scholarly journals The role of Tannerella forsythia and Porphyromonas gingivalis in pathogenesis of esophageal cancer

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Bartosz Malinowski ◽  
Anna Węsierska ◽  
Klaudia Zalewska ◽  
Maya M. Sokołowska ◽  
Wiktor Bursiewicz ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Porphyromonas Gingivalis ◽  
Tannerella Forsythia

scholarly journals PERIODONTOPHATOGENIC BACTERIA OF THE MAIN FACTORS OF EMERGENCE AND DEVELOPMENT OF PERIODONTITIS

2017 ◽  
pp. 101-112 ◽  
Author(s):  
V. N. Tsarev ◽  
E. N. Nikolaeva ◽  
E. V. Ippolitov
Keyword(s):  
Porphyromonas Gingivalis ◽  
Quantitative Evaluation ◽  
Inflammatory Diseases ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Actinobacillus Actinomycetemcomitans ◽  
Tannerella Forsythia ◽  
Main Factors ◽  
Level Of Importance ◽  
Development Risk

Presents a modern understanding of the role of periodontophatogenic bacteria types: Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans), Tannerella forsythia (Bacteroides forsythus) and Porphyromonas gingivalis as indicators of periodontitis emergence and development risk. Therminological definitions are given of factors, indicators and markers of risk of periodontium inflammatory diseases development that show the level of importance of their association with the disease as well as the quantitative evaluation of these associations.

scholarly journals Association between Porphyromonas gingivalis and tumor-promoting status in esophageal squamous cell carcinoma

2020 ◽  
Author(s):  
Miao-Fen Chen ◽  
Ming- Shian Lu ◽  
Ching-Chuan Hsieh ◽  
Wen-Cheng Chen
Keyword(s):  
Vitamin D ◽  
Squamous Cell Carcinoma ◽  
Animal Model ◽  
Esophageal Cancer ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Porphyromonas Gingivalis ◽  
Oral Biofilms ◽  
Underlying Mechanisms

Abstract Background The microbiota is reported to affect tumor growth and the microenvironment of gastrointestinal cancers. However, the possible role of keystone bacterial infection in the development of esophageal squamous cell carcinoma (EsoSCC) remains unclear. In the present study, we studied the relationship between the oral microbiome, the periodontal pathogen Porphyromonas gingivalis (PG), and EsoSCC and elucidated the underlying mechanisms.Methods The microbiota in oral biofilms from patients was studied to identify bacterial biomarkers associated with EsoSCC by bioinformatics analyses. We then performed immunohistochemistry to examine the presence of PG in the esophageal tissues and analyze its relationship with the clinicopathologic characteristics in 156 EsoSCC patients. Furthermore, we investigated the role of PG infection in the progression of EsoSCC and its relationship with tumor microenvironment.Results The microbiota profiles from oral biofilms revealed that the abundance of PG was associated with a higher risk of developing EsoSCC. The presence of PG was detected immunohistochemically in 57% of cancerous tissues and was associated with a higher clinical stage and poor prognosis. Using cellular experiments and a 4-nitroquinoline 1-oxide (4NQO)-induced tumor animal model, the presence of PG was found to be associated with a higher risk of esophageal cancer. Increased IL-6 expression associated with an augmented epithelial-mesenchymal transition and recruitment of myeloid-derived suppressor cells were possible underlying mechanisms. Furthermore, in animal model including 4NQO-induced tumor and xenograft tumor model, we showed that the increased vitamin D3 induced by UVB light treatment obviously down-regulated IL-6 signaling and subsequently attenuated the increased risk of esophageal cancer induced by PG infection.Conclusions Our findings suggested that the presence of PG played an important role in the progression of esophageal cancer. Directly targeting PG or increasing vitamin D3 could be a promising strategy for the treatment of EsoSCC patients with PG infection noted by oral microbiota screening.

THE ROLE OF BRACHYTHERAPY IN TREATMENT FOR ESOPHAGEAL CANCER

2017 ◽  
Vol 63 (4) ◽  
pp. 660-665
Author(s):  
Yelena Tyuryaeva
Keyword(s):  
Esophageal Cancer ◽  
Critical Review ◽  
Palliative Treatment ◽  
Combined Treatment ◽  
Neoadjuvant Treatment ◽  
Early Esophageal Cancer ◽  
Separate Section ◽  
Treatment Regimens ◽  
Contradictory Data

The article is devoted to various aspects of the use of intraluminal brachytherapy (IB) in treatment for esophageal cancer (EC). A critical review of the use of IB as a component of combined radiotherapy/chemoradiotherapy in neoadjuvant treatment regimens, for definitive CRT, as well as in palliative treatment of non-operable tumors of this localization is given. The contradictory data on the effectiveness of brachytherapy with locally distributed, inoperable EC are summarized. A separate section relates to the prospects for incorporating brachytherapy into combined treatment of early esophageal cancer. Carried out analysis testifies to the necessity of standardization of summary and daily doses of irradiation depending on the indications to the IB.

