Incidence trends for human papillomavirus-related (HPV-R) and unrelated (HPV-U) head and neck squamous cell carcinomas (HNSCC) in the United States (US)

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 6001-6001 ◽  
Author(s):  
A. Chaturvedi ◽  
E. Engels ◽  
W. Anderson ◽  
M. Gillison
Keyword(s):  
The United States ◽  
Underlying Disease ◽  
Birth Cohorts ◽  
Anatomic Site ◽  
Annual Percent Change ◽  
Absolute Increase ◽  
Incidence Trends ◽  
The Us ◽  
Smoking Behaviors ◽  
Regional Disease

6001 Background: HNSCC are etiologically heterogeneous, with one subset primarily attributable to HPV and another to tobacco and alcohol. Methods: Data from SEER9 program registries were used to investigate the potential influence of HPV on incidence and survival of HNSCC in the US from 1973–2003. HNSCCs (N=58,158) were classified by anatomic site as potentially HPV-R (base of tongue; tonsil; oropharynx; N=16,712) or HPV-U (lip; tongue; gum; floor of mouth; palate; other mouth; hypopharynx; ill-defined sites of lip, oral cavity, and pharynx; N=41,446). Joinpoint regression was used to assess incidence trends and life-table methods were used to compare survival for HPV-R and HPV-U HNSCCs. Results: For HPV-R HNSCCs, age-adjusted incidence increased significantly from 1973–2003 (annual percent change [APC] = 0.65), particularly among males (APC=1.02), whites (APC=0.89), and younger ages (APCs for 30–39 = 1.46; 40- 49=1.92; 50–59=0.61, and =60= -0.66). By contrast, HPV-U HNSCC incidence was stable from 1973–1983 and then decreased significantly from 1983–2003 (APC= -2.42). Mean age at diagnosis was younger for HPV-R HNSCC than HPV-U (61.1 vs. 64.5 years; p<0.001), and from 1973- 2003, decreased significantly for HPV-R, but increased for HPV-U. Improvements in overall survival (OS) were observed for HPV-R (all stages) and HPV-U (regional and distant) HNSCC treated by radiotherapy (RT) from 1973–2003, but were more marked for HPV-R HNSCC, e.g. absolute increase in two-year OS for regional disease of 24.4% (vs. 5.8% for HPV-U). OS for HPV-R (local and regional) was significantly better than HPV-U HNSCC if treated by RT, but worse if not so treated. Conclusions: The proportion of HNSCC that is potentially HPV- R increased in the US from 1973–2003, particularly among recent birth cohorts, perhaps due to changing sexual and smoking behaviors. Recent improvements in locoregional control with RT-based therapy may be due in part to a gradual shift in the etiology of the underlying disease. No significant financial relationships to disclose.

Incidence trends of gastroenteropancreatic neuroendocrine tumors in the United States from 1975 to 2012.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 231-231
Author(s):  
Mi Ri Lee ◽  
Cynthia Harris ◽  
Kiwoon Joshua Baeg ◽  
Juan P. Wisnivesky ◽  
Michelle Kang Kim
Keyword(s):  
The United States ◽  
Population Based ◽  
Incidence Rates ◽  
Birth Cohorts ◽  
Annual Percent Change ◽  
Gastroenteropancreatic Neuroendocrine Tumors ◽  
Incidence Trends ◽  
The Us ◽  
Population Based Registry ◽  
Adjusted Incidence

