scholarly journals Gender-specific associations of pregnancy-related anxiety with placental epigenetic patterning of glucocorticoid response genes and preschooler’s emotional symptoms and hyperactivity

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hui Liu ◽  
Yuwei Liu ◽  
Kun Huang ◽  
Shuangqin Yan ◽  
Jiahu Hao ◽  
...  
Keyword(s):  
Specific Effect ◽  
Birth Cohort Study ◽  
Dependent Manner ◽  
Emotional Symptoms ◽  
Third Trimester ◽  
The Third ◽  
Glucocorticoid Response ◽  
The Relationship ◽  
Gender Specific

Abstract Backgroud We have recently reported that maternal prenatal pregnancy-related anxiety predicts preschoolers’ emotional and behavioral development in a gender-dependent manner. This study aims to test for this gender-specific effect in a different cohort and investigate whether the gender difference was specific to placental methylation of genes regulating glucocorticoids. Methods A total of 2405 mother–child pairs from the Ma’anshan Birth Cohort Study were included in present study. The maternal pregnancy-related anxiety symptoms were evaluated with the Pregnancy-Related Anxiety Questionnaire in the third trimester of pregnancy. Child neurobehavior was assessed with the Strengths and Difficulties Questionnaire at 4 years old. Placental methylation of FKBP5, NR3C1 and HSD11B2 genes was quantified using the MethylTarget approach in 439 pregnant women. After exploratory factor analysis, the associations between methylation factor scores and pregnancy-related anxiety and child neurobehavior were examined using logistic regression analysis. Results After controlling for confounding factors, pregnancy-related anxiety in the third trimester of pregnancy increased the risk of hyperactivity only in boys and emotional symptoms only in girls. Decreased scores of the factor characterized by FKBP5 methylation were associated with maternal pregnancy-related anxiety only in boys. Furthermore, increased scores of the factors characterized by NR3C1 and HSD11B2 methylation were associated with hyperactivity (NR3C1: adjusted OR = 1.80, 95%CI = 1.15–2.83) and emotional symptoms (HSD11B2: adjusted OR = 0.53, 95%CI = 0.29–0.97; NR3C1: adjusted OR = 1.64, 95%CI = 1.03–2.59) only in boys. However, the scores of the factor characterized by FKBP5, NR3C1 and HSD11B2 did not mediate the relationship between maternal pregnancy-related anxiety and preschoolers’ emotional symptoms and hyperactivity. Conclusions Our results suggested that pregnancy-related anxiety in the third trimester of pregnancy predicted preschoolers’ emotional symptoms and hyperactivity in a gender-dependent manner. Although we did not find the mediation role of the placental methylation of genes regulating glucocorticoids, we found it was associated with both maternal pregnancy-related anxiety and preschoolers’ emotional symptoms and hyperactivity in a gender-dependent manner.

scholarly journals Gender-Specific Associations of Pregnancy-Related Anxiety with Placental Epigenetic Patterning of Glucocorticoid Response Genes and Preschooler’s Emotional Symptoms and Hyperactivity

2021 ◽  
Author(s):  
Hui Liu ◽  
Yuwei Liu ◽  
Kun Huang ◽  
Shuangqin Yan ◽  
Jiahu Hao ◽  
...  
Keyword(s):  
Specific Effect ◽  
Birth Cohort Study ◽  
Dependent Manner ◽  
Emotional Symptoms ◽  
Third Trimester ◽  
The Third ◽  
Glucocorticoid Response ◽  
The Relationship ◽  
Gender Specific

