Validation of repeated self-reported n-3 PUFA intake using serum phospholipid fatty acids as a biomarker in breast cancer patients during treatment

Objective: To determine the relationship between the dietary characteristics of breast cancer patients. Methods: Patients with breast cancer whose treatments have finished and are in remission formed the study group and healthy people formed the control group. Demographic, anthropometric characteristics, food consumption frequency form and exercise status were recorded with all groups. Data analysis was done by SPSS 22. Results: In the study group, mean carbohydrate percentage was lower, while fat, fat percentage, monosaccharide, glucose, fructose, omega3(n3), saturated fatty acids(SFA), monounsaturated fatty acids (MUFA), vitamin A, C, E, B6, biotin and copper values were significantly higher (p<0.05). Recurrence was observed in seven patients (7.1%) during the follow-up period, hormone receptor levels (ER) and vitamin B2 intake (accuracy 93.9%) were inversely related to the recurrence of the disease (p=0.02). Conclusions: While the percentage of carbohydrate taken was lower in study group; total fat, n3, SFA, MUFA, monosaccharide, glucose, fructose, water-soluble fiber, B6, biotin and copper values were higher. Further studies are needed for vitamin B2 deficiency in patients with recurrence. doi: https://doi.org/10.12669/pjms.36.7.2368 How to cite this:Tapan TK, Iyigun ZE, Ilgun S, Ozmen V. Evaluation of the eating habits of breast cancer patients. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.2368 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Altered Levels of Desaturation and ω-6 Fatty Acids in Breast Cancer Patients’ Red Blood Cell Membranes

Metabolites ◽

10.3390/metabo10110469 ◽

2020 ◽

Vol 10 (11) ◽

pp. 469

Author(s):

Javier Amézaga ◽

Gurutze Ugartemendia ◽

Aitziber Larraioz ◽

Nerea Bretaña ◽

Aizpea Iruretagoyena ◽

...

Keyword(s):

Breast Cancer ◽

Fatty Acids ◽

Fatty Acid ◽

Blood Cell ◽

Cancer Patients ◽

Red Blood Cell ◽

Breast Cancer Patients ◽

Disease Evolution ◽

Lipidomic Analysis ◽

Rbc Membrane

Red blood cell (RBC) membrane can reflect fatty acid (FA) contribution from diet and biosynthesis. In cancer, membrane FAs are involved in tumorigenesis and invasiveness, and are indicated as biomarkers to monitor the disease evolution as well as potential targets for therapies and nutritional strategies. The present study provides RBC membrane FA profiles in recently diagnosed breast cancer patients before starting chemotherapy treatment. Patients and controls were recruited, and their dietary habits were collected. FA lipidomic analysis of mature erythrocyte membrane phospholipids in blood samples was performed. Data were adjusted to correct for the effects of diet, body mass index (BMI), and age, revealing that patients showed lower levels of saturated fatty acids (SFA) and higher levels of monounsaturated fatty acid, cis-vaccenic (25%) than controls, with consequent differences in desaturase enzymatic index (∆9 desaturase, –13.1%). In the case of polyunsaturated fatty acids (PUFA), patients had higher values of ω-6 FA (C18:2 (+11.1%); C20:4 (+7.4%)). RBC membrane lipidomic analysis in breast cancer revealed that ω-6 pathways are favored. These results suggest new potential targets for treatments and better nutritional guidelines.

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Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers

Cancer Causes & Control ◽

10.1007/s10552-009-9314-2 ◽

2009 ◽

Vol 20 (4) ◽

pp. 497-504 ◽

Cited By ~ 19

Author(s):

Yumie Takata ◽

Irena B. King ◽

Marian L. Neuhouser ◽

Steve Schaffer ◽

Matt Barnett ◽

...

