Medicinal plants with hepatoprotective potentials against carbon tetrachloride-induced toxicity: a review

Abstract Background Carbon tetrachloride (CCl4) is a well-characterized hepatotoxic agent. With rising cases of liver diseases, the identification, assessment, and development of hepatoprotective agents from plants source has become imperative. Main body With arrays of literature on plants with hepatoprotective potentials, this review sourced published literatures between 1998 and 2020 and systematically highlighted about 92 medicinal plants that have been reported to protect against CCl4-induced liver injury in animal models. The results show that herbal plants provide protection for the liver against CCl4 by downregulation of the liver marker enzymes and activation of antioxidant capacity of the liver cells with the restoration of liver architecture. We also provided the traditional and accompanying pharmacological uses of the plants. A variety of phytochemicals mostly flavonoids and polyphenols compounds were suggested to offer protection against liver injuries. Conclusion It can be concluded that there are a variety of phytochemicals in plant products with hepatoprotective activity against CCl4-induced toxicity in animal models.

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Hepatoprotective Activity of Some Medicinal Plants in Sudan

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/2196315 ◽

2019 ◽

Vol 2019 ◽

pp. 1-16 ◽

Cited By ~ 1

Author(s):

Sumaia A. Ali ◽

Noha H. Sharief ◽

Yahya S. Mohamed

Keyword(s):

Animal Models ◽

Medicinal Plants ◽

Rural Areas ◽

Scientific Evidence ◽

Hepatoprotective Activity ◽

Active Principle ◽

Published Data ◽

Liver Disorders ◽

Herbal Plants ◽

Liver Markers

Background. Liver disorders are common in Sudan and elsewhere. These are traditionally treated by medicinal plants especially in rural areas where they are widely available. Methods. This review was based on scientific research in hepatoprotective plants performed in Sudan for the period between 2001 and 2016 AD. Data collection was done through scientific evidence of local and international published data, theses, and publications from some libraries in Sudanese universities. Internet was also used to collect published data in different international scientific journals. Results. In this study, 21 plants from different families were reviewed for the hepatoprotective activity in Sudan. These plants are widely used in traditional medicine for their availability and cheap prices. All of these plants have been scientifically investigated through experimental animal models which confirmed their hepatoprotective activities. This was evaluated by measuring several parameters including liver markers (AST, ALT, ALP, total protein, albumin, and bilirubin) and histopathological investigation. Nineteen (90.5%) of the herbal plants were found to possess significant hepatoprotective activity in animal models. Two (9.5%) of the plants were devoid of this activity. The action of these plants is largely attributed to their phytoconstituents such as flavonoids, antioxidant, and anti-inflammatory effects. Conclusion. Sudanese herbs may offer novel alternatives to treat liver disorders. Yet determination of the active principle responsible for hepatoprotection needs to be investigated. Further studies on these plants are necessary to establish the efficacy, safety, and exact mechanism of action as a moral alternative in the treatment of liver disorders.

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Pharmacoprophylaxis of liver diseases: creating a new hepatoprotector

BIO Web of Conferences ◽

10.1051/bioconf/20201700061 ◽

2020 ◽

Vol 17 ◽

pp. 00061

Author(s):

Svetlana Zykova ◽

Sergey Shurov ◽

Aleksey Savinkov ◽

Nino Gugushvili ◽

Vladimir Talismanov

Keyword(s):

