The Thyroid Gland in Bodily and Mental Disease. An Address with Lantern Demonstration

1924 ◽  
Vol 70 (291) ◽  
pp. 519-528 ◽  
Author(s):  
Frederick Mott

The subject which I intend to bring before you to-day mainly relates to the thyroid gland, a part of endocrinology I have been interested in for some time past.

1901 ◽  
Vol 47 (199) ◽  
pp. 729-737 ◽  
Author(s):  
Joseph Shaw Bolton

This demonstration was a further report on the subject laid before the Association at the meeting at Claybury in February last, viz., the morbid changes occurring in the brain and other intra-cranial contents in amentia and dementia. In a paper read before the Royal Society in the spring of 1900, and subsequently published in the Philosophical Transactions, it was stated, as the result of a systematic micrometric examination of the visuo-sensory (primary visual) and visuo-psychic (lower associational) regions of the cerebral cortex, that the depth of the pyramidal layer of nerve-cells varies with the amentia or dementia existing in the patient. At the meeting of the Association referred to it was further shown, from an analysis, clinical and pathological, of 121 cases of insanity which appeared consecutively in the post-mortem room at Claybury, that the morbid conditions inside the skull-cap in insanity, viz., abnormalities in the dura mater, the pia arachnoid, the ependyma and intra-cranial fluid, etc., are the accompaniments of and vary in degree with dementia alone, and are independent of the duration of the mental disease. Since that date the pre-frontal (higher associational) region has been systematically examined in nineteen cases, viz., normal persons and normal aments (infants), and cases of amentia, of chronic and recurrent insanity without appreciable dementia, and of dementia, and the results obtained form the subject of the present demonstration. A paper on the whole subject will shortly be published in the Archives of the Claybury Laboratory.


1888 ◽  
Vol 34 (147) ◽  
pp. 383-393
Author(s):  
Campbell Clark

In undertaking to introduce a discussion on this very large and important question, I am conscious of my inability to do it justice. No one can possibly cover the wide range of subjects comprised in it; and I am anxious rather to elicit the convictions of more experienced men than to obtrude my own crude and imperfect ideas. My purpose is, therefore, to state the case as briefly as possible, and to introduce questions for discussion in preference to merely ventilating my own ideas. In this way we may arrive at some common points of agreement and materially advance our knowledge of the subject. There can be no two opinions as to the advantage of bringing to a focus the collective experience and conclusions of the various sections of our profession interested in this field of research, and the present opportunity is a particularly good one. The title of the discussion embraces a great deal, and yet does not strictly include topics which might be considered relevant, particularly therapeutics. My aim at the outset will be to invite your special attention to a few questions only, and in order to make the most of our time and concentrate the discussion as much as possible I propose to take each division separately. The subject, viewed as a whole, is so far-reaching and practical as to possess uncommon interest, for it links together medicine and psychological medicine, it gives an open field of discussion to general medicine, obstetrics, and psychology, and it views insanity on its less speculative side, because the more materialistic functions are brought out in strong relief, and sometimes even overshadow the characters of mental disease.


1902 ◽  
Vol 48 (202) ◽  
pp. 434-450 ◽  
Author(s):  
T. S. Clouston

Dr. Clouston said that when he suggested toxæmia to the secretary as a suitable subject for a discussion at this meeting he had not intended to be the first speaker, because his object was to bring out more fully the views of the younger members who had recently committed themselves so strongly to the toxæmic and bacterial etiology of insanity, and so to get light thrown on some of the difficulties which he and others had felt in applying this theory to many of their cases in practice. It was not that he did not believe in the toxic theory as explaining the onset of many cases, or that he under-rated its importance, but that he could not see how it applied so universally or generally as some of the modern pathological school were now inclined to insist on. He knew that it was difficult for those of the older psychological and clinical school to approach the subject with that full knowledge of recent bacteriological and pathological doctrine which the younger men possessed, or to breathe that all-pervading pathological atmosphere which they seemed to inhale. He desired to conduct this discussion in an absolutely non-controversial and purely scientific spirit. To do so he thought it best to put his facts, objections, and difficulties in a series of propositions which could be answered and explained by the other side. He thought it important to define toxæmia, but should be willing to accept Dr. Ford Robertson's definition of toxines, viz., “Substances which are taken up by the (cortical nerve) cell and then disorder its metabolism.” He took the following extracts from his address at the Cheltenham meeting of the British Association (1) as representing Dr. Ford Robertson's views and the general trend of much investigation and hypothesis on the Continent.


