Venous thromboembolism in patients with pancreatic cancer: Incidence and effect on survival in east Asian ethnic groups.

2013 ◽  
Vol 31 (4_suppl) ◽  
pp. 151-151 ◽  
Author(s):  
Jong-Chan Lee ◽  
Junhyeon Cho ◽  
Yohan Park ◽  
Young Sun Ro ◽  
Hyejin Choi
Keyword(s):  
Pancreatic Cancer ◽  
Risk Factor ◽  
Head And Neck ◽  
Ethnic Groups ◽  
Pancreatic Adenocarcinoma ◽  
Medical Records ◽  
East Asian ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Overall Mortality

151 Background: Pancreatic cancer is known to be most frequently associated with venous thromboembolism (VTE), with the incidence of 10~20% in Western countries. As for the East Asian ethnic groups, just one small retrospective study showed lower incidence (5.3%) than other ethnic groups. However, there have been no large retrospective cohort studies of VTE in pancreatic cancer of East Asian ethnic group. Methods: We retrospectively reviewed the medical records of patients diagnosed with pancreatic adenocarcinoma in 2005~2010 at Severance Hospital, Seoul, Korea. Principal outcomes were incident VTE events and mortality. Cox proportional hazards models were used to analyze associations between specific risk factors and principal outcomes. Results: We investigated 1334 patients with pancreatic adenocarcinoma and 218 (16.3%) patients were excluded due to incomplete medical records and loss to follow-up. Among 1116 eligible patients, the overall and 1-year cumulative VTE incidence were 13.9% and 11.2% respectively. The incidence rate during the half year, 1-year and 2-years were 23.4, 17.7, 15.6 events per 100 person-years, respectively. Among total of 155 VTE patients, abdominal VTE was 52.9%, deep vein thrombosis was 21.3%, pulmonary thromboembolism was 19.4%, and head and neck VTE was 18.7%. In multivariable analyses, significant predictors of developing VTE included advanced metastatic stage (HR=2.08, 95% CI 1.37 to 3.17) and treatment of chemotherapy or radiotherapy, including CCRT (HR=1.52, 95% CI 16 to 1.99). VTE was a significant risk factor of 1-year and overall mortality (HR=1.44, 95% CI 1.15 to 1.79 and HR=1.45, 95% CI 1.21 to 1.73). Among 155 VTE patients, head and neck (H&N) VTE revealed highest risk of overall mortality (HR=2.05, 95% CI 1.27 to 3.33, versus non-H&N VTE). Conclusions: Approximately 13.9% of pancreatic adenocarcinoma patients developed VTE in East Asian ethnic group and this incidence was not significantly different from other ethnic groups. Advanced metastatic stage was the strongest predictor of VTE which would be a significant risk factor of 1-year mortality. Among VTE patients, head and neck VTE was 18.7% and showed the highest risk of overall death.

Abstract 126: Importance of Untreated Hypertension for Intracerebral Hemorrhage

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Kyle B Walsh ◽  
Opeolu Adeoye ◽  
Padmini Sekar ◽  
Jennifer Osborne ◽  
Charles J Moomaw ◽  
...  
Keyword(s):  
Risk Factor ◽  
Ethnic Groups ◽  
Case Control Study ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Case Control ◽  
Insurance Status ◽  
Race Ethnicity ◽  
Untreated Hypertension ◽  
Control Study

Introduction: Hypertension (HTN), particularly untreated HTN, has been found to be a significant risk factor for ICH in predominately white ICH populations. We evaluated the risk of treated and untreated HTN on ICH in a multi-ethnic case-control study. Hypothesis: Treated and untreated HTN confer variable risk for ICH by race/ethnicity. Methods: The Ethnic/Racial Variations of ICH (ERICH) study is a prospective, multicenter, case-control study of ICH among whites, blacks, and Hispanics. Cases were enrolled from 42 recruitment centers using hot-pursuit. Controls matched to cases 1:1 by age (±5 years), sex, race/ethnicity, and metropolitan area were recruited by random-digit dialing. Subjects were interviewed to determine whether they had a history of HTN and if they took medications to reduce blood pressure. Results: Between 9/2010 and 6/2015, 891 white, 833 black, and 599 Hispanic case/control pairs were enrolled. Higher proportions of black and Hispanic ICH with HTN were untreated, compared with whites (43.3% and 48.3% vs. 33.2%; p=.0002 and p<.0001, respectively). When adjusted for medical insurance status, a significant difference persisted for whites vs. Hispanics (p=.002), but not whites vs. blacks (p=.197). In multivariate analyses adjusted for alcohol use, anticoagulation, hypercholesterolemia, education, and insurance status, treated HTN was a significant risk factor for ICH in whites (OR=1.72, 95% CI 1.33-2.22, p<.0001), blacks (3.04, 2.13-4.34, <.0001), and Hispanics (2.57, 1.64-4.00, <.0001). Untreated HTN was a substantially greater risk factor for ICH for all three racial/ethnic groups: whites (9.53, 5.88-15.45, <.0001), blacks (11.10, 7.06-17.47, <.0001), Hispanics (9.65, 5.49-16.95, <.0001). In the subtype analyses of deep, lobar, and infratentorial ICH, untreated HTN resulted in ORs of 3.50 to 24.81, with statistical significance for all subtypes and ethnic groups. Conclusion: Treatment of HTN reduces the risk of ICH conferred by HTN markedly, but not completely. Untreated hypertension, which is significantly more prevalent among black and Hispanic ICH cases than among white cases, confers at least a 9-fold risk of ICH regardless of race. Treatment of hypertension is expected to have substantial impact on risk of ICH.

