scholarly journals Effectiveness of potential antiviral treatments in COVID-19 transmission control: a modelling study

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Sheng-Nan Lin ◽  
Jia Rui ◽  
Qiu-Ping Chen ◽  
Bin Zhao ◽  
Shan-Shan Yu ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Antiviral Treatment ◽  
Age Groups ◽  
Reduction Rate ◽  
Real Life ◽  
Older Age ◽  
Cumulative Number ◽  
Age Group ◽  
Fatality Rate ◽  
Transmission Control

Abstract Background Novel coronavirus disease 2019 (COVID-19) causes an immense disease burden. Although public health countermeasures effectively controlled the epidemic in China, non-pharmaceutical interventions can neither be maintained indefinitely nor conveniently implemented globally. Vaccination is mainly used to prevent COVID-19, and most current antiviral treatment evaluations focus on clinical efficacy. Therefore, we conducted population-based simulations to assess antiviral treatment effectiveness among different age groups based on its clinical efficacy. Methods We collected COVID-19 data of Wuhan City from published literature and established a database (from 2 December 2019 to 16 March 2020). We developed an age-specific model to evaluate the effectiveness of antiviral treatment in patients with COVID-19. Efficacy was divided into three types: (1) viral activity reduction, reflected as transmission rate decrease [reduction was set as v (0–0.8) to simulate hypothetical antiviral treatments]; (2) reduction in the duration time from symptom onset to patient recovery/removal, reflected as a 1/γ decrease (reduction was set as 1–3 days to simulate hypothetical or real-life antiviral treatments, and the time of asymptomatic was reduced by the same proportion); (3) fatality rate reduction in severely ill patients (fc) [reduction (z) was set as 0.3 to simulate real-life antiviral treatments]. The population was divided into four age groups (groups 1, 2, 3 and 4), which included those aged ≤ 14; 15–44; 45–64; and ≥ 65 years, respectively. Evaluation indices were based on outbreak duration, cumulative number of cases, total attack rate (TAR), peak date, number of peak cases, and case fatality rate (f). Results Comparing the simulation results of combination and single medication therapy s, all four age groups showed better results with combination medication. When 1/γ = 2 and v = 0.4, age group 2 had the highest TAR reduction rate (98.48%, 56.01–0.85%). When 1/γ = 2, z = 0.3, and v = 0.1, age group 1 had the highest reduction rate of f (83.08%, 0.71–0.12%). Conclusions Antiviral treatments are more effective in COVID-19 transmission control than in mortality reduction. Overall, antiviral treatments were more effective in younger age groups, while older age groups showed higher COVID-19 prevalence and mortality. Therefore, physicians should pay more attention to prevention of viral spread and patients deaths when providing antiviral treatments to patients of older age groups.

scholarly journals Estimating effective infection fatality rates during the course of the COVID-19 pandemic in Germany

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Christian Staerk ◽  
Tobias Wistuba ◽  
Andreas Mayr
Keyword(s):  
Age Distribution ◽  
Age Groups ◽  
Case Fatality ◽  
Time Dependent ◽  
Temporary Increase ◽  
International Studies ◽  
Age Group ◽  
Fatality Rate ◽  
Substantial Fraction ◽  
Second Wave

Abstract Background The infection fatality rate (IFR) of the Coronavirus Disease 2019 (COVID-19) is one of the most discussed figures in the context of this pandemic. In contrast to the case fatality rate (CFR), the IFR depends on the total number of infected individuals – not just on the number of confirmed cases. In order to estimate the IFR, several seroprevalence studies have been or are currently conducted. Methods Using German COVID-19 surveillance data and age-group specific IFR estimates from multiple international studies, this work investigates time-dependent variations in effective IFR over the course of the pandemic. Three different methods for estimating (effective) IFRs are presented: (a) population-averaged IFRs based on the assumption that the infection risk is independent of age and time, (b) effective IFRs based on the assumption that the age distribution of confirmed cases approximately reflects the age distribution of infected individuals, and (c) effective IFRs accounting for age- and time-dependent dark figures of infections. Results Effective IFRs in Germany are estimated to vary over time, as the age distributions of confirmed cases and estimated infections are changing during the course of the pandemic. In particular during the first and second waves of infections in spring and autumn/winter 2020, there has been a pronounced shift in the age distribution of confirmed cases towards older age groups, resulting in larger effective IFR estimates. The temporary increase in effective IFR during the first wave is estimated to be smaller but still remains when adjusting for age- and time-dependent dark figures. A comparison of effective IFRs with observed CFRs indicates that a substantial fraction of the time-dependent variability in observed mortality can be explained by changes in the age distribution of infections. Furthermore, a vanishing gap between effective IFRs and observed CFRs is apparent after the first infection wave, while an increasing gap can be observed during the second wave. Conclusions The development of estimated effective IFR and observed CFR reflects the changing age distribution of infections over the course of the COVID-19 pandemic in Germany. Further research is warranted to obtain timely age-stratified IFR estimates, particularly in light of new variants of the virus.