Oxidative Stress ◽

Carbon Tetrachloride ◽

Toxic Effect ◽

Alanine Aminotransferase ◽

Liver Diseases ◽

Hepatoprotective Activity ◽

Control Group ◽

Biochemical Indicators ◽

Intact Group ◽

Biochemical Studies

The article presents a study of the hepatoprotective activity of a tricyclic heterocycle, which refers to 5, 6, 7, 8-tetrahydroquinolines. The effect of 8, 8-dimethyl-5-p-tolyl-8, 9-dihydro-2H-pyrido [4, 3, 2-de] cinnolin-3 (7H) was studied on rats under the influence of the model of toxic hepatosis induced by carbon tetrachloride to find out the indicators of peroxidation and biochemical indicators. Biochemical studies have shown that modelling toxic fat hepatosis caused by the inception of carbon tetrachloride to rats increased the activity of alanine aminotransferase by 2.5 times more compared with the intact group, indicating the development of oxidative stress induced by the treatment of pyrido [4, 3, 2] Cinnol I that reduced the toxic effect of CTC by 79.9 %. Mexidol had a less pronounced hepatoprotective effect: the activity of Alanine aminotransferase on animals of the second group was lower by 29.2 % than on rats from the control group. Thus, a new compound with hepatoprotective activity has been developed and studied.

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KUNYIT PUTIH DAN BUAH MENGKUDU SEBAGAI HEPATOPROTEKTOR TERKAIT KARBON TETRAKLORIDA

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v19i1.389 ◽

2016 ◽

Vol 19 (1) ◽

pp. 34

Author(s):

Suprapto Ma’at

Keyword(s):

Carbon Tetrachloride ◽

Liver Diseases ◽

Hepatoprotective Activity ◽

Serum Analysis ◽

Morinda Citrifolia ◽

Herbal Remedies ◽

Curcuma Zedoaria ◽

Liver Functions ◽

Significant Protective Effect

Herbal remedies are prescribed for the treatment of various liver diseases including for Hepatoprotector purpose. The present study was aimed to investigate and to know the hepatoprotective activity of Curcuma zedoaria extract combined with Morinda citrifolia extract against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Liver functions were assessed by the determination of SGOT, SGPT, ALP, and bilirubin. The results of serum analysis suggest that the use of Curcuma zedoaria extract combined with Morinda citrifolia extract exhibited significant protective effect related to the hepatic damage in CCl4 induced hepatotoxicity model and further evidence of its hepatoprotective activity

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Animal Models of Alcoholic Liver Disease for Hepatoprotective Activity Evaluation

BIO Web of Conferences ◽

10.1051/bioconf/20214107007 ◽

2021 ◽

Vol 41 ◽

pp. 07007

Author(s):

Hidayah Dwi Renggani ◽

Triana Hertianti ◽

Retno Murwanti

Keyword(s):

Liver Disease ◽

Animal Models ◽

Liver Injury ◽

Alcoholic Liver Disease ◽

Hepatoprotective Activity ◽

Chronic Ethanol ◽

Injury Model ◽

Acute Ethanol ◽

Injury Models ◽

Hepatoprotective Agents

Background: The reported statistics suggest that alcoholic liver disease is on the rise. Furthermore, medications used to treat the disease have unpleasant effects, and this necessitates the need to continuously investigate hepatoprotective agents. This study investigates animal models of alcoholic liver disease used to evaluate hepatoprotective activity. Content: A good number of published articles evaluating hepatoprotective activity were summarized. The studies used three ethanol-induced liver injury models: the acute ethanol-induced liver injury model, the chronic ethanol-induced liver injury model, and Lieber– DeCarli model. Summary: Wistar rats were primarily used in the ethanol-induced liver injury model. High levels of alanine transaminase (ALT) and aspartate transaminase (AST) and histopathological alterations were found in all animal models (acute ethanol-induced liver injury, chronic ethanol-induced liver injury, and Lieber–DeCarli models). Severe steatosis was shown in both chronic ethanol-induced liver injury and Lieber–DeCarli models. However, fibrosis was undetected in all models.

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Pharmacological assessment of the aqueous extract of rose oil waste from Rosa x damascena Herrm cultivated in Georgia

World Journal of Biology Pharmacy and Health Sciences ◽

10.30574/wjbphs.2021.7.1.0069 ◽

2021 ◽

Vol 7 (1) ◽

pp. 001-008

Author(s):

Karen Mulkijanyan ◽

Natela Gogitidze ◽

Marine Sulakvelidze ◽

Nadezhda Mushkiashvili ◽

Zhana Novikova ◽

...

