scholarly journals Challenges in the control of COVID-19 outbreaks caused by the delta variant during periods of low humidity: an observational study in Sydney, Australia

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Michael P. Ward ◽  
Yuanhua Liu ◽  
Shuang Xiao ◽  
Zhijie Zhang

Abstract Background Since the appearance of severe acute respiratory coronavirus 2 (SARS-CoV-2) and the coronavirus disease 2019 (COVID-19) pandemic, a growing body of evidence has suggested that weather factors, particularly temperature and humidity, influence transmission. This relationship might differ for the recently emerged B.1.617.2 (delta) variant of SARS-CoV-2. Here we use data from an outbreak in Sydney, Australia that commenced in winter and time-series analysis to investigate the association between reported cases and temperature and relative humidity. Methods Between 16 June and 10 September 2021, the peak of the outbreak, there were 31,662 locally-acquired cases reported in five local health districts of Sydney, Australia. The associations between daily 9:00 am and 3:00 pm temperature (°C), relative humidity (%) and their difference, and a time series of reported daily cases were assessed using univariable and multivariable generalized additive models and a 14-day exponential moving average. Akaike information criterion (AIC) and the likelihood ratio statistic were used to compare different models and determine the best fitting model. A sensitivity analysis was performed by modifying the exponential moving average. Results During the 87-day time-series, relative humidity ranged widely (< 30–98%) and temperatures were mild (approximately 11–17 °C). The best-fitting (AIC: 1,119.64) generalized additive model included 14-day exponential moving averages of 9:00 am temperature (P < 0.001) and 9:00 am relative humidity (P < 0.001), and the interaction between these two weather variables (P < 0.001). Humidity was negatively associated with cases no matter whether temperature was high or low. The effect of lower relative humidity on increased cases was more pronounced below relative humidity of about 70%; below this threshold, not only were the effects of humidity pronounced but also the relationship between temperature and cases of the delta variant becomes apparent. Conclusions We suggest that the control of COVID-19 outbreaks, specifically those due to the delta variant, is particularly challenging during periods of the year with lower relative humidity and warmer temperatures. In addition to vaccination, stronger implementation of other interventions such as mask-wearing and social distancing might need to be considered during these higher risk periods. Graphical Abstract

2021 ◽  
Vol 2 (23) ◽  
pp. 1-15
Author(s):  
Mwana Said Omar ◽  
◽  
Hajime Kawamukai

Desertification is major issue in arid and semi-arid lands (ASAL) with devastating environmental and socio-economic impacts. Time series analysis was applied on 19 years’ pixel-wise monthly mean Normalized Difference Vegetation Index (NDVI) data. The aim of this study was to identify a time series model that can be used to predict NDVI at the pixel level in an arid region in Kenya. The Holt-Winters and Seasonal Auto Regressive Integrated Moving Average (SARIMA) models were developed and statistical analysis was carried out using both models on the study area. We performed a grid search to optimise and determine the best hyper parameters for the models. Results from the grid search identified the Holt-Winters model as an additive model and a SARIMA model with a trend autoregressive (AR) order of 1, a trend moving average (MA) order of 1 and a seasonal MA order of 2, with both models having a seasonal period of 12 months. It was concluded that the Holt-Winters model showed the best performance for 600 ✕ 600 pixels (MAE = 0.0744, RMSE = 0.096) compared to the SARIMA model.


Circulation ◽  
2019 ◽  
Vol 140 (Suppl_2) ◽  
Author(s):  
Alyssa Vermeulen ◽  
Marina Del Rios ◽  
Teri L Campbell ◽  
Hai Nguyen ◽  
Hoang H Nguyen

Introduction: Accurate forecasting could help in resource planning and evaluation of intervention efforts to reduce out-of-hospital cardiac arrest. Hypothesis: Generalized additive model can rapidly and accurately forecast the number of OHCA in the young (1-35 years old) when compared to other auto regressive moving average (ARIMA) based models. Methods: Data were obtained from CARES in Chicago from May 2013 to December 2017. Monthly forecasts of the number of OHCA were performed using a generative additive model framework using the open source software Prophet and R. The first 50 months served as training and the last 6 months served as testing. Results: Figure 1 shows the distribution of the number of cases over the 3-year study period showing yearly seasonality and upward trend. Figure 2 shows the forecast of the number of arrest (middle line) along with the actual number of arrest (dots). The shaded band represents the 95% confidence interval of the prediction. Figure 3 show the comparison of the 6-month forecast and actual data. This model has low root mean square error score when compared with other ARIMA based models (2 vs. 4). Conclusion: Accurate time series forecasting of the number of OHCA arrests could be achieved. Time series analysis and forecasting are essential tools in evaluating the effectiveness of intervention efforts to reduce OHCA as they allow for causality hypothesis testing.


2021 ◽  
Author(s):  
Riza C. Li ◽  
Cecelia K. Harrison ◽  
Claudine T. Jurkovitz ◽  
Mia A. Papas ◽  
Kevin Ndura ◽  
...  

