scholarly journals Interactions of neuroimmune signaling and glutamate plasticity in addiction

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Cassandra D. Gipson ◽  
Scott Rawls ◽  
Michael D. Scofield ◽  
Benjamin M. Siemsen ◽  
Emma O. Bondy ◽  
...  
Keyword(s):  
Substance Use ◽  
Drug Use ◽  
Substance Use Disorders ◽  
Drugs Of Abuse ◽  
Treatment Strategies ◽  
Glutamate Signaling ◽  
Open Questions ◽  
Seeking Behavior ◽  
Glutamate System ◽  
Chronic Use

AbstractChronic use of drugs of abuse affects neuroimmune signaling; however, there are still many open questions regarding the interactions between neuroimmune mechanisms and substance use disorders (SUDs). Further, chronic use of drugs of abuse can induce glutamatergic changes in the brain, but the relationship between the glutamate system and neuroimmune signaling in addiction is not well understood. Therefore, the purpose of this review is to bring into focus the role of neuroimmune signaling and its interactions with the glutamate system following chronic drug use, and how this may guide pharmacotherapeutic treatment strategies for SUDs. In this review, we first describe neuroimmune mechanisms that may be linked to aberrant glutamate signaling in addiction. We focus specifically on the nuclear factor-kappa B (NF-κB) pathway, a potentially important neuroimmune mechanism that may be a key player in driving drug-seeking behavior. We highlight the importance of astroglial-microglial crosstalk, and how this interacts with known glutamatergic dysregulations in addiction. Then, we describe the importance of studying non-neuronal cells with unprecedented precision because understanding structure-function relationships in these cells is critical in understanding their role in addiction neurobiology. Here we propose a working model of neuroimmune-glutamate interactions that underlie drug use motivation, which we argue may aid strategies for small molecule drug development to treat substance use disorders. Together, the synthesis of this review shows that interactions between glutamate and neuroimmune signaling may play an important and understudied role in addiction processes and may be critical in developing more efficacious pharmacotherapies to treat SUDs.

Substance Use Disorders

2020 ◽  
pp. 372-386
Author(s):  
Shirshendu Sinha ◽  
Bhanu Prakash Kolla ◽  
Meghna P. Mansukhani
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Sleep Disturbances ◽  
Time Course ◽  
Drugs Of Abuse ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Specific Treatment ◽  
Early Recovery ◽  
Individual Substance

Sleep disturbances although highly prevalent conditions in patients with substance use disorders, they are underreported, underrecognized, underdiagnosed, and often untreated. Alcohol and various drugs of abuse interfere with the initiation and maintenance of sleep. The sleep disturbances can be experienced during active substance use including intoxication as well as during early recovery. Literature also indicates insomnia is a risk factor for substance abuse. Thus sleep disturbances can play a major role in initiating and maintaining substance use and increase the risk of relapse. This review describes the existing literature on the bidirectional relationships between sleep disturbances and substance use disorders in the context of alcohol, cannabis, opioid, and cocaine use disorders. Evidence with regards the type and severity of the sleep disruption, its time course, relationship to relapse, and treatment options when available are discussed. Specific treatment strategies focused on individual substance-related sleep disturbances will improve global outcome in substance use disorders and sleep and enhance the quality of life of the patients.

Abstract 228: National Prevalence of Substance Use Disorders Among Hospitalized Heart Failure Patients

2018 ◽  
Vol 11 (suppl_1) ◽  
Author(s):  
Sarah C Snow ◽  
Gregg C Fonarow ◽  
Joseph A Ladapo ◽  
Donna L Washington ◽  
Katherine Hoggatt ◽  
...  
Keyword(s):  
Heart Failure ◽  
Substance Use ◽  
Native American ◽  
Drug Use ◽  
Substance Use Disorders ◽  
Age Groups ◽  
Opioid Use ◽  
Drug Use Disorders ◽  
Increased Risk ◽  
Drug Use Disorder

