Life Events and Mania

1987 ◽  
Vol 150 (2) ◽  
pp. 235-240 ◽  
Author(s):  
A. Ambelas

Fifty patients in their first manic episode were compared retrospectively with groups of (a) manic patients in other than first admissions and (b) acute surgical cases. They were then followed up for 3–8 years. First manic admissions were linked to life events far more frequently – 66%vs20% and 8% respectively for the other groups. Within-group comparisons showed patients with life events were much younger. The link between life events and manic episodes appeared immediate and selective, a view further supported by the findings of the follow-up. Later episodes precipitated by life events seem to require smaller amounts of stress. The possible role of life events in relation to mania is discussed.

2020 ◽  
Author(s):  
Adnan Kabaalioglu ◽  
Nesrin Gunduz ◽  
Ayse Keven ◽  
Emel Durmaz ◽  
Mine Aslan ◽  
...  

Kidney cysts are quite common in adults. Though small simple renal cysts in an adult over 30-40 years of age are not too unusual, however, if the same cysts are seen in a child, and especially if there are additional findings, then several diagnostic possibilities may come to mind. The role of ultrasound, together with the help of intravenous contrast agents and Doppler mode, are very critical in describing the morphologic features and follow-up of the complex or multiple and bilateral renal cysts. These sonographic signs are occasionally specific for diagnosis, but in many cases sonographic clues should be evaluated together with the other genetic and clinical data to reach diagnosis.The first part of this pictorial essay included the introduction into the subject and the classification of non-genetic cystic renal diseases. The key features for the non-genetic cystic renal diseases are illustrated. In the second part, eye-catching features of genetic cystic renal diseases are demonstrated.


2010 ◽  
Vol 8 (1) ◽  
pp. 71 ◽  
Author(s):  
Ester Villalonga-Olives ◽  
Sonia Rojas-Farreras ◽  
Gemma Vilagut ◽  
Jorge A Palacio-Vieira ◽  
José Valderas ◽  
...  

2019 ◽  
Vol 8 (1) ◽  
pp. 10-16
Author(s):  
Nafisa Huq ◽  
Tarzia Choudhury ◽  
Samia Aziz ◽  
SM Yasir Arafat ◽  
M Omar Rahman

Depression is the leading cause of disability worldwide. However, it is under recognized and undertreated. Self-rated health is a one-item question that has been used for population health monitoring. It was aimed to examine the prospect of using ‘self-rated health’ (SRH) in identifying people with depression among adult community-based population in Bangladesh over a one-year period controlling for socio-demographic, chronic diseases and symptoms, physical disability, smoking, and life events. We examined data from 3455 participants aged 18 years and above who participated in the 2015 January and 2016 January Health and Socio-Economic Survey of Independent University, Bangladesh. Using multiple logistic regressions, depression at baseline was examined to predict self-rated health at one-year follow-up adjusting for socio-demographic variables, chronic diseases, risk behaviors, and life events. Respondents with depression at baseline had 35% higher odds of reporting poor SRH in the follow-up round compared to those with no depression (OR=1.35, 95% CI=1.03 1.78, P<0.03). SRH may be used by community health workers as a preliminary indicator to identify people who may have depression followed by further screening and management for depression. South East Asia Journal of Public Health Vol.8(1) 2018: 10-16


2020 ◽  
Author(s):  
Reout Arbel ◽  
Marlyn Khouri ◽  
Jasmine Sagi ◽  
Noga Cohen

The COVID-19 outbreak has forced individuals to adjust to a new order in which their liberties are restricted and uncertainty rules. The current work examined the role of other-focusedemotion regulation (ER) training in enhancing coping efficacy and reducing COVID-19 worries. For that, during the first COVID-19 lockdown in Israel, we trained 59 young individuals to perform other-focused emotion regulation, by reappraising others’ written upsetting events. We compared this procedure to a self-reappraisal training, in which 49 participants were asked to reappraise own upsetting events. Both procedures were performed every other day for three weeks. Participants’ coping efficacy was assessed at the daily level, while worries concerning theCOVID-19 effects on health, economic status, and social life were assessed following the training and at a two-month follow-up. The results demonstrated that other-focused ER surpassed self-focused ER. Specifically, participants in the other-reappraisal group exhibited an increase in coping efficacy across the training sessions and a reduction in COVID-19 worries that persisted two months after the training. These findings highlight the role of interpersonal emotion regulation at times of crisis and social isolation.


