Eco-dyeing of wool with Rubia cordifolia root extract: Assessment of the effect of Acacia catechu as biomordant on color and fastness properties

The aim of this study was to compare the fastness properties and wastewater quality in obtaining the same color on 100% woven wool fabric with natural (madder) and synthetic (1:1 metal complex) dyes. The same color, with similar wet fastness properties, was obtained on the wool fabric when dyed with either dye. On the other hand, conductivity, chemical oxygen demand (COD), and the ammonia nitrogen (NH3-N) content of dyeings carried out with the synthetic dye mixture were considerably higher than dyeing with madder root extract, and its pH was more acidic. However, the amount of volatile suspended solids and color obtained in natural dyeing was higher than the amount in the synthetic dyeing wastewater.

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Crosstalk of Cancer Signaling Pathways by Cyclic Hexapeptides and Anthraquinones from Rubia cordifolia

Molecules ◽

10.3390/molecules26030735 ◽

2021 ◽

Vol 26 (3) ◽

pp. 735

Author(s):

Premalatha Balachandran ◽

Mohamed Ali Ibrahim ◽

Jin Zhang ◽

Mei Wang ◽

David S. Pasco ◽

...

Keyword(s):

Signaling Pathways ◽

Biological Fluid ◽

Luciferase Reporter ◽

Drug Candidate ◽

Root Extract ◽

Rubia Cordifolia ◽

Cancer Signaling ◽

Cyclic Hexapeptide ◽

Wide Range ◽

Cyclic Hexapeptides

The anticancer activities of Rubia cordifolia and its constituents have been reported earlier, but their influence on the crosstalk of complex cancer-related signaling metabolic pathways (i.e., transcription factors; TF) has not yet been fully investigated. In this study, R. cordifolia root extract was subjected to the cancer signaling assay based bioactivity-guided fractionation, which yielded the following compounds viz., three anthraquinones, namely alizarin (1), purpurin (2), and emodin (3); two lignans, namely eudesmin (4) and compound 5; and two cyclic hexapeptides, namely deoxybouvardin RA-V (6), and a mixture of 6+9 (RA-XXI). The structures of the isolated compounds were determined by NMR spectroscopy and HRESIMS. The isolated compounds 1, 2, 3, 6, and a mixture of 6+9 were tested against a panel of luciferase reporter genes that assesses the activity of a wide-range of cancer-related signaling pathways. In addition, reference anthraquinones viz., chrysophanol (11), danthron (12), quinizarin (13), aloe-emodin (14), and α-lapachone (15) were also tested. Among the tested compounds, the cyclic hexapeptide 6 was found to be very active against several signaling pathways, notably Wnt, Myc, and Notch with IC50 values of 50, 75, and 93 ng/mL, respectively. Whereas, the anthraquinones exhibited very mild or no inhibition against these signaling pathways. Compound 6 being the most active, we tested it for stability in simulated intestinal (SIF) and gastric fluids (SGF), since the stability in biological fluid is a key short-coming of cyclic hexapeptides. The anticancer activity of 6 was found to remain unchanged before and after the treatment of simulated gastric/intestinal fluids, indicating that RA-V was stable. As a result, it could be bioavailable when orally used in therapeutics and possibly a drug candidate for cancer treatment. The mechanism for the preferential inhibition of these pathways and the possible crosstalk effect with other previously reported signaling pathways has been discussed.

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Protective effect of hydroalcoholic root extract of Rubia cordifolia in indomethacin-induced enterocolitis in rats

Indian Journal of Pharmaceutical Sciences ◽

10.4103/0250-474x.91577 ◽

2011 ◽

Vol 73 (2) ◽

pp. 250 ◽

Cited By ~ 9

Author(s):

AT Pawar ◽

JV Ghodasara ◽

RM Anap ◽

BS Kuchekar

Keyword(s):

Protective Effect ◽

Root Extract ◽

Rubia Cordifolia

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Evaluation of antihyperlipidemic and antioxidant activity of Rubia Cordifolia Linn.

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i1.2216 ◽

2019 ◽

Vol 9 (1) ◽

pp. 211-215

Author(s):

Priyanka Kumari ◽

Satish Kumar Sharma ◽

Snigdha Tiwari

Keyword(s):

Aqueous Extract ◽

High Fat Diet ◽

Low Dose ◽

Ethanolic Extract ◽

High Dose ◽

Root Extract ◽

High Fat ◽

Rubia Cordifolia ◽

Group I ◽

Aqueous Root Extract

Hyperlipidemia is major problem among population those, who have sedentary life style. The effects of ethanolic and aqueous root extract of Rubiacordifoliain experimentally induced hyperlipidemic rats were investigated. 42 wistar rats of both sexes were used for the study. The animals were completely randomized into seven groups comprising 6 animals each. The groups were treated as follows: Group I: normal diet (ND); Group II: HFD ( Vanaspati ghee + coconut oil mixture in ratio of 3:2 at 10 ml/kg/day); Group III: HFD + Atorvastatin (10 mg/kg/day); Group IV: HFD+ ethanolic extract of roots of Rubia cordifolia low dose(200 mg/kg/day); Group V: HFD + ethanolic extract of roots of Rubia cordifolia high dose (400 mg/kg/day); Group VI: HFD + aqueous extract of roots of Rubia cordifolia low dose (200 mg/kg/day); Group VII: HFD + aqueous extract of roots of Rubia cordifolia high dose (400 mg/kg/day). Hypercholesterolemia was induced by feeding the animals with high fat diet for 21 days before administration of the extract. After 21thday of feeding, administration of extract lasted for 14 days. Preliminary phytochemical screening revealed that the ethanolic and aqueous root extract of Rubia cordifolia contains glycosides, triterpenoids, saponins, alkaloids and flavonoids. Overall, findings from the present study suggest that the antihyperlipidemic activity observed with Atorvastatin (10mg/kg oral) and the ethanolic extracts of Rubia cordifolia (400mg/kg) showed better activity thanaqueous extracts of Rubia cordifolia (200mg/kg). Keywords: Rubia cordifolia, body weight, high fat diet, serum lipid, anti-hyperlipidemic activity.

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Fastness and Printing Properties of Cotton Fabric Printed with Natural Dye from Acacia catechu Willd

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1030-1032.426 ◽

2014 ◽

Vol 1030-1032 ◽

pp. 426-429

Author(s):

Charoon Klaichoi ◽

Rattanaphol Mongkholrattanasit ◽

Nuttanan Sasivatchutikool ◽

Nattadon Rungruangkitkrai

Keyword(s):

Sodium Bicarbonate ◽

Cotton Fabric ◽

Natural Dye ◽

Fastness Properties ◽

Colour Fastness ◽

Thickening Agent ◽

Good Level ◽

Colour Strength ◽

Printing Technique ◽

Acacia Catechu

Cotton fabric samples were printed with acacia catechu willd. using reactive-printing technique has been investigated. The effect of different factors, i.e. quantities of urea, thickening agent and Sodium bicarbonate has been studied. The printed goods were evaluated by measuring the K/S values and the overall fastness properties. The results show that the colour strength (K/S) value of recipe 3 was the best printed result, and the next good result was obtained in the order of recipe 2 and recipe 1. The colour fastness results were ranging between fair and good level.

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