231 Background: Although multiple studies document a rise in gastroenteropancreatic neuroendocrine tumor (GEP-NET) incidence over the past several decades, there are limited national data regarding recent trends. Using a population-based registry, we evaluated GEP-NET incidence trends in the US population from 1975-2012 by age and calendar year at diagnosis and year of birth. Methods: GEP-NET cases between 1975-2012 were identified from the most recent version of the Surveillance, Epidemiology, and End Results (SEER) registry based on histologic and site codes. We calculated overall annual incidence, age-adjusted incidence (number of cases per 100,000), annual percent change (APC), and average APC by 5 year age intervals. We also evaluated the incidence rates by age, period, and birth year cohorts. Results: We identified 22,744 patients with GEP-NETs. In adults age 25-39 years, GEP-NET incidence rates declined from the mid 1970s to early 1980s, then increased until 2012 (Table 1). In adults age 40 and older and between ages 15-24 years, incidence rates generally increased continuously from 1975 to 2012. Adults age 40-69 years demonstrated the most rapid increases in average APC, approximately 4-6% per year. Overall incidence rates were highest in adults age 70-84 years. Since the late 1880s, GEP-NET incidence has increased in consecutive birth cohorts. Conclusions: Our study demonstrates that more recent generations have had higher incidence rates than more distant generations. In addition, GEP-NETs are more common among older adults and the number of GEP NETs has increased in past decades. [Table: see text]

scholarly journals Melanoma Incidence Among Non-Hispanic Whites in All 50 US States From 2001 Through 2015

2019 ◽  
Vol 112 (5) ◽  
pp. 533-539 ◽  
Author(s):  
Aaron P Thrift ◽  
Franciska J Gudenkauf
Keyword(s):  
Incidence Rate ◽  
Birth Cohort ◽  
Sun Exposure ◽  
The United States ◽  
Incidence Rates ◽  
Birth Cohorts ◽  
Annual Percent Change ◽  
Incidence Trends ◽  
Percent Change ◽  
Melanoma Incidence

Abstract Background The United States has large regional variation in primary prevention campaigns for skin cancer. We collected data from all 50 states to examine changes in melanoma incidence and performed age-period-cohort analyses to describe the simultaneous effects of age, period, and cohort on incidence rates. Methods Annual melanoma incidence rates for non-Hispanic whites from 2001 to 2015 were extracted from the US Cancer Statistics registry. Secular trends were examined overall and by sex and state. We used joinpoint regression to compute annual percent change and average annual percent change and corresponding 95% confidence intervals (CIs). We also analyzed incidence trends by 5-year age group and birth cohort using incidence rate ratios and age-period-cohort modeling. Results Melanoma incidence increased from 20.7 per 100 000 (95% CI = 20.5 to 20.9) in 2001 to 28.2 per 100 000 (95% CI = 28.0 to 28.5) in 2015, increasing by 3.90% (95% CI = 2.36% to 5.48%) annually between 2001 and 2005 and 1.68% (95% CI = 1.37% to 1.99%) annually from 2005 through 2015. The average annual percent change in melanoma incidence rates were similar for men (2.34%, 95% CI = 1.91 to 2.78) and women (2.25%, 95% CI = 1.60 to 2.91). Age-specific relative risk by birth cohort increased from circa 1921 to 1981 before decreasing. Compared with adults born circa 1956, those born circa 1991 had lower melanoma risk (incidence rate ratio  = 0.85; 95% CI = 0.77 to 0.94). Geographic variation was observed; some states still have melanoma rates trending upwards in all birth cohorts. Conclusions The continued increase in melanoma incidence among non-Hispanic whites, particularly in states where rates continue to rise among recent and current birth cohorts, underscores the need for increased public health campaigns aimed at reducing sun exposure.

Incidence Trends for Human Papillomavirus–Related and –Unrelated Oral Squamous Cell Carcinomas in the United States

2008 ◽  
Vol 26 (4) ◽  
pp. 612-619 ◽  
Author(s):  
Anil K. Chaturvedi ◽  
Eric A. Engels ◽  
William F. Anderson ◽  
Maura L. Gillison
Keyword(s):  
United States ◽  
Human Papillomavirus ◽  
Squamous Cell ◽  
The United States ◽  
Squamous Cell Carcinomas ◽  
Anatomic Site ◽  
Absolute Increase ◽  
Oral Squamous Cell Carcinomas ◽  
Incidence Trends ◽  
The Impact