Background: Several cardiotoxic substances contribute to the development of heart failure (HF). The burden of comorbid substance use disorders (SUD) among patients with HF is under-characterized. Objectives: To describe the national burden of comorbid SUD (tobacco, alcohol, or drug use disorders) among hospitalized HF patients in the U.S. Methods: We used data from the 2014 National Inpatient Sample to calculate the proportion of hospitalizations for a primary HF admission with tobacco, alcohol, or drug use disorder diagnoses, accounting for demographic factors. Drug use disorder analysis was further sub-divided into specific illicit substance categories. Results: There were a total of 989,080 HF hospitalizations of which 35.3% (n=348,995) had a documented SUD. Tobacco use disorder (TUD) was most common (n= 327,220, 33.1%) followed by drug use disorder (DUD) (n=34,600, 3.5%) and alcohol use disorder (AUD) (n=34,285, 3.5%). Female sex was associated with less TUD (OR 0.59; 95% CI, 0.58-0.60), AUD (OR 0.23; 95% CI, 0.22-0.25) or DUD (OR 0.58; 95% CI 0.55-0.62). Tobacco, alcohol, cocaine, and opioid use disorders were highest among HF patients age 45 to 55, while cannabis and amphetamine use was highest in those <45 years. Native American race (versus White) was associated with increased risk of AUD (OR 1.67; 95% CI 1.27-2.20). Black race was associated with increased risk of AUD (OR 1.09; 95% CI 1.02-1.16) or DUD (OR 1.63; 95% CI 1.53-1.74). Medicaid insurance (versus Medicare) was associated with greater TUD (OR 1.27; 95% CI 1.23-1.32), AUD (OR 1.74; 95% CI 1.62-1.87), and DUD (OR 2.15; 95% CI 2.01-2.30). Decreasing quartiles of median household income were associated with increasing SUD. Conclusions: Comorbid SUD disproportionately affects certain HF populations, including men, younger age groups, lower SES patients, and race/ethnic minorities. Further research on interventions to improve prevention and treatment of SUD among hospitalized HF patients are needed given the high rates of SUD in this population. Systematically screening hospitalized HF patients for SUD may reveal opportunities for treatment and secondary prevention.

Do men who have sex with men who report alcohol and illicit drug use before/during sex (chemsex) present moderate/high risk for substance use disorders?

2020 ◽  
Vol 209 ◽  
pp. 107908 ◽  
Author(s):  
Thiago S. Torres ◽  
Leonardo S. Bastos ◽  
Luciana Kamel ◽  
Daniel R.B. Bezerra ◽  
Nilo M. Fernandes ◽  
...  
Keyword(s):  
Substance Use ◽  
High Risk ◽  
Drug Use ◽  
Substance Use Disorders ◽  
Illicit Drug ◽  
Illicit Drug Use ◽  
Sex With Men

scholarly journals Declines in prevalence of adolescent substance use disorders and delinquent behaviors in the USA: a unitary trend?

2017 ◽  
Vol 48 (9) ◽  
pp. 1494-1503 ◽  
Author(s):  
R. A. Grucza ◽  
R. F. Krueger ◽  
Arpana Agrawal ◽  
A. D. Plunk ◽  
M. J. Krauss ◽  
...  
Keyword(s):  
Substance Use ◽  
Drug Use ◽  
Risk Behaviors ◽  
Substance Use Disorders ◽  
Adolescent Substance ◽  
Delinquent Behaviors ◽  
Adolescent Risk ◽  
The Usa ◽  
Item Response Theory Models ◽  
Adolescent Risk Behaviors

AbstractBackgroundDownward trends in a number of adolescent risk behaviors including violence, crime, and drug use have been observed in the USA in recent years. It is unknown whether these are separate trends or whether they might relate to a general reduction in propensity to engage in such behaviors. Our objectives were to quantify trends in substance use disorders (SUDs) and delinquent behaviors over the 2003–2014 period and to determine whether they might reflect a single trend in an Externalizing-like trait.MethodsWe analyzed data from 12 to 17 year old participants from the National Survey on Drug Use and Health, a representative survey of the household dwelling population of the USA, across the 2003–2014 period (N = 210 599). Outcomes included past-year prevalence of six categories of substance use disorder and six categories of delinquent behavior.ResultsTrend analysis suggested a net decline of 49% in mean number of SUDs and a 34% decline in delinquent behaviors over the 12-year period. Item Response Theory models were consistent with the interpretation that declines in each set of outcomes could be attributed to changes in mean levels of a latent, Externalizing-like trait.ConclusionsOur findings suggest that declines in SUDs and some delinquent behaviors reflect a single trend related to an Externalizing-like trait. Identifying the factors contributing to this trend may facilitate continued improvement across a spectrum of adolescent risk behaviors.