2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e21086-e21086
Author(s):  
Lucia Teijeira ◽  
Antonio Viudez ◽  
Maria L Antelo ◽  
Antonio Tarifa ◽  
Cruz Zazpe ◽  
...  

e21086 Background: Kinetic behavior of perioperative CTCs in pts with liver CRC M has been little explored. The aim of this study was to quantified CTCs performance before/just performed and 3 months after radical liver surgery (LS) in pts with CRC M and analyzed the surrogate role of CTCs determinations in DFS and OS. Methods: 7.5 ml of blood were drawn in CellSave tubes. CTCs were isolated and enumerated before/just perfomed and 3 months after radical LS. CTCs were immunomagnetically separated and fluorescently labeled using the CellSearch System (Veridex®/Immunicon Corp.) Results: From February 2009 to December 2011, 35 pts were included. Median age was 61 (45-77); 53.7 % men. Kras status: 66.7% wild-type and 33.3% mutated; 48.6% with synchronous disease. Fong-Criteria (FC) distribution: 31.4% pts with 1 FC, 37.1% pts with 2 FC and 31.4% pts with 3 FC, of whom 60% received neoadjuvant (90% fluoropirimidines-based; 33.3% cetuximab-based; 38% bevacizumab-based) and 77.1% adjuvant treatment. PR and SD were observed in 60% and 40% of pts, respectively. In 70.7% of cases, limited LS were done (68.3% R0, median metastases resected:3) Of the 17 pts analysed, pCR were observed in 2 (12%) with 7 other pts (41%) with major pathological response. With a median of follow-up of 20 months (media 21.3; 95% CI:17.3-41.4) progression disease occurred in 13 pts (55.6% with liver progression), and 5 pts died. Median CTCs was 1 before (0-2: 76%; ≥3: 24%) and just performed surgery (0-2: 65%; ³3: 35%) and 0 in the 3 months determination (0-2: 94.1%; ³3: 5.9%). In the presurgery analysis, DFS was 15 months for the CTCs ≥3 group and 33 months for <3 CTCs (HR: 0.95; 95% CI:0.34-2.64) while in the postsurgery analysis, DFS was 13 months in CTCs ≥3 group and 33 months for <3 CTCs (HR: 1.11; 95% CI:0.37-3.29) CTCs ≥3 group after surgery, OS was 33 months, not having reached in the other groups. Conclusions: There is a marked difference in DFS in favor of pts with CTCs levels 0-2 before and just performed surgery. Our study shows a slight increase in CTCs quantification after LS, instead a significant CTCs decrease was observed after adjuvant therapy. Role of radical LS in kinetic of CTCs should continue to be analysed in future studies.


1987 ◽  
Vol 17 (1) ◽  
pp. 191-201 ◽  
Author(s):  
Hillevi Aro

SynopsisSchool children (N = 2013) completed questionnaires in class on three occasions over a period of 17 months. Life stress data for 12 months were gathered retrospectively in the last questionnaire. Life events and interpersonal problems were associated with psychosomatic symptoms. In terms of change in symptoms, the impact of life events and interpersonal problems was demonstrated in boys but not in girls. Though boys with a history of no events or problems had lower symptom scores than girls, boys with a history of many events or problems caught up with the girls by the end of the follow-up period. On the other hand, symptom differences related to life stress scores were already apparent at the beginning of the study, and these differences were greater in girls than in boys.


Neurosurgery ◽  
2017 ◽  
Vol 82 (4) ◽  
pp. 465-472 ◽  
Author(s):  
Luca Massimi ◽  
Domenica Battaglia ◽  
Federico Bianchi ◽  
Simone Peraio ◽  
Elisabetta Peppucci ◽  
...  

Abstract BACKGROUND Postoperative seizures (PSs) after neurosurgical operations are common but little is known about the role of surgical brain incision on their genesis. This topic has not been addressed so far. OBJECTIVE To verify if the corticotomy affects the risk of PSs and postoperative epilepsy (PE) in children. METHODS One hundred forty-three consecutive pediatric cases operated on for supratentorial lesions at the same institution in the last 15 yr have been retrospectively reviewed by dividing them into group A, 68 children who required brain corticotomy mainly for hemispheric tumors, and group B, 75 children treated through extracortical approaches mainly for suprasellar and optic tumors. Patients with possible “epileptic” biases, like preoperative seizures, were excluded. RESULTS No significant differences have been found between group A and B as far as incidence of PSs (11.7% vs 14.5%) and PE (4.5% vs 6.5%), timing, and type of seizures are concerned after a mean 6.8 yr follow-up. The size of corticotomy in group A (&lt;3 cm2 vs &gt;3 cm2) had no impact on epileptogenesis as well as the other variables considered in both groups (age, sex, extent of lesion resection). CONCLUSION This study shows that the surgical cortical “trauma” would not represent a risk factor for PSs and PE. According to the present analysis and the literature, other causes seem to be involved (namely, electrolytic imbalance and brain gliosis). This information is important for preoperative surgical planning and postoperative management. A validation by both adult series and prospective studies is needed.


