende ◽  
Valdo José Dias da Silva ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Antiretroviral Therapy ◽  
Reverse Transcriptase ◽  
Autonomic Dysfunction ◽  
Control Group ◽  
Hiv Patients ◽  
Cold Face ◽  
Non Linear ◽  
Group 2

Abstract Background Cardiac autonomic dysfunction in HIV+ patients on different antiretroviral therapy (ART) regimens has been described. We aimed to characterize parameters of heart rate variability (HRV) and correlate with different classes of ART in HIV+ patients in three experimental conditions: rest, cold face, and tilt tests. Methods Cross-sectional study with three groups of age- and gender-matched individuals: group 1, 44 HIV+ patients undergoing combination therapy, with two nucleoside reverse transcriptase inhibitors (NRTI) and one non-nucleoside reverse transcriptase inhibitor (NNRTI); group 2, 42 HIV+ patients using two NRTI and protease inhibitors (PI’s); and group 3, 35 healthy volunteers with negative HIV serology (control group). Autonomic function at rest and during cold face- and tilt-tests was assessed through computerized analysis of HRV, via quantification of time- and frequency domains by linear and non-linear parameters in the three groups. Results Anthropometric and clinical parameters were similar between both HIV groups, except CD4+ T lymphocytes, which were significantly lower in group 2 (p = 0.039). At baseline, time-domain linear HRV parameters, RMSSD and pNN50, and the correlation dimension, a non-linear HRV parameter (p < 0.001; p = 0.018; p = 0.019, respectively), as well as response of RMSSD to cold face test were also lower in the HIV+ group than in the control individuals (p < 0.001), while no differences among groups were detected in HRV parameters during the tilt test. Conclusions Despite ART regimens, HIV+ patients presented lower cardiac vagal modulation than controls, whereas no difference was observed among the HIV groups, suggesting that higher cardiovascular risk linked to PIs may be associated with factors other than autonomic dysfunction.

Autonomic dysfunction in HIV patients on antiretroviral therapy: studies of heart rate variability

2007 ◽  
Vol 27 (6) ◽  
pp. 363-367 ◽  
Author(s):  
Anne-Mette Lebech ◽  
Ulrik Sloth Kristoffersen ◽  
Jesper Mehlsen ◽  
Niels Wiinberg ◽  
Claus Leth Petersen ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Antiretroviral Therapy ◽  
Autonomic Dysfunction ◽  
Hiv Patients ◽  
Therapy Studies

scholarly journals Evaluation of Autonomic Nervous System in Children With Cerebral Palsy: Clinical and Electophysiological Study

2021 ◽  
Author(s):  
Hanan Galal Azouz ◽  
Ali M Abdel Mohsen ◽  
Rana M Mohamed ◽  
hayam mostafa abdelghany
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cerebral Palsy ◽  
Autonomic Dysfunction ◽  
Sympathetic Skin Response ◽  
Spastic Cerebral Palsy ◽  
Control Group ◽  
Healthy Children ◽  
Children With Cerebral Palsy ◽  
Skin Response

Abstract Cerebral palsy (CP) is the most prevalent severe motor disability among children. The aim of this work was to assess autonomic dysfunction in children with cerebral palsy clinically and electrophysiologically .The study was carried out on forty children with cerebral palsy their age ranged from 4-12 years and twenty healthy children with matched age and sex as control group. CP children were subjected to questionnaire for autonomic dysfunction symptoms. Both CP children and Control group were assessed for Sympathetic Skin Response and Heart rate variability. Most of children had quadriplegic spastic cerebral palsy (82.5%). Based on Gross motor function classification system (GMFCS) classification the majority of children were in levels 4 and 5. The prevalence of autonomic dysfunction symptoms was 80% for thermoregulatory abnormalities (cold extremities), chronic constipation 65%, sleep disturbance 52.5%, loss of appetite 47.5%, sweating abnormalities 40% , recurrent nausea and/or vomiting 25%, increased sensitivity to light or dark 22.5% and bloating 15%. The percentage of unelicited Sympathetic skin response in CP children was 47.5% and 60% in upper limbs and lower limbs respectively, all of them were in level 4 and 5 of GMFCS. 20% of CP children had postural hypotension. Mean Heart rate of CP children was significantly increased more than healthy children upon head tilt test. Sympathetic Skin Response and Heart rate variability were proven to be simple and non invasive procedures in investigating autonomic dysfunction in CP children.

