The role of radiotherapy in metaplastic breast cancer: a propensity score-matched analysis of the SEER database

Abstract Background Only few studies, with small patient cohorts, have evaluated the effect of radiotherapy (RT) for metaplastic breast cancer (MBC). Hence, it is important to investigate the role of RT in MBC survival using a large population-database. Methods A retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) from 1973 to 2015 was performed. We compared MBC patients with or without RT for overall survival (OS) and breast cancer-specific survival (BCSS) using univariate and multivariate Cox proportional hazard regressions before and after propensity score matching (PSM). Results From a total of 2267 patients diagnosed with MBC between 1998 and 2015, 1086 (47.9%) received RT. In the multivariate analysis before PSM, RT provided a better OS (HR 0.73; 95% CI 0.61–0.88; p = 0.001) and BCSS (HR 0.71; 95% CI 0.58–0.88; p = 0.002). Multivariate analyses after PSM (n = 1066) confirmed that patients receiving RT (n = 506) survived longer than those without RT (OS, HR 0.64; 95% CI 0.51–0.80; p < 0.001 and BCSS, HR 0.64; 95% CI 0.50–0.83; p = 0.001). A longer OS was observed when RT was given to older patients (p = 0.001) and in case of large tumor size (p = 0.002). Intriguingly, patients with N0 stage showed better OS after RT (HR 0.69, P = 0.012). Conclusions Our findings support the beneficial effect of RT for MBC patients. In particular, older patients or with large tumor size have a greater survival benefit from RT. In conclusion, we have assessed the importance of the use of RT in MBC as survival factor and this could lead to the development of guidelines for this rare sub-type of tumors.

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Comparison of Lobectomy and Sublobar Resection for Stage IA Elderly NSCLC Patients (≥70 Years): A Population-Based Propensity Score Matching’s Study

Frontiers in Oncology ◽

10.3389/fonc.2021.610638 ◽

2021 ◽

Vol 11 ◽

Author(s):

Bo Zhang ◽

Renwang Liu ◽

Dian Ren ◽

Xiongfei Li ◽

Yanye Wang ◽

...

Keyword(s):

Lung Cancer ◽

Propensity Score ◽

Tumor Size ◽

Cox Regression ◽

Large Tumor ◽

Cox Regression Analysis ◽

Large Tumor Size ◽

Significant Difference ◽

Stage Ia ◽

Nsclc Patients

BackgroundTo investigate the differences in survival between lobectomy and sub-lobar resection for elderly stage I non-small-cell lung cancer (NSCLC) patients using the Surveillance, Epidemiology, and End Results (SEER) registry.MethodThe data of stage IA elderly NSCLC patients (≥ 70 years) with tumors less than or equal to 3 cm in diameter were extracted. Propensity-matched analysis was used. Lung cancer-specific survival (LCSS) was compared among the patients after lobectomy and sub-lobar resection. The proportional hazards model was applied to identify multiple prognostic factors.ResultsA total of 3,504 patients met criteria after propensity score matching (PSM). Although the LCSS was better for lobectomy than for sub-lobar resection in patients with tumors ≤ 3 cm before PSM (p < 0.001), no significant difference in the LCSS was identified between the two treatment groups after PSM (p = 0.191). Multivariate Cox regression showed the elder age, male gender, squamous cell carcinoma (SQC) histology type, poor/undifferentiated grade and a large tumor size were associated with poor LCSS. The subgroup analysis of tumor sizes, histologic types and lymph nodes (LNs) dissection, there were also no significant difference for LCSS between lobectomy and sub-lobar resection. The sub-lobar resection was further divided into segmentectomy or wedge resection, and it demonstrated that no significant differences in LCSS were identified among the treatment subgroups either. Multivariate Cox regression analysis showed that the elder age, poor/undifferentiated grade and a large tumor size were a statistically significant independent factor associated with survival.ConclusionIn terms of LCSS, lobectomy has no significant advantage over sub-lobar resection in elderly patients with stage IA NSCLC if lymph node assessment is performed adequately. The present data may contribute to develop a more suitable surgical treatment strategy for the stage IA elderly NSCLC patients.