Abstract Objective Healthcare systems globally were shocked by coronavirus disease 2019 (COVID-19). Policies put in place to curb the tide of the pandemic resulted in a decrease of patient volumes throughout the ambulatory system. The future implications of COVID-19 in healthcare are still unknown, specifically the continued impact on the ambulatory landscape. The primary objective of this study is to accurately forecast the number of COVID-19 and non-COVID-19 weekly visits in primary care practices.Materials and Methods This retrospective study was conducted in a single health system in Delaware. All patients’ records were abstracted from our electronic health records system (EHR) from January 1, 2019 to July 25, 2020. Patient demographics and comorbidities were compared using t-tests, Chi square, and Mann Whitney U analyses as appropriate. ARIMA time series models were developed to provide an 8-week future forecast for two ambulatory practices (AmbP) and compare it to a naïve moving average approach.Results Among the 271,530 patients considered during this study period, 4,195 patients (1.5%) were identified as COVID-19 patients. The best fitting ARIMA models for the two AmbP are as follows: AmbP1 COVID-19+ ARIMAX(4,0,1), AmbP1 nonCOVID-19 ARIMA(2,0,1), AmbP2 COVID-19+ ARIMAX(1,1,1), and AmbP2 nonCOVID-19 ARIMA(1,0,0).Discussion and Conclusion: Accurately predicting future patient volumes in the ambulatory setting is essential for resource planning and developing safety guidelines. Our findings show that a time series model that accounts for the number of positive COVID-19 patients delivers better performance than a moving average approach for predicting weekly ambulatory patient volumes in a short-term period.


2020 ◽  
Author(s):  
Debjyoti Talukdar ◽  
Dr. Vrijesh Tripathi

BACKGROUND Rapid spread of SARS nCoV-2 virus in Caribbean region has prompted heightened surveillance with more than 350,000 COVID-19 confirmed cases in 13 Caribbean countries namely Antigua and Barbados, Bahamas, Barbados, Cuba, Dominica, Dominican Republic, Grenada, Haiti, Jamaica, Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines, Trinidad and Tobago. OBJECTIVE The aim of our study is to analyze the impact of coronavirus (SARS nCoV-2) in 13 Caribbean countries in terms of confirmed cases, number of deaths and recovered cases. Current and projected forecasts using advanced autoregressive integrated moving average (ARIMA) models will enable local health organisations to plan future courses of action in terms of lockdown and managing essential public services. METHODS The study uses the auto regressive integrated moving average (ARIMA) model based upon time series pattern as per data retrieved from John Hopkins University, freely accessible on public domain and used for research and academic purposes. The data was analyzed using STATA 14 SE software between the time period - Jan 22, 2020 till May 27, 2020 using ARIMA time series analysis. It involves generalizing an autoregressive moving average model to better understand the data and predict future points in the time series until June 15, 2020. RESULTS The results show the predicted trend in terms of COVID-19 confirmed, mortality and recovered cases for 13 Caribbean countries. The projected ARIMA model forecast for the time period - May 25, 2020 to May 31, 2020 show 20278 (95% CI 19433.21 - 21123.08) confirmed cases, 631 (95% CI 615.90 - 646.51) deaths and 11501 (95% CI 10912.45 - 12089) recovered cases related to SARS nCoV-2 virus. The final ARIMA model chosen for confirmed COVID-19 cases, number of deaths and recovered cases are ARIMA (4,2,2), ARIMA (2,1,2) and ARIMA (4,1,2) respectively. All chosen models were compared with other models in terms of various factors like AIC/BIC (Akaike Information Criterion/Bayesian Information Criterion), log likelihood, p-value significance, coefficient < 1 and 5% significance. The autocorrelation function (ACF) and partial autocorrelation function (PACF) graphs were plotted to reduce bias and select the best fitting model. CONCLUSIONS As per the results of the forecasted COVID-19 models, there is a steady rise in terms of confirmed, recovered and mortality cases during the time period March 1, 2020 until May 27, 2020. It shows an increasing trend for confirmed and recovered COVID-19 cases and slowing of the number of mortality cases over a period of time. The predicted model will help the local health administration to devise public policies in terms of awareness measures, lockdown and essential health services accordingly.


2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chao Zhang ◽  
Xiao Fu ◽  
Yuanying Zhang ◽  
Cuifang Nie ◽  
Liu Li ◽  
...  

Abstract Shandong Province is an area of China with a high incidence of haemorrhagic fever with renal syndrome (HFRS); however, the general epidemic trend of HFRS in Shandong remains unclear. Therefore, we established a mathematical model to predict the incidence trend of HFRS and used Joinpoint regression analysis, a generalised additive model (GAM), and other methods to evaluate the data. Incidence data from the first half of 2018 were included in a range predicted by a modified sum autoregressive integrated moving average-support vector machine (ARIMA-SVM) combination model. The highest incidence of HFRS occurred in October and November, and the annual mortality rate decreased by 7.3% (p < 0.05) from 2004 to 2017. In cold months, the incidence of HFRS increased by 4%, −1%, and 0.8% for every unit increase in temperature, relative humidity, and rainfall, respectively; in warm months, this incidence changed by 2%, −3%, and 0% respectively. Overall, HFRS incidence and mortality in Shandong showed a downward trend over the past 10 years. In both cold and warm months, the effects of temperature, relative humidity, and rainfall on HFRS incidence varied. A modified ARIMA-SVM combination model could effectively predict the occurrence of HFRS.