scholarly journals Prevalence of Gastroesophageal Reflux in Infants with Recurrent Brief Apneic Episodes

1999 ◽  
Vol 6 (5) ◽  
pp. 401-404 ◽  
Author(s):  
Shahid Sheikh ◽  
Thomas C Stephen ◽  
Barbara Sisson
Keyword(s):  
Risk Factor ◽  
Gastroesophageal Reflux ◽  
Medical Records ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Acid Reflux ◽  
Diagnostic Dilemma ◽  
Esophageal Ph ◽  
Life Threatening ◽  
The Relationship

BACKGROUND: Apnea in an infant can be a diagnostic dilemma for the treating pediatrician. It is suggested that in some infants, gastroesophageal reflux (GER) might be a factor in the pathogenesis of apnea, although its role as a cause of apnea is still controversial.OBJECTIVE: To evaluate the prevalence of GER in infants presenting with recurrent brief apneic periods.PATIENTS AND METHODS: A retrospective review of the medical records of all the infants who underwent prolonged esophageal pH studies for brief apneic episodes (n=105) at the Kosair Children’s Hospital in the six years from January 1992 to December 1997 was performed. Infants presenting with apparent life-threatening episodes were excluded.RESULTS: Of 105 infants, 72 (68.6%) were younger than two months of age and 22 (21%) were born preterm. Fifty of 105 infants (47.6%) had positive esophageal pH studies for acid reflux. Among infants with positive pH studies, only 21 (42%) had associated gastrointestinal or feeding complaints.CONCLUSION: GER is present in a large number of infants presenting with brief apneic episodes. Though the relationship between the two is still not fully established, GER may be a significant risk factor for such apneic episodes in infants.

Serum SPan-1 Is a Significant Risk Factor for Early Recurrence of Pancreatic Cancer after Curative Resection

2016 ◽  
Vol 34 (2) ◽  
pp. 125-132 ◽  
Author(s):  
Yuichi Hosokawa ◽  
Yuichi Nagakawa ◽  
Yatsuka Sahara ◽  
Chie Takishita ◽  
Kenji Katsumata ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Risk Factor ◽  
Curative Resection ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Early Recurrence

scholarly journals Age Is a Risk Factor for Contralateral Tendon Rupture in Patients with Acute Achilles Tendon Rupture

2019 ◽  
Vol 4 (4) ◽  
pp. 2473011419S0033
Author(s):  
Young Hwan Park ◽  
Jae Young Kim ◽  
Gi Won Choi ◽  
Hak Jun Kim
Keyword(s):  
Risk Factor ◽  
Achilles Tendon ◽  
Medical Records ◽  
Tendon Rupture ◽  
Achilles Tendon Rupture ◽  
Significant Risk ◽  
Clinical Importance ◽  
Significant Risk Factor ◽  
Patient Characteristics ◽  
Increased Risk

Category: Ankle Introduction/Purpose: Rupture of the contralateral Achilles tendon following Achilles tendon rupture can lead to devastating outcomes. However, despite the clinical importance, the risk factors and incidence of contralateral Achilles tendon rupture have not been well-studied. This study aimed to determine the incidence of contralateral tendon rupture after Achilles tendon rupture and to identify associated patient characteristics. Methods: Medical records for 226 consecutive patients with Achilles tendon rupture were retrospectively reviewed. The occurrence of contralateral Achilles tendon rupture and patient characteristics were determined through review of medical records and telephone surveys. Results: The cumulative incidences of contralateral Achilles tendon rupture at one, three, five, and seven years after Achilles tendon rupture were 0.4%, 1.8%, 3.4%, and 5.1%, respectively. The only statistically significant risk factor was age between 30 and 39 years at the time of initial Achilles tendon rupture (hazard ratio = 4.9). Conclusion: Patients who sustain Achilles tendon rupture in their 30 s have significantly increased risk for contralateral tendon rupture.

