scholarly journals High-density lipoproteins attenuate high glucose-impaired endothelial cell signaling and functions: potential implications for improved vascular repair in diabetes

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Xing Chen ◽  
My-Ngan Duong ◽  
Peter J. Psaltis ◽  
Christina A. Bursill ◽  
Stephen J. Nicholls
Keyword(s):  
Endothelial Cell ◽  
Cell Signaling ◽  
High Glucose ◽  
High Density ◽  
High Density Lipoproteins ◽  
Vascular Repair

scholarly journals The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis

2020 ◽  
Vol 21 (10) ◽  
pp. 3633 ◽  
Author(s):  
Khalia R. Primer ◽  
Peter J. Psaltis ◽  
Joanne T.M. Tan ◽  
Christina A. Bursill
Keyword(s):  
Endothelial Cell ◽  
Cell Metabolism ◽  
High Density ◽  
Metabolic Reprogramming ◽  
High Density Lipoproteins ◽  
Impaired Wound Healing ◽  
Endothelial Cell Function ◽  
Positive Effects ◽  
Impaired Angiogenesis ◽  
Endothelial Cell Metabolism

Diabetes mellitus affects millions of people worldwide and is associated with devastating vascular complications. A number of these complications, such as impaired wound healing and poor coronary collateral circulation, are characterised by impaired ischaemia-driven angiogenesis. There is increasing evidence that high-density lipoproteins (HDL) can rescue diabetes-impaired angiogenesis through a number of mechanisms, including the modulation of endothelial cell metabolic reprogramming. Endothelial cell metabolic reprogramming in response to tissue ischaemia is a driver of angiogenesis and is dysregulated by diabetes. Specifically, diabetes impairs pathways that allow endothelial cells to upregulate glycolysis in response to hypoxia adequately and impairs suppression of mitochondrial respiration. HDL rescues the impairment of the central hypoxia signalling pathway, which regulates these metabolic changes, and this may underpin several of its known pro-angiogenic effects. This review discusses the current understanding of endothelial cell metabolism and how diabetes leads to its dysregulation whilst examining the various positive effects of HDL on endothelial cell function.

scholarly journals Suppression of Endothelial Cell Apoptosis by High Density Lipoproteins (HDL) and HDL-associated Lysosphingolipids

2001 ◽  
Vol 276 (37) ◽  
pp. 34480-34485 ◽  
Author(s):  
Jerzy-Roch Nofer ◽  
Bodo Levkau ◽  
Iza Wolinska ◽  
Ralf Junker ◽  
Manfred Fobker ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Apoptosis ◽  
High Density ◽  
High Density Lipoproteins ◽  
Endothelial Cell Apoptosis
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