scholarly journals TSH enhancement of FT4 to FT3 conversion is age dependent

2016 ◽  
Vol 175 (1) ◽  
pp. 49-54 ◽  
Author(s):  
David Strich ◽  
Gilad Karavani ◽  
Shalom Edri ◽  
David Gillis
Keyword(s):  
Age Groups ◽  
Thyroid Stimulating Hormone ◽  
Older Age ◽  
Age Group ◽  
Free T4 ◽  
Free T3 ◽  
Age Related ◽  
Differential Increase ◽  
Retrospective Examination ◽  
Tsh Levels

ObjectiveWe previously reported increasing free T3 (FT3) to free T4 (FT4) ratios as thyroid-stimulating hormone (TSH) increases within the normal range in children. It is not known if this phenomenon is age-related among humans, as previously reported in rats. This study examines the relationships between TSH and FT3/FT4 ratios in different ages.DesignRetrospective examination of thyroid tests from patients without thyroid disease from community clinics.MethodsFree T3, free T4, and TSH levels from 527 564 sera collected from patients aged 1 year or greater were studied. Exclusion criteria were the following: missing data, TSH greater than 7.5mIU/L, and medications that may interfere with thyroid hormone activity. A total of 27 940 samples remaining after exclusion were stratified by age. Samples with available anthropometric data were additionally stratified for body mass index (BMI). Correlations of TSH to FT4, FT3, and FT3/FT4 ratios by age group were examined.ResultsUp to age 40, for each increasing TSH quartile, FT3 and the FT3/FT4 ratio increased and FT4 decreased significantly (for both FT3, FT4 and FT3/FT4 ratio,P<0.05 for every TSH quartile when compared with the 1st quartile, except FT3 in the 30–40 age group). In older age groups, increasing TSH was not associated with increased FT3/FT4 ratio.ConclusionAs TSH levels increase, FT3/FT4 ratios increase until age 40, but this differential increase does not occur in older age groups. This may reflect a decrease in thyroxine (T4) to triiodothyronine (T3) conversion with age, which may be part of the aging process.

scholarly journals SAT-168 Adrenal Incidentalomas: Impact of Patient Age on Referral Rates for Endocrine Evaluation

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Anthony Fryer ◽  
Sarah Hancock ◽  
Cherian George ◽  
Basil George Issa ◽  
Simon Lea ◽  
...  
Keyword(s):  
Age Groups ◽  
Adrenal Incidentaloma ◽  
Older Age ◽  
Age Group ◽  
Adrenal Incidentalomas ◽  
Patient Age ◽  
Radiology Reports ◽  
Patient Âgé ◽  
Mri Scans ◽  
Ct And Mri

Abstract It is estimated that the prevalence of adrenal incidentaloma increases with age: ~3% of those aged 50 years, rising to 10% in those &gt;70 years (1). Given the aging population together with increased utilisation of cross-sectional imaging in the UK (eg CT urogram, MR angiogram), we explored the proportion of patients with adrenal incidentaloma by age based on current imaging trends. Furthermore, there is no information currently available on the relationship between age and pattern of endocrine referrals. We extracted data for all CT and MRI scans from Jan 2018-Oct 2019 and used key phrases in radiology reports (eg adrenal adenoma/lesion/mass/nodule/incidentaloma, incidental adrenal, indeterminate adrenal) to identify potential lesions. We also extracted data on patient age and referral patterns as identified by a logged referral or an attendance (new or follow-up) to endocrine clinic 3 months post index scan, stratified by 10 year age groups. Where possible, we excluded false hits (eg no adrenal lesion). Preliminary data showed that, of the 2604 potential lesions identified by CT and MRI scans, 78.7% were on patients aged over 60 years. The numbers of identified lesions gradually increased with age to a peak in the 71-80 year age group after which these declined. Whilst patients younger that 60 years had fewer potential lesions identified, they were more likely to be referred to endocrine services (73 out of 55 patients; 13.2%) than those in the older age group (168 out of 2049; 8.2%; p&lt;0.001). Indeed there was a statistically significant trend towards decreasing referral with age group (Chi-squared test for trend; p&lt;0.001). In conclusion, patients over 60 years have a higher number of potential adrenal incidentalomas. However, this group is less likely to be referred for endocrine evaluation. This is particularly concerning given the large number of scans requested and the higher prevalence of incidentalomas in this age group. This study represents preparatory work on innovations to enhance case detection, particularly in the older age groups (2). 1. Fassnacht M, Arlt W, Bancos I, et al. Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline. Eur J Endocrinol. 2016;175:G1-G34 2. Hanna FWF, Issa BG, Lea SC, George C, Golash A, Firn M, Ogunmekan S, Maddock E, Sim J, Xydopoulos G, Fordham R, Fryer AA. Adrenal lesions found incidentally: how to improve clinical and cost-effectiveness. BMJ Open Quality. 2019;In press.

