Angiogenesis factors in esophageal tumors of various histogenesis.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 87-87
Author(s):  
Elena Mikhaylovna Frantsiyants ◽  
Oleg Ivanovich Kit ◽  
Evgeniy N. Kolesnikov ◽  
Natalia D. Cheryarina ◽  
Larisa Kozlova ◽  
...  
Keyword(s):  
Growth Factors ◽  
Negative Correlation ◽  
Malignant Tumors ◽  
Standard Test ◽  
Strong Positive Correlation ◽  
Strong Negative Correlation ◽  
Tissue Samples ◽  
Positive Correlation ◽  
Esophageal Tumors ◽  
Tgf Β1

87 Background: Study of biological nature of tumors can provide important information on the malignant process course and contribute to the drug therapy development. The purpose of the study was to analyze levels of some growth factors in tissues of malignant esophageal tumors of various histogenesis. Methods: Levels of VEGF-А and its receptor sVEGF-R1, VEGF-С and its receptor sVEGF-R2, EGF, IFR-1, IFR-2 and TGF-β1 were studied by the ELISA using standard test-systems in tissue samples obtained from 39 patients: 27 – esophageal squamous cell carcinoma (ESCC), 12 – esophageal adenocarcinoma (EA). All patients had stage II disease (G2, pTNM). Results: Development of the pathogenic vascularization mechanism in ESCC and EA tissues was found to have both similar and different characteristics associated with the expression of growth factors. Similarities included activation of VEGF-А, VEGF-С, VEGF-R1, VEGF-R3, TGF-β1 and EGF in tissues of malignant tumors despite their histogenesis, while differences involved IGF-I and IGF-II content. A strong positive correlation between levels of VEGF-А and IGF-1 (r = 76; p < 0.01), but not IGF-II, was registered in EA tissues only, while in ESCC we found the negative correlation between VEGF-А and IGF-1(r = - 81; p < 0.01) and VEGF-А and IGF-2 (r = -79; p < 0.01). The same was observed for VEGF-С: a strong positive correlation with IGF-1(r = 79; p < 0.01), but not with IGF-II in EA, and a strong negative correlation with IGF-1(r = - 83; p < 0.01) and IGF-2 (r = -87; p < 0.01) in ESCC. EGF appears to be the only VEGF-А and VEGF-С inductor in ESCC, as a strong correlation with it was noted: r = 75 (p < 0.01) and r = 77 (p < 0.01) respectively, while activators of angio- and lymphogenesis factors in EA were presented by IGF-1 and EGF (r = 76 at p < 0.01 and r = 79 at p < 0.01 with VEGF-А and VEGF-С, respectively). Conclusions: Apparently, the two histological types of esophageal cancer are two different diseases with their own pathogenesis, prognosis and therefore approach to the targeted therapy.

scholarly journals Spatial Variation of the Relationship between PM2.5Concentrations and Meteorological Parameters in China

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Gang Lin ◽  
Jingying Fu ◽  
Dong Jiang ◽  
Jianhua Wang ◽  
Qiao Wang ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Meteorological Parameters ◽  
Semiarid Region ◽  
Strong Positive Correlation ◽  
Annual Average ◽  
Strong Negative Correlation ◽  
Positive Correlation ◽  
Humid Region ◽  
The Relationship ◽  
Warm Temperate

Epidemiological studies around the world have reported that fine particulate matter (PM2.5) is closely associated with human health. The distribution of PM2.5concentrations is influenced by multiple geographic and socioeconomic factors. Using a remote-sensing-derived PM2.5dataset, this paper explores the relationship between PM2.5concentrations and meteorological parameters and their spatial variance in China for the period 2001–2010. The spatial variations of the relationships between the annual average PM2.5, the annual average precipitation (AAP), and the annual average temperature (AAT) were evaluated using the Geographically Weighted Regression (GWR) model. The results indicated that PM2.5had a strong and stable correlation with meteorological parameters. In particular, PM2.5had a negative correlation with precipitation and a positive correlation with temperature. In addition, the relationship between the variables changed over space, and the strong negative correlation between PM2.5and the AAP mainly appeared in the warm temperate semihumid region and northern subtropical humid region in 2001 and 2010, with some localized differences. The strong positive correlation between the PM2.5and the AAT mainly occurred in the mid-temperate semiarid region, the humid, semihumid, and semiarid warm temperate regions, and the northern subtropical humid region in 2001 and 2010.

