Metronidazole and Alcoholism

1968 ◽  
Vol 114 (512) ◽  
pp. 859-861 ◽  
Author(s):  
Julius Merry ◽  
Arnold Whitehead
Keyword(s):  
Effective Treatment ◽  
Chronic Alcoholic ◽  
Epigastric Discomfort ◽  
Type Reaction ◽  
The Face ◽  
Alcoholic Drinks ◽  
Husband And Wife

Metronidazole (Flagyl) is an established and effective treatment of urogenital trichomoniasis. J. A. T. Taylor (1964) was using metronidazole to treat a husband and wife for this condition, when she observed the following. The husband, who was a chronic alcoholic, seemed to lose his craving for alcoholic drinks. Sometimes he experienced flushing of the face and shoulders and epigastric discomfort when he took metronidazole soon after alcohol, i.e. he experienced a disulfiram type reaction. The wife reported that alcohol drinks tasted unpleasant to her during therapy. Taylor then studied 53 alcoholic patients and concluded that metronidazole (i) decreased tolerance for alcohol, (ii) diminished craving for alcohol and (iii) produced an uncomfortable reaction to alcohol.

Thomas Vavasour M.D.

1991 ◽  
Vol 20 (4) ◽  
pp. 436-454 ◽  
Author(s):  
Richard Rex
Keyword(s):  
Long Period ◽  
The Face ◽  
Basic Documentation ◽  
Do So ◽  
Husband And Wife

The names of Dr. Thomas Vavasour and of his wife Dorothy are not uncommon in the chronicles of English Catholic recusancy and in related studies. The poignancy of their story—of a husband and wife practising their religion in the face of persecution and ending their lives in different prisons after a long period of enforced separation—and the relative richness of the relevant sources have together assured them at least a passing mention in such diverse works as Aveling’s studies of Yorkshire recusancy, Cliffe’s account of the Yorkshire gentry, and Claire Cross’ biography of Henry Hastings, third earl of Huntingdon. Although Thomas Vavasour has been described as ‘a very shadowy figure’, he and his wife are in fact among the best documented of the early lay recusants. It is all the more surprising, then, that no attempt has previously been made to bring together the disparate sources to give a reasonably full and coherent account of Thomas Vavasour’s career and family. This article aims to fill that gap. Its attempt to do so is greatly facilitated by the availability in print of much of the basic documentation.

scholarly journals Cutaneous and systemic plasmacytosis on the face: Effective treatment of a case using thalidomide

2016 ◽  
Vol 11 (3) ◽  
pp. 1923-1925 ◽  
Author(s):  
SHENG FANG ◽  
KUI SHAN ◽  
AI-JUN CHEN
Keyword(s):  
Effective Treatment ◽  
The Face

scholarly journals Future prospects in depression research

2006 ◽  
Vol 8 (2) ◽  
pp. 175-189
Keyword(s):  
Major Depression ◽  
Effective Treatment ◽  
Treatment Options ◽  
Future Prospects ◽  
Full Remission ◽  
Specific Focus ◽  
Treatment Of Depression ◽  
Increased Risk ◽  
The Face ◽  
Optimized Treatment

Major depression is a common, disabling, and often difficult-to-treat illness. Decades of research into the neurobiology and treatment of depression have greatly advanced our ability to manage this disorder. However, a number of challenges remain. A substantial number of depressed patients do not achieve full remission despite optimized treatment. For patients who do achieve resolution of symptoms, depression remains a highly recurrent illness, and repeated episodes are common. Finally, little is known about how depression might be prevented, especially in individuals at increased risk. In the face of these challenges, a number of exciting research efforts are currently under way and promise to greatly expand our knowledge of the etiology, pathophysiology, and treatment of depression. This review highlights these future prospects for depression research with a specific focus on lines of investigation likely to generate novel, more effective treatment options.

scholarly journals Concerns About the Special Article on Hydroxychloroquine and Azithromycin in High Risk Outpatients with COVID-19 by Dr. Harvey Risch

2020 ◽  
Author(s):  
Matthew P Fox ◽  
Lucy D'Agostino McGowan ◽  
Bryan D James ◽  
Justin Lessler ◽  
Shruti H Mehta ◽  
...  
Keyword(s):  
High Risk ◽  
Effective Treatment ◽  
Scientific Evidence ◽  
Scale Up ◽  
New Information ◽  
Open Debate ◽  
The Face ◽  
Risk Patients ◽  
The Many