scholarly journals The economic burden of NCDs due to low fruit and vegetables consumption in the Russia in 2016

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
D Mukaneeva ◽  
A Kontsevaya ◽  
Y Balanova ◽  
A Myrzamatova ◽  
M Khudyakov
Keyword(s):  
Ovarian Cancer ◽  
Pancreatic Cancer ◽  
Risk Factor ◽  
Kidney Cancer ◽  
Economic Burden ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Direct Costs ◽  
Fruit And Vegetables ◽  
Economic Losses

Abstract Introduction A significant risk factor for NCDs is low fruit and vegetables (F/V) consumption, which leads to economic and social costs in all countries, regardless of income level. Aim To evaluate the economic burden of NCDs associated with low F/V consumption in the RF in 2016, including the direct costs and the economic losses caused by reduced productivity. Materials and Methods An analytical review of the literature on the search for relative risks (RR) of morbility and mortality from NCDs associated with low F/V consumption was carried out. Based on data on the prevalence of low F/V consumption in the RF (41.9%) and RR, the attributive risk for the population (PAR) was calculated for CVD, diabetes and several types of cancer. To assess the economic burden, the proportion of risk factor in morbidity and mortality from NCDs included in the analysis based on PAR was determined. Direct costs were calculated on the basis of tariffs for the provision of medical care in the RF in 2016 and the amount of disability benefits. Indirect costs included the loss of gross domestic product due to premature mortality and disability. Results PAR of low F/V consumption in the RF in 2016 in mortality for all CVD was 5%, in morbility about 7%, in morbility of stroke - 10%. PAR of low F/V consumption in morbility of diabetes was 6%, COPD - about 5%. PAR of low F/V consumption in mortality for ovarian cancer was 27%, for kidney cancer - 20%, in morbility from 3% for stomach cancer to 40% for pancreatic cancer. The economic burden associated with low F/V consumption in the RF in 2016 amounted to about 162 billion rubles (0.19% of GDP). A significant contribution to the economic burden was made by cancer: pancreatic cancer (38.2%), colorectal cancer (21.3%), ovarian cancer (26.3%), kidney cancer (26.4%). Conclusions An assessment of the economic burden will be an argument for justifying the feasibility of investing in the prevention of NCDs associated with low F/V consumption. Key messages To evaluate the economic burden of NCDs associated with low F/V consumption in the RF in 2016, including the direct costs and the economic losses caused by reduced productivity. The economic burden associated with low F/V consumption in the RF in 2016 amounted to about 162 billion rubles (0.19% of GDP).

Survival of resectable pancreatic cancer patients with diabetes

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 4098-4098 ◽  
Author(s):  
N. L. Busaidy ◽  
C. F. Yazbeck ◽  
P. Shah ◽  
D. B. Evans ◽  
D. Li ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Risk Factor ◽  
Cancer Patients ◽  
Pancreatic Adenocarcinoma ◽  
Median Survival ◽  
Resectable Pancreatic Cancer ◽  
Specific Mortality ◽  
Disease Specific Mortality ◽  
Disease Specific ◽  
Overall Mortality

4098 Background: Pancreatic cancer is the fourth leading cause of cancer mortality in the United States. Determining modifiable prognostic factors may be a key step in improving outcomes of these patients with overall poor survival. Pancreatic adenocarcinoma is often associated with diabetes. Our aim is to determine whether diabetes worsens disease specific mortality in resectable pancreatic cancer patients. Methods: In this study, we reviewed 298 patients with resected pancreatic adenocarcinoma in our surgical database at MD Anderson Cancer Center between August 1992 and July 2003. Patients were classified into diabetics (N = 87) (defined as those carrying the diagnosis of diabetes (DM) at time of presentation or on long term therapy for DM) and nondiabetics (N = 211). Univariate (log-rank) and Multivariate (Cox Regression) analyses were performed. Results: Compared to nondiabetics, patients with DM had a poorer overall survival with a median survival of 19.8 vs 29.2 months (p = 0.01). On multivariate analysis, correcting for known poor prognosticators in resectable patients: staging, histologic tumor differentiation and retroperitoneal margin status, diabetes was a significant independent risk factor for increased overall mortality (OR 1.55, 95% CI 1.15–2.07, p = 0.004). Disease-specific mortality was also higher in diabetics vs. non-diabetics with a median survival of 29.87 vs. 21.47 months (OR 1.37 95% CI 1.00–1.89 p = 0.048). Stage specific mortality was also higher among diabetics. Potential etiologies will be discussed. Conclusions: Diabetes worsens disease specific and overall mortality in patients with pancreatic cancer. Diabetes may be a modifiable risk factor and should be considered while prognosticating patients with resectable pancreatic cancer. Further studies are needed to determine whether treatment of diabetes improves outcomes. No significant financial relationships to disclose.

