scholarly journals The comparison of serum TGF-beta levels and associated polymorphisms in patients with coronary artery ectasia and normal coronary artery

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Özgür Selim Ser ◽  
Gökhan Çetinkal ◽  
Onur Kiliçarslan ◽  
Yalçın Dalgıç ◽  
Servet Batit ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Transforming Growth Factor ◽  
Protective Role ◽  
Coronary Artery Ectasia ◽  
Increased Risk ◽  
Coronary Artery Segment ◽  
Artery Segment ◽  
Atherosclerotic Process ◽  
Atherosclerotic Changes ◽  
Tgf Β1

Abstract Background Coronary artery ectasia (CAE) is described as the enlargement of a coronary artery segment by 1.5 times or more, which is generally associated with the atherosclerotic process. Atherosclerotic changes lead to arterial remodeling result in CAE. In our study, we measured serum transforming growth factor (TGF)-β1 levels, which have a protective role against atherosclerosis. Further, we aimed to assess the TGF-β1 gene variants rs1800469 (–509C>T, c.−1347C>T) and rs1800470 (c.+29T>C, p.Pro10Leu, rs1982073), which might have an effect on TGF production. Overall, 2877 patients were screened including 56 patients with CAE and 44 patients with normal coronary arteries who were included in the study. Serum TGF-β1 levels were measured using ELISA and compared between two groups. Additionally, TGF-β1 rs1800469 and rs1800470 gene variations were determined using TaqMan® SNP Genotyping Assays. Results Serum TGF-β1 levels were significantly lower in patients with CAE than in controls (p=0.012). However, there was no difference in terms of the genotype and allele distributions of TGF-β1 rs1800469 and rs1800470 polymorphisms. Serum TGF-β1 levels were higher in individuals carrying the TGF-β1 rs1800470 G allele (GG+AG) than in individuals with normal homozygous AA genotype in the CAE group (p=0.012). Conclusion Our findings suggest that lower serum TGF-β1 levels are associated with an increased risk for CAE development and that TGF-β1 polymorphisms exert a protective effect. Furthermore, TGF-β1 rs1800470 G allele carriers were shown to have higher TGF-β1 levels in the CAE group. This suggests that having the G allele in the TGF-β1 rs1800470 polymorphism could prevent CAE development.

Apigenin Alleviates Renal Fibroblast Activation through AMPK and ERK Signaling Pathways In Vitro

2020 ◽  
Vol 21 (11) ◽  
pp. 1107-1118
Author(s):  
Ningning Li ◽  
Zhan Wang ◽  
Tao Sun ◽  
Yanfei Lei ◽  
Xianghua Liu ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Transforming Growth Factor ◽  
Therapeutic Potential ◽  
Protective Role ◽  
Fibroblast Proliferation ◽  
Fibroblast Activation ◽  
And Function ◽  
Activated Fibroblasts ◽  
Tgf Β1

Objective: Renal fibrosis is a common pathway leading to the progression of chronic kidney disease. Activated fibroblasts contribute remarkably to the development of renal fibrosis. Although apigenin has been demonstrated to play a protective role from fibrotic diseases, its pharmacological effect on renal fibroblast activation remains largely unknown. Materials and Methods: Here, we examined the functional role of apigenin in the activation of renal fibroblasts response to transforming growth factor (TGF)-β1 and its potential mechanisms. Cultured renal fibroblasts (NRK-49F) were exposed to apigenin (1, 5, 10 and 20 μM), followed by the stimulation of TGF-β1 (2 ng/mL) for 24 h. The markers of fibroblast activation were determined. In order to confirm the anti-fibrosis effect of apigenin, the expression of fibrosis-associated genes in renal fibroblasts was assessed. As a consequence, apigenin alleviated fibroblast proliferation and fibroblastmyofibroblast differentiation induced by TGF-β1. Result: Notably, apigenin significantly inhibited the fibrosis-associated genes expression in renal fibroblasts. Moreover, apigenin treatment significantly increased the phosphorylation of AMP-activated protein kinase (AMPK). Apigenin treatment also obviously reduced TGF-β1 induced phosphorylation of ERK1/2 but not Smad2/3, p38 and JNK MAPK in renal fibroblasts. Conclusion: In a summary, these results indicate that apigenin inhibits renal fibroblast proliferation, differentiation and function by AMPK activation and reduced ERK1/2 phosphorylation, suggesting it could be an attractive therapeutic potential for the treatment of renal fibrosis.