scholarly journals Effects of Exercise Training on Heart Rate Variability After Coronary Angioplasty

2006 ◽  
Vol 86 (5) ◽  
pp. 626-635 ◽  
Author(s):  
Mei-Wun Tsai ◽  
Wei-Chu Chie ◽  
Terry BJ Kuo ◽  
Ming-Fong Chen ◽  
Jen-Pei Liu ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Exercise Training ◽  
Autonomic Dysfunction ◽  
Coronary Angioplasty ◽  
Exercise Program ◽  
Percutaneous Transluminal Coronary Angioplasty ◽  
Exercise Group ◽  
Control Group ◽  
Cardiac Autonomic Dysfunction

Abstract Background and Purpose. Cardiac autonomic dysfunction is associated with risk of restenosis and cardiovascular mortality in patients after percutaneous transluminal coronary angioplasty (PTCA). Analysis of heart rate variability (HRV) is an important, widely used method for assessing cardiac autonomic regulation. The purpose of this study was to investigate the effect of exercise training on HRV in subjects after PTCA. Subjects and Methods. A total of 84 subjects who had undergone PTCA were recruited for this study. The subjects (age [mean±SD]=57.0±9.3 years) were randomly assigned to either an exercise group to undergo an 8-week outpatient exercise program or a control group to undergo usual care. Heart rate variability was measured for 5 minutes in the supine resting position at baseline and at the end of 8 weeks. Results. The parasympathetically modulated HRV of the subjects in the exercise group increased significantly compared with the HRV of subjects in the control group. The effects of training on HRV were independent of angioplasty type (balloon or stent) and were unrelated to whether the subjects had received previous PTCA. Discussion and Conclusion. Exercise training can increase parasympathetic modulation of cardiac function in people after they have undergone successful PTCA. Our results suggest that analysis of HRV can be extended to assess the effect of exercise training on cardiac autonomic dysfunction in people after coronary angioplasty.

scholarly journals Correlation between adipocytokine profile and heart rate variability in patients with obesity

2020 ◽  
Vol 37 (3) ◽  
pp. 12-17
Author(s):  
S. G. Shulkina ◽  
E. N. Smirnova ◽  
E. A. Laurent ◽  
N. Yu. Kolomeets ◽  
V. V. Konovalov ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Uric Acid ◽  
Autonomic Nervous System ◽  
Spectral Characteristics ◽  
Heart Rhythm ◽  
Control Group ◽  
Autonomic Nervous ◽  
Group 2

Objective. The high prevalence of obesity in employable population dictates the necessity for preclinical diagnosis of diseases associated with it, including the study of the autonomic regulation of heart rhythm. The objective was to study the correlations between the adipocytokine profile and heart rate variability in patients with obesity. Materials and methods. 300 persons were examined, the average age was 46.2 6.4 years; Group 1 was metabolically unhealthy obesity phenotype (MUHOP) 90 patients; group 2 was obesity without metabolic disorders [Ob(+)MD(-)] (MHOP) 50 persons; the control group consisted of 100 healthy respondents. We studied the following indices: blood serum adipocytokines: leptin, insulin, resistin, adiponectin. Heart rate variability was studied using Poly-Spectrum Rhythm 2012 computer electrocardiograph. Results. In the course of the study, decrease in the total heart rate variability and reactivity of the parasympathetic part of the autonomic nervous system in patients from MUHOP group was found, while there were no differences with the control in the MHOP group. It was established that a decrease in the parasympathetic effect on the regulation of heart rhythm is associated with the presence of abdominal obesity, insulin resistance, and an increase in the level of TG, glucose, resistin, and uric acid. Conclusions. The received relationships between indicators of carbohydrate and lipid metabolism, the level of uric acid and adipocytokines with temporal and spectral characteristics of the autonomic nervous system confirm their contribution to the development of autonomic dysfunction in obese persons.

scholarly journals Gastrointestinal transit time and heart rate variability in patients with mild acquired brain injury

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4912
Author(s):  
Johannes Enevoldsen ◽  
Simon T. Vistisen ◽  
Klaus Krogh ◽  
Jørgen F. Nielsen ◽  
Karoline Knudsen ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Brain Injury ◽  
Transit Time ◽  
Autonomic Dysfunction ◽  
Gastrointestinal Transit ◽  
Acquired Brain Injury ◽  
Functional Independence ◽  
Control Group ◽  
Gastrointestinal Transit Time

