scholarly journals Clinical outcome of patients with COVID-19 Pneumonia treated with corticosteroids and colchicine in Colombia

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Miguel Alejandro Pinzón ◽  
Doris Cardona Arango ◽  
Juan Felipe Betancur ◽  
Santiago Ortiz ◽  
Héctor Holguín ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Supplemental Oxygen ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Oxygen Fraction ◽  
Management Protocol ◽  
Polymerase Chain ◽  
Inspired Oxygen ◽  
Specific Antiviral Therapy

Abstract Background To date, there is no specific antiviral therapy for severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) that causes Coronavirus disease 2019 (Covid-19). Since there is no specific therapy against SARS-CoV2, current efforts aim to prevent contagion through public health measures and develop a protective vaccine. While waiting for the latter, it is necessary to evaluate the drugs that at least, in initial studies, suggested some degree of utility in the management of Covid-19 or its complications. The main objective of the study was to describe the clinical manifestations and outcomes of patients with severe Covid-19 Pneumonia treated with corticosteroids and colchicine. Materials and methods A cross sectional study of 301 adult patients with Covid-19 Pneumonia confirmed by Real-Time Polymerase Chain Reaction for SARS-CoV2 (RT-PCR SARS-CoV2), Berlin protocol, who required hospitalization in three hospitals in Antioquia, Colombia. Patients were treated according to the institutional protocol (from March 20, 2020 to June 30, 2020) with corticosteroid if the patient required supplemental oxygen. From July 1, 2020, the management protocol changed with the addition of colchicine to all patients admitted to the institutions. The treatment was supervised and monitored by the same specialist in Infectology of the institutions. We describe the clinical manifestations and outcomes of the patients who received these treatments. The information of the patients was analyzed according to the outcome of interest (alive/dead) with univariate, bivariate, and multivariate measures to adjust the variables that presented statistical association. Results All patients had pneumonia documented by chest computed tomography with ground glass images and presented an alveolar pressure/inspired oxygen fraction (PaFi) less than 300. Three hundred one patients were included, 240 (79.7%) received corticosteroids, within these 145 (48.2%) received colchicine also, and the remaining 61 (20.3%) patients did not receive corticosterioids or colchicine. Mortality in the group that received colchicine was lower compared to the group that did not receive it (9.6 vs 14.6%, p-value = 0.179). Conclusions Treatment with corticosteroids and colchicine for managing patients with severe Covid-19 Pneumonia was associated with low mortality at the hospital level. Randomized, placebo-controlled studies are required to evaluate the effect of corticosteroids and colchicine on complications or death from Covid-19.

scholarly journals Clinical Outcome of Patients with COVID-19 Pneumonia Treated with Corticosteroids and Colchicine in Colombia

2020 ◽  
Author(s):  
Miguel Alejandro Pinzón ◽  
Doris Cardona Arango ◽  
Juan Felipe Betancur ◽  
Héctor Holguín ◽  
Carolina Arias Arias ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Supplemental Oxygen ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Oxygen Fraction ◽  
Management Protocol ◽  
Patient’S Information ◽  
Polymerase Chain ◽  
Inspired Oxygen ◽  
Specific Antiviral Therapy