Keyword(s):

Carbon Tetrachloride ◽

Animal Models ◽

Aqueous Extract ◽

Pharmacological Study ◽

Oil Production ◽

Hepatoprotective Activity ◽

Gastric Injury ◽

Pharmacological Properties ◽

Active Constituents ◽

Rose Oil

Among Rosaceae family's most popular and important plants Rosa x damascena Herrm. holds one of the top places due to its centuries-long application in perfumery, cosmetics, aromatherapy and medicine. Despite this, the chemical and pharmacological study of different products obtained from R. damascena still does not lose its relevance. Currently, considerable attention is paid to the valorization of the waste from rose oil production in order to fully utilize valuable physiologically active constituents. The present study provides data on some pharmacological properties of the aqueous extract of rose oil waste from the R. damascena cultivated in Georgia. In particular, evaluation of gastro- and hepatoprotective activity of the aforesaid extract has been carried out in animal models and revealed its efficacy. The extract appeared to dose dependently stimulate leucopoiesis (up to 75%) and prevent ethanol-induced gastric injury (20-80%). As well, the extract ameliorated hepatoxic effects of carbon tetrachloride by 63%.

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A LITERARY REVIEW ON KALMEGH AND BHUMYAMLAKI AS HEPATOPROTECTIVE MEDICINAL PLANTS

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj2009042021 ◽

2021 ◽

Vol 9 (4) ◽

pp. 810-817

Author(s):

Nabaruna Bose ◽

Gupta O.P.

Keyword(s):

Medicinal Plants ◽

Liver Diseases ◽

Lifestyle Modification ◽

Holistic Approach ◽

Hepatoprotective Activity ◽

The Body ◽

New Drugs ◽

Liver Disorders ◽

Synthetic Drugs ◽

Medicinal Properties

India is rich in flora of various kinds having several medicinal properties which are already known to us while some are yet to be discovered and used for the betterment of the human mankind. The practice of using indige- nous plants for the treatment of various health ailments has been an age-old practice. With the advancement in technology and lifestyle modification people are suffering from liver diseases and it is a worldwide problem now. Liver is a vital organ which plays a major role in the metabolism and excretion of xenobiotics from the body. The currently available synthetic drugs cause damage to the liver so it is imperative to find new drugs with least side effects. In Ayurveda, various medicinal plants are mentioned which are efficient in protecting liver from various harmful agents or toxins causing diseases. Kalmegha and Bhumyamlaki mentioned in various Ayurvedic texts has hepatoprotective activity. Ayurveda has a holistic approach. It believes in organic way of treatment by eliminating the toxins and balancing the Tridosha. The review has been done based on both Ayurvedic text and modern exper- imental studies. In this regard, their morphology, phytochemistry, Ayurvedic pharmacology, effects and trial stud- ies and dosages are focused on. The introduced medicinal plants can be used for production of new drugs via an- tioxidant related properties, hepatoprotective activities for the prevention and treatment of liver disorders. Keywords: Ayurveda, Kalmegha, Bhumyamlaki, Hepatoprotective.

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Evaluation of hepatoprotective activity of the Acacia nilotica flowers on carbon tetrachloride-induced liver damage in rats

Planta Medica ◽

10.1055/s-0033-1351981 ◽

2013 ◽

Vol 79 (13) ◽

Author(s):

EA Omara ◽

SA Nada ◽

SA El-Toumy

Keyword(s):

Carbon Tetrachloride ◽

Liver Damage ◽

Hepatoprotective Activity ◽

Acacia Nilotica

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Biological and Phytochemical Screening of Tephrosia purpurea extract on Chemically Induced Hepatocellular Carcinoma with Reference to Biochemical Parameters

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.10.2.26 ◽

2019 ◽

Vol 10 (02) ◽

Author(s):

Irfan Aziz ◽

Birendra Shrivastava ◽

Chandana Venkateswara Rao ◽

Sadath Ali

Keyword(s):