2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e18054-e18054
Author(s):  
S.P. Somashekhar ◽  
Rohit Kumar C. ◽  
Ashwin K. Rajgopal ◽  
Ramya Yethadka ◽  
Shabber Zaveri ◽  
...  

e18054 Background: Our study aims to describe role of CRS & HIPEC in stage IIIC epithelial ovarian malignancy & compare the oncological outcome (DFS & OS) of extensive CRS+ HIPEC in comparison with CRS & IV chemotherapy & CRS + IP chemotherapy. Methods: Patients diagnosed of stage IIIc EOC underwent extensive CRS + HIPEC. All data prospectively entered in the HIPEC registry was analysed. Outcome of CRS & IV group (n = 50), CRS + IP group (n = 60) operated around same period was compared with the CRS & HIPEC group. Results: Out of 135 patients, upfront, interval and secondary cytoreduction plus HIPEC was done in 29.6%, 44.4% & 25.9% & mean PCI was 14.1, 9.6 & 13.0 respectively. Multi-visceral resection, diaphragmatic resection & bowel resection was required in 12.7%, 50% & 41.8% respectively. Overall G3- G5 morbidity was seen in 25.4% with major being electrolyte imbalance 16.3%, hematological 12.7% & surgical 11.8%. Mean ICU & hospital stay 1.5 & 11 days respectively. Overall 30 day mortality was 4.5%. With a median follow up of 42 months DFS was 30, 33 & 16 months and OS was 70%, 67% & 51% at 4 year for upfront, interval and the recurrent settings respectively. Detailed description presented in Table. Most of the recurrences in CRS & IV group were in peritoneum whereas the other two groups had lesser peritoneal & systemic recurrence. Conclusions: Optimal cytoreduction & some form of IP therapy is needed to improve outcomes. CRS+ HIPEC is feasible in all groups of ovarian cancer with acceptable morbidity & mortality. However the role of single HIPEC in comparison to 6 cycles of IP chemotherapy needs to be evaluated with a well-designed multi-institutional randomised study. [Table: see text]


Neurosurgery ◽  
2019 ◽  
Vol 66 (Supplement_1) ◽  
Author(s):  
Jeffrey Pollock ◽  
Donald A Ross ◽  
Jung U Yoo ◽  
Ningcheng P Li

Abstract INTRODUCTION In light of a recent award-winning publication questioning the effectiveness of polyetheretherketone (PEEK) interbody devices in anterior cervical arthrodesis when compared to allograft and our own published good experience with such devices, we were skeptical of the results reported. It was our hypothesis that it was the fusion adjunct placed within the PEEK device that resulted in widely disparate likelihood of an arthrodesis, rather than an intrinsic failure of the PEEK device. METHODS We retrospectively reviewed the results of 2 surgeons using an identical PEEK interbody device for anterior cervical arthrodesis, one using demineralized bone matrix (DBM) within the lumen of the device, and the other local autograft bone. Arthrodesis was determined independently by a surgeon and 2 blinded neuroradiologists. RESULTS We reviewed 122 patients with DBM and 97 with local autograft bone within the PEEK devices. Ages (mean 60 and 61 yr), smoking status (43% and 32%), diabetes mellitus (18% and 28%), mean body mass index (31 and 30), and immunosuppressive status were determined for all patients. Follow-up for each group averaged 19 and 18 mo. A radiographic arthrodesis was seen in 22% of the patients with DBM and 76% of the patients with local autograft. Refusion at the index level was required in 5% of the DBM and 0% of the autograft patients. CONCLUSION A PEEK interbody device filled with local autograft resulted in a higher radiographic fusion rate and a lower need for reoperation at the index level than an identical device filled with DBM. Caution is warranted in assigning fusion failure to the PEEK device alone in anterior cervical discectomy and fusion surgery.


2020 ◽  
Author(s):  
Adnan Kabaalioglu ◽  
Nesrin Gunduz ◽  
Ayse Keven ◽  
Emel Durmaz ◽  
Mine Aslan ◽  
...  

Kidney cysts are quite common in adults.  Though small simple renal cysts in an adult over 30-40 years of age are not too unusual, however, if the same cysts are seen in a child, and especially if there are additional findings, then several diagnostic possibilities may come to mind. The role of ultrasound, together with the help of intravenous contrast agents and Doppler mode, is very critical in describing the morphologic features and follow-up of the complex or multiple and bilateral renal cysts. Sonographic signs are occasionally specific for diagnosis, but in many cases they should be evaluated together with the other genetic and clinical data to reach a diagnosis.The first part of this pictorial essay includes “non-genetic cystic renal diseases” and the second part will include “genetic cystic renal diseases”.


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