Metabolic distress in lipid & one carbon metabolic pathway through low vitamin B-12: a population based study from North India

ABSTRACT Background Vitamin B-12 and folate deficiencies in women and children have important public health implications. However, the evidence is conflicting and limited on whether the influence of inflammation on biomarker concentrations may be sufficiently and consistently influenced by inflammation to require adjustment for interpreting concentrations or estimating population prevalence of deficiencies. Objective We examined correlations between concentrations of the inflammation biomarkers C-reactive protein (CRP) and α1-acid glycoprotein (AGP) and serum vitamin B-12 and serum and RBC folate among nonpregnant women of reproductive age (WRA; 15–49 yr) and preschool children (PSC; 6–59 mo). Methods We analyzed cross-sectional data from 16 nationally representative nutrition surveys conducted in WRA (n = 32,588) and PSC (n = 8,256) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia project. Spearman correlations between CRP or AGP and vitamin B-12 or folate concentrations were examined, taking into account complex survey design effects. Results Correlations between inflammation and vitamin B-12 or folate were weak, with no clear pattern of association in either WRA or PSC. Correlation coefficients between CRP and vitamin B-12 for WRA and PSC ranged from −0.25 to 0.16, and correlations between AGP and vitamin B-12 ranged between −0.07 and 0.14. Similarly, correlations between CRP and serum folate ranged from −0.13 to 0.08, and correlations between AGP and serum folate between −0.21 and 0.02. Only 3 surveys measured RBC folate, and among them, correlations for WRA ranged from −0.07 to 0.08 for CRP and −0.04 for AGP (1 country). Conclusions Based on the weak and inconsistent correlations between CRP or AGP and vitamin B-12 or folate biomarkers, there is no rationale to adjust for inflammation when estimating population prevalence of vitamin B-12 or folate deficiencies in WRA or PSC.

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Effect of Low Levels of Serum Vitamin B12 and Folic Acid on Cognitive Performance in Old Age: A Population-Based Study

Developmental Neuropsychology ◽

10.1207/875656401753549799 ◽

2001 ◽

Vol 20 (3) ◽

pp. 565-571 ◽

Cited By ~ 1

Author(s):

Marko Jelicic ◽

Cees Jonker ◽

Dorly J. H. Deeg

Keyword(s):

Folic Acid ◽

Cognitive Performance ◽

Old Age ◽

Serum Vitamin ◽

Population Based ◽

Vitamin B ◽

Population Based Study ◽

Low Levels

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FACTOR ANALYSIS OF DIABETES MELLITUS WITH CO-EXISTING HYPERTENSION: A POPULATION-BASED STUDY FROM NORTH INDIA

10.22541/au.160387208.80073745/v1 ◽

2020 ◽

Author(s):

Amit Sharma ◽

Ashish Baldi ◽

Dinesh Kumar Sharma

Keyword(s):

Diabetes Mellitus ◽

Factor Analysis ◽

Population Based ◽

North India ◽

Population Based Study

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Prevalence of metabolic syndrome in young adults: a study from North India

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20171042 ◽

2017 ◽

Vol 4 (2) ◽

pp. 463 ◽

Cited By ~ 1

Author(s):

Manish Chandey ◽

Sukhjeet Kaur ◽

Harjot Kaur

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Biochemical Parameters ◽

Population Based ◽

North India ◽

Age Group ◽

Medical Sciences ◽

Lifestyle Modifications ◽

Population Based Study ◽

Complete Physical Examination

Background: Metabolic syndrome is a cluster of risk factors for CVD and is on rise globally as well as in india.Methods: This was a population based study conducted on 356 individuals of the age of 16-45 years, attending Medicine OPD for routine check-up at Sri guru ram das institute of medical sciences and research. Participants were subjected for anthropometric measurements, complete physical examination and evaluation of biochemical parameters in context of metabolic syndrome.Results: On applying, NCEP-ATPIII criteria, the prevalence of MS was found to be 22.47%. The prevalence of MS was comparable in both genders, though MS was significantly higher in females of 36-45 years age group (25.64%). About 82% of the participants were either overweight or obese.Conclusions: Since obesity was the most common entity prevalent and a major risk factor for MS and CVD, early detection and lifestyle modifications to prevent obesity and dyslipidemia should be promoted at all levels in community.

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Vitamin B12 Deficiency in Jordan: A Population-Based Study

Annals of Nutrition and Metabolism ◽

10.1159/000355440 ◽

2014 ◽

Vol 64 (2) ◽

pp. 101-105 ◽

Cited By ~ 9

Author(s):

Mohammed El-Khateeb ◽

Yousef Khader ◽

Anwar Batieha ◽

Hashem Jaddou ◽

Dana Hyassat ◽

...

Keyword(s):

Population Based ◽

Vitamin B ◽

Population Based Study

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Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status

American Journal of Clinical Nutrition ◽

10.3945/ajcn.116.139337 ◽

2017 ◽

Vol 105 (4) ◽

pp. 897-904 ◽

Cited By ~ 18

Author(s):

Björn Gylling ◽

Robin Myte ◽

Jörn Schneede ◽

Göran Hallmans ◽

Jenny Häggström ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Population Based ◽

Colorectal Cancer Risk ◽

Vitamin B ◽

Population Based Study ◽

Plasma Markers

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Defining the plasma folate concentration associated with the red blood cell folate concentration threshold for optimal neural tube defects prevention: a population-based, randomized trial of folic acid supplementation

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqz027 ◽

2019 ◽

Vol 109 (5) ◽

pp. 1452-1461 ◽

Cited By ~ 10

Author(s):

Meng-Yu Chen ◽

Charles E Rose ◽

Yan Ping Qi ◽

Jennifer L Williams ◽

Lorraine F Yeung ◽

...