Abstract Background: To date, there is no specific antiviral therapy for severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) that causes Coronavirus disease 2019 (Covid-19). Since there is no specific therapy against SARS-CoV2, current efforts aim to prevent contagion through public health measures and develop a protective vaccine. While waiting for the latter, it is necessary to evaluate the drugs that at least, in initial studies, suggested some degree of utility in the management of Covid-19 or its complications.The Objective of the study was to describe the clinical manifestations and outcomes of patients with severe Covid-19 Pneumonia treated with corticosteroids and colchicine.Materials and Methods: A cross sectional study of 301 adult patients with Covid-19 Pneumonia confirmed by Real-Time Polymerase Chain Reaction for SARS-CoV2 (RT-PCR SARS-CoV2), Berlin protocol, who required hospitalization in three hospitals in Antioquia, Colombia. Patients were treated according to the institutional protocol (from March 20, 2020 to June 30, 2020) with corticosteroid if the patient required supplemental oxygen. From July 1, 2020, the management protocol changed with the addition of colchicine to all patients admitted to the institutions. The treatment was supervised and monitored by the same specialist in infectology of the institutions. We describe the clinical manifestations and outcomes of the patients who received these treatments. The patient’s information was analyzed according to the outcome of interest (alive/dead) with univariate, bivariate, and multivariate measures to adjust the variables that presented statistical association.Results: All patients had pneumonia documented by chest computed tomography with ground glass images and presented an alveolar pressure / inspired oxygen fraction (PaFi) less than 300. 240 (79.7%) of patients received corticosteroids, and 145 (48.2%) also received colchicine; of these, 14 (9.6%) died vs. 23 (14.7%) of those who did not receive it. Hospital mortality due to severe Covid-19 Pneumonia was 12.3% in three hospitals in Colombia.Conclusions: Treatment with corticosteroids and colchicine for managing patients with severe Covid-19 pneumonia was associated with low mortality at the hospital level. Randomized, placebo-controlled studies are required to evaluate the effect of corticosteroids and colchicine on complications or death from Covid-19.

scholarly journals Epidemiological Pattern of Poisoning in Children under the Age of 15 Admitted to the Referral Teaching Hospitals of Yazd and Taft Cities (2014-2019)

2021 ◽  
Author(s):  
Mahdieh Momayyezi ◽  
Parisa Peigan ◽  
Hossein Fallahzadeh
Keyword(s):  
Urban Areas ◽  
Pearson Correlation ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Teaching Hospitals ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Epidemiological Pattern ◽  
Poisoning In Children

Introduction: Understanding the epidemiological pattern and causes of poisoning is the first step to prevent and reduce complications and mortality due to poisoning in children. Given that no study has been conducted on this subject in Yazd, this study aimed to determine the epidemiology pattern of poisoning in children admitted to the referral teaching hospitals in Yazd and Taft cities during 2014-2019. Materials and Methods: This descriptive cross-sectional study was conducted on 238 children under the age of 15 who have been admitted to Shahid Sadoughi hospital in Yazd and Shahid Beheshti hospital in Taft city during 2014-2019. The data were analyzed by SPSS version 20.0 using descriptive statistics, Pearson correlation, and Chi-square. In all the statistical analyses, a P-value of less than 0.05 was considered significant. Results: The results showed that the frequency of poisonings was higher in girls (58%), in summer (31.1%), and in urban areas (82.8%). Most cases of poisoning aged less than 15 years (75.1%). The main cause of poisoning in children was drug poisoning (60.5%), followed by cleansing products (10.1%). The most common clinical manifestations included neurological signs (33.6%). During 2014-2019, the frequency of drugs and pesticide poisonings decreased; while poisoning due to drug-opioids and cleansing products increased (P = 0.04). Also, 3 deaths occurred due to poisoning during this period. Conclusion: The higher prevalence of drug and cleansing products poisoning in children under the age of 15 indicates involuntary poisoning in this group. Therefore, proper storage of these substances and more parental care can reduce poisonings in children.

T Allele of the DRD2 Taq1A Gene Polymorphism Increases the Predisposition to Drug Addiction in Indonesia Population

2020 ◽  
Vol 17 ◽  
Author(s):  
Viren Ramadhan ◽  
Faisal Rahman ◽  
Ahmad Hamim Sadewa ◽  
Zullies Ikawati
Keyword(s):  
Gene Polymorphism ◽  
Drug Addiction ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Control Subjects ◽  
Allele Specific ◽  
Pcr Method ◽  
Polymerase Chain ◽  
And Control