Purpose To investigate the impact of human papillomavirus (HPV) on the epidemiology of oral squamous cell carcinomas (OSCCs) in the United States, we assessed differences in patient characteristics, incidence, and survival between potentially HPV-related and HPV-unrelated OSCC sites. Patients and Methods Data from nine Surveillance, Epidemiology, and End Results program registries (1973 to 2004) were used to classify OSCCs by anatomic site as potentially HPV-related (n = 17,625) or HPV-unrelated (n = 28,144). Joinpoint regression and age-period-cohort models were used to assess incidence trends. Life-table analyses were used to compare 2-year overall survival for HPV-related and HPV-unrelated OSCCs. Results HPV-related OSCCs were diagnosed at younger ages than HPV-unrelated OSCCs (mean ages at diagnosis, 61.0 and 63.8 years, respectively; P < .001). Incidence increased significantly for HPV-related OSCC from 1973 to 2004 (annual percentage change [APC] = 0.80; P < .001), particularly among white men and at younger ages. By contrast, incidence for HPV-unrelated OSCC was stable through 1982 (APC = 0.82; P = .186) and declined significantly during 1983 to 2004 (APC = −1.85; P < .001). When treated with radiation, improvements in 2-year survival across calendar periods were more pronounced for HPV-related OSCCs (absolute increase in survival from 1973 through 1982 to 1993 through 2004 for localized, regional, and distant stages = 9.9%, 23.1%, and 18.6%, respectively) than HPV-unrelated OSCCs (5.6%, 3.1%, and 9.9%, respectively). During 1993 to 2004, for all stages treated with radiation, patients with HPV-related OSCCs had significantly higher survival rates than those with HPV-unrelated OSCCs. Conclusion The proportion of OSCCs that are potentially HPV-related increased in the United States from 1973 to 2004, perhaps as a result of changing sexual behaviors. Recent improvements in survival with radiotherapy may be due in part to a shift in the etiology of OSCCs.

The Difference in the Incidence and the Trend of Malignant Lymphomas in Japan and the United States.

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 2695-2695
Author(s):  
Dai Chihara ◽  
Hidemi Ito ◽  
Tomohiro Matsuda ◽  
Akiko Shibata ◽  
Tomotaka Sobue ◽  
...  
Keyword(s):  
Cancer Registry ◽  
Hematologic Malignancies ◽  
The United States ◽  
Cumulative Exposure ◽  
Malignant Lymphomas ◽  
Annual Percent Change ◽  
Percent Change ◽  
Nodular Sclerosis ◽  
The Us ◽  
The Difference

Abstract Abstract 2695 Background: Malignant lymphomas (ML) are heterogeneous groups that the detailed classification is evolving dramatically. An incidence of malignant disease in certain population reflects cumulative exposure to environment, genetics and their combination overtime. Therefore, a comparison of incidences in various population and their secular trends is very helpful to understand etiology of disease. The aim of this study is to assess the incidence and the trend of each ML subtypes and to evaluate the difference between Japan and US. Materials and Methods: We used the data from a population-based cancer registry in Japan and from the Surveillance Epidemiology and End Results (SEER) program 9. Registry data of the US, SEER 9 included 95,155 cases and the data of Japan included 48,658 cases. The period covered in this analyses was 1993 to 2006 in Japan and 1993 to 2008 in the US. Rates of sex-specific, age-standardized incidence with 95% confidence intervals were estimated and standardized by age-adjustment according to the world standard population. We also estimated the annual percent change using joinpoint regression analysis and evaluated the significance of the trend. Results: The overall age-standardized incidence rate of all malignant lymphomas per 100,000 in 2006 was 22.4 for males and 16.0 for females in the US, 7.4 for males and 4.9 for females in Japan. The incidence is higher in the US than Japan with most of the subtypes especially for the nodular sclerosis HL, CLL/SLL and FL. In general, B-cell lymphomas showed large difference in incidence while T-cell lymphomas (TCL) showed similar incidence between Japan and the US. The total numbers of ML are constantly increasing in Japan but not in the US as shown in the figure {annual percent change (95%CI), Japan; +2.6% (2.1, 3.1), US; +0.2% (−0.0, 0.4)}. As for details, follicular lymphoma, mantle cell lymphoma, Burkitt lymphoma and the total numbers of TCL are constantly increasing in both countries. Conclusion: In conclusion, we showed the marked difference in the incidence and the trend of hematologic malignancies between Japan and the US. The incidence of hematologic malignancies is lower in Japan than the US, but is increasing significantly. The most remarkable difference in the incidence was seen with nodular sclerosis HL, CLL/SLL and FL which was consistent with previous reports. Even with the TCL, the incidence seems to be similar to higher in the US except for the ATLL. The improvement in the quality of cancer registry systems and the organization of these registries between countries enables us to unite the data worldwide that will bring us new insights. Solid line and circle are the data of the US. Dashed line and hollow circle are the data of Japan. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Trends in the Incidence of Pancreatic Adenocarcinoma in All 50 United States Examined Through an Age-Period-Cohort Analysis

