Adipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer

Abstract Background and objectives Laparoscopic colorectal surgery causes a lower stress response than open surgery. Adiponectin is mainly derived from adipocytes and has antidiabetic, antioxidative, and anti-inflammatory capabilities. The objective of the present study was to investigate the protein expression of adiponectin in adipose tissue, and the serum levels of adiponectin, oxidative stress markers and proinflammatory factors during laparoscopic colorectal surgery and open surgery periods. Methods Forty patients aged 60 to 80, with American Society of Anesthesiologists (ASA) I ~ II who underwent radical resection of colorectal cancer were recruited to the study. Laparoscopic group and open group included 20 patients each. Mesenteric adipose tissue and venous blood before (T1) and at the end (T2) of surgery were collected to examine adiponectin levels, and venous blood was collected to examine serum levels of oxidative stress related markers (superoxide dismutase (SOD), glutathione (GSH), lipid peroxide (LPO), malondialdehyde (MDA)), and inflammation-related factors (interleukin (IL)-1β, interleukin (IL)-6, tumor necrosis factor-α (TNF-α)). Results Protein and serum levels of adiponectin were analyzed, and adiponectin levels were significantly increased at T2 than T1 in the laparoscopic surgery, while adiponectin levels were significantly higher in the laparoscopic surgery than in the open surgery at T2. In addition, the serum levels of SOD and GSH were significantly higher in the laparoscopic surgery than in open surgery at T2. However, the serum levels of LPO, TNF-α, IL-1β, and IL-6 were significantly lower in the laparoscopic group than in open group at T2. Conclusion Laparoscopic surgery induced higher levels of adiponectin in both adipose tissue and the bloodstream. Oxidative stress and the inflammatory response were lower during laparoscopic colorectal surgery than during conventional open surgery. These data suggest that adipose tissue may alleviate the stress response during laparoscopic surgery by releasing adiponectin in patients with colorectal cancer.

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Persistent Descending Mesocolon as a Risk Factor of Laparoscopic Surgery for Colorectal Cancer: A Single Institution Experience

International Surgery ◽

10.9738/intsurg-d-16-00085.1 ◽

2019 ◽

Vol 104 (9-10) ◽

pp. 439-445

Author(s):

Hidekazu Takahashi ◽

Nobuo Tanaka ◽

Osamu Takayama ◽

Masashi Baba ◽

Masaru Murata ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Laparoscopic Surgery ◽

Colorectal Surgery ◽

Laparoscopic Colorectal Surgery ◽

Three Dimensional ◽

Tumor Location ◽

Computed Tomographic ◽

Preoperative Diagnostic ◽

Tomographic Slice

The objectives of this study are to clarify the significance of persistent descending mesocolon (PDM), a kind of intestinal malrotation, in laparoscopic colorectal surgery and present potentially useful preoperative diagnostic methods for PDM. Although several risk factors for laparoscopic colorectal surgery have been convincingly reported, the impact of PDM on laparoscopic surgery for colorectal cancer remains less studied. This was an observational study with a retrospective analysis. A consecutive 110 patients undergoing laparoscopic colorectal surgery for colorectal cancer were included. To identify risk factors for operative time of laparoscopic surgery for colorectal cancer, we examined age, sex, body mass index, American Society of Anesthesiologists Performance Status score, tumor location, depth of tumor invasion, lymph node metastasis, and PDM as potential risk factors. For identification of appropriate preoperative diagnostic imaging, we reviewed three-dimensional vessel images reconstructed from computed tomographic slice data of all patients. During the study period, no effective pre- or intraoperative diagnoses of PDM were achieved. A total of 4 patients were diagnosed with PDM. Sex (P = 0.0032); tumor location (P = 0.0044); lymph node metastasis (P = 0.022); and PDM (P = 0.0007) were identified as risk factors based on multivariate analysis. A ventrally branched left colic artery visualized by three-dimensional imaging appeared to be a highly specific feature of PDM. Laparoscopic surgery for colorectal cancer with PDM was difficult without the recognition of PDM. PDM was well-defined preoperatively using three-dimensional vessels images reconstructed from computed tomographic slice data.