Background: Dopamine plays an important role in mediating the rewarding properties in the abuse of drugs. The Taq1A polymorphism is a commonly studied DRD2 gene variant whereby carriers of the low-function T allele (T/T or T/C genotypes) show reduced brain dopamine function. Therefore, individuals who have the DRD2 Taq1A polymorphism will experience higher levels of drug addiction because the T allele is associated with a reduced number of dopamine binding sites in the brain. A study of this gene has been conducted in some areas but there is no research for the population of Indonesia. Objective: This study will focus on the frequency of DRD2 Taq1A gene polymorphism in the population of Indonesia and define its association with drug addiction. Method: This is an a-cross sectional study in which 182 subjects are divided into 91 drug-addicted patients and 91 nondrug-addicted control subjects. The genotype analysis was carried out by a modified allele-specific Polymerase Chain Reaction (PCR) method. Results: The frequency of the T/T and C/T was significantly higher in the addicted than control subjects. They are 6.6% and 63.7% compared to 0% and 3.3%. Likewise, the T allele is more frequent in the addicted equal to 38% compared to only 2% in the control subjects. The frequency of the T allele between the addicted and control subjects shows a significantly different (p-value < 0.0001; 95% CI), with the addicted being at a higher risk of having the T allele (OR = 37.3; 95% CI [11.46-121.29]). Results: The frequency of the T/T and C/T was significantly higher in the addicted than control subjects. They are 6.6% and 63.7% compared to 0% and 3.3%. Likewise, the T allele is more frequent in the addicted equal to 38% compared to only 2% in the control subjects. The frequency of the T allele between the addicted and control subjects shows a significantly different (p-value < 0.0001; 95% CI), with the addicted being at a higher risk of having the T allele (OR = 37.3; 95% CI [11.46-121.29]). Conclusion: A high frequency of the DRD2 Taq1A gene polymorphism between addicted patients and control subject groups. Thus, there is an association between the DRD2 Taq1A gene polymorphism and the development of drug addiction with T allele increases the predisposition to addiction.

scholarly journals РАСПРОСТРАНЕННОСТЬ КИШЕЧНЫХ ПАРАЗИТОЗОВ У ВИЧ-ПОЗИТИВНЫХ ПАЦИЕНТОВ

2019 ◽  
pp. 16-20
Author(s):  
Шагинян В. Р. ◽  
Данько О. П. ◽  
Антоняк С. Н. ◽  
Казека В. Г. ◽  
Федоренко С. В.
Keyword(s):  
Intestinal Parasites ◽  
Cross Sectional Study ◽  
P Value ◽  
People Living With Hiv ◽  
Hiv Replication ◽  
Cross Sectional ◽  
Hiv Rna ◽  
High Prevalence ◽  
Polymerase Chain ◽  
Living With Hiv

A cross-sectional study among people living with HIV (PLHIV), who are naive and who are on antiretroviral treatment (ART) was conducted in Kyiv, Ukraine from January 2017 to June 2019. In 200 samples of feces from PLHIV were detection intestinal parasites and helminthes. Also in all patients was measure of CD4 T cells by flow cytometry technique and the viral load of HIV (HIV VL) by reverse transcription and polymerase chain reaction, sensitivity of test – 40 copies HIV RNA / ml. The study shows high prevalence of intestinal parasitic in population of PLHIV – 30,0%. The most prevalent parasites were Cryptosporidium (10,5%), Ascaris lumbricoides (1,5%), G. lamblia (0,5%). Opportunistic protozoans (B. Hominis) were found in 15.5% of PLHIV. Among PLHIV with intestinal parasites severe immunosuppression (< 200 CD4 cells/ml) were more common (66.7%) than among PLHIV without intestinal parasites (45.7%); patients with undetectable HIV VL (35.0%), patients receiving ART for more than 6 months (28.3%) were less common (55.7% and 54.3% respectively). In all cases P value was less than 0.05. Our data show that detection even opportunistic intestinal protozoans in PLHIV can be used as a marker of immune suppression and HIV replication activity, and confirms the importance of parasitological surveillance in this group of patients.

A Cross-Sectional Study of Clinical Profiles and Complications Associated with Fever with Thrombocytopenia

2021 ◽  
Vol 8 (8) ◽  
pp. 445-449
Author(s):  
Melvin Dominic ◽  
Hari Hara C. Sudhan ◽  
Karthik Narayan ◽  
Ram Kirubakar Thangaraj ◽  
Abdussamad M ◽  
...  
Keyword(s):  
Platelet Count ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Spontaneous Bleeding ◽  
Cross Sectional ◽  
General Physical Examination ◽  
The Mean ◽  
General Physical