scholarly journals The effects of cardiac rehabilitation on haemodynamic parameters measured by impedance cardiography in patients with coronary artery disease

2020 ◽  
pp. 126-126
Author(s):  
Milovan Stojanovic ◽  
Marina Deljanin-Ilic ◽  
Stevan Ilic ◽  
Dejan Petrovic ◽  
Bojan Ilic
Keyword(s):  
Coronary Artery Disease ◽  
Negative Correlation ◽  
Impedance Cardiography ◽  
Exercise Stress ◽  
Strong Positive Correlation ◽  
Physical Strain ◽  
Strong Negative Correlation ◽  
Positive Correlation ◽  
Strain Tolerance ◽  
Artery Disease

Background / Aim. Well-organized cardiovascular rehabilitation (CVR) reduces cardiovascular burden by influencing cardiovascular risk factors, improving the quality of life and reducing mortality and hospital readmission. However, its effects on hemodynamic status are largely unknown. The aim of our study was to evaluate the influence of three-week CVR program on hemodynamic status and to investigate if there is a correlation between physical strain tolerance and hemodynamic parameters measured by impedance cardiography (ICG) before and after CVR program in patients with coronary artery disease. Methods. Fifty-two patients attended a three-week CVR program. At the beginning and at the end of rehabilitation program laboratory tests, exercise stress tests (EST) and ICG measurements were taken. Results. Patients showed better strain tolerance on the second exercise stress test (EST2) by achieving higher strain level (Z=2,315; p=0,021) and longer duration of test (Z=2,305; p=0,021). There was a strong positive correlation between the level of EST2 and cardiac output (CO) (r=0,538; p<0,001) and stroke volume (SV) (r=0,380; p=0,017) on the second ICG (ICG2). Also, there was a strong negative correlation between EST2 level and systemic vascular resistance (SVR) (r=-0,472; p=0,002) and SVR index (SSVRI) (r=-0,407; p=0,010) on ICG2. There was a strong positive correlation between EST2 duration and CO (r=0.517; p=0.001) as well as between EST2 duration and SV (r=0.340; p=0.034), and a strong negative correlation between EST2 duration and SVR (r=-0.504; p=0.001) as well as between EST2 duration and SVRI (r=-0.448; p=0.004), according to ICG2. Conclusion. Our study showed that a well-designed CVR program can lead to better physical strain tolerance. Furthermore, CVR led to a significant positive correlation between EST and cardiac output as well as between EST and stroke volume measured by ICG. On the other hand, there was a significant negative correlation between EST and vascular related parameters according to ICG at the end of the CVR program.

scholarly journals Relationship Between Sperm Quality and Male Reproductive Hormones Among Male Partners with Fertility Complications: Attending CHUB

2020 ◽  
Vol 3 (3) ◽  
pp. 315-328
Author(s):  
Herbert Mapira Tendayi ◽  
Jerome Ndayisenga ◽  
Solange Nyiramahirwe ◽  
Jacqueline Mukanshuti ◽  
Valens Karenzi ◽  
...  
Keyword(s):  
Sperm Motility ◽  
Negative Correlation ◽  
Sperm Quality ◽  
Sperm Count ◽  
Reproductive Hormones ◽  
Strong Positive Correlation ◽  
Male Partners ◽  
Strong Negative Correlation ◽  
Cross Sectional ◽  
Positive Correlation