Introduction and Overview

2016 ◽  
Author(s):  
Kenneth J. Sher ◽  
Alvaro Vergés
Keyword(s):  
Substance Use ◽  
Genetic Variation ◽  
Substance Use Disorders ◽  
Drugs Of Abuse ◽  
Psychological Processes ◽  
Cultural Contexts ◽  
Fundamental Nature ◽  
Chronic Effects ◽  
Multidisciplinary Perspective ◽  
Acute And Chronic Effects

Substance use and substance use disorders (SUDs) have been documented in a number of cultures since the beginnings of recorded time and represent major societal concerns in the present day. The chapters in this Handbook review a number of different areas of inquiry into the fundamental nature of substance use and SUDs, their features, their causes, their consequences, their course, their treatment, and their prevention. It is clear that understanding these various aspects of substance use and SUDs requires a multidisciplinary perspective that considers the pharmacology of drugs of abuse, genetic variation in these acute and chronic effects, and psychological processes in the context of the interpersonal and cultural contexts. This chapter provides a general overview of most (but not all) of the topics covered in the Handbook, guiding the reader to the relevant chapters that address each topic in more detail.

scholarly journals Illicit Drug Use and Problem Gambling

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Peter Ferentzy ◽  
W. J. Wayne Skinner ◽  
Flora I. Matheson
Keyword(s):  
Substance Use ◽  
Drug Use ◽  
Problem Gambling ◽  
Substance Use Disorders ◽  
Illicit Drug ◽  
Illicit Drug Use ◽  
Future Research ◽  
Review Of The Literature ◽  
And Gender ◽  
Legal Substances

Problem gambling, substance use disorders, and their cooccurrence are serious public health concerns. We conducted a comprehensive review of the literature to understand the present state of the evidence on these coaddictions. Our main focus was illicit drug use rather than misuse of legal substances. The review covers issues related to gambling as a hidden problem in the illicit drug use community; prevalence, problem gambling, and substance use disorders as kindred afflictions; problem gambling as an addiction similar to illicit drug use; risk factors and problems associated with comorbidity, and gender issues. We end with some suggestions for future research.

Differences in prevalence and patterns of substance use in schizophrenia and bipolar disorder

2007 ◽  
Vol 38 (9) ◽  
pp. 1241-1249 ◽  
Author(s):  
P. A. Ringen ◽  
T. V. Lagerberg ◽  
A. B. Birkenæs ◽  
J. Engn ◽  
A. Færden ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Substance Use ◽  
Drug Use ◽  
Treatment Strategies ◽  
Specific Treatment ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Use Patterns ◽  
Bipolar Spectrum Disorder ◽  
Frequent Use

BackgroundSchizophrenia and bipolar disorder have partly overlapping clinical profiles, which include an over-representation of substance-use behaviour. There are few previous studies directly comparing substance-use patterns in the two disorders. The objective of the present study was to compare the prevalence of substance use in schizophrenia and bipolar disorder, and investigate possible differences in pattern and frequency of use.MethodA total of 336 patients with schizophrenia or bipolar spectrum disorder from a catchment area-based hospital service were included in a cross-sectional study. In addition to thorough clinical assessments, patients were interviewed about drug-use history, habits and patterns of use. The prevalence and drug-use patterns were compared between groups.ResultsPatients with bipolar disorder had higher rates of alcohol consumption, while schizophrenia patients more often used centrally stimulating substances, had more frequent use of non-alcoholic drugs and more often used more than one non-alcoholic drug. Single use of cannabis was more frequent in bipolar disorder.ConclusionThe present study showed diagnosis-specific patterns of substance use in severe mental disorder. This suggests a need for more disease-specific treatment strategies, and indicates that substance use may be an important factor in studies of overlapping disease mechanisms.

Early adolescent gateway drug use in sons of fathers with substance use disorders

1998 ◽  
Vol 23 (4) ◽  
pp. 561-566 ◽  
Author(s):  
Duncan B. Clark ◽  
Levent Kirisci ◽  
Howard B. Moss
Keyword(s):  
Substance Use ◽  
Drug Use ◽  
Substance Use Disorders ◽  
Early Adolescent
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