1990 ◽  
Vol 14 (11) ◽  
pp. 663-665
Author(s):  
Bruce G. Charlton

Within psychiatry there are two distinct tendencies. On the one hand there is the tendency for the subject to expand beyond its concern with psychological medicine and encroach upon diverse aspects of society. “The psychiatrist who believes that the phenomena of mental illness can be explained on the basis of a universal theory … finds little difficulty in inflating his theory to explain not only mental disease but also normal human behaviour, interpersonal relations, and ultimately human affairs” (Miller, 1970)


1930 ◽  
Vol 76 (315) ◽  
pp. 632-640 ◽  
Author(s):  
Alexander George Gibson

Mental change in cardiac disease, though a rare complication, is a subject that can be properly and usefully discussed at a meeting of psychiatrists at which physicians are asked to take part. For while the physician may be able to assess accurately the physical defect in the circulatory apparatus, he is trained only in a rough-and-ready way to interpret different types of character, and the way in which they react to disease, and is liable to go astray in his interpretation of mental states. There is also this advantage—that in the present state of uncertainty as to the physical basis of mental disease we cannot look at the subject from too many points of view.


1895 ◽  
Vol 41 (175) ◽  
pp. 622-635
Author(s):  
W. F. Robertson

There is at the present time great need of more complete and definite knowledge as to the pathology of the very marked structural changes that so commonly affect the pia-arachnoid in the insane. The subject is one of much importance to all of us as medical psychologists, for not only is the condition in question one of the most conspicuous lesions associated with mental disease, but it implicates a structure of primary importance in the economy of the central nervous system. It is by way of vessels that course through this membrane that nutriment is conveyed to the brain cortex, and the waste products resulting from metabolism in the cerebral tissues are mainly conveyed away in the fluid that circulates in its lymph spaces. Therefore it is evident that these morbid changes may very seriously interfere with the functions both of nutrition and excretion in the brain.


Author(s):  
Ю. Кураченко ◽  
Yu. Kurachenko ◽  
Н. Санжарова ◽  
N. Sanzharova ◽  
Г. Козьмин ◽  
...  

Purpose: This work aims first to improve the reliability of absorbed dose calculation in critical organs of cattle during internal irradiation immediately after radiation accidents by a) improving the compartmental model of radionuclide metabolism in animal body; b) the use of precision computing technologies for modeling as the domain, and the actual radiation transport. In addition, the aim of the work is to determine the agreed values of the 131I critical dose in the cattle thyroid, leading to serious gland dysfunction and its follow-up destruction. Material and methods: To achieve aforecited goals, comprehensive studies were carried out to specify the parameters of the compartmental model, based on reliable experimental and theoretical data. Voxel technologies were applied for modeling the subject domain (thyroid gland and its environment). Finally, to solve the 131I radiation transport equation, the Monte Carlo code was applied, which takes into account the contribution of gamma and beta radiation source, and the contribution of the entire chain of secondary radiations in the dose calculation, up to the total energy dissipation. Results: As the main theoretical result, it is necessary to emphasize the conversion factor from the 131I activity, distributed uniformly in volume of the thyroid gland, to the average dose rate in the gland (Bq × Gy/s). This factor was calculated for both cows and calves in the selected domain configuration and thyroid morphology. The main practical result is a reliable estimation the lower bound of the absorbed dose in the thyroid, which in a short time leads to its destruction under internal 131I irradiation: ~300 Gy. Conclusion: Usage a compartmental model of the 131I metabolism with biokinetic parameters, received on the basis of reliable experimental data, and precise models of both the subject area and radiation transport for evaluation the dose in the cattle thyroid after the radiation accident allowed to obtain reliable values of the thyroid dose, adducting to its destruction at short notice.


1866 ◽  
Vol 12 (59) ◽  
pp. 348-367
Author(s):  
Franz Meschede ◽  
G. F. Blandford

The disorder commonly called “general paralysis of the insane” presents so many points of interest to the pathologist and the physician, that as a necessary consequence it forms the commonest topic among the writings of those who specially study insanity. But after so much observation and so many treatises, it is disheartening to find that even now scarcely more than one fact with regard to it is laid down as settled and established beyond the possibility of doubt. One there is, the saddest that can be. It is, that for this malady we hitherto have found no cure; that to diagnose it is to pronounce the sentence, not only of incurable insanity, but also of speedy death. The marvel of the whole is, that although death occurs in every case at no very distant period, though postmortem examinations of general paralytics are made by hundreds every year in this and other countries, yet even at this day no two observers are agreed as to the pathology and morbid anatomy, as to the part in which it has its origin, or which constitutes its peculiar and proper seat. No wonder that the whole of the morbid anatomy of insane brain is vague and ill-defined, when this, the specially fatal form of mental disease, still hides itself from usâ still wraps itself in the mystery which envelopes all that relates to mind. I make no apology for drawing the attention of the readers of this Journal to a paper on the subject, published in the October and November numbers of ‘ Virchow's Archives/ 1865, and for giving a short and necessarily imperfect summary of its contents, it being too long for reproduction. But as every outline must needs be unsatisfactory, I trust my readers will go themselves to the original. In default of opportunity of examining many brains of paralytic patients, I present as a contribution to the English treatises on the subject these observations of another.