2020 ◽  
Vol 16 (2) ◽  
pp. 151
Author(s):  
Nurhamidah Nurhamidah ◽  
Nusyirwan Nusyirwan ◽  
Ahmad Faisol

The purpose of this study was to predict seasonal time series data using the Holt-Winters exponential smoothing additive model.  The data used in this study is data on the number of passengers departing at Hasanudin Airport in 2009-2019, the source of the data obtained from the official website of the Central Statistics Agency.  The results showed that the Holt-Winters exponential smoothing method on the passenger's number at Hasanudin Airport in 2009 to 2019 contained trend patterns and seasonal patterns, by first determining the initial values and smoothing parameters that could minimize forecasting errors.


2020 ◽  
Vol 73 ◽  
pp. 01020
Author(s):  
Valerii Matskul ◽  
Diana Okara ◽  
Nataliia Podvalna

This article is the first to study, simulate and forecast the monthly dynamics of the trade balance between Ukraine and the European Union for the period from 2005 to 2019. In the presented work, three types of models were used for modeling and forecasting: Automated Neural Networks, additive models ARIMA *ARIMAS (Autoregressive integrated moving average with season component) and Holts model with a damped trend. When modeling using the Automated Neural Networks module, various ensembles of networks and neuron activation functions in hidden layers were used. It turned out that Automated Neural Networks have poor prognostic ability (as in the case considered by us, when modeling insufficiently long series of dynamics). Therefore, when modeling and forecasting the dynamics of the Ukraine-EU trade balance, classical (so-called Box-Jenkins) time series models were used. In this case, the time series is divided into several components (in our case, terms): the main trend is the trend, the seasonal component and the random component (the so-called white noise). By smoothing the initial series, a trend was found, and an analysis of the autocorrelation functions revealed a one-year seasonality. Eliminating the trend and the seasonal component, we obtained a random component, which has a Gaussian distribution. This made it possible to apply first the ARIMA* ARIMAS additive model, and then the Holt model of exponential smoothing with a damped trend. Adequate models of Ukraine-EU trade balance dynamics have been obtained, according to which the forecast has been made. A comparative analysis of the models used. The best model was chosen for forecasting, which allowed to get a good forecast (in comparison with actual data).


Atmosphere ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 905
Author(s):  
Sabrina Islam ◽  
C. Emdad Haque ◽  
Shakhawat Hossain ◽  
John Hanesiak

Numerous studies on climate change and variability have revealed that these phenomena have noticeable influence on the epidemiology of dengue fever, and such relationships are complex due to the role of the vector—the Aedes mosquitoes. By undertaking a step-by-step approach, the present study examined the effects of climatic factors on vector abundance and subsequent effects on dengue cases of Dhaka city, Bangladesh. Here, we first analyzed the time-series of Stegomyia indices for Aedes mosquitoes in relation to temperature, rainfall and relative humidity for 2002–2013, and then in relation to reported dengue cases in Dhaka. These data were analyzed at three sequential stages using the generalized linear model (GLM) and generalized additive model (GAM). Results revealed strong evidence that an increase in Aedes abundance is associated with the rise in temperature, relative humidity, and rainfall during the monsoon months, that turns into subsequent increases in dengue incidence. Further we found that (i) the mean rainfall and the lag mean rainfall were significantly related to Container Index, and (ii) the Breteau Index was significantly related to the mean relative humidity and mean rainfall. The relationships of dengue cases with Stegomyia indices and with the mean relative humidity, and the lag mean rainfall were highly significant. In examining longitudinal (2001–2013) data, we found significant evidence of time lag between mean rainfall and dengue cases.


2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
C. L. Karmaker ◽  
P. K. Halder ◽  
E. Sarker

In today’s competitive environment, predicting sales for upcoming periods at right quantity is very crucial for ensuring product availability as well as improving customer satisfaction. This paper develops a model to identify the most appropriate method for prediction based on the least values of forecasting errors. Necessary sales data of jute yarn were collected from a jute product manufacturer industry in Bangladesh, namely, Akij Jute Mills, Akij Group Ltd., in Noapara, Jessore. Time series plot of demand data indicates that demand fluctuates over the period of time. In this paper, eight different forecasting techniques including simple moving average, single exponential smoothing, trend analysis, Winters method, and Holt’s method were performed by statistical technique using Minitab 17 software. Performance of all methods was evaluated on the basis of forecasting accuracy and the analysis shows that Winters additive model gives the best performance in terms of lowest error determinants. This work can be a guide for Bangladeshi manufacturers as well as other researchers to identify the most suitable forecasting technique for their industry.


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