scholarly journals Propranolol therapy in infantile hemangioma: correlation of age and duration of treatment to the outcomes

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
Ali Farooq Al-Mayoof ◽  
Ali Egab Joda ◽  
Osama Esmaeel Almushhadany

Abstract Background Infantile hemangioma (IH) is the commonest vascular tumor affecting children that appears in the first 2 weeks of life and follows a proliferative phase that continues during the first year of life. After then, it undergoes involution, which lasts for several months or years depending on the size, site, gender, and development of complications. The purpose of this prospective study was to evaluate the correlation of age and duration of propranolol therapy to the outcomes of infantile hemangioma. Methods A prospective study included 28 patients with IH in which the propranolol therapy was initiated in a dose of 3 mg/kg/day divided into two to three doses. The surface area of IH was calculated monthly using AutoCAD software. Treatment with propranolol was discontinued when there was no more decrease in the surface area for two consecutive visits. Eleven males and 17 females completed the study. The age at initiation of therapy ranged from 2 to 16 months while at the end of therapy it was 9 to 23 months. Results The mean difference percent of surface area at 6 months was (51.1 ± 16.3), while at the end of the treatment course was (75.0±16.8) which was statistically significant (P < 0.0001). In addition, a significant inverse correlation was found between the age at the beginning of treatment and the difference percent of surface area. A similar inverse correlation was observed between the age at the beginning of treatment and the duration of treatment. Conclusion In addition to the safety and efficacy of propranolol therapy for IH, a higher response rate can be gained with early treatment and a prolonged course of therapy. In addition, propranolol therapy should be continued until there is no more response for two consecutive months regardless of the age of therapy initiation and the duration of treatment.

2019 ◽  
Vol 7 (14) ◽  
pp. 2292-2297
Author(s):  
Manahap Verarius F. Pardosi ◽  
Bahagia Loebis ◽  
Muhammad Surya Husada ◽  
Nazli M. Nasution ◽  
Elmeida Effendy ◽  
...  

BACKGROUND: Schizophrenia is a psychopathological syndrome clinic involving cognition, emotion, perception and other aspects from the individual which interferences. This interference is normally started before age 25, and it can affect all social classes. AIM: To find out the difference in total positive and negative syndrome scale (PANSS) scores in schizophrenia between Bataknese and Javanese who have received treatment with risperidone. METHODS: This study is a prospective study. This study used numeric comparative analytic two unpaired groups to observe the differences of PANSS score of the man with schizophrenia between Bataknese and Javanese who had received risperidone treatment. RESULTS: Our study found that the average score of PANSS for Bataknese was 49.76 ± 12.65 and Javanese was 42.43 ± 9.05. CONCLUSION: There was a difference score of PANSS for the man with schizophrenia between Bataknese and Javanese who had received risperidone treatment for 6 weeks (p = 0.037).


2021 ◽  
Vol Volume 17 ◽  
pp. 119-125
Author(s):  
Tong Qiu ◽  
Kaiying Yang ◽  
Shiyi Dai ◽  
Siyuan Chen ◽  
Yi Ji

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Chuan Wang ◽  
Qi Wang ◽  
Bo Xiang ◽  
Siyuan Chen ◽  
Fei Xiong ◽  
...  

Background. The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs). Methods. Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy children with no history of propranolol therapy. Patients received propranolol therapy for at least 3 months. Gesell developmental schedules (GDS) were used to evaluate neurodevelopment outcomes in the two groups. The scores of each GDS domain were compared between the two groups. Results. There were no significant differences in developmental quotient (DQ) values for any of the five domains between the patients and healthy controls (P<0.05). Multiple stepwise regression analyses showed that none of the domains in the control group were influenced by the children’s gender or age (P<0.05). In addition, we found that gender, age at the initiation of therapy, age at the time of the neurodevelopment test, and treatment duration had no effect on any domain of the GDS in the patient group (P>0.05). Conclusion. Propranolol has no obvious effect on neurodevelopmental outcomes in children. Early treatment and treatment duration had no negative effect on central nervous system (CNS) development.