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Wilson L da Costa ◽  
Abiodun O Oluyomi ◽  
Aaron P Thrift
Keyword(s):  
United States ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cohort Analysis ◽  
The United States ◽  
Incidence Rates ◽  
Ductal Adenocarcinoma ◽  
Birth Cohorts ◽  
Men And Women ◽  
Cancer Statistics ◽  
Incidence Trends

Abstract Background Pancreatic ductal adenocarcinoma is a major contributor to cancer-related mortality in the United States. We aimed to investigate trends in incidence rates from all 50 states from 2001 to 2016, overall and by race, sex, and state and using age-period-cohort analyses. Methods Age-adjusted incidence rates and trends in adults aged 35 years and older were calculated using data from the US Cancer Statistics registry. We used joinpoint regression to compute annual percent changes (APC) and average annual percent changes. We also analyzed incidence trends by age groups and birth cohorts through age-period-cohort modeling. Results Age-standardized incidence rates increased by 1.23% (95% confidence interval [CI] = 0.92% to 1.54%) annually between 2001 and 2008 but were stable between 2008 and 2016 (APC = 0.11%, 95% CI = -0.13% to 0.35%). APCs and inflection points were no different for men and women. Rates increased statistically significantly among non-Hispanic whites (NHW) and non-Hispanic blacks between 2001 and 2007 and between 2001 and 2008, respectively, but, in later years, rates increased slowly among NHWs (APC = 0.36%, 95% CI = 0.12% to 0.60%), and were stable among non-Hispanic blacks (APC = -0.40%, 95% CI = -0.89% to 0.10%). The number of states with age-standardized incidence rates no less than 20.4 per 100 000 increased from 16 in 2001–2003 to 40 by 2015–2016. We found a strong birth cohort effect in both men and women and increasing rates among successive birth cohorts of NHWs. Conclusions The incidence of pancreatic ductal adenocarcinoma has consistently increased in the United States, albeit at slower rates recently. We observed notable increases among NHWs and in some states in the central and southern part of the country.

scholarly journals Incidence trends, rates, and ethnic variations of primary CNS tumors in Texas from 1995 to 2013

2017 ◽  
Vol 5 (3) ◽  
pp. 154-160 ◽  
Author(s):  
Solomon N Ambe ◽  
Kristopher A Lyon ◽  
Damir Nizamutdinov ◽  
Ekokobe Fonkem
Keyword(s):  
United States ◽  
American Indians ◽  
Large Population ◽  
Ethnic Disparities ◽  
The United States ◽  
Incidence Rates ◽  
Cns Tumors ◽  
Annual Percent Change ◽  
Incidence Trends ◽  
Percent Change