Background Infertility remains a highly prevalent global condition in the second decade of the new millennium. Reproductive hormones determine sperm quality as they initiate and maintain spermatogenesis. Hormonal imbalance can cause abnormal sperm quality that can be treated by hormonal replacement therapy. Objective To assess the relationship between sperm quality and male reproductive hormones among male partners with fertility complications attending CHUB. Methods The study was a descriptive cross-sectional, and a convenient sampling strategy was used to recruit subjects at CHUB. Sixty-two male subjects with fertility complications provided both semen and blood sample to analyze sperm quality and reproductive hormones. Descriptive statistics were used to analyze data. Results Both FSH and LH showed a strong negative correlation with sperm count which is more profound with FSH (r= -0.722) than LH (r= -0.545). Testosterone showed a strong positive correlation with sperm count (r= 0.712). FSH and LH showed a negative correlation with sperm motility which is more profound in FSH (r= -0.312) than LH (r= -0.302). Testosterone also showed a positive correlation with sperm motility (r= 0.360). Conclusion Our study found a correlation between sperm quality and male reproductive hormones. We further suggest other studies to investigate predictive power of male reproductive hormones. Rwanda J Med Health Sci 2020;3(3):315-328

scholarly journals An examination of jump kinematics in dogs over increasing hurdle heights

2016 ◽  
Vol 12 (2) ◽  
pp. 91-98 ◽  
Author(s):  
E. Birch ◽  
A. Carter ◽  
J. Boyd
Keyword(s):  
Lumbar Spine ◽  
Negative Correlation ◽  
Maximum Height ◽  
Strong Positive Correlation ◽  
Kinematic Parameters ◽  
Strong Negative Correlation ◽  
Positive Correlation ◽  
Sports Science ◽  
Dorsal Aspect ◽  
Dorsal Extension

Research examining kinematic parameters of the canine athlete is markedly behind equivalent human and equine research. With increasing participation and popularity, canine sports science needs to bridge this gap with comparable equine research. The aim of this study was to examine changes to specific kinematic parameters as hurdle height increases. Twenty border collies and border collie crosses were analysed jumping over a single hurdle at increasing heights, starting with a pole on the floor and increasing to a maximum height of 65 cm. Length of trajectory and jump speed were analysed, alongside apparent (without the use of markers) neck, lumbar spine and shoulder angles using Dartfish software. For each dog, the percentage of the hurdle height in relation to their height at the dorsal aspect of the scapula (withers) was used to normalise the dogs evenly. Overall jump speed decreased as percentage height increased (P<0.001), with a strong negative correlation between the two (r=-0.815). Length of trajectory significantly increased with percentage height (P<0.001) with a strong positive correlation between the two (r=0.740). However, length of trajectory decreased when a dog jumped ≥126% of its height to the withers. This is supported by a significantly more flexed apparent neck angle upon landing at this percentage height (P<0.001). Apparent lumbar spine angles showed greater dorsal extension upon landing as percentage height increased (P<0.001). Apparent shoulder angles become significantly more flexed as percentage height increased during the suspension phase of the jump (P<0.001). These results suggest that dogs significantly alter their jump kinematics as hurdle height increases.

Relationships between milk fatty acid profiles and enteric methane production in dairy cattle fed grass- or grass silage-based diets

2016 ◽  
Vol 56 (3) ◽  
pp. 541 ◽  
Author(s):  
J. Dijkstra ◽  
S. van Gastelen ◽  
E. C. Antunes-Fernandes ◽  
D. Warner ◽  
B. Hatew ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Dairy Cattle ◽  
Negative Correlation ◽  
Methane Production ◽  
Methane Yield ◽  
Milk Fatty Acid ◽  
Strong Positive Correlation ◽  
Strong Negative Correlation ◽  
Positive Correlation ◽  
Grass Silage

