scholarly journals Successful treatment of acquired reactive perforating collagenosis with itraconazole

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Binrong Ye ◽  
Yi Cao ◽  
Yeqiang Liu
Keyword(s):  
Skin Biopsy ◽  
Fungal Infection ◽  
Successful Treatment ◽  
Rare Form ◽  
Case Presentation ◽  
Therapeutic Benefits ◽  
Immunological Tests ◽  
Anti Inflammatory ◽  
Reactive Perforating Collagenosis

Abstract Background Acquired reactive perforating collagenosis (ARPC) is a rare form of transepithelial elimination in which altered collagen is extruded through the epidermis. Case presentation A 23-year-old male presented with cup-like ulcerated lesions on his limbs since 3 months. A series of serological and immunological tests showed no abnormalities. A diagnosis of ARPC was based on skin biopsy findings. The patient was cured using treatment with itraconazole for 8 weeks, in the absence of a fungal infection. Conclusions The anti-inflammatory and anti-angiogenic effects of itraconazole can have good therapeutic benefits for ARPC.

The use of glimepiride for the treatment of neonatal diabetes mellitus caused by a novel mutation of the ABCC8 gene

2020 ◽  
Vol 33 (12) ◽  
pp. 1605-1608
Author(s):  
Xiao Qin ◽  
Jingzi Zhong ◽  
Dan Lan
Keyword(s):  
Diabetes Mellitus ◽  
Novel Mutation ◽  
Male Infant ◽  
Neonatal Diabetes ◽  
Monogenic Diabetes ◽  
Neonatal Diabetes Mellitus ◽  
Rare Form ◽  
Case Presentation ◽  
Abcc8 Gene

AbstractObjectivesNeonatal diabetes mellitus (NDM) is a rare form of monogenic diabetes that is usually diagnosed in the first six months of life.Case presentationWe report on a male infant with neonatal diabetes who presented with diabetic ketoacidosis at two months and 16 days. A novel homozygous missense mutation (c.259T>G) was identified in the ABCC8 gene. In this case, insulin was replaced with glimepiride at a dosage of 0.49 mg/kg/day at five months, and this achieved metabolic control and satisfactory growth as observed at follow-up.ConclusionsThis report improves our understanding of the mutational spectrum of ABCC8, which is normally associated with NDM, and shows that the treatment regimen for this condition can be successfully switched from insulin therapy to the use of sulfonylurea.

scholarly journals Successful treatment of gastrointestinal mucormycosis in an adult with acute leukemia: case report and literature review

2017 ◽  
Vol 24 (1) ◽  
pp. 61 ◽  
Author(s):  
A. Alghamdi ◽  
A. Lutynski ◽  
M. Minden ◽  
C. Rotstein
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Acute Leukemia ◽  
Fungal Infection ◽  
Antifungal Therapy ◽  
Successful Treatment ◽  
Invasive Fungal Infection ◽  
Hematologic Malignancies ◽  
Considerable Morbidity ◽  
Delays In Diagnosis

Mucormycosis has emerged as an important cause of invasive fungal infection in patients with hematologic malignancies. Gastrointestinal mucormycosis is an unusual presentation of this invasive fungal infection, and it causes considerable morbidity and mortality. Such outcomes are due in part to a nonspecific presentation that results in delays in diagnosis and treatment. Successful treatment of gastrointestinal mucormycosis involves surgical debridement and appropriate antifungal therapy.

scholarly journals An Over View of Ovine and Caprine Dermatophytosis

2019 ◽  
pp. 1-10
Author(s):  
Wisal G. Abdalla
Keyword(s):  
Skin Biopsy ◽  
Fungal Infection ◽  
Predisposing Factors ◽  
Diagnostic Methods ◽  
Molecular Diagnostic ◽  
Fungal Culture ◽  
Direct Examination

Dermatophytosis is a superficial fungal infection of hair and keratinized layers of the epidermis and is caused by keratinophilic and keratinolytic genera such as Microsporum, Trichophyton and Epidermophyton. The animal age and trauma are important predisposing factors of disease. Show lambs are more susceptible to ringworm. T. verrucosum has been cited as a major agent encountered in cases of ovine and caprine ringworm. Lesions in lambs are most often noticed on the head while in goats lesions can occur beside head in pinnae, neck, and legs. The disease can be diagnosed by direct examination, fungal culture, skin biopsy and molecular diagnostic methods. This review will forecast more light on the different aspects of this disease.

scholarly journals A young adult with COVID-19 and multisystem inflammatory syndrome in children (MIS-C)-like illness: a case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Aaron D. Kofman ◽  
Emma K. Sizemore ◽  
Joshua F. Detelich ◽  
Benjamin Albrecht ◽  
Anne L. Piantadosi
Keyword(s):  
Cardiac Dysfunction ◽  
Clinical Characteristics ◽  
Kidney Injury ◽  
Clinical Findings ◽  
Low Grade ◽  
Rare Form ◽  
Case Presentation ◽  
Lymph Node Swelling ◽  
Inflammatory Syndrome

Abstract Background A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age. Case presentation The patient presented with 1 week of weakness, dyspnea, and low-grade fevers, followed by mild cough, sore throat, vomiting, diarrhea, and lymph node swelling. She was otherwise healthy, with no prior medical history. Her hospital course was notable for profound acute kidney injury, leukocytosis, hypotension, and cardiac dysfunction requiring ICU admission and vasopressor support. MIS-C-like illness secondary to COVID-19 was suspected due to physical exam findings of conjunctivitis, mucositis, and shock. She improved following IVIG, aspirin, and supportive care, and was discharged on hospital day 5. Conclusion MIS-C-like illness should be considered in adults presenting with atypical clinical findings and concern for COVID-19. Further research is needed to support the role of IVIG and aspirin in this patient population.