Abstract Background Although rare, primary central nervous system (CNS) tumors are associated with significant morbidity and mortality. Texas is a representative sample of the United States population given its large population, ethnic disparities, geographic variations, and socio-economic differences. This study used Texas data to determine if variations in incidence trends and rates exist among different ethnicities in Texas. Methods Data from the Texas Cancer Registry from 1995 to 2013 were examined. Joinpoint Regression Program software was used to obtain the incidence trends and SEER*Stat software was used to produce average annual age-adjusted incidence rates for both nonmalignant and malignant tumors in Texas from 2009 to 2013. Results The incidence trend of malignant primary CNS tumors in whites was stable from 1995 to 2002, after which the annual percent change decreased by 0.99% through 2013 (95% CI, -1.4, -0.5; P = .04). Blacks and Asian/Pacific Islanders showed unchanged incidence trends from 1995 to 2013. Hispanics had an annual percent change of -0.83 (95% CI, -1.4, -0.2; P = .009) per year from 1995 through 2013. From 2009 to 2013, the incidence rates of nonmalignant and malignant primary CNS tumors were highest among blacks, followed by whites, Hispanics, Asians, and American Indians/Alaskan Natives. Conclusions Consistent with the 2016 Central Brain Tumor Registry of the United States report, the black population in Texas showed the highest total incidence of CNS tumors of any other race studied. Many factors have been proposed to account for the observed differences in incidence rate including geography, socioeconomic factors, and poverty factors, although the evidence for these external factors is lacking.

scholarly journals Future Burden of Multiple Myeloma in the United States

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 1292-1292
Author(s):  
Philip S Rosenberg ◽  
Kimberly A Barker ◽  
William F Anderson
Keyword(s):  
United States ◽  
Multiple Myeloma ◽  
Ethnic Group ◽  
Age Groups ◽  
The United States ◽  
Age Group ◽  
Birth Cohorts ◽  
Men And Women ◽  
The Us ◽  
Hispanic Men

Abstract BACKGROUND: Multiple myeloma (MM) is the second most common hematological malignancy in the United States (US), representing 1.4% of all new cancers. MM incidence increases rapidly with age, is twice as common among African Americans versus other groups, and is a top ten cause of cancer deaths among African Americans. Although the absolute number of new MM cases per year, or MM burden, is expected to be higher in future years because of predictable changes in the demographic profile of the US, to date no study has made detailed forecasts of future MM incidence or burden by age, race/ethnicity, and sex. In this study we construct such forecasts for the period 2011 through 2034 using cancer incidence data from the National Cancer Institute’s Surveillance Epidemiology and End Results (SEER) Program, a novel age-period-cohort (APC) forecasting model, and official projections of population sizes produced by the US Bureau of the Census. METHODS: We obtained MM case and population data from the SEER 13 Registries Database for 1993 – 2010 for all men and women, and for non-Hispanic whites, Hispanics, Blacks, and Asian and Pacific Islanders (API). To obtain stable APC estimates for each population, we aggregated single-year data into sixteen 3-year age groups (37 – 39 through 82 – 84) and six 3-year periods (1993 – 1995 through 2008 – 2010) spanning 21 partially overlapping 6-year birth cohorts centered on birth-years 1911, 1914, through 1971. Cohort effects in our APC models enabled us to make incidence forecasts allowing for different time trends in different age groups and to extrapolate incidence trends to future birth cohorts. We estimated future numbers of new cases for each sex by race/ethnic group by multiplying APC incidence rate forecasts from SEER 13 (which covers 14% of the US) by US Census population projections for the entire US for each sex and race/ethnic group. RESULTS: APC-based age incidence curves estimated from SEER13 data for incorporation into national projections reflected the contemporary epidemiology of MM: age incidence was higher among men than women in every race/ethnic group especially at ages 64 – 84 years, was highest in Blacks and lowest in API, and was similar in non-Hispanic Whites and Hispanics. In APC analyses, observed MM incidence from 1993 – 2010 was stable among men ages 37 – 63, increasing by around 0.5 percent per year among men ages 64 – 84, and stable among women in all age groups. Projected incidence for 2011 – 2034 was stable or slightly increasing in every age group. Projected MM burdens (numbers of new cases per year) were stable or slightly increasing for men and women ages 37 – 63. In contrast, large increases in the numbers of Americans ages 64 – 84 are expected to result in substantial increases in MM burden in this age group. In 2011-2013 we estimate a total of 11,200 new MM cases in men and 8,500 new cases in women. For 2032-2034 we forecast a total of 18,500 new cases in men and 13,700 new cases in women (65% and 61% increases, respectively). Among older persons ages 64 – 84, corresponding estimates are 7,300 male and 5,400 female cases in 2011 – 2013 approximately doubling to 14,100 male and 10,300 female cases in 2032-2034. Among older black men, who have the highest MM incidence and whose population is expected to increase by 4.3% per year, the projected increase in burden is 152% (from 1,210 to 3,050 cases per year). Among older Hispanic men (stable MM incidence, population increasing by 5.5% per year) the burden is expected to triple (from 460 to 1,370 cases per year). Among all older men, increases in MM burden above population growth reflect a modest increase in MM incidence. Increases in MM burden in other groups are in line with corresponding increases in population. DISCUSSION: MM incidence has been relatively stable in the US during 1993 – 2010. Our forecast is that MM incidence will continue to be quite stable during 2011 – 2032. Nonetheless, because of predictable demographic shifts in the US, the number of new MM cases per year is expected to increase by 65% in men and 61% in women between 2011-2013 and 2032-2034. Almost all of these increases will occur among older Americans ages 64 – 84. In this age group, the number of new cases overall will double, and more than double among Black and Hispanic men and women. IMPACT: Detailed forecasts quantify increasing demands for health services personnel and resources, and highlight the need for more effective MM therapies, especially for patients ages 64 – 84. Disclosures No relevant conflicts of interest to declare.