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Périphérique laparoscopic colorectal course

Bulletin of The Royal College of Surgeons of England ◽

10.1308/bull.2010.92.1.20 ◽

2010 ◽

Vol 92 (1) ◽

pp. 20-20

Author(s):

Ceri Beaton

Keyword(s):

Colorectal Cancer ◽

Colorectal Surgery ◽

Open Surgery ◽

Laparoscopic Colorectal Surgery ◽

Training Programme ◽

Open Resection ◽

Training Scheme ◽

Wet Lab ◽

Training Schemes ◽

National Training

Following the guidance from NICE in 2006 that stated that laparoscopic (including laparoscopically assisted) resection is recommended as an alternative to open resection for individuals with colorectal cancer in whom both laparoscopic and open surgery are considered suitable, training schemes in laparoscopic colorectal surgery (LCS) have been developed. The National Training Programme in Laparoscopic Colorectal Surgery was developed to provide LCS training for consultants in England and the Welsh Laparoscopic Colorectal Training Scheme [see article above] is open to SpRs and colorectal consultants in Wales. Wet-lab courses are generally seen as the first of many platforms in LCS training and can be followed by clinical immersion courses, inreach and outreach preceptorship, and masterclasses.

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Short- and Long-Term Outcomes of Laparoscopic Surgery for Colorectal Cancer in the Elderly Aged Over 80 Years Old Versus Non-Elderly: A Retrospective Cohort Study

10.21203/rs.3.rs-36719/v1 ◽

2020 ◽

Author(s):

Yoshitake Ueda ◽

Norio Shiraishi ◽

Takahide Kawasaki ◽

Tomonori Akagi ◽

Shigeo Ninomiya ◽

...

Keyword(s):

Colorectal Cancer ◽

Laparoscopic Surgery ◽

Colorectal Surgery ◽

Elderly Patients ◽

Laparoscopic Colorectal Surgery ◽

The Elderly ◽

Long Term Outcomes ◽

Short And Long Term ◽

Surgery In Elderly

Abstract Background Recently, colorectal cancer has increased in elderly patients worldwide, with laparoscopic colorectal surgery increasing in elderly patients with colorectal cancer. However, whether laparoscopic colorectal surgery is an optimal procedure for colorectal cancer in the elderly remains unclear.Objective This study aimed to verify safety and curability of laparoscopic colorectal surgery in elderly patients ≥80 years old.Methods Patients undergoing curative colorectal surgery from 2006 to 2014 were enrolled and classified into the laparoscopic surgery in elderly patients aged ≥80 years (LAC-E) group, open surgery in elderly patients (OC-E) group, and laparoscopic surgery in non-elderly patients (LAC-NE) group. Short- and long-term outcomes were compared between these groups.Results The LAC-E, OC-E, and LAC-NE groups comprised 85, 25, and 358 patients, respectively. Intraoperative blood loss and incidence of postoperative complications were significantly lower in the LAC-E versus OC-E group (97 vs. 440 mL, p<.01 and 14% vs. 32%, p<.05, respectively). Long-term outcomes were not different between these two groups. Operation time was significantly shorter in the LAC-E versus LAC-NE group (249 vs. 288 min, p<.01). Intraoperative blood loss and postoperative complications were similar between the groups. Although the 5-year overall survival rate in the LAC-E group was lower than that in the LAC-NE group (64% vs. 80%, p<.01), there was no difference in 5-year disease-specific survival between the groups.Conclusions Laparoscopic colorectal surgery is technically and oncologically safe for colorectal cancer in the elderly as well as the non-elderly and can be an optimal procedure for colorectal cancer in the elderly.

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Short- and long-term outcomes of laparoscopic surgery for colorectal cancer in the elderly aged over 80 years old versus non-elderly: a retrospective cohort study

BMC Geriatrics ◽

10.1186/s12877-020-01779-2 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Yoshitake Ueda ◽

Norio Shiraishi ◽

Takahide Kawasaki ◽

Tomonori Akagi ◽

Shigeo Ninomiya ◽

...

Keyword(s):

Colorectal Cancer ◽

Laparoscopic Surgery ◽

Colorectal Surgery ◽

Elderly Patients ◽

Laparoscopic Colorectal Surgery ◽

The Elderly ◽

Long Term Outcomes ◽

Short And Long Term ◽

Surgery In Elderly

Abstract Background Recently, colorectal cancer has increased in elderly patients worldwide, with laparoscopic colorectal surgery increasing in elderly patients with colorectal cancer. However, whether laparoscopic colorectal surgery is an optimal procedure for colorectal cancer in the elderly remains unclear. This study aimed to verify safety and curability of laparoscopic colorectal surgery in elderly patients ≥80 years old. Methods Patients undergoing curative colorectal surgery from 2006 to 2014 were enrolled and classified into the laparoscopic surgery in elderly patients aged ≥80 years (LAC-E) group, open surgery in elderly patients (OC-E) group, and laparoscopic surgery in non-elderly patients (LAC-NE) group. Short- and long-term outcomes were compared between these groups. Results The LAC-E, OC-E, and LAC-NE groups comprised 85, 25, and 358 patients, respectively. Intraoperative blood loss and incidence of postoperative complications were significantly lower in the LAC-E versus OC-E group (97 vs. 440 mL, p < .01 and 14% vs. 32%, p < .05, respectively). Long-term outcomes were not different between these two groups. Operation time was significantly shorter in the LAC-E versus LAC-NE group (249 vs. 288 min, p < .01). Intraoperative blood loss and postoperative complications were similar between the groups. Although the 5-year overall survival rate in the LAC-E group was lower than that in the LAC-NE group (64% vs. 80%, p < .01), there was no difference in 5-year disease-specific survival between the groups. Conclusion Laparoscopic colorectal surgery is technically and oncologically safe for colorectal cancer in the elderly as well as the non-elderly and can be an optimal procedure for colorectal cancer in the elderly.