Background Constipation is suspected to occur frequently after acquired brain injury (ABI). In patients with ABI, heart rate variability (HRV) is reduced suggesting autonomic dysfunction. Autonomic dysfunction may be associated with prolonged gastrointestinal transit time (GITT). The primary aim of this study was to investigate if GITT is prolonged in patients with ABI. Secondarily, HRV and its correlation with GITT was investigated. Methods We included 25 patients with ABI (18 men, median age: 61.3 years, range [30.7–74.5]). GITT was assessed using radio-opaque markers and HRV was calculated from 24-hour electrocardiograms. Medical records were reviewed for important covariates, including primary diagnosis, time since injury, functional independence measure, and use of medication. The GITT assessed in patients was compared to a control group of 25 healthy subjects (18 men, median age: 61.5 years, range [34.0–70.9]). Results In ABI patients, the mean GITT was significantly longer than in healthy controls (2.68 days, 95% CI [2.16–3.19] versus (1.92 days, 95% CI [1.62–2.22], p = 0.011)). No correlation was found between HRV and GITT. Conclusion Patients with mild to moderate ABI have prolonged GITT unrelated to the HRV.

scholarly journals Cardiac Parasympathetic Withdrawal and Sympathetic Activity: Effect of Heat Exposure on Heart Rate Variability

2021 ◽  
Vol 18 (11) ◽  
pp. 5934
Author(s):  
Oriol Abellán-Aynés ◽  
Pedro Manonelles ◽  
Fernando Alacid
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Environmental Conditions ◽  
Sympathetic Activity ◽  
Heat Exposure ◽  
Repeated Measurements ◽  
Control Group ◽  
Poincaré Plot ◽  
Activity Effect ◽  
And Control

(1) Background: Research on heart rate variability has increased in recent years and the temperature has not been controlled in some studies assessing repeated measurements. This study aimed to analyze how heart rate variability may change based on environmental temperature during measurement depending on parasympathetic and sympathetic activity variations. (2) Methods: A total of 22 volunteers participated in this study divided into an experimental (n = 12) and control group (n = 10). Each participant was assessed randomly under two different environmental conditions for the experimental group (19 °C and 35 °C) and two identical environmental conditions for the control group (19 °C). During the procedure, heart rate variability measurements were carried out for 10 min. (3) Results: Significantly changes were observed for time and frequency domains as well as Poincaré plot variables after heat exposure (p < 0.05). These findings were not observed in the control group, whose conditions between measurements did not change. (4) Conclusions: The reduction of heart rate variability due to exposure to hot conditions appears to be produced mostly by a parasympathetic withdrawal rather than a sympathetic activation. Therefore, if consecutive measurements have to be carried out, these should always be done under the same temperature conditions.

scholarly journals Effect of Acupuncture on Heart Rate Variability: A Systematic Review

2014 ◽  
Vol 2014 ◽  
pp. 1-19 ◽  
Author(s):  
Joanne W. Y. Chung ◽  
Vincent C. M. Yan ◽  
Hongwei Zhang
Keyword(s):  
Systematic Review ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
High Frequency ◽  
Healthy Subjects ◽  
Keyword Search ◽  
Data Extraction ◽  
Meta Analysis ◽  
Low Frequency ◽  
Control Group

Aim.To summarize all relevant trials and critically evaluate the effect of acupuncture on heart rate variability (HRV).Method.This was a systematic review with meta-analysis. Keyword search was conducted in 7 databases for randomized controlled trials (RCTs). Data extraction and risk of bias were done.Results.Fourteen included studies showed a decreasing effect of acupuncture on low frequency (LF) and low frequency to high frequency ratio (LF/HF ratio) of HRV for nonhealthy subjects and on normalized low frequency (LF norm) for healthy subjects. The overall effect was in favour of the sham/control group for high frequency (HF) in nonhealthy subjects and for normalized high frequency (HF norm) in healthy subjects. Significant decreasing effect on HF and LF/HF ratio of HRV when acupuncture was performed on ST36 among healthy subjects and PC6 among both healthy and nonhealthy subjects, respectively.Discussion.This study partially supports the possible effect of acupuncture in modulating the LF of HRV in both healthy and nonhealthy subjects, while previous review reported that acupuncture did not have any convincing effect on HRV in healthy subjects. More published work is needed in this area to determine if HRV can be an indicator of the therapeutic effect of acupuncture.

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