Adverse drug reactions and drug interactions as causes of hospital admission in oncology

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e20656-e20656 ◽  
Author(s):  
A. Del Giglio ◽  
V. Miranda ◽  
A. Fede ◽  
M. Nobuo ◽  
M. Miranda ◽  
...  
Keyword(s):  
Hospital Admission ◽  
Drug Interactions ◽  
Cancer Patients ◽  
Adverse Drug Reactions ◽  
Adverse Drug Event ◽  
Odds Ratio ◽  
Hospital Admissions ◽  
Population Based ◽  
Drug Event ◽  
Drug Reactions

e20656 Background: Previous studies have shown that cancer patients are at risk of drug interactions. But the proportion of potential adverse events that turn into clinical consequences is unknown. We sought to evaluate how many hospital admissions in oncology are due to drug-drug interactions (DDI) or adverse drug reactions (ADR). Methods: All cancer patients admitted to an oncology ward during an 8-month period had their charts retrospectively evaluated for reasons of hospitalization. Clinical trial patients were excluded. Each hospital admission was independently evaluated by two blinded investigators using a 4-point scale that was developed to classify sadmissions by their probability to be associated with either a DDI or an ADR (definitely, probably, possibly or unlikely associated). All medical records were thoroughly reviewed and discussed by experts. Results: From September 2007 to May 2008, there were 550 hospital admissions and 458 were eligible. Among unplanned admissions (N=298), 39 (13.0%, 95% CI 9.4 - 17.4%) were considered to be associated with an adverse drug event: 33 (11.0%, 95% CI 7.7 - 15.2%) were associated with an ADR and 6 (2.0%, 95% CI 0.7 - 4.3%) with a DDI. The most common DDI involved warfarin, captopril and anti-inflammatory agents and the most frequent ADR was neutropenic fever post chemotherapy. Most patients were discharged completely recovered but 2 patients died. Use of chemotherapy within 4 weeks of hospital admission (Odds Ratio 10.8, 95% CI 5.3 - 22.1; p < 0.0001) and presence of hematological tumors (Odds Ratio 12.1, 95% CI 5.9 - 25; p < 0.0001) were risk factors for being hospitalized to treat an ADR. Conclusions: Approximately one in 10 unplanned hospitalizations of cancer patients is associated with an adverse drug event. Prospective and population-based studies are warranted to evaluate their magnitude in oncology. [Table: see text]

scholarly journals Urgent Hospital Admissions Caused by Adverse Drug Reactions and Medication Errors—A Population-Based Study in Spain

2020 ◽  
Vol 11 ◽  
Author(s):  
Gina Mejía ◽  
Miriam Saiz-Rodríguez ◽  
Beatriz Gómez de Olea ◽  
Dolores Ochoa ◽  
Francisco Abad-Santos
Keyword(s):  
Medication Errors ◽  
Adverse Drug Reactions ◽  
Hospital Admissions ◽  
Population Based ◽  
Drug Reactions ◽  
Population Based Study

scholarly journals An opportunity for clinical pharmacology trained physicians to improve patient drug safety: A retrospective analysis of adverse drug reactions in teenagers

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 677 ◽  
Author(s):  
Andy R. Eugene ◽  
Beata Eugene
Keyword(s):  
Clinical Pharmacology ◽  
Drug Interactions ◽  
Adverse Drug Reactions ◽  
Hospital Admissions ◽  
The United States ◽  
Drug Reactions ◽  
The Third ◽  
Data Limitations ◽  
Ondansetron Hydrochloride ◽  
Improve Patient

Background: Adverse drug reactions (ADRs) are a major cause of hospital admissions, prolonged hospital stays, morbidity, and drug-related mortality. In this study, we sought to identify the most frequently reported medications and associated side effects in adolescent-aged patients in an effort to prioritize clinical pharmacology consultation efforts for hospitals seeking to improve patient safety.   Methods: Quarterly reported data were obtained from the United States Food and Drug Administration Adverse Events Reporting System (FAERS) from the third quarter of 2014 and ending in the third quarter of 2017. We then used the GeneCards database to map the pharmacogenomic biomarkers associated with the most reported FAERS drugs. Data homogenization and statistics analysis were all conducted in R for statistical programming. Results: We identified risperidone (10.64%) as the compound with the most reported ADRs from all reported cases. Males represented 90.1% of reported risperidone cases with gynecomastia being the most reported ADR. Ibuprofen OR=188 (95% CI, 105.00 – 335.00) and quetiapine fumarate OR=116 (95% CI, 48.40 – 278.00) were associated with the highest odds of completed suicide in teenagers. Ondansetron hydrochloride OR=7.12 (95% CI, 1.59 – 31.9) resulted in the highest odds of pneumothorax. Lastly, olanzapine (8.96%) represented the compound with the most reported drug-drug interactions cases, while valproic acid OR=221 (95% CI, 93.900 – 522.00) was associated with the highest odds of drug-drug interactions. Conclusion: Despite any data limitations, physicians prescribing risperidone in males should be aware of the high rates of adverse drug events and an alternative psychotropic should be considered in male patients. Further, patients with a history of pneumothorax or genetically predisposed to pneumothorax should be considered for an alternative antiemetic to ondansetron hydrochloride, due to increased odds associated with the drug and adverse event.

scholarly journals Methodology for Estimating the Risk of Adverse Drug Reactions in Pregnant Women: Analysis of the Japanese Adverse Drug Event Report Database

2016 ◽  
Vol 136 (3) ◽  
pp. 499-505 ◽  
Author(s):  
Takamasa Sakai ◽  
Fumiko Ohtsu ◽  
Yasuaki Sekiya ◽  
Chiyo Mori ◽  
Hiroshi Sakata ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Adverse Drug Reactions ◽  
Adverse Drug Event ◽  
Drug Event ◽  
Drug Reactions ◽  
Event Report

scholarly journals Sex differences associated with adverse drug reactions resulting in hospital admissions