scholarly journals PS01.42: Predictors of Incomplete Esophageal Cancer Resection: Questionable Role of Preoperative Therapy

2016 ◽  
Vol 11 (11) ◽  
pp. S295
Author(s):  
Mohamed Kamel ◽  
Paul C. Lee ◽  
Mohamed Rahouma ◽  
Galal Ghaly ◽  
Abu Nasar ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Preoperative Therapy ◽  
Cancer Resection

FAM196B promotes proliferation and migration via regulating epithelial-mesenchymal transition in esophageal cancer

2021 ◽  
pp. 1-8
Author(s):  
Haifeng Xia ◽  
Fang Hu ◽  
Liangbin Pan ◽  
Chengcheng Xu ◽  
Haitao Huang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Western Blot ◽  
Cox Regression ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Cox Regression Analysis ◽  
Ec Cells ◽  
And Migration ◽  
Proliferation And Migration

BACKGROUND: EC (esophageal cancer) is a common cancer among people in the world. The molecular mechanism of FAM196B (family with sequence similarity 196 member B) in EC is still unclear. This article aimed to clarify the role of FAM196B in EC. METHODS: The expression of FAM196B in EC tissues was detected using qRT-PCR. The prognosis of FAM196B in EC patients was determined by log-rank kaplan-Meier survival analysis and Cox regression analysis. Furthermore, shRNA was used to knockdown the expression of FAM196B in EC cell lines. MTT, wound healing assays and western blot were used to determine the role of FAM196B in EC cells. RESULTS: In our research, we found that the expression of FAM196B was up-regulated in EC tissues. The increased expression of FAM196B was significantly correlated with differentiation, lymph node metastasis, stage, and poor survival. The proliferation and migration of EC cells were inhibited after FAM196B-shRNA transfection in vitro and vivo. The western blot result showed that FAM196B could regulate EMT. CONCLUSION: These results suggested that FAM196B severs as an oncogene and promotes cell proliferation and migration in EC. In addition, FAM196B may be a potential therapeutic target for EC patients.

scholarly journals Corrigendum to “Subchronic Infection of Porphyromonas gingivalis and Tannerella forsythia Stimulates an Immune Response but Not Arthritis in Experimental Murine Model”

2018 ◽  
Vol 2018 ◽  
pp. 1-2
Author(s):  
Jorday Hernández-Aguas ◽  
José Luis Montiel-Hernández ◽  
Myriam A. De La Garza-Ramos ◽  
Rosa Velia Ruiz-Ramos ◽  
Erandi Escamilla García ◽  
...  
Keyword(s):  
Immune Response ◽  
Porphyromonas Gingivalis ◽  
Murine Model ◽  
Tannerella Forsythia ◽  
Experimental Murine Model

scholarly journals Porphyromonas gingivalis lipopolysaccharide stimulation in human periodontal ligament stem cells: role of epigenetic modifications to the inflammation

2017 ◽  
Vol 61 (3) ◽  
Author(s):  
Francesca Diomede ◽  
Soundara Rajan Thangavelu ◽  
Ilaria Merciaro ◽  
Monica D'Orazio ◽  
Placido Bramanti ◽  
...  
Keyword(s):  
Stem Cells ◽  
Porphyromonas Gingivalis ◽  
Inflammatory Disease ◽  
Periodontal Ligament ◽  
Model System ◽  
Epigenetic Mechanism ◽  
Periodontal Ligament Stem Cells ◽  
Porphyromonas Gingivalis Lipopolysaccharide

<p>Periodontitis is a chronic oral inflammatory disease produced by bacteria. Gingival retraction and bone and connective tissues resorption are the hallmarks of this disease. Chronic periodontitis may contribute to the risk of onset or progression of neuroinflammatory pathological conditions, such as Alzheimer’s disease. The main goal of the present study was to investigate if the role of epigenetic modulations is involved in periodontitis using human periodontal ligament stem cells (hPDLSCs) as an <em>in vitro</em> model system. hPDLSCs were treated with lipopolysaccharide of <em>Porphyromonas gingivalis</em> and the expression of proteins associated with DNA methylation and histone acetylation, such as DNMT1 and p300, respectively, and inflammatory transcription factor NF-kB, were examined. Immunofluorescence, Western blot and next generation sequencing results demonstrated that <em>P. gingivalis </em>lipopolysaccharide significantly reduced DNA methylase DNMT1, while it markedly upregulated the level of histone acetyltransferase p300 and NF-kB in hPDLSCs. Our results showed that <em>P. gingivalis </em>lipopolysaccharide markedly regulate the genes involved in epigenetic mechanism, which may result in inflammation induction. We propose that <em>P. gingivalis </em>lipopolysaccharide-treated hPDLSCs could be a potential in vitro model system to study epigenetics modulations associated with periodontitis, which might be helpful to identify novel biomarkers linked to this oral inflammatory disease.</p>

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