scholarly journals Trends in the Utilization of Radiation Therapy (XRT) Among Patients with Non-Hodgkin's Lymphoma (NHL) in the United States (US)

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 4765-4765
Author(s):  
Vivek Kumar ◽  
Taimur Sher ◽  
Prakash Vishnu ◽  
Vivek Roy ◽  
Anne M Hazen ◽  
...  
Keyword(s):  
Subgroup Analysis ◽  
Age Groups ◽  
The United States ◽  
Significant Decline ◽  
P Value ◽  
Significant Heterogeneity ◽  
Cell Transplant ◽  
Annual Percent Change ◽  
The Us ◽  
Facility Level

Abstract Background: The treatment of NHL has witnessed a paradigm shift over time, with targeted immunotherapy, stem cell transplant (SCT) among others. Historically, XRT was used quite frequently for the management of NHL but with advent of better systemic therapy, its utilization has changed. Trends and patterns of care for XRT use have never been formally reported. Methods: We identified patients with NHL diagnosis in the National Cancer Database (NCDB) between years 2004 and 2015. Demographic, clinical, facility level, initial treatment and outcome data were collected. The utilization of XRT in diffuse large B-cell (DLBCL) and non-DLBCL NHL were analyzed separately by univariate and multivariate analyses. To analyze the trends in the rates of XRT, we applied segmented linear regression to calculate the average annual percent change (AAPC) and 95% confidence Interval (CI) with a 'p' value. AAPC and CIs were calculated using the segmented package in R studio v1.1.49. Rest of the analyses was conducted using StataCorp version 15.1. Results: A total of 133,182 DLBCL and 204,933 non-DLBCL patients were identified. Among patients with DLBCL, 27,895 (20.9%) patients received RT. The rate of XRT declined from 25% in 2004 to 18.4% in 2015 with estimated AAPC of -0.59% (95%CI: -0.70- -0.49), p= 0.03 (Figure 1). In a subgroup analysis, a similar decline in the rate of XRT was evident across all the age groups, combined stages I and II vs stages III and IV and nodal vs extra nodal DLBCL (Table 1). Among non DLBCL, 33,369 (16.3%) patients received XRT. There was a statistically significant decline in the rate of XRT from 18.03% in 2004 to 16.3% in 2014 with an AAPC of -0.26 (95%CI: -0.38- -0.14) p <0.001 (Figure 1). On the subgroup analysis, the utilization of XRT declined across all the studied subgroups except among patients aged 80 years and above (Table 1). On multivariate analysis, several demographic, clinical and facility level factors were found to be significantly associated with XRT utilization in NHL (Table 2). In particular, older age groups, racial/ethnic minorities, advanced stages, higher Charlson comorbidity scores and diagnosis in the more recent calendar years were associated with lesser chances of receiving RT. Extranodal DLBCL had lower utilization while extranodal non-DLBCL had increased XRT utilization. Conclusion: There has been a significant decline in the utilization of XRT among patients with NHL (DLBCL and non-DLBCL) in the US since 2004, likely due to introduction of practice changing systemic therapeutics. There is still significant heterogeneity noted in practice patterns regarding utilization of XRT across the US. Having more standardized guidelines will help streamline delivery of evidence-based patient care. Disclosures Ailawadhi: Celgene: Consultancy; Janssen: Consultancy; Amgen: Consultancy; Takeda: Consultancy; Pharmacyclics: Research Funding.