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Short- and long-term outcomes of laparoscopic surgery for colorectal cancer in the elderly aged over 80 years old versus non-elderly: a retrospective cohort study

10.21203/rs.3.rs-36719/v2 ◽

2020 ◽

Author(s):

Yoshitake Ueda ◽

Norio Shiraishi ◽

Takahide Kawasaki ◽

Tomonori Akagi ◽

Shigeo Ninomiya ◽

...

Keyword(s):

Colorectal Cancer ◽

Laparoscopic Surgery ◽

Colorectal Surgery ◽

Elderly Patients ◽

Laparoscopic Colorectal Surgery ◽

The Elderly ◽

Long Term Outcomes ◽

Short And Long Term ◽

Surgery In Elderly

Abstract Background Recently, colorectal cancer has increased in elderly patients worldwide, with laparoscopic colorectal surgery increasing in elderly patients with colorectal cancer. However, whether laparoscopic colorectal surgery is an optimal procedure for colorectal cancer in the elderly remains unclear. This study aimed to verify safety and curability of laparoscopic colorectal surgery in elderly patients ≥80 years old. Methods Patients undergoing curative colorectal surgery from 2006 to 2014 were enrolled and classified into the laparoscopic surgery in elderly patients aged ≥80 years (LAC-E) group, open surgery in elderly patients (OC-E) group, and laparoscopic surgery in non-elderly patients (LAC-NE) group. Short- and long-term outcomes were compared between these groups. Results The LAC-E, OC-E, and LAC-NE groups comprised 85, 25, and 358 patients, respectively. Intraoperative blood loss and incidence of postoperative complications were significantly lower in the LAC-E versus OC-E group (97 vs. 440 mL, p<.01 and 14% vs. 32%, p<.05, respectively). Long-term outcomes were not different between these two groups. Operation time was significantly shorter in the LAC-E versus LAC-NE group (249 vs. 288 min, p<.01). Intraoperative blood loss and postoperative complications were similar between the groups. Although the 5-year overall survival rate in the LAC-E group was lower than that in the LAC-NE group (64% vs. 80%, p<.01), there was no difference in 5-year disease-specific survival between the groups. Conclusion Laparoscopic colorectal surgery is technically and oncologically safe for colorectal cancer in the elderly as well as the non-elderly and can be an optimal procedure for colorectal cancer in the elderly.

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1083 Proteomic analysis reveals increased Nrf2-mediated oxidative stress response in adipose tissue of late pregnant dairy cows during summer heat stress

Journal of Animal Science ◽

10.2527/jam2016-1083 ◽

2016 ◽

Vol 94 (suppl_5) ◽

pp. 519-520

Author(s):

M. Zachut ◽

G. Kra ◽

G. Friedlander ◽

Y. Levin

Keyword(s):

Oxidative Stress ◽

Adipose Tissue ◽

Heat Stress ◽

Stress Response ◽

Dairy Cows ◽

Proteomic Analysis ◽

Oxidative Stress Response ◽

Summer Heat

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Improved perioperative outcomes and reduced inflammatory stress response in malignant robotic-assisted colorectal resections: a retrospective cohort study of 298 patients

10.21203/rs.3.rs-278055/v1 ◽

2021 ◽

Author(s):

Pedja Cuk ◽

Randi Maria Simonsen ◽

Mirjana Komljen ◽

Michael Festersen Nielsen ◽

Per Helligsø ◽

...