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Increased lymph node metastases at mastectomy for breast cancer associated with host obesity, cigarette smoking, age, and large tumor size

Cancer ◽

10.1002/1097-0142(19880715)62:2<429::aid-cncr2820620230>3.0.co;2-4 ◽

1988 ◽

Vol 62 (2) ◽

pp. 429-435 ◽

Cited By ~ 64

Author(s):

Harry W. Daniell

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Cigarette Smoking ◽

Lymph Node Metastases ◽

Tumor Size ◽

Large Tumor ◽

Large Tumor Size ◽

Node Metastases

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Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China: A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG)

BioMed Research International ◽

10.1155/2019/3692093 ◽

2019 ◽

Vol 2019 ◽

pp. 1-14

Author(s):

Kang Wang ◽

Yu-Tuan Wu ◽

Xiang Zhang ◽

Li Chen ◽

Wen-Ming Zhu ◽

...

Keyword(s):

Breast Cancer ◽

Body Mass Index ◽

Body Mass ◽

Tumor Size ◽

Prognostic Significance ◽

Western China ◽

Large Tumor ◽

Large Tumor Size ◽

Significant Difference ◽

The Impact

Introduction. Clinicopathologic and prognostic significance of body mass index (BMI) in breast cancer (BC) patients remained conflicting. We aimed to investigate and modify the impact of BMI on clinicopathological significance and survival in western Chinese BC patients.Materials and Methods. 8,394 female BC patients from Western China Clinical Cooperation Group (WCCCG) between 2005 and 2015 were identified. Multivariable logistic regression and Cox proportion hazard regressions were used to examine the difference of clinicopathologic and survival characteristics between BMI categories.Results. For the premenopausal, overweight and obese (OW) patients tended to have large tumor size (>5cm) (odds ratio [OR], 1.30, P<0.01) and triple-negative BC (OR, 1.31; P=0.01) compared with normal weight (NW) patients. Premenopausal underweight (UW) patients had a significantly higher risk of HER2 positive (OR, 1.71; P=0.02) and distant metastasis (OR, 2.59; P=0.01). For postmenopausal patients, OW patients showed higher risks of large tumor size (>5cm) (OR, 1.46; P=0.01), nuclear grade III (OR, 1.24; P=0.04), and lymphovascular invasion (OR, 1.46; P=0.01) compared with NW patients. An “U” shaped relationship between BMI and DFS was found (UW versus NW, adjusted hazard ratio (HR), 2.80, P<0.001; OW versus NW, adjusted HR, 1.40, P=0.02), whereas no significant difference of disease-free survival (DFS) between OW and NW premenopausal patients (adjusted HR=1.34, P=0.18) was revealed.Conclusion. We concluded that UW and OW were associated with aggressively clinicopathological characteristics, regardless of menopausal status. An “U” shaped association of BMI and DFS was revealed, and no significant difference of DFS between OW and NW in postmenopausal subgroup was revealed.

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Large Tumor Size is an Indicator for the Timely Administration of Adjuvant Radiotherapy in Luminal Breast Cancer with Positive Lymph Node

Cancer Management and Research ◽

10.2147/cmar.s293470 ◽

2021 ◽

Vol Volume 13 ◽

pp. 1325-1332

Author(s):

Kai-Yun You ◽

Wei-Liang Zou ◽

Lin Ding ◽

Zhuo-Fei Bi ◽

He-Rui Yao

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Tumor Size ◽

Adjuvant Radiotherapy ◽

Positive Lymph Node ◽

Luminal Breast Cancer ◽

Large Tumor ◽

Large Tumor Size ◽

Timely Administration

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Effect of Large Tumor Size on Cancer-Specific Mortality in Node-Negative Breast Cancer

Mayo Clinic Proceedings ◽

10.1016/j.mayocp.2012.07.023 ◽

2012 ◽

Vol 87 (12) ◽

pp. 1171-1180 ◽

Cited By ~ 21

Author(s):

Ke-Da Yu ◽

Yi-Zhou Jiang ◽

Sheng Chen ◽

Zhi-Gang Cao ◽

Jiong Wu ◽

...

Keyword(s):

Breast Cancer ◽

Tumor Size ◽

Large Tumor ◽

Node Negative ◽

Large Tumor Size ◽

Node Negative Breast Cancer ◽

Specific Mortality ◽

Cancer Specific Mortality

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Clinicopathological and Imaging Features Predictive of Clinical Outcome in Metaplastic Breast Cancer

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405615666190219105810 ◽

2020 ◽

Vol 16 (6) ◽

pp. 729-738

Author(s):

Ga Young Yoon ◽

Joo Hee Cha ◽

Hak Hee Kim ◽

Hee Jung Shin ◽

Eun Young Chae ◽

...