scholarly journals Age and Cohort Trends of Malignant Melanoma in the United States

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3866
Author(s):  
Stephanie G. Lashway ◽  
Robin B. Harris ◽  
Leslie V. Farland ◽  
Mary Kay O’Rourke ◽  
Leslie K. Dennis
Keyword(s):  
United States ◽  
Malignant Melanoma ◽  
Cancer Registries ◽  
The United States ◽  
Cancer Type ◽  
Birth Cohorts ◽  
Anatomic Site ◽  
Melanoma Incidence ◽  
Adjusted Incidence

The incidence of malignant melanoma in the United States is increasing, possibly due to changes in ultraviolet radiation (UVR) exposure due to lifestyle or increased awareness and diagnosis of melanoma. To determine if more recent birth cohorts experience higher rates of melanoma as they age, we examined age and birth cohort trends in the United States stratified by anatomic site and cancer type (in situ vs. malignant) of the melanoma diagnosed from 1975–2017. Poisson regression of cutaneous melanoma cases per population for 1975–2017 from the Surveillance, Epidemiology, and End Results (SEER) cancer registries was used to estimate age adjusted incidence for five-year birth cohorts restricted to Whites, ages 15–84. The rate of melanoma incidence across birth cohorts varies by anatomic site and sex. Melanomas at all anatomic sites continue to increase, except for head and neck melanomas in men. Much of the increase in malignant melanoma is driven by cases of thin (<1.5 mm) lesions. While increased skin exams may contribute to the increased incidence of in situ and thin melanoma observed across birth cohorts, the shifts in anatomic site of highest melanoma incidence across birth cohorts suggest changes in UVR exposure may also play a role.

scholarly journals Oral Cavity and Pharynx Cancer Incidence Trends by Subsite in the United States: Changing Gender Patterns

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Linda Morris Brown ◽  
David P. Check ◽  
Susan S. Devesa
Keyword(s):  
Oral Cavity ◽  
Tongue Cancer ◽  
The United States ◽  
Sexual Practices ◽  
Birth Cohorts ◽  
Oral Tongue ◽  
Incidence Trends ◽  
Oral Tongue Cancer ◽  
Cancer Rates ◽  
Pharynx Cancer

Objective. To evaluate oral cavity and pharynx cancer (OCPC) patterns by gender.Methods. We used Surveillance, Epidemiology, and End Results program data for 71,446 cases diagnosed during 1975–2008 to classify OCPC by anatomic subsite as potentially HPV-related or not, with oral tongue cancer considered a separate category.Results. Total OCPC rates among men were 2–4 times those among women. Among whites, total OCPC rates rose in the younger age groups due to substantial increases in successive birth cohorts for HPV-related cancers, more rapid among men than women, and oral tongue cancers, more rapid among women than men. Among blacks, total OCPC rates declined among cohorts born since 1930 reflecting the strong downward trends for HPV-unrelated sites. Among Hispanics and Asians, HPV-unrelated cancer rates generally declined, and oral tongue cancer rates appeared to be converging among young men and women.Conclusions. Decreases in total OCPC incidence reflect reductions in smoking and alcohol drinking. Rising HPV-related cancers among white men may reflect changing sexual practices. Reasons for the increasing young oral tongue cancer rates are unknown, but the narrowing of the gender differences provides a clue.

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