Age groups changes in self-rated health: A prospective longitudinal study over a 20-year period using Health Survey of North Trøndelag data

2020 ◽  
pp. 140349482090462
Author(s):  
Frode Lysberg ◽  
Siw Tone Innstrand ◽  
Milada Cvancarova Småstuen ◽  
Cathrine Lysberg ◽  
Magnhild Mjåvatn Høie ◽  
...  
Keyword(s):  
Sex Differences ◽  
Health Survey ◽  
Age Groups ◽  
Older Age ◽  
Age Group ◽  
Middle Aged ◽  
Prospective Longitudinal Study ◽  
Future Studies ◽  
Self Rated Health ◽  
Prospective Longitudinal

Background: The aim of the study was to investigate changes in self-rated health (SRH) between different age groups and sexes over a 20-year period. Methods: Data were retrieved from the large longitudinal Health Survey of North Trøndelag, Norway, which includes data collected from more than 190,000 participants aged 20–70+ years between the years 1984 and 2008. Data were analysed using logistic regression and adjusted for sex. Results: From 1984 to 2008, the odds of scoring higher on SRH decreased by 46% in the youngest age group (20–29 years) and increased by approximately 35% in the middle-aged and older age groups (40–70+ years). When considering sex differences, women in most age groups scored lower than the men on their SRH. Conclusions: Our finding suggest a trending shift in SRH, with a reduction in the youngest age group (20–29 years) and an increase in the middle-aged and older age groups (40–70+ years). Despite the sex differences being small, our data indicate that in most age groups, women tend to score lower than men on their SRH. Future studies should focus on these trends to understand better the mechanisms underlying these changes in SRH and to follow future trends to see if the trend is reinforced or diminished.

scholarly journals Comparison of anthropometric data quality in children aged 6-23 and 24-59 months: lessons from population-representative surveys from humanitarian settings

BMC Nutrition ◽  
2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Oleg Bilukha ◽  
Alexia Couture ◽  
Kelly McCain ◽  
Eva Leidman
Keyword(s):  
Data Quality ◽  
Age Groups ◽  
Older Age ◽  
Demographic And Health Surveys ◽  
Age Group ◽  
Anthropometric Data ◽  
Digit Preference ◽  
Anthropometric Indicators ◽  
Younger Age

Abstract Background Ensuring the quality of anthropometry data is paramount for getting accurate estimates of malnutrition prevalence among children aged 6–59 months in humanitarian and refugee settings. Previous reports based on data from Demographic and Health Surveys suggested systematic differences in anthropometric data quality between the younger and older groups of preschool children. Methods We analyzed 712 anthropometric population-representative field surveys from humanitarian and refugee settings conducted during 2011–2018. We examined and compared the quality of five anthropometric indicators in children aged 6–23 months and children aged 24–59 months: weight for height, weight for age, height for age, body mass index for age and mid-upper arm circumference (MUAC) for age. Using the z-score distribution of each indicator, we calculated the following parameters: standard deviation (SD), percentage of outliers, and measures of distribution normality. We also examined and compared the quality of height, weight, MUAC and age measurements using missing data and rounding criteria. Results Both SD and percentage of flags were significantly smaller on average in older than in younger age group for all five anthropometric indicators. Differences in SD between age groups did not change meaningfully depending on overall survey quality or on the quality of age ascertainment. Over 50% of surveys overall did not deviate significantly from normality. The percentage of non-normal surveys was higher in older than in the younger age groups. Digit preference score for weight, height and MUAC was slightly higher in younger age group, and for age slightly higher in the older age group. Children with reported exact date of birth (DOB) had much lower digit preference for age than those without exact DOB. SD, percentage flags and digit preference scores were positively correlated between the two age groups at the survey level, such as those surveys showing higher anthropometry data quality in younger age group also tended to show higher quality in older age group. Conclusions There should be an emphasis on increased rigor of training survey measurers in taking anthropometric measurements in the youngest children. Standardization test, a mandatory component of the pre-survey measurer training and evaluation, of 10 children should include at least 4–5 children below 2 years of age.