Keyword(s):

Folic Acid ◽

Intervention Group ◽

Population Based ◽

Folic Acid Supplementation ◽

Reproductive Age ◽

Vitamin B ◽

Acid Supplementation ◽

Folate Concentration ◽

Plasma Folate ◽

Vitamin B 12

ABSTRACT Background For women of reproductive age, a population-level red blood cell (RBC) folate concentration below the threshold 906 nmol/L or 400 ng/mL indicates folate insufficiency and suboptimal neural tube defect (NTD) prevention. A corresponding population plasma/serum folate concentration threshold for optimal NTD prevention has not been established. Objective The aim of this study was to examine the association between plasma and RBC folate concentrations and estimated a population plasma folate insufficiency threshold (pf-IT) corresponding to the RBC folate insufficiency threshold (RBCf-IT) of 906 nmol/L. Methods We analyzed data on women of reproductive age (n = 1673) who participated in a population-based, randomized folic acid supplementation trial in northern China. Of these women, 565 women with anemia and/or vitamin B-12 deficiency were ineligible for folic acid intervention (nonintervention group); the other 1108 received folic acid supplementation for 6 mo (intervention group). We developed a Bayesian linear model to estimate the pf-IT corresponding to RBCf-IT by time from supplementation initiation, folic acid dosage, methyltetrahydrofolate reductase (MTHFR) genotype, body mass index (BMI), vitamin B-12 status, or anemia status. Results Using plasma and RBC folate concentrations of the intervention group, the estimated median pf-IT was 25.5 nmol/L (95% credible interval: 24.6, 26.4). The median pf-ITs were similar between the baseline and postsupplementation samples (25.7 compared with 25.2 nmol/L) but differed moderately (±3–4 nmol/L) by MTHFR genotype and BMI. Using the full population-based baseline sample (intervention and nonintervention), the median pf-IT was higher for women with vitamin B-12 deficiency (34.6 nmol/L) and marginal deficiency (29.8 nmol/L) compared with the sufficient group (25.6 nmol/L). Conclusions The relation between RBC and plasma folate concentrations was modified by BMI and genotype and substantially by low plasma vitamin B-12. This suggests that the threshold of 25.5 nmol/L for optimal NTD prevention may be appropriate in populations with similar characteristics, but it should not be used in vitamin B-12 insufficient populations. This trial was registered at clinicaltrials.gov as NCT00207558.

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Association of air pollution and homocysteine with global DNA methylation: A population-based study from North India

PLoS ONE ◽

10.1371/journal.pone.0260860 ◽

2021 ◽

Vol 16 (12) ◽

pp. e0260860

Author(s):

Suniti Yadav ◽

Imnameren Longkumer ◽

Priyanka Rani Garg ◽

Shipra Joshi ◽

Sunanda Rajkumari ◽

...

Keyword(s):

Dna Methylation ◽

Air Pollution ◽

Methylation Status ◽

Population Based ◽

North India ◽

Nutritional Deficiencies ◽

Global Dna Methylation ◽

Vitamin B ◽

Global Methylation ◽

B Vitamin

Background Anthropogenic air pollution has been implicated in aberrant changes of DNA methylation and homocysteine increase (>15μM/L). Folate (<3 ng/mL) and vitamin B12 (<220 pg/mL) deficiencies also reduce global DNA methylation via homocysteine increase. Although B-vitamin supplements can attenuate epigenetic effects of air pollution but such understanding in population-specific studies are lacking. Hence, the present study aims to understand the role of air pollution, homocysteine, and nutritional deficiencies on methylation. Methods We examined cross-sectionally, homocysteine, folate, vitamin B12 (chemiluminescence) and global DNA methylation (colorimetric ELISA Assay) among 274 and 270 individuals from low- and high- polluted areas, respectively, from a single Mendelian population. Global DNA methylation results were obtained on 254 and 258 samples from low- and high- polluted areas, respectively. Results Significant decline in median global DNA methylation was seen as a result of air pollution [high-0.84 (0.37–1.97) vs. low-0.96 (0.45–2.75), p = 0.01]. High homocysteine in combination with air pollution significantly reduced global DNA methylation [high-0.71 (0.34–1.90) vs. low-0.93 (0.45–3.00), p = 0.003]. Folate deficient individuals in high polluted areas [high-0.70 (0.37–1.29) vs. low-1.21 (0.45–3.65)] showed significantly reduced global methylation levels (p = 0.007). In low polluted areas, despite folate deficiency, if normal vitamin B12 levels were maintained, global DNA methylation levels improved significantly [2.03 (0.60–5.24), p = 0.007]. Conversely, in high polluted areas despite vitamin B12 deficiency, if normal folate status was maintained, global DNA methylation status improved significantly [0.91 (0.36–1.63)] compared to vitamin B12 normal individuals [0.54 (0.26–1.13), p = 0.04]. Conclusions High homocysteine may aggravate the effects of air pollution on DNA methylation. Vitamin B12 in low-polluted and folate in high-polluted areas may be strong determinants for changes in DNA methylation levels. The effect of air pollution on methylation levels may be reduced through inclusion of dietary or supplemented B-vitamins. This may serve as public level approach in natural settings to prevent metabolic adversities at community level.

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