Physical Illness and Suicide Risk in Rural Residents of Contemporary China

Crisis ◽  
2014 ◽  
Vol 35 (5) ◽  
pp. 330-337 ◽  
Author(s):  
Cun-Xian Jia ◽  
Lin-Lin Wang ◽  
Ai-Qiang Xu ◽  
Ai-Ying Dai ◽  
Ping Qin
Keyword(s):  
Risk Factor ◽  
Family Income ◽  
Rural China ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Health Condition ◽  
Physical Illness ◽  
Rural Residents ◽  
Increased Risk ◽  
Study Population

Background: Physical illness is linked with an increased risk of suicide; however, evidence from China is limited. Aims: To assess the influence of physical illness on risk of suicide among rural residents of China, and to examine the differences in the characteristics of people completing suicide with physical illness from those without physical illness. Method: In all, 200 suicide cases and 200 control subjects, 1:1 pair-matched on sex and age, were included from 25 townships of three randomly selected counties in Shandong Province, China. One informant for each suicide or control subject was interviewed to collect data on the physical health condition and psychological and sociodemographic status. Results: The prevalence of physical illness in suicide cases (63.0%) was significantly higher than that in paired controls (41.0%; χ2 = 19.39, p < .001). Compared with suicide cases without physical illness, people who were physically ill and completed suicide were generally older, less educated, had lower family income, and reported a mental disorder less often. Physical illness denoted a significant risk factor for suicide with an associated odds ratio of 3.23 (95% CI: 1.85–5.62) after adjusted for important covariates. The elevated risk of suicide increased progressively with the number of comorbid illnesses. Cancer, stroke, and a group of illnesses comprising dementia, hemiplegia, and encephalatrophy had a particularly strong effect among the commonly reported diagnoses in this study population. Conclusion: Physical illness is an important risk factor for suicide in rural residents of China. Efforts for suicide prevention are needed and should be integrated with national strategies of health care in rural China.

scholarly journals Higher premature atrial complex burden from the Holter examination predicts poor cardiovascular outcome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ting-Chun Huang ◽  
Po-Tseng Lee ◽  
Mu-Shiang Huang ◽  
Pei-Fang Su ◽  
Ping-Yen Liu
Keyword(s):  
Risk Factor ◽  
Dose Response ◽  
Cox Model ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Cardiovascular Death ◽  
Specific Model ◽  
Distribution Model ◽  
All Cause Mortality ◽  
Quartile Group

AbstractPremature atrial complexes (PACs) have been suggested to increase the risk of adverse events. The distribution of PAC burden and its dose–response effects on all-cause mortality and cardiovascular death had not been elucidated clearly. We analyzed 15,893 patients in a medical referral center from July 1st, 2011, to December 31st, 2018. Multivariate regression driven by ln PAC (beats per 24 h plus 1) or quartiles of PAC burden were examined. Older group had higher PAC burden than younger group (p for trend < 0.001), and both genders shared similar PACs distribution. In Cox model, ln PAC remained an independent risk factor for all-cause mortality (hazard ratio (HR) = 1.09 per ln PAC increase, 95% CI = 1.06‒1.12, p < 0.001). PACs were a significant risk factor in cause-specific model (HR = 1.13, 95% CI = 1.05‒1.22, p = 0.001) or sub-distribution model (HR = 1.12, 95% CI = 1.04‒1.21, p = 0.004). In ordinal PAC model, 4th quartile group had significantly higher risk of all-cause mortality than those in 1st quartile group (HR = 1.47, 95% CI = 1.13‒1.94, p = 0.005), but no difference in cardiovascular death were found in competing risk analysis. In subgroup analysis, the risk of high PAC burden was consistently higher than in low-burden group across pre-specified subgroups. In conclusion, PAC burden has a dose response effect on all-cause mortality and cardiovascular death.

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