scholarly journals A man with recurrent fever, arthritis, and rashes-brucellosis? A case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wen Wang ◽  
Xu Lu ◽  
Chengbo Li ◽  
Myong Jun Ri ◽  
Wei Cui
Keyword(s):  
Infectious Disease ◽  
Bone Marrow ◽  
Case Report ◽  
Myelodysplastic Syndrome ◽  
Skin Biopsy ◽  
Rare Case ◽  
Glucocorticoid Therapy ◽  
Recurrent Fever ◽  
Neutrophilic Dermatosis ◽  
Case Presentation

Abstract Background We report a rare case of chronic brucellosis accompanied with myelodysplastic syndrome and neutrophilic dermatosis, which to the best of our knowledge, has never been reported. Case presentation A young man was admitted to our hospital complaining of recurrent fever, arthritis, rashes and anemia. He had been diagnosed with brucellosis 6 years prior and treated with multiple courses of antibiotics. He was diagnosed with myelodysplastic syndrome and neutrophilic dermatosis following bone marrow puncture and skin biopsy. After anti-brucellosis treatment and glucocorticoid therapy, the symptoms improved. Conclusions Clinicians should consider noninfectious diseases when a patient who has been diagnosed with an infectious disease exhibits changing symptoms.

scholarly journals Dried Ginger (Zingiber officinalis) Inhibits Inflammation in a Lipopolysaccharide-Induced Mouse Model

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
You Yeon Choi ◽  
Mi Hye Kim ◽  
Jongki Hong ◽  
Sung-Hoon Kim ◽  
Woong Mo Yang
Keyword(s):  
Water Extract ◽  
Clinical Settings ◽  
Protein Factor ◽  
Therapeutic Benefits ◽  
History Of ◽  
Human Use ◽  
Anti Inflammatory ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide ◽  
Inflammatory Effect

Objectives. Ginger rhizomes have a long history of human use, especially with regards to their anti-inflammatory properties. However, the mechanisms by which ginger acts on lipopolysaccharide-(LPS-)induced inflammation have not yet been identified. We investigated the anti-inflammatory effects of driedZingiber officinalis(DZO) on LPS-induced hepatic injury.Methods. ICR mice were given a DZO water extract (100, 1000 mg/kg) orally for three consecutive days. On the third day, they were administered by LPS intraperitoneally. To investigate the anti-inflammatory effects of DZO, histological, cytokine expression, and protein factor analyses were performed.Results. Oral administration of DZO significantly reduced pathological changes in the liver and proinflammatory cytokines including interferon-(IFN-)γand interleukin-(IL-)6 in the serum. In addition, DZO inhibited LPS-induced NF-κB activation by preventing degradation of the IκB-α, as well as the phosphorylation of ERK1/2, SAPK/JNK, and p38 MAPKs. These were associated with a decrease in the expression of inducible nitric oxide synthase (iNOS) and cyclooxyenase-2 (COX-2).Conclusions. Our data provide evidence for the hepatoprotective mechanisms of DZO as an anti-inflammatory effect. Furthermore, use of DZO to treat could provide therapeutic benefits in clinical settings.

Successful treatment of fingolimod-associated macular edema with intravitreal triamcinolone with continued fingolimod use

2014 ◽  
Vol 21 (2) ◽  
pp. 249-251 ◽  
Author(s):  
Sophie Thoo ◽  
Sudha Cugati ◽  
Andrew Lee ◽  
Celia Chen
Keyword(s):  
Adverse Effect ◽  
Macular Edema ◽  
Intravitreal Injection ◽  
Successful Treatment ◽  
Treatment Modalities ◽  
Intravitreal Triamcinolone ◽  
Anti Inflammatory

The occurrence of macular edema as an adverse effect of fingolimod is well documented. Treatment modalities used to manage fingolimod-associated macular edema (FAME) have included nonsteroidal anti-inflammatory agents and sub-tenon injection. We describe two cases where intravitreal injection is used to successfully treat FAME in patients who were previously unsuccessfully treated with topical nonsteroidal anti-inflammatories.

scholarly journals An Update of Pitted Keratolysis: A Review

2018 ◽  
Vol 4 (1) ◽  
pp. 27-30
Author(s):  
Tania Hoque ◽  
Bhuiya Mohammad Mahatab Uddin
Keyword(s):  
Skin Biopsy ◽  
Bacterial Infection ◽  
Fungal Infection ◽  
Medical Research ◽  
Oral Medication ◽  
Skin Scraping ◽  
Histopathological Feature ◽  
Present Information ◽  
Hygienic Measures ◽  
Soles Of The Feet

Pitted keratolysis is a bacterial infection of the soles of the feet or less commonly, the palms of the hands. Pitted keratolysis is easily identified by its shallow, crater-like pits. Collection of specimen using swab may be helpful to identify causative bacteria and skin scraping is often taken to exclude fungal infection. The diagnosis is sometimes made by skin biopsy revealing characteristic histopathological feature of Pitted Keratolysis. Treatment generally consists of hygienic measures, sometimes supplemented by medication and perhaps on oral medication. This review is aimed to consolidate present information about aetiopathogenesis, diagnosis and management of Pitted Keratolysis. It is worth mentioning that Pitted Keratolysis is non-contagious.Journal of Current and Advance Medical Research 2017;4(1):27-30

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