2020 ◽  
Vol 134 (8) ◽  
pp. 717-720 ◽  
Author(s):  
MH Hussain ◽  
M Mair ◽  
P Rea

AbstractObjectiveTo evaluate the prevalence of severe acute respiratory syndrome coronavirus-2 infection in patients presenting with epistaxis to a tertiary otolaryngology unit.MethodsA prospective study was conducted of 40 consecutive patients presenting with epistaxis referred to our tertiary otolaryngology unit. A group of 40 age-matched controls were also included. All patients underwent real-time reverse transcriptase polymerase chain reaction testing for severe acute respiratory syndrome coronavirus-2. Symptoms of fever, cough and anosmia were noted in the study group.ResultsThe mean age was 66.5 ± 22.4 years in the study group. There were 22 males (55 per cent) and 18 females (45 per cent). The mean age in the control group was 66.3 ± 22.4 years (p = 0.935). There were six positive cases for severe acute respiratory syndrome coronavirus-2 (15 per cent) in the epistaxis group and one case (2.5 per cent) in the control group. The difference was statistically significant (p = 0.05).ConclusionEpistaxis may represent a presenting symptom of severe acute respiratory syndrome coronavirus-2 infection. This may serve as a useful additional criterion for screening patients.


Viruses ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1392
Author(s):  
Ignacio Parrón ◽  
Irene Barrabeig ◽  
Miquel Alseda ◽  
Thais Cornejo-Sánchez ◽  
Susana Guix ◽  
...  

Norovirus outbreaks frequently occur in closed or semiclosed institutions. Recent studies in Catalonia and various countries indicate that, during outbreaks in these institutions, norovirus is detected in between 23% and 60% of workers, and the prevalence of infection in asymptomatic workers involved in outbreaks ranges from 17% to 40%. In this work, we carried out a prospective study to investigate the involvement of workers in closed and semiclosed institutions during outbreaks. The attack rates (ARs) and the rate ratios (RRs) were calculated according to the type of transmission and occupational category. The RRs and 95% confidence intervals (CIs) between workers and users were calculated. The mean cycle of quantification (Cq) values were compared according to the genogroup and the presence of symptoms. ARs were higher in person-to-person transmission than in common vehicle outbreaks, and 38.8% of workers were symptomatic. The RR between workers and users was 0.46 (95% CI 0.41–0.52). The ARs in workers were high, particularly in workers with closer contact with users. The mean Cq was lower in patients than in asymptomatic infected persons, although the difference was only significant for genogroup I (GI). The frequency of asymptomatic infected persons suggests that personal hygiene measures should be followed by all workers in the centers affected.


2020 ◽  
Vol 24 (12) ◽  
pp. 1241-1246
Author(s):  
H. Zhang ◽  
X. Cao ◽  
D. Wang ◽  
H. Xin ◽  
Z. Liu ◽  
...  

BACKGROUND: Occupational exposure-related risk of Mycobacterium tuberculosis infection has been reported for village doctors in China. This prospective study aims to estimate the infection acquisition in this key population.METHODS: At baseline, all village doctors registered in Zhongmu County were tested by QuantiFERON®-TB Gold In-Tube (QFT) and QuantiFERON®-TB Gold Plus (QFT-Plus) in parallel. Those negatives for either of the tests were retested to identify conversions at the 2-year follow-up investigation.RESULTS: A total of 367 eligible participants completed the 2-year follow-up survey with frequency of conversion of 5.0% (18/361) for QFT and 6.1% (21/343) for QFT-Plus. The agreement of follow-up results between the tests was 93.2% with a κ coefficient of 0.43 (95%CI 0.20–0.65). Among QFT-Plus convertors, the difference between TB1 and TB2 tubes (TB2-TB1) was significantly increased as compared with baseline results (P = 0.039). Participants from the villages with occurrence of microbiologically confirmed pulmonary TB showed higher frequency of QFT conversions (11.0% vs. 3.2%, P = 0.011) and QFT-Plus conversions (12.3% vs. 4.4%, P = 0.027) than those from the villages without occurrence.CONCLUSION: Our results consistently suggest that capability on occupational protection and M. tuberculosis infection control should be improved in village doctors in China.