Abstract In May, this journal published an opinion piece by one of the members of the Editorial Board, Dr. Harvey Risch, that reviewed several papers and argued that using hydroxychloroquine (HCQ) + azithromycin (AZ) early to treat symptomatic COVID-19 cases in high-risk patients should be broadly applied. As members of the journal's editorial board, we are strongly supportive of open debate in science, which is essential even on highly contentious issues. However, we must also be thorough in our examination of the facts and open to changing our minds when new information arises. In this commentary, we document several important errors in the manuscript by Dr. Risch, review the literature he presented and demonstrate why it is not of sufficient quality to support scale up of HCQ+AZ, and then discuss the literature that has been generated since his publication, which also does not support use of this therapy. Unfortunately, the current scientific evidence does not support HCQ+AZ as an effective treatment for COVID-19, if it ever did; and even suggests many risks. Continuing to push the view that it is an essential treatment in the face of this evidence is irresponsible and harmful to the many people already suffering from infection.

scholarly journals A neurobiological approach to the cognitive deficits of psychiatric disorders

2013 ◽  
Vol 15 (4) ◽  
pp. 419-429 ◽  
Keyword(s):  
Cognitive Function ◽  
Effective Treatment ◽  
Psychiatric Disorders ◽  
Cognitive Deficits ◽  
Cognitive Neuroscience ◽  
Brain Networks ◽  
Daily Lives ◽  
The Face ◽  
Regulatory Functions ◽  
Regulatory Problems

Deficits in brain networks that support cognitive regulatory functions are prevalent in many psychiatric disorders. Findings across neuropsychology and neuroimaging point to broad-based impairments that cross traditional diagnostic boundaries. These dysfunctions are largely separate from the classical symptoms of the disorders, and manifest in regulatory problems in both traditional cognitive and emotional domains. As such, they relate to the capacity of patients to engage effectively in their daily lives and activity, often persist even in the face of symptomatically effective treatment, and are poorly targeted by current treatments. Advances in cognitive neuroscience now allow us to ground an understanding of these cognitive regulatory deficits in the function and interaction of key brain networks. This emerging neurobiological understanding furthermore points to several promising routes for novel neuroscience-informed treatments targeted more specifically at improving cognitive function in a range of psychiatric disorders.

Pictorial Misrepresentation of Spatial Relations of the Face by Certain Chronic Alcoholic Men: An Interpretation Implicating Spatial Aspects of Memory

1983 ◽  
Vol 57 (3) ◽  
pp. 895-910 ◽  
Author(s):  
Anneliese A. Pontius
Keyword(s):  
Mental Representation ◽  
Spatial Relations ◽  
Chronic Alcoholism ◽  
Human Face ◽  
Frontal View ◽  
Chronic Alcoholic ◽  
Memory Processes ◽  
Parietal Lobes ◽  
The Face ◽  
The Brain

Specific deficit in the pictorial (and implied mental) representation of subtle spatial relations of the upper part of the pattern of the human face is demonstrated in 22% of 344 chronic alcoholic skid row men as against 12% of 406 controls, based on protocols for a novel Draw-A-Person-With-The-Face-In-Frontal-View Test This drawing was previously shown to be sensitive to the detection of ability to represent visually subtle yet elementary spatial relations. A speculative interpretation of the present data and of mnemonic techniques described in the literature suggests that accurate mental representation of these spatial relations may be required particularly during the encoding phase of memory processes which appears to be especially inefficient for those with chronic alcoholism. Aside from the brain systems of the frontal and occipital-parietal lobes, the hippocampal mediation of elementary spatial relations particularly may be implicated.

Liver Damage in Addictive Alcoholics

1959 ◽  
Vol 105 (440) ◽  
pp. 748-754 ◽  
Author(s):  
W. W. Kay ◽  
K. C. Murfitt ◽  
M. M. Glatt
Keyword(s):  
World Health ◽  
Hospital Treatment ◽  
Expert Committee ◽  
Relative Importance ◽  
Drinking Habits ◽  
The Face ◽  
Infective Hepatitis ◽  
Alcoholic Drinks ◽  
Health Organization ◽  
Eventual Death