scholarly journals Prevalence of pathological FFRCT values without coronary artery stenosis in an asymptomatic marathon runner cohort

2021 ◽  
Author(s):  
Sebastian Gassenmaier ◽  
Ilias Tsiflikas ◽  
Simon Greulich ◽  
Jens Kuebler ◽  
Florian Hagen ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Fractional Flow ◽  
Marathon Runners ◽  
Coronary Artery Segment ◽  
Relevance Evaluation ◽  
Artery Segment ◽  
Distal Vessel

Abstract Objectives To evaluate computed tomography fractional flow reserve (FFRCT) values in distal parts of the coronaries in an asymptomatic cohort of marathon runners without any coronary stenosis for potentially false-positive values. Methods Ninety-eight asymptomatic male marathon runners (age 53 ± 7 years) were enrolled in a prospective monocentric study and underwent coronary computed tomography angiography (CCTA). CCTA data were analyzed for visual coronary artery stenosis. FFRCT was evaluated in 59 participants without coronary artery stenosis in proximal, mid, and distal coronary sections using an on-site software prototype. Results In participants without coronary artery stenosis, abnormal FFRCT values ≤ 0.8 in distal segments were found in 22 participants (37%); in 19 participants in the LAD; in 5 participants in the LCX; and in 4 participants in the RCA. Vessel diameters in participants with FFRCT values > 0.80 compared to ≤ 0.80 were 1.6 ± 0.3 mm versus 1.5 ± 0.3 mm for distal LAD (p = 0.025), 1.8 ± 0.3 mm versus 1.6 ± 0.5 mm for distal LCX (p = 0.183), and 2.0 ± 0.4 mm versus 1.5 ± 0.2 mm for distal RCA (p < 0.001). Conclusions Abnormal FFRCT values of ≤ 0.8 frequently occurred in distal coronary segments in subjects without any anatomical coronary artery stenosis. This effect is only to some degree explainable by small distal vessel diameters. Therefore, the validity of hemodynamic relevance evaluation using FFRCT in distal coronary artery segment stenosis is reduced. Key Points • Abnormal FFRCT values (≤ 0.8) occurred in over a third of the subjects in the distal LAD despite the absence of coronary artery stenosis.. • Therefore, the validity of hemodynamic relevance evaluation in distal coronary artery segment stenosis is reduced. • Decision-making based on abnormal FFRCT values in distal vessel sections should be performed with caution and only in combination with visual assessment of the grade of stenosis..

Abstract 915: The Effect of Gender and Race on Outcomes in Patients Undergoing PCI for Proximal Coronary Artery Lesions: A Report from the NHLBI Dynamic Registry of PCI

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Sandy M Green ◽  
Faith Selzer ◽  
Suresh Mulukutla ◽  
Ashley Lee ◽  
Lee S Joon ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Female Gender ◽  
Adverse Outcomes ◽  
High Risk Population ◽  
Gender And Race ◽  
Repeat Revascularization ◽  
Coronary Artery Segment ◽  
Artery Segment ◽  
Coronary Lesions ◽  
Proximal Coronary Artery

Background: Little is known about the effect of gender and race on outcomes in patients after revascularization of proximal coronary lesions (PCL). We investigated their effect on outcomes using the NHLBI Dynamic Registry. Methods: Of the 9962 patients receiving PCI, 3918 (39%) were treated for disease in a proximal coronary artery segment. Left main and PCI for graft lesions were excluded. Primary outcomes were death/MI or need for repeat revascularization at 1 year after the index procedure. Results: 80% of the patients were white (n=3144), 11% black (n=469), 63% male (n=2461), and 37% female (n=1457). Patients with PCL had lower rates of HTN, prior MI, but where older and had more concomitant medical disease. Compared to non-proximal lesions, patients with PCL had higher rate of death (5.4% vs. 4%, p=0.001) and repeat revascularization (16.3% vs. 14.3%, p=0.01). The effect of gender and race were then included in the multivariate model for predicting risk in patients with PCL (Table 1 ). Race did not modify the risk associated with PCL but females had a 32% greater relative risk (p=0.002) of repeat revascularization when compared to men. Conclusions: Treatment of proximal coronary lesions is associated with a more adverse outcomes compared to non-proximal coronary lesions. In this high-risk population, female gender is an independent predictor for the need for repeat revascularization. Table 1: Event rates, unadjusted and adjusted hazard ratios and 95% confidence intervals in patients undergoing proximal vessel PCI