1881 ◽  
Vol 27 (118) ◽  
pp. 147-155 ◽  
Author(s):  
Geo. H. Savage

The subject of moral insanity has already been considered from several points of view, but I think that when typical cases occur it is well to record them, so that, by a careful examination of published cases, more general information may be obtained concerning this malady. It may seem to the philosopher rather a mistaken way of considering the mind to divide it into intellectual and moral, but we in asylums have constantly to take notice of cases in which the moral side of the patient suffers very much more than the intellectual; and though I should not deem any person capable of being intellectually complete and yet morally defective, I would maintain that the defect on the intellectual side may be so little appreciated, or of so little importance in reference to the individual's relationships with the outer world, that it may be disregarded. In considering the cases at present under notice we shall have to point out that most of them have undoubtedly some defect or excess, if I may use the term, in their intellectual processes. When I say excess I refer to the presence of hallucinations and false perceptions that frequently occur in such cases. In attempting to define moral insanity it is easier to describe what it is not than to come to a comprehensive definition which will include all the cases falling into this group, and no others; and, by way of clearing up the condition, I would say that I look upon the moral relationships, so called, of the individual, as among the highest of his mental possessions, that long after the evolution of the mere organic lower parts, the moral side of man developed; that the recognition of property and of right in property developed with the appreciation of the value of human life, so that the control of one's passions, and of one's desires for possession, and of one's passion for power developed quite late in man, and, as might be expected, the last and highest acquisitions are those which are lost most readily. It is frequently noticed that in cases in which slow progressive nervous change takes place the moral relationships are the first, or among the first, to be affected; and in the same way after an intellectual storm it is no uncommon thing to see the intellect partly restored to its normal equilibrium, but still wanting the highest and most humane of its attributes—high moral control; so in the emotional states of acute mania, of general paralysis, or of chronic insanity we have corresponding defects in this highest intellectual control. From this point we shall have to notice moral insanity, it being in many cases a state or stage of mental disease, and not a fixed or permanent condition itself; so that in very many, if not in all, acute cases of insanity there is a period of moral perversion, just as in nearly all such cases there is a period of mental depression. I hardly think it worth my while to make very elaborate distinctions between the varieties of moral insanity. I would take it for granted that all admit what I have already said—that there is a condition in which the moral nature or the moral side of the character is affected greatly in excess of the intellectual side—and I will take the opportunity in this paper of discussing in detail a few of such cases, leaving for myself at another time, or for others, the consideration of cases bearing on the other parts of the subject. I should say that the cases of moral insanity are best considered under the heads of “primary” or “secondary,” and when speaking of “primary” I would refer to those cases which, from the first development, have some peculiarity or eccentricity of character exhibited purely on their social side. Such cases may be divided into the morally eccentric and the truly insane. The eccentric person who neglects his relationship to his fellow men and to the society and social position into which he was born must be looked upon as morally insane. Other cases seem from infancy prone to wickedness, and I would most emphatically state my belief that very many so-called spoiled children are nothing more nor less than children who are morally of unsound mind, and that the spoiled child owes quite as much to his inheritance as to his education. In many cases, doubtless, the parent who begets a nervous child is very likely to further spoil such child by bad or unsuitable education. In considering these latter cases—those that from childhood show some peculiarity of temper and character—it is all-important to remember that inheritance of neurosis plays a very prominent part indeed—that, in fact, the inheritance of neurosis may mean that the children are naturally unstable and unfitted to control their lower natures; that they come into the world unfitted to suit themselves to their surroundings; and, but for the conventional states of society, would soon lose their places and become exterminated. We shall, later, consider cases of this kind more in detail, but I would state before leaving the subject of primary moral insanity as seen in children, that I have seen a state of this kind occur in children of parents who have suffered from some febrile disease, or some constitutional disease like syphilis, before the begetting of the morally insane child, and I have no doubt that more will be discovered in time as to the relationship between the health of the parent at the time of the begetting and the moral state of the offspring.


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