Abstract Backgroud: We have recently reported that maternal prenatal pregnancy-related anxiety predicts preschoolers’ emotional and behavioral development in a gender-dependent manner. This study aims to test for this gender-specific effect in a different cohort and investigate whether the gender difference was specific to placental methylation of genes regulating glucocorticoids.Methods: A total of 2405 mother–child pairs from the Ma’anshan Birth Cohort Study were included in present study. The maternal pregnancy-related anxiety symptoms were evaluated with the Pregnancy-Related Anxiety Questionnaire in the third trimester of pregnancy. Child neurobehavior was assessed with the Strengths and Difficulties Questionnaire at 4 years old. Placental methylation of FKBP5, NR3C1 and HSD11B2 genes was quantified using the MethylTarget approach in 439 pregnant women. After exploratory factor analysis, the associations between methylation factor scores and pregnancy-related anxiety and child neurobehavior were examined using logistic regression analysis.Results: After controlling for confounding factors, pregnancy-related anxiety in the third trimester of pregnancy increased the risk of hyperactivity only in boys and emotional symptoms only in girls. Decreased scores of the factor characterized by FKBP5 methylation were associated with maternal pregnancy-related anxiety only in boys. Furthermore, increased scores of the factors characterized by NR3C1 and HSD11B2 methylation were associated with hyperactivity (NR3C1: adjusted OR = 1.80, 95 %CI = 1.15–2.83) and emotional symptoms (HSD11B2: adjusted OR = 0.53, 95 %CI = 0.29–0.97; NR3C1: adjusted OR = 1.64, 95 %CI = 1.03–2.59) only in boys. However, the scores of the factor characterized by FKBP5、NR3C1 and HSD11B2 did not mediate the relationship between maternal pregnancy-related anxiety and preschoolers’ emotional symptoms and hyperactivity.Conclusions: Our results suggested that pregnancy-related anxiety in the third trimester of pregnancy predicted preschoolers’ emotional symptoms and hyperactivity in a gender-dependent manner. Although we did not find the mediation role of the placental methylation of genes regulating glucocorticoids, we found it was associated with both maternal pregnancy-related anxiety and preschoolers’ emotional symptoms and hyperactivity in a gender-dependent manner.

Role of vasopressin in fetal homeostasis

1982 ◽  
Vol 242 (6) ◽  
pp. F740-F744
Author(s):  
S. S. Daniel ◽  
R. I. Stark ◽  
M. K. Husain ◽  
L. V. Baxi ◽  
L. S. James
Keyword(s):  
Urine Output ◽  
Plasma Osmolality ◽  
Urine Osmolality ◽  
Maternal Plasma ◽  
Third Trimester ◽  
The Third ◽  
Plasma Vasopressin ◽  
The Relationship ◽  
Linear Correlations

The role of vasopressin (VP) and the kidney in the maintenance of solute and volume homeostasis was studied in chronically instrumented fetal lambs during the third trimester. Plasma VP, urine and plasma osmolality, and urine output were measured in 74 simultaneous samples. The results show a strong positive nonlinear correlation between plasma VP and osmolality when a latter is higher than 290 mosmol/kg (r = 0.803, P = 0.03) and between plasma VP and urine osmolality (r = 0.806, P = 0.05). No correlation was found between fetal and maternal plasma VP. However, linear correlations were found in plasma osmolality and sodium concentrations between mother and fetus; mean maternal-fetal gradients were 4 mosmol/kg and 3.1 meq/liter, respectively. The highest values for plasma VP and osmolality found in our study were 7.0 pg/ml and 317 mosmol/kg, respectively. There values corresponded to urine output of 0.02 ml.kg-1.min-1 and osmolality of 517 mosmol/kg. In conclusion, there studies demonstrate that the relationship among plasma osmolality, plasma vasopressin concentration, and urine osmolality in the lamb fetus are qualitatively similar to those of the adult. The results suggest that the fetal neurohypophysis and kidney may participate in the maintenance of fetal osmolar and volume homeostasis.

Women’s Liberation and the Agrarian Question: Insights from Peasant Movements in India

2021 ◽  
Vol 10 (1) ◽  
pp. 15-40
Author(s):  
Archana Prasad
Keyword(s):  
Social Transformation ◽  
Historical Context ◽  
Class Consciousness ◽  
Land Reforms ◽  
Agrarian Question ◽  
The Third ◽  
Peasant Movements ◽  
Participation Of Women ◽  
The Relationship

This article explores some questions arising from recent debates on patriarchy and capitalism. The focus is on the role of women in communist-led peasant movements in India and the implications of such struggles on the project of women’s emancipation. The first section lays out a framework for discussing the interface between class consciousness and the anti-patriarchal project, whereby patriarchy is located within the structural contradictions arising out of the contestations within the process of accumulation. The second section documents the historical context, focusing on the relationship between land reforms and social transformation in semi-feudal and early capitalist contexts, and analyzes the extent to which communist-led struggles are anti-patriarchal in character. The third section turns to the participation of women in the contemporary struggles of both agricultural workers and peasant movements and underlines the new emerging dialectics between women’s and peasant organizations under a neoliberal state and with deepening agrarian distress.

