scholarly journals Intraperitoneal, but not retroperitoneal, visceral adipose tissue is associated with diabetes mellitus: a cross-sectional, retrospective pilot analysis

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Muhei Tanaka ◽  
Hiroshi Okada ◽  
Yoshitaka Hashimoto ◽  
Muneaki Kumagai ◽  
Hiromi Nishimura ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Lumbar Vertebrae ◽  
Area Ratio ◽  
Adverse Outcomes ◽  
Cross Sectional ◽  
Area Index ◽  
Unenhanced Computed Tomography ◽  
Visceral Adipose

Abstract Aim Diabetes mellitus (DM) is associated with adverse outcomes, and visceral adipose tissue (VAT), classified into intraperitoneal VAT (IVAT) and retroperitoneal VAT (RVAT), is associated with insulin resistance. This study aimed to evaluate the association of IVAT and RVAT with the prevalence or incidence of DM. Methods In this cross-sectional, retrospective, cohort study, the prevalence and incidence of DM was analyzed in 803 and 624 middle-aged Japanese participants, respectively. The cross-sectional area of the abdominal adipose tissue was evaluated from an unenhanced computed tomography scan at the third lumbar vertebrae, and the IVAT or RVAT was analyzed using specialized software. The areas were normalized for the square value of the participants’ height in meters and described as the IVAT or RVAT area index. Results The IVAT area index (adjusted odds ratio [OR], 1.04; 95% confidence intervals [CI], 1.02–1.07, per 1.0 cm2/m2) or IVAT/RVAT area ratio (1.89; 1.23–2.85, per 1.0) was independently associated with the prevalence of DM, whereas the RVAT area index was not. During a follow-up (mean) of 3.7 years, 30 participants were diagnosed with DM. The IVAT area index (adjusted hazards ratio [HR], 1.02; 95% CI 1.003–1.04, per 1.0 cm2/m2) or IVAT/RVAT area ratio (2.25; 1.40–3.43, per 1.0) was independently associated with the incidence of DM, whereas the RVAT area index was not. Conclusions IVAT, but not RVAT, is associated with the prevalence or incidence of DM.

scholarly journals Urinary Eicosanoid Metabolites in HIV-Infected Women with Central Obesity Switching to Raltegravir: An Analysis from the Women, Integrase, and Fat Accumulation Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Todd Hulgan ◽  
M. Sean Boger ◽  
Diana H. Liao ◽  
Grace A. McComsey ◽  
Christine A. Wanke ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Hiv Infection ◽  
Visceral Adipose Tissue ◽  
Oxidant Stress ◽  
Integrase Inhibitor ◽  
Metabolic Effects ◽  
Prostaglandin E ◽  
Cross Sectional ◽  
Visceral Adipose ◽  
Adjusted Model

Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E2(PGE-M), prostacyclin (PGI-M), and thromboxane B2(TxB2) in HIV-infected women switching to RAL-containing antiretroviral therapy (ART). Thirty-seven women (RAL = 17; PI/NNRTI = 20) with a median age of 43 years and BMI 32 kg/m2completed week 24. TxB2increased in the RAL versus PI/NNRTI arm (+0.09 versus −0.02;P=0.06). Baseline PGI-M was lower in the RAL arm (P=0.005); no other between-arm cross-sectional differences were observed. In the PI/NNRTI arm, 24-week visceral adipose tissue change correlated with PGI-M (rho=0.45;P=0.04) and TxB2(rho=0.44;P=0.005) changes, with a trend seen for PGE-M (rho=0.41;P=0.07). In an adjusted model, age ≥ 50 years (N=8) was associated with increased PGE-M(P=0.04). In this randomized trial, a switch to RAL did not significantly affect urinary eicosanoids over 24 weeks. In women continuing PI/NNRTI, increased visceral adipose tissue correlated with increased PGI-M and PGE-M. Older age (≥50) was associated with increased PGE-M. Relationships between aging, adiposity, ART, and eicosanoids during HIV-infection require further study.

scholarly journals Visceral Adipose Tissue Depth in Early Pregnancy and Gestational Diabetes Mellitus - a Cohort Study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
João Guilherme Alves ◽  
Alex Sandro Rolland Souza ◽  
José Natal Figueiroa ◽  
Carla Adriane Leal de Araújo ◽  
Angélica Guimarães ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Adipose Tissue ◽  
Cohort Study ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Visceral Adipose Tissue ◽  
Early Pregnancy ◽  
Visceral Adipose

Cross-talk between fetal membranes and visceral adipose tissue involves HMGB1–RAGE and VIP–VPAC2 pathways in human gestational diabetes mellitus

