scholarly journals Affective neuroscience and psychiatry

2007 ◽  
Vol 191 (3) ◽  
pp. 192-194 ◽  
Author(s):  
Neil A. Harrison ◽  
Hugo D. Critchley
Keyword(s):  
Conceptual Framework ◽  
Mood Disorders ◽  
Social Behaviour ◽  
Neural Control ◽  
Affective Neuroscience ◽  
Therapeutic Approaches ◽  
Current Therapies ◽  
Emotional Behaviour ◽  
The Brain ◽  
Novel Therapeutic

SummaryAffective neuroscience addresses the brain mechanisms underlying emotional behaviour. In psychiatry, affective neuroscience finds application not only in understanding the neurobiology of mood disorders, but also by providing a framework for understanding the neural control of interpersonal and social behaviour and processes that underlie psychopathology. By providing a coherent conceptual framework, affective neuroscience is increasingly able to provide a mechanistic explanatory understanding of current therapies and is driving the development of novel therapeutic approaches.

scholarly journals Cognitive and affective neuroscience of chronic pain: relevance for Physiotherapy

2018 ◽  
Vol 8 (1) ◽  
pp. 131-137
Author(s):  
Pedro Montoya
Keyword(s):  
Chronic Pain ◽  
Emotional Regulation ◽  
Behavioral Therapy ◽  
Emotional States ◽  
Affective Neuroscience ◽  
Literature Study ◽  
Regulatory Processes ◽  
Current Therapies ◽  
World Center ◽  
The Brain

Background: Chronic pain is the main reason for medical consultation, as well as one of the main burdens of the health system in the developed world. However, current therapies are still inadequate for certain types of chronic pain, as in the case of fibromyalgia syndrome, or cause intolerable side effects (such as opioids). Understanding the neurophysiological and psychobiological bases of chronic pain is crucial to develop adequate and efficient strategies for the multidisciplinary evaluation and treatment of pain. Objective: The aim of this work is to provide a brief summary of the current state of the art to clarify the most effective strategies for the treatment of chronic pain. Methods: Narrative literature study developed in a reference world center to study of chronic pain. Results: In the last decades, it has been demonstrated that the plastic changes that occur in the brain are key for understanding the maintenance of pain over time. Research has provided evidence that patients with chronic pain displayed abnormal brain processing of body information and that negative emotional states can significantly alter brain functioning and amplify the suffering associated with pain. On the other hand, it has been suggested that strengthening emotional regulation skills through cognitive reassessment and suppression as used in cognitive-behavioral therapy or mindfulness can help regulate pain and emotion in patients with chronic pain. However, the brain mechanisms involved in these regulatory processes must still be elucidated, before being transferred to clinical practice. Conclusion: Cognitive and affective neuroscience is fundamental to physiotherapists understanding chronic pain.

scholarly journals A molecular approach to Glioblastoma Multiforme

2016 ◽  
Vol 1 (1) ◽  
pp. 35
Author(s):  
Amit Verma ◽  
Swetha Gunasekar ◽  
Vineeta Goel ◽  
Randeep Singh ◽  
Ramandeep Singh Arora ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Poor Prognosis ◽  
Molecular Profiling ◽  
Molecular Approach ◽  
Genomic Information ◽  
Therapeutic Approaches ◽  
Detailed Understanding ◽  
The Central Nervous System ◽  
The Brain ◽  
Novel Therapeutic

<p>Glioma is a tumor of the central nervous system that occurs in the glial cells, Which it surrounds and protects the nerve cells. Glioblastoma Multiforme (GBM) is the most common and malignant sub-type of gliomas that arises from star-shaped cells called “astrocytes”, which constitute the supportive tissue of the brain. GBM are known to be heterogeneous in outcome with majority having a poor prognosis, thus there is an urgent need for novel therapeutic approaches. The detailed understanding of GBM is established by the combination of histopathology and genomic information of the tumor that aids in the best choice of Personalized Medicine. In this article, seven GBM patients are discussed who underwent tissue diagnosis as well as tumor molecular profiling; the significance of the genes and associated mutations/variations picked up in each individual.</p>

scholarly journals CD99 antibody disrupts T-cell acute lymphoblastic leukemia adhesion to meningeal cells and attenuates chemoresistance

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maryam Ebadi ◽  
Leslie M. Jonart ◽  
Jason Ostergaard ◽  
Peter M. Gordon
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Transmembrane Protein ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Therapeutic Approaches ◽  
Meningeal Cells ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Brain And Spinal Cord ◽  
The Brain ◽  
Novel Therapeutic