scholarly journals Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 533
Author(s):  
Rania F. Zaarour ◽  
Bilal Azakir ◽  
Edries Y. Hajam ◽  
Husam Nawafleh ◽  
Nagwa A. Zeinelabdin ◽  
...  
Keyword(s):  
Cell Death ◽  
Type I ◽  
Dependent Manner ◽  
Destruction Process ◽  
Tumor Cell Death ◽  
Complex Regulation ◽  
Cancer Immunotherapies ◽  
The Relationship ◽  
Shed Light

Programmed cell death or type I apoptosis has been extensively studied and its contribution to the pathogenesis of disease is well established. However, autophagy functions together with apoptosis to determine the overall fate of the cell. The cross talk between this active self-destruction process and apoptosis is quite complex and contradictory as well, but it is unquestionably decisive for cell survival or cell death. Autophagy can promote tumor suppression but also tumor growth by inducing cancer-cell development and proliferation. In this review, we will discuss how autophagy reprograms tumor cells in the context of tumor hypoxic stress. We will illustrate how autophagy acts as both a suppressor and a driver of tumorigenesis through tuning survival in a context dependent manner. We also shed light on the relationship between autophagy and immune response in this complex regulation. A better understanding of the autophagy mechanisms and pathways will undoubtedly ameliorate the design of therapeutics aimed at targeting autophagy for future cancer immunotherapies.

Deoxyribonuclease activity negative correlates with extracellular DNA in uncomplicated singleton pregnancies in the third trimester

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Barbora Vlková ◽  
Ľubica Janovičová ◽  
Petra Pšenková ◽  
Lívia Melníková ◽  
Barbora Balažovjechová ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Extracellular Dna ◽  
Dnase Activity ◽  
Diffusion Method ◽  
Third Trimester ◽  
The Third ◽  
Healthy Women ◽  
Mitochondrial Origin ◽  
Singleton Pregnancies

Abstract Objectives It is not clear, which factors affect extracellular DNA (ecDNA) concentrations in healthy women with singleton uncomplicated pregnancies, although deoxyribonucleases (DNases) are hypothesized to be responsible for the cleavage of plasma ecDNA. The aim of this study was to analyze potential determinants of total ecDNA including plasma DNase activity. Methods Plasma samples were collected from 48 healthy women with singleton uncomplicated pregnancies in the third trimester (gestation week 37). DNA was isolated and quantified using fluorometry and real time PCR. DNase activity was assessed using the single radial enzyme-diffusion method. Results Neither ecDNA, nor DNase activity were affected by maternal age or BMI. DNase activity negatively correlated with total plasma ecDNA (r=−0.40, p=0.007). Similar associations were found for ecDNA of nuclear and mitochondrial origin, but not with fetal DNA quantified using Y-targeted PCR in male fetus-bearing pregnancies. Conclusions The role of plasma ecDNA of fetal and maternal origin is studied in the pathogenesis of pregnancy-complications. The results indicate that plasma DNase activity could negatively regulate ecDNA concentrations and should, thus, be analyzed in preeclampsia, preterm birth and other ecDNA-related pregnancy complications.

scholarly journals The Relationship between Restless Legs Syndrom and Sleep Quality in the Third Trimester Pregnant Women

2019 ◽  
Vol 6 (1) ◽  
pp. 22-27
Author(s):  
Semiha Aydın Özkan ◽  
Gülay Rathfisch ◽  
Özlem Karabulut ◽  
Türkan Karaca
Keyword(s):  
Sleep Quality ◽  
Pregnant Women ◽  
Third Trimester ◽  
Restless Legs ◽  
The Third ◽  
The Relationship ◽  
Restless Legs Syndrom

Daring to differ? Strategies of inclusion in peacemaking

2020 ◽  
Vol 51 (4) ◽  
pp. 305-322 ◽  
Author(s):  
Andreas T Hirblinger ◽  
Dana M Landau
Keyword(s):  
Research Policy ◽  
Policy And Practice ◽  
The Third ◽  
Peace Processes ◽  
Single Identity ◽  
Sociopolitical Structures ◽  
The Relationship ◽  
Do So ◽  
Specific Identity