Keyword(s):

Breast Cancer ◽

Fatty Acids ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Phospholipid Fatty Acids ◽

Serum Phospholipid ◽

Cigarette Smokers

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Diet quality and its relationship with overweight and laboratory parameters in breast cancer patients undergoing treatment

10.21203/rs.2.11380/v2 ◽

2019 ◽

Author(s):

Krystal Ng LS ◽

Chan Yoke Mun ◽

Zalilah MS

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Fatty Acids ◽

Serum Albumin ◽

Cancer Patients ◽

Diet Quality ◽

Short Form ◽

Healthy Eating Index ◽

Breast Cancer Patients ◽

Laboratory Parameters

Abstract Background Overweight is the common issue existed among breast cancer patients, leading to poor cancer prognosis and survival. However, previous studies have focused merely on single nutrients or food groups. This study aimed to determine whether diet quality was associated with overweight and laboratory parameters among breast cancer patients undergoing treatment.Methods A cross sectional study comprises of 163 patients was conducted from January to May 2017. Diet quality and level of physical activity of patients were ascertained using Healthy Eating Index (HEI)-2015 and International Physical Activity Questionnaire (IPAQ)-short form, respectively. Data were available on body mass index and biochemical data, including of serum albumin, serum hemoblogbin and neutrophils count. Logistic regression was performed to identify the association between diet quality and overweight, serum albumin, serum hemoglobin and neutrophils count.Results The mean total HEI score (standard deviation) of the breast cancer patients was 63.86 (8.75). More than 80% of the subjects did not adhere to the dietary guidelines for whole grains, dairy, refined grains, ratio of poly- and mono-unsaturated fatty acids to saturated fatty acids components. In the multivariate model, those who perceived higher score of total HEI-2015 were less likely to experience overweight (Q4 vs Q1: OR=0.36; 95% CI=0.13, 0.99) while reported higher concentration of serum hemoglobin (Q4 vs Q1: OR=0.36; 95% CI=0.13, 0.98; Q3 vs Q1: OR=0.35; 95% CI=0.13, 0.92). Non-significant associations of diet quality were shown for serum albumin and neutrophils count.Conclusions A majority of breast cancer patients require dietary modification, especially for fatty acids, grains and dairy products. Diet quality may associate with overweight. A balanced diet that address the problem of overweight may help to maintain a good nutritional status and to improve cancer care in breast cancer patients during treatment. Future prospective studies are required to confirm this association.

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Diet quality and its relationship with overweight and laboratory parameters in breast cancer patients undergoing treatment

10.21203/rs.2.11380/v3 ◽

2019 ◽

Author(s):

Krystal Ng LS ◽

Chan Yoke Mun ◽

Zalilah MS

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Fatty Acids ◽

Serum Albumin ◽

Cancer Patients ◽

Diet Quality ◽

Short Form ◽

Healthy Eating Index ◽

Breast Cancer Patients ◽

Laboratory Parameters

Abstract Background Overweight is the common issue existed among breast cancer patients, leading to poor cancer prognosis and survival. However, previous studies have focused merely on single nutrients or food groups. This study aimed to determine whether diet quality was associated with overweight and laboratory parameters among breast cancer patients undergoing treatment.Methods A cross sectional study comprises of 163 patients was conducted from January to May 2017. Diet quality and level of physical activity of patients were ascertained using Healthy Eating Index (HEI)-2015 and International Physical Activity Questionnaire (IPAQ)-short form, respectively. Data were available on body mass index and biochemical data, including of serum albumin, serum hemoblogbin and neutrophils count. Logistic regression was performed to identify the association between diet quality and overweight, serum albumin, serum hemoglobin and neutrophils count.Results The mean total HEI score (standard deviation) of the breast cancer patients was 63.86 (8.75). More than 80% of the subjects did not adhere to the dietary guidelines for whole grains, dairy, refined grains, ratio of poly- and mono-unsaturated fatty acids to saturated fatty acids components. In the multivariate model, those who perceived higher score of total HEI-2015 were less likely to experience overweight (Q4 vs Q1: OR=0.36; 95% CI=0.13, 0.99) while reported higher concentration of serum hemoglobin (Q4 vs Q1: OR=0.36; 95% CI=0.13, 0.98; Q3 vs Q1: OR=0.35; 95% CI=0.13, 0.92). Non-significant associations of diet quality were shown for serum albumin and neutrophils count.Conclusions A majority of breast cancer patients require dietary modification, especially for fatty acids, grains and dairy products. Diet quality may associate with overweight. A balanced diet that address the problem of overweight may help to maintain a good nutritional status and to improve cancer care in breast cancer patients during treatment. Future prospective studies are required to confirm this association.