Keyword(s):

Breast Cancer ◽

Clinical Outcome ◽

Clinical Outcomes ◽

Tumor Size ◽

Multivariable Analysis ◽

Disease Free Survival ◽

Imaging Features ◽

Peritumoral Edema ◽

Imaging Findings ◽

Metaplastic Breast Cancer

Background: Metaplastic breast cancer (MC) is a rare disease, thus it is difficult to study its clinical outcomes. Objective: To investigate whether any clinicopathological or imaging features were associated with clinical outcome in MC. Methods: We retrospectively evaluated the clinicopathological and imaging findings, and the clinical outcomes of seventy-two pathologically confirmed MCs. We then compared these parameters between triple-negative (TNMC) and non-TNMCs (NTNMC). Results: Oval or round shape, and not-circumscribed margin were the most common findings on mammography, ultrasound (US), and magnetic resonance imaging (MRI). It was mostly a mass without calcification on mammography, and revealed complex or hypoechoic echotexture, and posterior acoustic enhancement on US, and rim enhancement, wash-out kinetics, peritumoral edema, and intratumoral necrosis on MRI. Of all 72, 64 were TNMCs, and eight were NTNMCs. Clinicopathological and imaging findings were similar between the two groups, except that MRI showed peritumoral edema more frequently in TNMCs than NTNMCs (p=0.045). There were 21 recurrences and 13 deaths. Multivariable analysis showed that larger tumor size and co-existing DCIS were significantly predictive of Disease free survival (DFS), and larger tumor size and neoadjuvant chemotherapy were significantly predictive of overall survival (OS). Conclusion: MC showed characteristic imaging findings, and some variables associated with survival outcome may help to predict prognosis.

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The prognostic role of tumor size in early breast cancer in the era of molecular biology

PLoS ONE ◽

10.1371/journal.pone.0189127 ◽

2017 ◽

Vol 12 (12) ◽

pp. e0189127 ◽

Cited By ~ 9

Author(s):

Anaid Anna Kasangian ◽

Giorgio Gherardi ◽

Elena Biagioli ◽

Valter Torri ◽

Anna Moretti ◽

...

Keyword(s):

Breast Cancer ◽

Molecular Biology ◽

Early Breast Cancer ◽

Tumor Size ◽

Prognostic Role

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Intraocular retinoblastoma group V: an analysis of prognostic factors.

Journal of Clinical Oncology ◽

10.1200/jco.1985.3.5.680 ◽

1985 ◽

Vol 3 (5) ◽

pp. 680-685 ◽

Cited By ~ 58

Author(s):

C M Rubin ◽

L L Robison ◽

J D Cameron ◽

W G Woods ◽

M E Nesbit ◽

...

Keyword(s):

Risk Factors ◽

Prognostic Factors ◽

Optic Nerve ◽

Life Table ◽

Tumor Size ◽

Large Tumor ◽

Group V ◽

Large Tumor Size ◽

Poor Risk ◽

Undifferentiated Histology

A retrospective analysis of the University of Minnesota (Minneapolis) experience with retinoblastoma is presented. Seventy-five patients were diagnosed with retinoblastoma between 1958 and 1983, of which 53 (71%) had at least one Reese-Ellsworth group V eye. Nineteen group V patients and one group II patient developed extraocular disease recurrence. The cumulative actuarial rate of recurrence at 12 years was 36% for patients with group V disease. The median time from diagnosis to recurrence for unilateral patients was seven months and for bilateral patients 28 months (P = .001). Patients developing extraocular disease had a 10-year actuarial survival rate postrecurrence of 34%. The four long-term survivors of extraocular recurrences had had isolated orbital or local soft tissue recurrences only. Features of group V patients associated with extraocular recurrences were identified by univariate life table analyses. Clinical poor-risk factors included the nongenetic form of the disease (P = .03) and male sex (P = .02). Pathologic poor risk factors included rubeosis (P = .01), undifferentiated histology (P = .03), large tumor size (P = .05), and intraocular extension to the anterior segment (P = .02), retinal pigment epithelium (P = .03), choroid (P less than .001), and optic nerve beyond the lamina cribrosa (P = .02). Treatment-associated poor-risk factors included an optic nerve length of less than 5 mm removed at enucleation (P = .003). Multivariate life table analyses demonstrated the following parameters to be independent poor-prognostic factors: optic nerve length of less than 5 mm removed at enucleation (P = .001), optic nerve involvement (P = .004), and large tumor size (P = .01). These results will help to identify patients with retinoblastoma who are at greatest risk for extraocular recurrence.

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