2016 ◽  
Vol 50 (3) ◽  
pp. 141-147
Author(s):  
Puneet Chhabra ◽  
Rajesh Gupta ◽  
Vishal Sharma ◽  
Surinder S Rana ◽  
Deepak K Bhasin ◽  
...  

ABSTRACT Background and aims The appendix may be involved in ulcerative colitis (UC) to variable extent. Clinical significance of appendicular involvement is not clear and it has long been considered an innocent bystander. This study prospectively investigated appendiceal histology and its clinical significance in patients with UC. Materials and methods Colonoscopy was performed in 60 patients and biopsies were taken from appendiceal orifice, cecum, and colon. Appendiceal histology was classified as active if there was presence of neutrophils with crypt distortion. Inactive inflammation was defined as positive for crypt distortion and negative for neutrophils. Otherwise the histology was reported as normal or nonspecific changes. The patients were followed for a minimum period of 6 months. Results In patients evaluated endoscopically, 63% patients had histological involvement of the appendiceal orifice. Pancolitis was seen more commonly in patients with appendicular orifice inflammation than in patients with normal appendicular histology (44.7 vs 9%, p = 0.001). Most patients with appendiceal orifice inflammation had involvement of the cecum. Skip lesion of the appendix without cecum involvement was seen in 37% of the patients. The patients with appendiceal orifice inflammation had a significantly higher grade of endoscopic colitis compared to patients with normal histology (p = 0.006). Relapse rate was higher in patients with appendiceal orifice inflammation than in patients with normal appendiceal histology (18.4 vs 9%), although the difference was insignificant (p = 0.329). Conclusion Appendicular involvement in ulcerative colitis is not uncommon. Its involvement may predict the course, extent, and severity of colitis. How to cite this article Parvez N, Rana SS, Nada R, Sharma V, Sharma R, Chhabra P, Gunjan D, Dhalaria L, Gupta R, Bhasin DK. Appendicular Histology and Its Clinical Significance in Patients with Ulcerative Colitis: A Prospective Study from North India. J Postgrad Med Edu Res 2016;50(3):141-147.


2021 ◽  
Vol 8 (12) ◽  
pp. 3645
Author(s):  
Dinesh Prasad ◽  
Darshit Kalaria ◽  
Yogesh Satani

Background: Breast abscesses, localized collection of pus in the breast, are most common in young lactating women. Traditional treatment of breast abscesses is by surgical incision, digital disruption of septa, evacuation of contents with occasional placement of surgical drains, and administration of systemic antibiotics. Percutaneous large-bore needle aspiration with or without ultrasound guidance is generally employed as the first line treatment of breast abscesses. It is generally done for medium to large sized unilateral abscesses and requires repeated aspirations for complete resolution of the abscess cavity.Methods: We have conducted this prospective study at SMIMER Hospital, Surat, Gujarat, India from January 2020 to January 2021. After ethical approval a group of 25 patients with unilateral breast abscesses irrespective of the lactational status were treated by percutaneous double catheter drains inserted under ultrasound guidance under the effect of local anaesthesia and evaluated for 3 months.Results: The resultant cosmetic effect was good, with no reported recurrence on 3 month follow-up.Conclusions: Double pigtail catheter drainage in appropriately selected cases of beast abscess has superior outcome in compare to published result of other technique for drainage of beast abscess specially in minimal scarring, early resolution of abscess cavity and decreases in the total duration of treatment.


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