‘Inclusion’ has emerged as a prominent theme in peacemaking. However, its exact meaning remains vague, as do assumptions about the relationship between inclusion and peace. This article seeks to problematize the research, policy and practice of inclusion. Focusing on United Nations (UN) peacemaking, we ask how the object of inclusion has been framed, and based on what strategies and underlying rationales. We do so against the backdrop of emerging debates about an agonistic peace, which suggest that violent antagonistic relationships can be overcome if peace processes enable contestation between adversaries. This requires that peacemakers recognize the constitutive role of difference in political settlements. We identify three distinct strategies for inclusion, with corresponding framings of the included. Firstly, inclusion can be used to build a more legitimate peace; secondly, to empower and protect specific actor groups; and thirdly, to transform the sociopolitical structures that underlie conflict. The first strategy frames the included in open terms that can accommodate a heterogeneity of actors, the second in closed terms pertaining to specific identity traits, and the third in relational terms emerging within a specific social, cultural and political context. In practice, this leads to tensions in the operationalization of inclusion, which are evidence of an inchoate attempt to politicize peace processes. In response, we argue for an approach to relational inclusion that recognizes the power relations from which difference emerges; neither brushing over difference, nor essentializing single identity traits, but rather remaining flexible in navigating a larger web of relationships that require transformation.

scholarly journals The “Natural Ally” of the “Developing World”: Bulgarian Culture in India and Mexico

Slavic Review ◽  
2018 ◽  
Vol 77 (3) ◽  
pp. 661-684
Author(s):  
Theodora Dragostinova
Keyword(s):  
Cold War ◽  
Developing World ◽  
Cultural Diplomacy ◽  
Global South ◽  
Cultural Relations ◽  
The Third ◽  
The Cold War ◽  
The Relationship ◽  
Second World

This article examines Bulgarian cultural relations with India and Mexico in the 1970s to explore the role of cultural diplomacy in the relationship between the Second and the Third Worlds during the Cold War. In 1975, Liudmila Zhivkova, the daughter of the Bulgarian leader, became the head of the Committee for Culture; under her patronage, Bulgarian officials organized literally hundreds of exhibitions, concerts, academic conferences, book readings, cultural weeks, and visits that involved the three countries in an intense cultural romance. Even though Bulgaria was known as the “Soviet master satellite,” culture provided a considerable level of independence in Bulgarian dealings with international actors, which often caused Soviet irritation. In the end, by using culture, in addition to political and economic aid, Bulgaria managed to forge its role as an intermediary between the Second World and the Global South, and to project its notions of development on a global scene.

A Dyadic Study on Perceived Stress and Couple Adjustment During Pregnancy: The Mediating Role of Depressive Symptoms

2020 ◽  
Vol 41 (11) ◽  
pp. 1935-1955 ◽  
Author(s):  
Franco Baldoni ◽  
Michele Giannotti ◽  
Giulia Casu ◽  
Valerio Luperini ◽  
Federico Spelzini
Keyword(s):  
Depressive Symptoms ◽  
Relationship Satisfaction ◽  
Perceived Stress ◽  
Transition To Parenthood ◽  
Dyadic Adjustment ◽  
Third Trimester ◽  
Mediating Role ◽  
Couple Adjustment ◽  
The Relationship

Stress is associated with dyadic adjustment during transition to parenthood, but little is known about mechanisms underlying this link, particularly during prenatal period. This dyadic study explored the mediating role of depressive symptoms in the relationship between perceived stress and dyadic adjustment in expectant couples. One hundred and fourteen couples at the third trimester of pregnancy completed self-reports of perceived stress, depression, and dyadic adjustment. Results indicated that both parents’ perceived stress was associated with their own lower relationship satisfaction directly and indirectly, through their own higher depressive symptoms. Mothers’ perceived stress was also linked to higher fathers’ depressive symptoms, and thus also to lower fathers’ relationship satisfaction. Both parents’ perceived stress was only directly associated with their own dyadic consensus, and their own and their partners’ affectional expression. Findings suggest that interventions aimed at reducing expectant parents’ perceived stress could protect against depressive symptoms and promote the couple’s adjustment during pregnancy.

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