Keyword(s):

Colorectal Cancer ◽

Laparoscopic Surgery ◽

Stress Response ◽

Retrospective Cohort ◽

Interquartile Range ◽

Short Term ◽

Inflammatory Stress ◽

Robotic Assisted ◽

Robotic Assisted Surgery ◽

Colorectal Resections

Abstract Background Robotic-assisted surgery is increasingly implemented for the resection of colorectal cancer, although the scientific evidence for adopting this technique is still limited. This study's main objective was to compare short-term complications, oncological outcomes, and the inflammatory stress response after colorectal resection for cancer performed laparoscopic or robotic-assisted. Methods We conducted a retrospective cohort study comparing the robotic-assisted approach to laparoscopic surgery for elective malignant colorectal neoplasm. Certified colorectal and da Vinci ® robotic surgeons performed resections at a Danish tertiary colorectal high volume centre from May 2017 – March 2019. We analyzed the two surgical groups using uni- and multivariate regression analyses to detect differences in intra- and postoperative clinical outcomes and the inflammatory stress response. Results Two hundred and ninety-eight patients were enrolled in the study. Significant differences favoring robotic-assisted surgery was demonstrated for; length of hospital stay (4 days, interquartile range (4–5) versus 5 days, interquartile range (4–7), p < 0.001) and intraoperative blood loss (50 mL, interquartile range (20–100) versus 100 mL, interquartile range (50–150), p < 0.001) compared to laparoscopic surgery. The inflammatory stress response was significantly higher after laparoscopic compared to robotic-assisted surgery reflected by an increase in C-reactive protein concentration (exponentiated coefficient = 1.20, 95% confidence interval (1.04–1.40), p < 0.001). No differences between the two groups were found concerning mortality, microradical resection rate, conversion to open surgery and surgical or medical short-term complications. Conclusion Robotic-assisted surgery is feasible and can be safely implemented for colorectal resections. The robotic-assisted approach, when compared to laparoscopic surgery, was associated with improved intra- and postoperative outcomes. Extensive prospective studies are needed to determine the short and long-term outcomes of robotic surgery for colorectal cancer.

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Open surgery induces a dramatic decrease in circulating intact IGFBP-3 in patients with colorectal cancer not seen with laparoscopic surgery

Surgical Endoscopy ◽

10.1007/s00464-004-8906-x ◽

2004 ◽

Vol 19 (1) ◽

pp. 55-59 ◽

Cited By ~ 32

Author(s):

I. Kirman ◽

V. Cekic ◽

N. Poltoratskaia ◽

P. Sylla ◽

S. Jain ◽

...

Keyword(s):

Colorectal Cancer ◽

Laparoscopic Surgery ◽

Open Surgery ◽

Dramatic Decrease ◽

Igfbp 3

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Comparison of Short-Term Outcomes Between Robotic-Assisted and Laparoscopic Surgery in Colorectal Cancer

Surgical Innovation ◽

10.1177/1553350618797822 ◽

2018 ◽

Vol 26 (1) ◽

pp. 57-65 ◽

Cited By ~ 1

Author(s):

Xiao-Long Zhu ◽

Pei-Jing Yan ◽

Liang Yao ◽

Rong Liu ◽

De-Wang Wu ◽

...

Keyword(s):

Colorectal Cancer ◽

Laparoscopic Surgery ◽

Colorectal Surgery ◽

Hospital Stay ◽

Bowel Function ◽

Postoperative Recovery ◽

Postoperative Hospital Stay ◽

Robot Assisted ◽

Short Term ◽

Robotic Colorectal Surgery

Aim. The robotic technique has been established as an alternative approach to laparoscopy in colorectal surgery. The aim of this study was to compare short-term outcomes of robot-assisted and laparoscopic surgery in colorectal cancer. Methods. The cases of robot-assisted or laparoscopic colorectal resection were collected retrospectively between July 2015 and October 2017. We evaluated patient demographics, perioperative characteristics, and pathologic examination. A multivariable linear regression model was used to assess short-term outcomes between robot-assisted and laparoscopic surgery. Short-term outcomes included time to passage of flatus and postoperative hospital stay. Results. A total of 284 patients were included in the study. There were 104 patients in the robotic colorectal surgery (RCS) group and 180 in the laparoscopic colorectal surgery (LCS) group. The mean age was 60.5 ± 10.8 years, and 62.0% of the patients were male. We controlled for confounding factors, and then the multiple linear model regression indicated that the time to passage of flatus in the RCS group was 3.45 days shorter than the LCS group (coefficient = −3.45, 95% confidence interval [CI] = −5.19 to −1.71; P < .001). Additionally, the drainage of tube duration (coefficient = 0.59, 95% CI = 0.3 to 0.87; P < .001) and transfers to the intensive care unit (coefficient = 7.34, 95% CI = 3.17 to 11.5; P = .001) influenced the postoperative hospital stay. The total costs increased by 15501.48 CNY in the RCS group compared with the LCS group ( P = .008). Conclusions. The present study suggests that colorectal cancer robotic surgery was more beneficial to patients because of shorter postoperative recovery time of bowel function and shorter hospital stays.

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