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
L. C. Hendriksen ◽  
P. D. van der Linden ◽  
A. L. M. Lagro-Janssen ◽  
P. M. L. A. van den Bemt ◽  
S. J. Siiskonen ◽  
...  
Keyword(s):  
Sex Differences ◽  
Hospital Admission ◽  
Adverse Drug Reactions ◽  
Adverse Drug Events ◽  
Hospital Admissions ◽  
Health Concern ◽  
Subdural Haemorrhage ◽  
Drug Reactions ◽  
Major Health ◽  
Unplanned Hospital Admissions

Abstract Background Adverse drug events, including adverse drug reactions (ADRs), are responsible for approximately 5% of unplanned hospital admissions: a major health concern. Women are 1.5–1.7 times more likely to develop ADRs. The main objective was to identify sex differences in the types and number of ADRs leading to hospital admission. Methods ADR-related hospital admissions between 2005 and 2017 were identified from the PHARMO Database Network using hospital discharge diagnoses. Patients aged ≥ 16 years with a drug possibly responsible for the ADR and dispensed within 3 months before admission were included. Age-adjusted odds ratios (OR) with 95% CIs for drug-ADR combinations for women versus men were calculated. Results A total of 18,469 ADR-related hospital admissions involving women (0.35% of all women admitted) and 14,678 admissions involving men (0.35% of all men admitted) were included. Most substantial differences were seen in ADRs due to anticoagulants and diuretics. Anticoagulants showed a lower risk of admission with persistent haematuria (ORadj 0.31; 95%CI 0.21, 0.45) haemoptysis (ORadj 0.47, 95%CI 0.30,0.74) and subdural haemorrhage (ORadj 0.61; 95%CI 0.42,0.88) in women than in men and a higher risk of rectal bleeding in women (ORadj 1.48; 95%CI 1.04,2.11). Also, there was a higher risk of admission in women using thiazide diuretics causing hypokalaemia (ORadj 3.03; 95%CI 1.58, 5.79) and hyponatraemia (ORadj 3.33, 95%CI 2.31, 4.81) than in men. Conclusions There are sex-related differences in the risk of hospital admission in specific drug-ADR combinations. The most substantial differences were due to anticoagulants and diuretics.

scholarly journals Adverse Drug Reactions and Drug Interactions as Causes of Hospital Admission in Oncology

2011 ◽  
Vol 42 (3) ◽  
pp. 342-353 ◽  
Author(s):  
Vanessa Miranda ◽  
Angelo Fede ◽  
Melissa Nobuo ◽  
Veronica Ayres ◽  
Auro Giglio ◽  
...  
Keyword(s):  
Hospital Admission ◽  
Drug Interactions ◽  
Adverse Drug Reactions ◽  
Drug Reactions

Hospital Admissions Resulting from Preventable Adverse Drug Reactions

2002 ◽  
Vol 36 (9) ◽  
pp. 1331-1336 ◽  
Author(s):  
Patrick J McDonnell ◽  
Michael R Jacobs
Keyword(s):  
Hospital Admission ◽  
Adverse Drug Reactions ◽  
Drug Exposure ◽  
Hospital Admissions ◽  
Average Length ◽  
Retrospective Chart Review ◽  
University Hospital ◽  
Drug Reactions ◽  
Life Threatening ◽  
Patient Noncompliance

BACKGROUND: Adverse drug reactions (ADRs) are a significant cause of hospital admissions. These events can lead to significant morbidity and mortality and financial costs. ADRs that may be preventable might be considered a form of medication error. OBJECTIVE: To assess the potential preventability of ADRs directly related to a patient's hospital admission. METHODS: A retrospective chart review of 437 ADRs occurring during an 11-month period was conducted at a university hospital. A subset of these events leading to hospital admissions was identified for further review. Those that resulted in admission were further examined to determine probability of causality, severity, and preventability. RESULTS: Over 11 months, 158 ADRs were directly related to hospital admission. The relationship of these admissions to drug exposure was determined to be probable or highly probable in 154 (97.4%) of these cases. From this group, 96 (62.3%) of these events were considered potentially preventable, with 23 (24%) considered severe to life-threatening. Characteristics associated with these ADRs included documentation of a toxic drug concentration or abnormal laboratory value (80%), inadequate monitoring of a patient's drug therapy (67%), inappropriate dose (51%), patient noncompliance (33%), drug—drug interaction (26%), contraindication to therapy (3%), and documented allergy (1%). These ADRs resulted in 595 hospital days, with an average length of stay of 6.1 days. CONCLUSIONS: ADRs leading to hospital admissions are often preventable. Approximately 25% of these events were serious to life-threatening. Most resulted from inadequate monitoring of therapy or inappropriate dosing. Patient noncompliance and drug interactions were also common causes. Multidisciplinary prevention strategies among physicians, pharmacists, other healthcare professionals, and patients focusing on communication and education should be targeted.

Estimated incidence per population of adverse drug reactions to Kampo medicines from the Japanese adverse drug event report database (JADER)

2020 ◽  
Vol 7 (1) ◽  
pp. 3-16 ◽  
Author(s):  
Ichiro Arai ◽  
Yusuke Harada ◽  
Hiroshi Koda ◽  
Kiichiro Tsutani ◽  
Yoshiharu Motoo
Keyword(s):  
Adverse Drug Reactions ◽  
Adverse Drug Event ◽  
Drug Event ◽  
Drug Reactions ◽  
Event Report
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