scholarly journals A comparative study of the clinical characteristics and outcomes of HR-positive HER2-negative breast cancer patients over and under 65 years old

2021 ◽  
Vol 17 (1) ◽  
pp. 1-7
Author(s):  
Chang Shin Jung ◽  
Youn Joo Jung ◽  
Dong Il Kim ◽  
Seungju Lee ◽  
Seok Kyung Kang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Clinical Characteristics ◽  
Age Groups ◽  
Older Age ◽  
Age Group ◽  
Breast Cancer Patients ◽  
Her2 Breast Cancer ◽  
Surgical Methods ◽  
Two Age Groups

Purpose: The purpose of this study was to compare the clinical characteristics and outcomes of hormone receptor-positive (HR+) human epidermal growth factor 2-negative (HER2–) breast cancer among elderly patients (over 65 years old) and younger patients.Methods: This was a retrospective cohort study of 328 patients who were treated for breast cancer at Pusan National University Yangsan Hospital between January 2009 and December 2014. Tumor characteristics, surgical methods, and survival outcomes were compared between the two age groups (<65 and ≥65 years old). Kaplan-Meier curves for disease-free survival (DFS) and overall survival (OS) were also constructed according to the age groups.Results: Among the 328 patients with HR+ HER2– breast cancer, 184 (56.1%) were <65 years old and 144 (43.9%) were ≥65 years old. Breast cancer stages were similar between the two age groups, but the older patients were treated less often with chemotherapy (81% vs. 66%, P=0.002). During the follow-up period, 17 deaths and 36 cases of recurrence or metastasis were reported. There was no difference in DFS between the two groups (P=0.840); however, the OS of the older age group was significantly lower than that of the younger age group (P=0.015).Conclusion: This study suggested that HR+ HER2– breast cancer patients belonging to the two age groups had no significant difference in DFS. However, older age is an independent factor affecting OS rate. Therefore, even if patients are old, but their physical condition is satisfactory, standard and active treatment may be necessary, similar to that given to younger patients.

scholarly journals Assessment of the Relationship between the Maxillary Sinus and the Canine Root tip using Cone Beam Computed Tomography

2021 ◽  
Author(s):  
Leila Khojastepour ◽  
Najmeh Movahhedian ◽  
Mohadeseh Zolghadrpour
Keyword(s):  
Maxillary Sinus ◽  
Age Groups ◽  
Older Age ◽  
Anterior Region ◽  
Cone Beam ◽  
Type I ◽  
Age Group ◽  
Vertical Distance ◽  
Significant Difference ◽  
Maxillary Sinuses

Abstract Background: The purpose of the present study is to investigate the frequency and amount of extension of the maxillary sinus to the anterior region and to evaluate the vertical distance between the maxillary sinus floor and canine apices.Methods: Cone beam computed tomographic images of 300 individuals (154 males and 146 females) over 20 years (with mean age of 35.12 ± 8.40 years) were evaluated. The subjects were categorized into three age groups (20-30, 30-40 and 40-50 years). When maxillary sinus extended to the canine area, the vertical distance between them were recorded and their relationship were classified into three types: I (> 2 mm distance), II (2 mm < distance or in-contact) and III (interlock). Results: 413 out of 600 maxillary sinuses (68.8%) were extended into the canine area or beyond. Among them, 15 maxillary sinuses pneumatized into the incisor area (2.5%). The prevalence of the maxillary sinuses extended to the anterior region of the jaw was not significantly different between genders, but it was significantly less frequent in older age group and more frequent in the left side. The mean amount of anterior extension of maxillary sinus (mm) was significantly lower in older age group. Type I was the most frequent vertical relationship between the maxillary sinuses and canine apices with no significant difference in gender, side and age groups.Conclusions: Most of the maxillary sinuses extended to the canine area. Maxillary sinus extended into incisor area with the frequency of 2.5% . The amount of extension of the maxillary sinus to the anterior region and its vertical distance with canine apices decreased in older age group.

scholarly journals Covid-19 Incidence and Mortality by Age Strata and Comorbidities in Mexico City: A Focus in the Pediatric Population

2021 ◽  
Vol 9 ◽  
Author(s):  
Nadia González-García ◽  
María F. Castilla-Peón ◽  
Fortino Solórzano Santos ◽  
Rodolfo Norberto Jiménez-Juárez ◽  
Maria Elena Martínez Bustamante ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Age Groups ◽  
Population Data ◽  
Older Age ◽  
Age Group ◽  
Education Policies ◽  
Infected People ◽  
Risk Of Death ◽  
Incidence And Mortality ◽  
Pediatric Populations