Free Radicals ◽

Ethanolic Extract ◽

Hepatoprotective Activity ◽

Control Group ◽

Marker Enzymes ◽

Tephrosia Purpurea ◽

Single Intraperitoneal Injection ◽

Chemically Induced ◽

Ccl4 Treatment ◽

Dose Dependent

Tephrosia purpurea possesses hepatoprotective activity as evidenced by the significant and dose dependent restoring the activities of entire liver cancer marker enzymes, diminution in tumor incidence, decrease in lipid peroxidation (LPO) and increase in the level of antioxidant enzymes (GSH, CAT, SOD, GPx and GST) through scavenging of free radicals, or by enhancing the activity of antioxidant, which then detoxify free radicals. These factors protect cells from ROS damage in NDEA and CCl4-induced hepatocarcinogenesis. Histopathological observations of liver tissues too correlated with the biochemical observations. Thus, present investigation suggested that the Tephrosia purpurea would exert a chemoprotective effect by reversing the oxidant-antioxidant imbalance during hepatocarcinogenesis induced by NDEA and CCl4. Besides Tephrosia purpurea is very much effective in preventing NDEA-induced multistage hepatocarcinogenesis possibly through antioxidant and antigenotoxic nature, which was confirmed by various liver injury and biochemical tumour markers enzymes. The hepatoprotective activity of aTephrosia purpurea of 50 % ethanolic extract was studied using rats. The animals received a single intraperitoneal injection of N-nitrosodiethylamine 200mg/kg body wt followed by subcutaneous injection of CCl4 in a dose of 3 ml/kg body wt.Tephrosia purpureaextract dose dependently and significantly the increase in serum hepatic enzyme levels after NDEAand CCl4 treatment compared to the toxin control group. The results of this study confirmed the antioxidant and hepatoprotective activity of the Tephrosia purpurea extract against carbon tetrachlorideand N-nitrosodiethylamine induced hepatotoxicity in rats.

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Phytotherapy for wound healing: The most important herbal plants in wound healing based on Iranian etnobotanical documents

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557520666201119122608 ◽

2020 ◽

Vol 20 ◽

Cited By ~ 1

Author(s):

Kamal Solati ◽

Mehrdad Karimi ◽

Mahmoud Rafieian-Kopaei ◽

Naser Abbasi ◽

Saber Abbaszadeh ◽

...

Keyword(s):

Wound Healing ◽

Medicinal Plants ◽

Aloe Vera ◽

Datura Stramonium ◽

New Drugs ◽

Mentha Pulegium ◽

Accelerate Wound Healing ◽

Healing Tissue ◽

Herbal Plants ◽

Echium Amoenum

: Wound healing is a process which starts with inflammatory response after damage occurrence. This process happens by restoring the wound surface coating tissue, migrating fibroblasts to form the needed collagen, forming a healing tissue and finally contortion and extraction of the wound. Today, various drugs are used to heal the wound. However, the used drugs to repair wounds have some defects and side effects. In spite of all attempts to accelerate wound healing definitely, no safe drug has been introduced for this purpose. Therefore, the necessity of identifying herbal plants in ethnopharmacology and ethnobotany documents with healing effect is felt essential. In this article we tried to review and present Iranian effective medicinal plants and herbal compounds used for wound healing. Searching was performed on databases including ISI Web of Science, PubMed, PubMed Central, Scopus, ISC, SID, Magiran and some other databases. The keywords used included wound healing, skin treatment, medicinal plants, ethnobotany, and phytotherapy. In this regard, 139 effective medicinal plants on wound healing were identified based on ethnopharmacology and ethnobotanical sources of Iran. Medicinal plants such as Salvia officinalis, Echium amoenum, Verbascum spp., G1ycyrrhiza glabra, Medicago sativa, Mentha pulegium, Datura stramonium L., Alhagi spp., Aloe vera, Hypericum perforatum, Pistacia atlantica and Prosopis cineraria were the most important and effective medicinal plants on wound healing in Iran. These native Iranian medicinal plants are full of antioxidants and biological compounds and might be used for wound healing and preparation of new drugs.

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