BACKGROUND Fever is the commonest cause of thrombocytopenia that narrows the differential diagnosis and management of fever. The complexity of thrombocytopenia and its control can also be determined through fever. Lack of proper surveillance system and limited laboratory services pose a definite challenge for a perfect diagnosis leading to case management primarily based on clinical manifestations. METHODS A cross-sectional study was conducted on 90 patients attending outpatient department of Vinayaka Missions Kirupananda Variyar Medical College & Hospitals, during the period of April 2017 to September 2017 (6 months). In patients with fever with thrombocytopenia, a careful history was recorded, general physical examination, laboratory and technical investigation reports were noted down from regular investigations. Culture sensitivity and serology were considered as primary outcome variables. The continuous data was expressed as mean ± standard deviation (SD) and for independent sample “t” test was used to compare the data. A probability value (“P” value) of ≤ 0.05 at 95 % confidence interval was considered as statistically significant using Statistical Package for the Social Sciences (SPSS). RESULTS The mean age was 44.73 ± 21.18 years in the study population. 39 (43.33 %) were males and 51 (56.67 %) were females. The average period of stay in the hospital was 8.84 ± 5.73 days; the most common chief complaint was chills & rigors seen in 65 (72.22 %) patients. The most commonly observed comorbidity in the patients was diabetes mellitus. The mean and SD of platelet count was 91522.22 ± 32265.13 per µL. 21 (23.33 %) people had dengue. The mean platelet count at discharge was 192215.19 ± 49481.85 per µL. CONCLUSIONS The commonest cause is infection, for fever with decreased platelet count. A significant number of cases of febrile thrombocytopenia were diagnosed as sepsis in the present study. KEYWORDS Infection, Dengue, Septicaemia, Petechiae / Purpura, Spontaneous Bleeding, Fever

scholarly journals Impact of malaria on haematological parameters of urban, peri-urban and rural patients in the Ashanti region of Ghana: a cross-sectional study

2019 ◽  
Vol 2 ◽  
pp. 27
Author(s):  
Abdul-Hakim Mutala ◽  
Kingsley Badu ◽  
Christian Owusu ◽  
Samuel Kekeli Agordzo ◽  
Austine Tweneboah ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Urban Areas ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Haematological Parameters ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Difference

Background: This study aimed at investigating haematological changes in malaria patients across different demographic settlements. Malaria parasites trigger changes in certain haematological parameters, which may result in a number of clinical manifestations. Differences in demographic settlements, such as rural, peri-urban and urban settlements, may also influence these changes, but this has rarely been studied. Methods: We conducted a hospital-based, cross-sectional study from January to December 2018 in three different settlements. A total of 598 participants were recruited. Giemsa-stained blood smears were examined to detect and quantify malaria parasitaemia, while haematological parameters were measured using a haematology analyser. Results: The rural settlement had the highest malaria prevalence compared to the other study communities (p=0.009). The difference in parasite densities across the three communities was also significant (p=0.0149). When the malaria-infected population was compared to the uninfected, there were differences in red blood cell count (p=0.0170), haemoglobin levels (p=0.0165), mean corpuscular volume (p=0.0139) and platelet counts (p<0.0001). The difference in median white blood cell (p-value <0.0001), neutrophil (p-value <0.0001) and lymphocyte (p-value <0.0269) count were significantly higher in infected patients from the peri-urban area compared to malaria patients from the rural and urban areas. There were also significant differences in platelet (p=0.0002), plateletcrit (p=0.0041), mean platelet volume (p=0.0009) and platelet large cell ratio (p=0.0046) levels between patients from the urban, peri-urban and rural areas. Conclusions: Patients infected with malaria generally had low red blood cell, haemoglobin and platelets in comparison to uninfected patients. There were also significant differences in several haematological parameters between malaria-infected patients from the three demographic settlements. Atypical results from routine haematological assays, especially findings of anaemia and thrombocytopenia, may be indicative of malaria and, in cases where the infection is asymptomatic, may improve diagnosis by prompting a more thorough search for the parasite in the peripheral circulation.

scholarly journals Occupational Determinants of Leptospirosis among Urban Service Workers