Accuracy and rate of coronary artery segment visualization with CT angiography for the non-invasive detection of coronary artery stenoses

2007 ◽  
Vol 23 (6) ◽  
pp. 771-780 ◽  
Author(s):  
Edith Bordeleau ◽  
Alexandre Lamonde ◽  
Julie Prenovault ◽  
Assia Belblidia ◽  
Gilles Coté ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Ct Angiography ◽  
Non Invasive ◽  
Coronary Artery Segment ◽  
Coronary Artery Stenoses ◽  
Artery Segment

scholarly journals Stenosis Detection Algorithm for Coronary Angiograms

2019 ◽  
Vol 8 (9) ◽  
pp. 2362-2367
Keyword(s):  
Coronary Artery ◽  
Coronary Vessels ◽  
Ground Truth ◽  
Detection Algorithm ◽  
Vital Role ◽  
Coronary Artery Segment ◽  
Blob Analysis ◽  
Artery Segment ◽  
Stenosis Detection ◽  
Background Image

Automatic detection of blocks in the angiographic images is a challenging task. The features such as contrast and gradient of the vessels and the background image are playing a vital role in the detection of the blocks in the X-Ray angiograms. Nowadays, doctors manually identify blocks in the coronary vessels. The automation tool is necessary to identify the blocks in the blood vessels of the heart to help the doctors in the diagnosing process. Spatiotemporal nature of the angiography sequences is used to isolate the coronary artery tree. The coronary artery segment is tracked and in each image frame by frame and the arterial width surface is detected. The stenosis identification is done by using coronary vessel surface’s persistent minima and blob analysis. The proposed method is experimented on 42 patients’ dataset. The performance of the proposed method was evaluated by comparing the blocks identified by the algorithm with the hand-labelled ground truth images given by the experts. The proposed method provides an accuracy of 95.5% on 42 patients with a total of 60 image runs.

Aortic sclerosis: therapy

ESC CardioMed ◽  
2018 ◽  
pp. 2583-2589
Author(s):  
Raimund Erbel
Keyword(s):  
Blood Pressure ◽  
Coronary Artery ◽  
Thoracic Aorta ◽  
Coronary Artery Calcification ◽  
Pulse Wave ◽  
Surgical Interventions ◽  
Fibrous Cap ◽  
Increased Risk ◽  
Aortic Sclerosis ◽  
Atherosclerotic Process

Aortic sclerosis is a very common disease and is related to the atherosclerotic process which can start in young adulthood. The loss of compliance of the aortic ‘Windkessel’ is a major drawback of the disease, leading to enhanced blood pressure amplitude—elevated pulse pressure—due to a higher systolic and a lower diastolic blood pressure. The pressure pulse wave augmentation index and the pulse wave velocity increase. Ultrasound is able to visualize only limited aortic segments, whereas computed tomography and magnetic resonance imaging are the best tools to detect and quantify aortic atheromas. Nevertheless, transoesophageal echocardiography can image the descending thoracic aorta down to the coeliac trunk. An aortic atheroma, particularly one greater than 4 mm in size in the aortic arch, indicates an increased risk of stroke and other cardiovascular events. A grading is helpful. Plaque rupture is quite frequent and often found in multiple segments of the aorta indicating an increased risk of cholesterol emboli due to the wash-out of debris with or without thrombotic material. Free-floating structures, possible remnants of fibrous cap, are found as well as mobile thrombi. Calcification of the thoracic aorta is often found when coronary artery calcification is present, but may be present when coronary artery calcification is absent. Risk prediction of events is, however, not improved. Therapy for aortic sclerosis is based on common and recent guidelines for prevention and treatment of risk factors. Endovascular or surgical interventions are limited to rare situation in which blood flow is not preserved.

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