Almost 125 years ago Addison (1836) suggested the existence of a causal relationship between alcoholism and cirrhosis of the liver and more than 100 years ago Rokitansky noted accumulation of fat as the earliest effect on the liver of over-indulgence in alcohol (cited from Connor, 1938). Though the relative importance of infective hepatitis and alcoholism as aetiological agents in liver cirrhosis may vary a great deal in different countries, “alcohol and infective hepatitis are at present the only two unequivocal aetiological factors” (Annotation,Brit. Med. J., 1957). It is usually accepted that over-indulgence in alcoholic drinks often produces liver dysfunction—maybe in an indirect manner—which though reversible at first, tends to become irreversible as over-indulgence is continued and prolonged (Leevy, Cunniff, Walton and Healey, 1954). The terminal phases are characterized by cirrhosis, hypertrophic at first and then contracted, with ascites and eventual death. When individuals whose drinking habits lead them to this state need hospital treatment, they seem to find their way into general hospitals rather than into mental hospitals. Among them may be alcoholics of the type described by a World Health Organization Expert Committee as “habitual symptomatic excessive drinkers” (W.H.O. Rep., 1952) or “non-addictive alcoholics”, and those excessive drinkers whose alcoholism manifests itself in their “inability to stop” continual daily drinking in the face of dangerous consequences (W.H.O. Rep., 1955).

scholarly journals Treatment of Superficial Cutaneous Vascular Lesions: Experience with the Long-Pulsed 1064 nm Nd:YAG Laser

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Kemal Ozyurt ◽  
Emine Colgecen ◽  
Halit Baykan ◽  
Perihan Ozturk ◽  
Mehmet Ozkose
Keyword(s):  
Effective Treatment ◽  
Nd:Yag Laser ◽  
Test Dose ◽  
Optimal Treatment ◽  
Vascular Lesions ◽  
Efficacy And Safety ◽  
Pulsed Nd:Yag Laser ◽  
The Face

Recent published studies evaluating the long-pulsed 1064 nm Nd:YAG laser for superficial cutaneous vascular lesions have limited subjects and optimal treatment parameters have not been established. To determine the efficacy and safety of the long-pulsed 1064 nm Nd:YAG laser on superficial cutaneus vascular lesions and analyse retrospectively our experience of a 3-year period are the aims of this study. Over the 3-year period, 255 patients were treated [189 female and 66 male; median age 35 (range 7–65) years; Fitzpatrick skin types II-V]. Twenty-six patients with spider angioma, 130 with facial telangiectasia, and 99 with leg telangiectasia were treated. A long-pulsed 1064 nm Nd:YAG laser was used. A test dose was performed at the initial consultation and thereafter patients were reviewed and treated at 4-week intervals for 5 months. Of those patients who completed treatment and followup, 26/26 (100%) of spider angiomas, 125/130 (97%) of facial telangiectasia, and 80/99 (80,8%) of leg telangiectasia markedly improved or cleared. We suggest that the long pulsed Nd:YAG laser is a safe and effective treatment for common superficial cutaneous vascular lesions. However, it is not the first choise to use to treat superficial vessels on the face where depth is not the concern.

scholarly journals The effects ofcombined diamond microdermabrasion and a mixture of cosmetic acids on the condition of acne prone skin: a case report

2021 ◽  
Vol 15 (SUPPLEMENT 2) ◽  
pp. 1-11
Author(s):  
Karolina Chilicka
Keyword(s):  
Case Report ◽  
Effective Treatment ◽  
Acne Vulgaris ◽  
Skin Lesions ◽  
Severity Scale ◽  
Entire Surface ◽  
The Face

Background: Exfoliating treatments are widely used in cosmetology and dermatology forthe treatment of skin lesions and, above all, toreduce the number of skin eruptions that occur with acne vulgaris. An effective treatment that can be offered to people suffering from this disease is diamond microdermabrasion. The addition of acid peeling to this treatment may lead to even better results than in the case of monotherapy. Aim of the study: To assess the effectiveness of a combination of microdermabrasion and acid peeling on a 21-year-old woman suffering from acne vulgaris. Case report: The patient suffered from acne vulgaris, too high a level of sebum on the entire surface of the face, and, over the course of the disease, developed open and closed blackheads and inflammatory pustules. The sebum level was measured with a DermaUnitSCC3 device and the number of skin eruptions was determined using the global acne severity scale (GAGS). Conclusion: The series of cosmetological treatments led to a reduction in the sebum on the surface of the epidermis and the number of skin eruptions.

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