2020 ◽  
Vol 17 (2) ◽  
pp. 427 ◽  
Author(s):  
Azman Atil ◽  
Mohammad Saffree Jeffree ◽  
Syed Sharizman Syed Abdul Rahim ◽  
Mohd Rohaizat Hassan ◽  
Khamisah Awang Lukman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Significant Risk ◽  
Occupational Exposures ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Service Workers ◽  
Validated Questionnaire ◽  
Urban Service ◽  
Polymerase Chain

This study was carried out to determine the risk factors of leptospirosis infection among local urban service workers in Sabah. This is a cross-sectional study involving 394 workers in Kota Kinabalu City, Sabah, conducted from February to March 2017. Information on demography, occupational exposures and environmental factors was obtained by a modified validated questionnaire. Polymerase Chain Reaction (PCR) was used to determine the prevalence of positive leptospirae. The overall figure for positive leptospirae was 9.4% (95% CI: 6.8–12.8). Urban sweepers and lorry drivers made up the highest proportion of positive leptospirae respondents, contributing 15.5% and 9.4%, respectively. The significant risk factors for positive leptospirae were older age (p-value = 0.001), higher monthly salary (p-value = 0.039), longer duration of employment (p-value = 0.011) and working as an urban sweeper (p-value = 0.021). Leptospirae was prevalent among healthy urban service workers and relates to their working activities.

scholarly journals COVID-19 Clinical Manifestations & Concerns among the Kingdom of Saudi Arabia's 937 Health Hotline Callers in Jeddah

2021 ◽  
pp. 46-56
Author(s):  
Khalid Moammer ◽  
Najlaa Ahmed Mandoura
Keyword(s):  
Risk Factors ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
P Value ◽  
Kingdom Of Saudi Arabia ◽  
Cross Sectional ◽  
Quality Healthcare ◽  
Immunocompromised State ◽  
Disease Epidemics ◽  
And Control

The on-going COVID-19 pandemic has highlighted telehealth as a crucial tool in delivering high quality healthcare with increased efficiency. In the Kingdom of Saudi Arabia this has been evidently clear with the establishment of the robust Ministry of Health 937 COVID-19 hotline.  The objectives of our study are to describe the clinical patterns of COVID-19, identify the most common concerns of the 937 hotline callers and to identify the associations between the clinical presentation of COVID-19 and risk factors of the patients.through an Analytic Cross-Sectional study design. Results : The average age was 36.8 ± 15.7 years,  61.1% were males and 38.9% were females. 69.3% were Saudi and 30.7% were non-Saudis. 82.5% employed, whilst 17.5% were unemployed.The most commonly reported symptoms were fever, followed by fatigue and cough respectively. With 41.8%, 28.2% and 23.2% of participants reporting those symptoms respectively.  The most significant predictors of developing shortness of breath due to COVID-19 was chronic lung disease OR=5.7pvalue >0.01, chronic kidney disease, OR = 4.8 p value >0.02 and immunocompromised state OR = 19  >0.01. 82% of all calls to the hotline were related to COVID-19 testing, and 11% of all calls resulted in the caller receiving medical counselling and/or treatment without having to make a physical visit to a healthcare provider. Conclusion :  A  well-designed telehealth program can mitigate the need for a physical visit to the emergency room or clinic and as such reduce the load on front-line healthcare workers, reducing transmission and improving outcomes during infectious disease epidemics. It can also provide valuable insights into the presentation and risk factors of a new disease to aid in the prevention, diagnosis, management and control of the disease.

scholarly journals Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy

2021 ◽  
Vol 15 (9) ◽  
pp. 4000-4004
Author(s):  
Rahmat Ali ◽  
Muhammad Sohrab Khan ◽  
Shakeel Ahmad ◽  
Syed Imad Hussain ◽  
Tahir Mukhtar Sayed
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Neuropathy ◽  
Subclinical Hypothyroidism ◽  
Diabetic Peripheral Neuropathy ◽  
Clinical Manifestations ◽  
Clinical History ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Level Of Significance