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A combination of hydroxytyrosol, omega-3 fatty acids and curcumin improves pain and inflammation among early stage breast cancer patients receiving adjuvant hormonal therapy: results of a pilot study

Clinical & Translational Oncology ◽

10.1007/s12094-018-1950-0 ◽

2018 ◽

Vol 21 (4) ◽

pp. 489-498 ◽

Cited By ~ 16

Author(s):

N. Martínez ◽

M. Herrera ◽

L. Frías ◽

M. Provencio ◽

R. Pérez-Carrión ◽

...

Keyword(s):

Breast Cancer ◽

Fatty Acids ◽

Pilot Study ◽

Cancer Patients ◽

Hormonal Therapy ◽

Early Stage ◽

Adjuvant Hormonal Therapy ◽

Omega 3 Fatty Acids ◽

Breast Cancer Patients ◽

Omega 3

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Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients

International Journal of Cancer ◽

10.1002/ijc.28491 ◽

2013 ◽

Vol 134 (7) ◽

pp. 1725-1733 ◽

Cited By ~ 26

Author(s):

Mika Hilvo ◽

Stephan Gade ◽

Tuulia Hyötyläinen ◽

Valentina Nekljudova ◽

Tuulikki Seppänen-Laakso ◽

...

Keyword(s):

Breast Cancer ◽

Fatty Acids ◽

Neoadjuvant Chemotherapy ◽

Cancer Patients ◽

Monounsaturated Fatty Acids ◽

Breast Cancer Patients ◽

Response To Neoadjuvant Chemotherapy

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Adipose Tissue Fatty Acids in Breast Cancer Patients versus Healthy Control Women from Crete

Annals of Nutrition and Metabolism ◽

10.1159/000229508 ◽

2009 ◽

Vol 54 (4) ◽

pp. 275-282 ◽

Cited By ~ 13

Author(s):

G. Mamalakis ◽

C. Hatzis ◽

E. de Bree ◽

E. Sanidas ◽

D.D. Tsiftsis ◽

...

Keyword(s):

Breast Cancer ◽

Fatty Acids ◽

Adipose Tissue ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Healthy Control

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Diet quality and its relationship with overweight and laboratory parameters in breast cancer patients undergoing treatment

10.21203/rs.2.11380/v5 ◽

2020 ◽

Author(s):

Krystal Ng LS ◽

Chan Yoke Mun ◽

Zalilah MS

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Fatty Acids ◽

Serum Albumin ◽

Cancer Patients ◽

Diet Quality ◽

Short Form ◽

Healthy Eating Index ◽

Breast Cancer Patients ◽

Laboratory Parameters

Abstract Background Overweight is the common issue existed among breast cancer patients, leading to poor cancer prognosis and survival. However, previous studies have focused merely on single nutrients or food groups. This study aimed to determine whether diet quality was associated with overweight and laboratory parameters among breast cancer patients undergoing treatment. Methods A cross sectional study comprises of 163 patients was conducted from January to May 2017. Diet quality and level of physical activity of patients were ascertained using Healthy Eating Index (HEI)-2015 and International Physical Activity Questionnaire (IPAQ)-short form, respectively. Data were available on body mass index and biochemical data, including of serum albumin, serum hemoblogbin and neutrophils count. Logistic regression was performed to identify the association between diet quality and overweight, serum albumin, serum hemoglobin and neutrophils count. Results The mean total HEI score (standard deviation) of the breast cancer patients was 63.86 (8.75). More than 80% of the subjects did not adhere to the dietary guidelines for whole grains, dairy, refined grains, ratio of poly- and mono-unsaturated fatty acids to saturated fatty acids components. In the multivariate model, those who perceived higher score of total HEI-2015 were less likely to experience overweight (Q4 vs Q1: OR=0.36; 95% CI=0.13, 0.99) while reported higher concentration of serum hemoglobin (Q4 vs Q1: OR=0.36; 95% CI=0.13, 0.98; Q3 vs Q1: OR=0.35; 95% CI=0.13, 0.92). Non-significant associations of diet quality were shown for serum albumin and neutrophils count. Conclusions A majority of breast cancer patients require dietary modification, especially for fatty acids, grains and dairy products. Diet quality may associate with overweight. A balanced diet that address the problem of overweight may help to maintain a good nutritional status and to improve cancer care in breast cancer patients during treatment. Future prospective studies are required to confirm this association.

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