2019 ◽  
Vol 56 (6) ◽  
pp. 681-689 ◽  
Author(s):  
Carmela Santangelo ◽  
Tiziana Filardi ◽  
Giuseppina Perrone ◽  
Marianna Mariani ◽  
Emanuela Mari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Adipose Tissue ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Visceral Adipose Tissue ◽  
Cross Talk ◽  
Fetal Membranes ◽  
Visceral Adipose

scholarly journals The Value of Anthropometric Measures in Nutrition and Metabolism: Comment on Anthropometrically Predicted Visceral Adipose Tissue and Blood-Based Biomarkers: A Cross-Sectional Analysis

2019 ◽  
Vol 12 ◽  
pp. 117863881983171 ◽  
Author(s):  
Justin C Brown ◽  
Michael O Harhay ◽  
Meera N Harhay
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Abdominal Cavity ◽  
Health Conditions ◽  
Imaging Modalities ◽  
Resonance Imaging ◽  
Anthropometric Measures ◽  
Cross Sectional ◽  
Sectional Analysis ◽  
Visceral Adipose

Visceral adipose tissue (VAT)—fat stored deep in the abdominal cavity that surrounds vital organs—is associated with a variety of chronic health conditions. Computed tomography and magnetic resonance imaging are the gold standards to quantify VAT. However, the high cost, limited accessibility, and potential exposure to radiation limit the use of these imaging modalities. In this commentary, we review the application of a previously validated regression equation that estimates anthropometrically predicted VAT (apVAT) to explain variance in blood-based biomarkers and predict mortality in a large sample of adults. In our first study (Brown et al. 2018 Eur J Nutr; doi:10.1007/s00394-016-1308-8), apVAT accounted for more variance in biomarkers of glucose homeostasis, inflammation, and lipid metabolism, than body mass index (BMI), waist circumference (WC), or the combination of BMI + WC. In our second study (Brown et al. 2017 Am J Hum Biol; doi:10.1002/ajhb.22898), compared with BMI, WC, and BMI + WC, apVAT more accurately predicted mortality from all causes, cardiovascular disease, and cancer. These studies demonstrate that apVAT can be used in clinical practice and in clinical nutrition and metabolism research when imaging modalities to quantify VAT may not be feasible.

scholarly journals Daily Consumption of Coffee and Eating Bread at Breakfast Time Is Associated with Lower Visceral Adipose Tissue and with Lower Prevalence of Both Visceral Obesity and Metabolic Syndrome in Japanese Populations: A Cross-Sectional Study

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3090
Author(s):  
Teruhide Koyama ◽  
Mizuho Maekawa ◽  
Etsuko Ozaki ◽  
Nagato Kuriyama ◽  
Ritei Uehara
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Green Tea ◽  
Visceral Adipose Tissue ◽  
Coffee Consumption ◽  
Visceral Obesity ◽  
Tea Consumption ◽  
Daily Consumption ◽  
Cross Sectional ◽  
Visceral Adipose

Background: The study aimed to investigate the association between daily consumption of coffee or green tea, with and without habitual bread consumption for breakfast, and components and prevalence of metabolic syndrome in Japanese populations. Methods: The study population consisted of 3539 participants (1239 males and 2300 females). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression analyses to evaluate the associations of daily coffee and green tea consumption with the prevalence of obesity, visceral obesity, and metabolic syndrome. Results: Coffee consumption was associated with significantly lower proportions of visceral obesity (OR: 0.746, CI: 0.588–0.947) and metabolic syndrome (OR: 0.706, CI: 0.565–0.882). On the other hand, green tea was not associated with visceral obesity (OR: 1.105, CI: 0.885–1.380) or metabolic syndrome (OR: 0.980, CI: 0.796–1.206). The combination of daily drinking coffee and eating bread at breakfast time was associated with significantly lower proportions of obesity (OR: 0.613, CI: 0.500–0.751) (p = 0.911 for interaction), visceral obesity (OR: 0.549, CI: 0.425–0.710) (p = 0.991 for interaction), and metabolic syndrome (OR: 0.586, CI: 0.464–0.741) (p = 0.792 for interaction). Conclusion: Coffee consumption was significantly associated with lower visceral adipose tissue and lower proportions of visceral obesity, but the same was not true for green tea consumption. Furthermore, in combination with coffee consumption, the addition of eating bread at breakfast time significantly lowered proportions of visceral obesity and metabolic syndrome, although there was no interaction between coffee and bread.

Subclinical Inflammation and Lymphocytes in Subcutaneous and Visceral Adipose Tissue—The Influence of Pregnancy and Gestational Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1413-P
Author(s):  
ANNA CINKAJZLOVA ◽  
KATEřINA ANDERLOVÁ ◽  
PATRIK SIMJAK ◽  
ZDENA LACINOVÁ ◽  
JANA KLOUCKOVA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Adipose Tissue ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Visceral Adipose Tissue ◽  
Subclinical Inflammation ◽  
Visceral Adipose
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