Background and Objective: The diabetic Mellitus common and spiking complication is Diabetic peripheral neuropathy (DPN). It is frequently associated with thyroid dysfunction. The subclinical hypothyroidism prevalence and clinical outcomes have been investigated by various studies. The present study aims to determine the prevalence of subclinical hypothyroidism in diabetic peripheral neuropathy patients. Methods: This cross-sectional study was carried out on 164 diabetic neuropathy patients attending the medicine department of Qazi Hussain Ahmad Medical Complex, Nowshera KPK during the study period from 2020 to 2021. Patients’ demographic details, clinical history, and neurological examination were recorded. Normal free thyroxin value was set as a referential standard for subclinical hypothyroidism diagnosis among all the patients. Diabetic neuropathy patients’ clinical manifestations were recorded as per neurological screening instrument. The clinical scoring system was utilized for DPN severity categorization into mild (6-8), moderate (9-11), and severe (>12). SPSS version 20 and a logistic regression model were used for data analysis. Results: This study enrolled 164 diabetic peripheral neuropathy patients. Of the total 164, 69 (42.1%) were male and 95 (57.9%) were female. The overall mean age was 49.61±13.72 years. The prevalence of subclinical hypothyroidism was 32 [19.5%; 95% CI; 14.3%-23.7%]. The diabetic peripheral neuropathy patients with subclinical hypothyroidism had a higher prevalence of severity 86 [52.4%; 95%CI] compared to DNP patients without SCH 46 [28.04%; 95% CI] with a 3% level of significance. A higher HbA1c and HOMA-IR was found in patients with their respective values were (8.3±1.1 against 7.2±1.3) where p-value <0.001 and (3.5 ± 0.9 vs. 2.6 ± 0.8, p<0.001) respectively. Conclusion: The diabetic peripheral neuropathy patients are susceptible to have frequent subclinical hypothyroidism independently associated with severity and complications of DPN. Thyroid function should be tested in DM patients and given to DM patients with SCH. Keywords: Diabetes mellitus; Subclinical hypothyroidism; Diabetic peripheral neuropathy

Brief Overview and Experience of Visual Evoked Potential of First 67 cases at Referral Neuroscience Hospital in Bangladesh

2020 ◽  
Vol 6 (2) ◽  
pp. 74-77
Author(s):  
Mohammad Enayet Hussain ◽  
Bithi Debnath ◽  
AFM Al Masum Khan ◽  
Md Ferdous Mian ◽  
Md Nahidul Islam ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Clinical Diagnosis ◽  
Optic Neuropathy ◽  
Cross Sectional Study ◽  
P Value ◽  
Pattern Reversal ◽  
Cross Sectional ◽  
The Mean ◽  
Visual Evoked

Background: The visual evoked potentials (VEP) is a valuable tool to document occult lesions of the central visual channels especially within the optic nerve. Objectives: The purpose of the present study was to observe the findings of first few cases of VEP done in the neurophysiology department of the National Institute of Neurosciences (NINS), Dhaka, Bangladesh. Methodology: This cross-sectional study was conducted in the Department of Neurophysiology at the National Institute of Neurosciences and Hospital, Dhaka, Bangladesh from September 2017 to March 2020. All patients referred to the Neurophysiology Department of NINS for VEP were included. Pattern reversal VEPs were done using standard protocol set by International Federation of Clinical Neurophysiology (IFCN). Results: The mean age of the study population was 30.70 (±12.11) years (6-68 years) with 31 (46.3%) male and 36 (53.7%) female patients. The mean duration of illness was 8.71 (±1.78) months (3 days- 120 months). Most common presenting symptom was blurring of vision (37.3%) and dimness of vision (32.8%). Patterned VEP revealed mixed type (both demyelinating and axonal) of abnormality in most cases [29(43.35)]. The most common clinical diagnosis was multiple sclerosis (29.85%) and optic neuropathy (26.87%). In the clinically suspected cases of multiple sclerosis, optic neuropathy and optic neuritis most of the cases of VEP were abnormal and the p value is 0.04 in optic neuropathy and optic neuritis. Conclusion: The commonest presentation of the patients in this series were blurring of vision and dimness of vision. The most common clinical diagnosis for which VEP was asked for, was optic neuritis and multiple sclerosis. Most abnormalities were of mixed pattern (demyelinating and axonal). Journal of National Institute of Neurosciences Bangladesh, 2020;6(2): 74-77

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