Background: SARS-COV2 appears less frequently and less severely in the pediatric population than in the older age groups. There is a need to precisely estimate the specific risks for each age group to design health and education policies suitable for each population.Objective: This study aimed to describe the risk of death in SARS-COV2 infected subjects by age group and according to the presence of comorbidities.Methods: We analyzed data of confirmed SARS-COV2 infection cases where symptoms began between February 22th, 2020, and April 18th, 2021, as published by the General Epidemiology Direction (DGE) of the Mexican Ministry of Health. We calculated COVID-19 incidence and mortality by age group using population data from the Statistics and Population National Institute (INEGI), and estimated the association between risk of death and the presence of comorbidities.Results: Mortality in SARS-COV2 infected people varied considerably, between 7 and 155 deaths per million per year in the under-20 age groups compared to 441 to 15,929 in the older age groups. Mortality in pediatric populations is strongly associated with comorbidities (OR: 4.6-47.9) compared to the milder association for older age groups (OR: 3.16–1.23).Conclusion: The risk of death from SARS-COV2 infection in children is low and is strongly associated with comorbidities.

scholarly journals Covid-19 Incidence And Mortality By Age Strata And Comorbidities In Mexico City: A Focus In The Pediatric Population

2021 ◽  
Author(s):  
MARIA FERNANDA CASTILLA PEON ◽  
Nadia Gonzalez-Garcia ◽  
Fortino Solorzano-Santos ◽  
Rodolfo Jimenez Juarez ◽  
Maria Elena Martinez Bustamante ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Age Groups ◽  
Population Data ◽  
Older Age ◽  
Age Group ◽  
Infected People ◽  
Risk Of Death ◽  
Incidence And Mortality ◽  
The Face ◽  
Pediatric Populations

Introduction: SARS-COV2 appears less frequently and less severely in the pediatric population than in older age groups. In the face of the urgent need to reactivate activities suspended during the lockdown, mainly those essential for child development, this study aims to describe the risks of death of persons infected with SARS-COV2 by age group and according to the presence of comorbidities. Methodology: We analyzed data of confirmed SARS-COV2 infection cases where symptoms began between February 22th, 2020, and March 31, 2021, as published by the General Epidemiology Direction (DGE) of the Mexican Ministry of Health. We calculated COVID-19 incidence and mortality by age group with population data from the Statistics and Population National Institute (INEGI), estimating the correlation between risk of death and the presence of comorbidities. Results: Mortality in SARS-COV2 infected people varied considerably, between 7 to 155 deaths per million per year in the under-20 age groups compared to 441 to 15929 in the older age groups. Mortality in pediatric populations is strongly associated with comorbidities (OR: 4.6- 47.9) compared to the milder association for older age groups (OR: 3.16-1.23). Conclusions: The risk of death from SARS-COV2 infection in children is low and strongly associated with comorbidities.

scholarly journals The state of psychophysiological functions in handball players with different experience of sports training

2020 ◽  
Vol 81 (2) ◽  
pp. 42-45
Author(s):  
S. Fedorchuk ◽  
Ye. Petrushevskyi
Keyword(s):  
Nervous System ◽  
Age Groups ◽  
The State ◽  
Functional Mobility ◽  
Older Age ◽  
Moving Object ◽  
Age Group ◽  
Sports Training ◽  
Psychophysiological Functions ◽  
The Individual

The aim of the study was to compare the state of psychophysiological functions of highly qualified handball players with different experience of sports training (special training). To determine the state of psychophysiological functions of athletes diagnostic complex "Diagnostics-1" was used (MV Makarenko, VS Lyzogub). In accordance with the purpose of the work, we studied the properties of the nervous system (functional mobility and strength of nervous processes), the efficiency of sensorimotor activity and the dynamics of nervous processes in feedback, the latency of complex response reactions of choice, the accuracy of response to a moving object. Higher psychophysiological status in terms of the strength of nervous processes (both in the feedback mode and during long-term sensorimotor loads in the mode of imposed rhythm) was demonstrated by athletes of the older age group with more experience of sports training. Athletes of older and younger age groups did not differ in the level of functional mobility of nervous processes and accuracy of reaction to a moving object. Therefore, we can assume that athletes with less experience of sports training in the state of these psychophysiological functions have reached the level of athletes of the older age group, ie the level of maximum realization of individual capabilities. The identified differences in the individual-typological properties of the higher parts of the central nervous system in female handball players with different sports experience can have prognostic value and be used to optimize sports improvement in this sport.

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