AbstractCentral nervous system (CNS) relapse is a significant cause of treatment failure among patients with acute lymphoblastic leukemia. In prior work we found that the meninges, the thin layer of tissue that covers the brain and spinal cord, harbor leukemia cells in the CNS. Importantly, direct interactions between leukemia and meningeal cells enabled leukemia chemoresistance. Herein, we show that an antibody targeting CD99, a transmembrane protein expressed on meningeal cells and many leukemia cells, disrupts adhesion between leukemia and meningeal cells and restores sensitivity of the leukemia cells to chemotherapy. This work identifies a mechanism regulating critical intercellular interactions within the CNS leukemia niche and may lead to novel therapeutic approaches for overcoming niche-mediated chemoresistance.

Lessons From the Neural Bases of Speech and Voice

2011 ◽  
Vol 21 (1) ◽  
pp. 5-14
Author(s):  
Christy L. Ludlow
Keyword(s):  
Brain Networks ◽  
Neural Substrates ◽  
Voice Behavior ◽  
Therapeutic Approaches ◽  
Neural Bases ◽  
Sound Foundation ◽  
The Brain ◽  
Normal Speech

The premise of this article is that increased understanding of the brain bases for normal speech and voice behavior will provide a sound foundation for developing therapeutic approaches to establish or re-establish these functions. The neural substrates involved in speech/voice behaviors, the types of muscle patterning for speech and voice, the brain networks involved and their regulation, and how they can be externally modulated for improving function will be addressed.

Adipocytes-released Peptides Involved in the Control of Gastrointestinal Motility

2019 ◽  
Vol 20 (6) ◽  
pp. 614-629 ◽  
Author(s):  
Eglantina Idrizaj ◽  
Rachele Garella ◽  
Roberta Squecco ◽  
Maria Caterina Baccari
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adipose Tissue ◽  
Gastrointestinal Motility ◽  
Diagnostic Tools ◽  
Therapeutic Approaches ◽  
Motor Responses ◽  
Gastrointestinal Motor ◽  
Treatment Of Obesity ◽  
Novel Therapeutic

The present review focuses on adipocytes-released peptides known to be involved in the control of gastrointestinal motility, acting both centrally and peripherally. Thus, four peptides have been taken into account: leptin, adiponectin, nesfatin-1, and apelin. The discussion of the related physiological or pathophysiological roles, based on the most recent findings, is intended to underlie the close interactions among adipose tissue, central nervous system, and gastrointestinal tract. The better understanding of this complex network, as gastrointestinal motor responses represent peripheral signals involved in the regulation of food intake through the gut-brain axis, may also furnish a cue for the development of either novel therapeutic approaches in the treatment of obesity and eating disorders or potential diagnostic tools.

Reflex Epilepsy with Hot Water: Clinical and EEG Findings, Treatment, and Prognosis in Childhood

2020 ◽  
Vol 51 (05) ◽  
pp. 336-340 ◽  
Author(s):  
Fatma Hanci ◽  
Sevim Türay ◽  
Paşa Balci ◽  
Nimet Kabakuş
Keyword(s):  
Seizure Control ◽  
Hot Water ◽  
Reflex Epilepsy ◽  
Therapeutic Approaches ◽  
Water Age ◽  
Epileptiform Discharges ◽  
Neurology Clinic ◽  
Neuromuscular Development ◽  
The Brain ◽  
International League

AbstractHot water epilepsy (HWE) is a subtype of reflex epilepsy in which seizures are triggered by the head being immersed in hot water. Hot water or bathing epilepsy is the type of reflex epilepsy most frequently encountered in our clinic. We describe our patients with HWE and also discuss the clinical features, therapeutic approaches, and prognosis. Eleven patients (10 boys, 1 girl), aged 12 months to 13 years, admitted to the pediatric neurology clinic between January 2018 and August 2019, and diagnosed with HWE or bathing epilepsy based on International League Against Epilepsy (ILAE)-2017, were followed up prospectively for ∼18 months. Patients' clinical and electroencephalography (EEG) findings and treatment details were noted. All 11 patients' seizures were triggered by hot water. Age at first seizure was between 2 months and 12 years. Seizure types were generalized motor seizures, absence, and atonic. EEG was normal in two patients, but nine patients had epileptiform discharges. Magnetic resonance imaging of the brain was performed and reported as normal (except in one case). Histories of prematurity were present in two patients, unprovoked seizures in one, and low birth weight and depressed birth in the other. Patients with HWE have normal neuromuscular development and neurological examination results, together with prophylaxis or seizure control with a single antiepileptic drug, suggesting that it is a self-limited reflex epilepsy.

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