We quantified relationships between methane production and milk fatty acid (FA) profile in dairy cattle fed grass- or grass silage-based diets, and determined whether recent prediction equations for methane, based on a wide variety of diets, are applicable to grass- and grass silage-based diets. Data from three studies were used, encompassing four grass herbage and 14 grass silage treatments and 132 individual cow observations. Methane production was measured using respiration chambers and milk fatty acids (FAs) analysed using gas chromatography. The proportion of grass or grass silage (dry matter (DM) basis) was 0.80 ± 0.037. Methane yield averaged 22.3 ± 2.10 g/kg DM intake (DMI) and 14.2 ± 2.90 g/kg fat- and protein-corrected milk (FPCM). Mixed model univariate regression including a random study effect on intercept was applied to predict methane yield, with individual milk FA concentrations (g/100 g FA) as fixed effects. Of the 42 milk FAs identified, no single FA had a strong positive correlation (r; strong correlation defined as |r| ≥ 0.50) with methane yield (g/kg DMI), and cis-12 C18:1 and cis-9,12,15 C18:3 had a strong negative correlation with methane yield (g/kg DMI). C14:0 iso, C15:0, C15:0 iso, C15:0 anteiso, C16:0, C20:0, cis-11,14 C20:2, cis-5,8,11,14 C20:4, C22:0, cis-7,10,13,16,19 C22:5 and C24:0 had a strong positive correlation with methane yield (g/kg FPCM), and trans-15+cis-11 C18:1, cis-9 C18:1, and cis-11 C20:1 had a strong negative correlation with methane yield (g/kg FPCM). Observed methane yield was compared with methane yield predicted by the equations of van Lingen et al. (2014; Journal of Dairy Science 97, 7115–7132). These equations did not accurately predict methane yield as grams per kilogram DMI (concordance correlation coefficient (CCC) = 0.13) or as grams per kilogram FPCM (CCC = 0.22), in particular related to large differences in standard deviation between predicted and observed values. In conclusion, quantitative relationships between milk FA profile and methane yield in cattle fed grass- or grass silage-based diets differ from those determined for other types of diets.

scholarly journals Association between lung function, thoracoabdominal mobility and posture in cystic fibrosis: pilot study

2020 ◽  
Vol 33 ◽  
Author(s):  
Francisca Pereira Pinto ◽  
Gustavo Vieira Paterlini de Souza ◽  
Karine Jacon Sarro ◽  
Cintia Carvalho Bragança Garcia ◽  
Flávia Marini Paro
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Pulmonary Function ◽  
Negative Correlation ◽  
Strong Positive Correlation ◽  
Strong Negative Correlation ◽  
Positive Correlation ◽  
Horizontal Alignment ◽  
Postural Alignment ◽  
Postural Assessment

Abstract Introduction: Deterioration of lung function is the main cause of mortality in cystic fibrosis (CF), so it is essential to study different related factors. Objective: To assess the association of pulmonary function with thoracoabdominal mobility and postural alignment in individuals with CF. Method: A cross-sectional study was performed in individuals with CF (8-17 years). Pulmonary function was assessed by spirometry. Thoracoabdominal mobility and postural alignment were evaluated by photogrammetry using the Postural Assessment Software (PAS/Sapo). Pearson correlation coefficient analysis was performed, and p < 0.05 was considered significant. Results: The following spirometric variables showed a decrease compared to predicted values: FEV1, FEV1/FVC, PEF and FEF25-75%. Postural assessment showed alterations in head horizontal alignment (HHA; 2.71 ± 2.23o), acromion horizontal alignment (AHA; 1.33 ± 1.35o), anterior superior iliac spine (ASIS) horizontal alignment (ASISHA; 1.11 ± 0.89o), angle between acromia and ASIS (AAASIS; 0.89 ± 0.39o), scapula horizontal asymmetry - T3 (SHAT3; 16.95 ± 12.03%), and asymmetry of the projection of the center of gravity within the base of support in the frontal (11.45 ± 8.10%) and sagittal (48.98 ± 18.55%) planes. A strong positive correlation was found between pulmonary function and thoracoabdominal mobility in the variables anteroposterior mobility of the upper chest (APMUC) and FVC (r = 0.818, p = 0.024), APMUC and FEV1 (r = 0.874, p = 0.010), and APMUC and FEF25-75% (r = 0.797, p = 0.032). A strong negative correlation was detected between FEV1/FVC and AHA (r = -0.761, p = 0.047). Conclusion: Our study showed in CF a reduction in pulmonary function, strong positive correlation between APMUC and pulmonary function, high prevalence of kyphoscoliosis and strong negative correlation between AHA and pulmonary function.

scholarly journals Correlation between femoral offset and other morphometric parameters

2017 ◽  
Vol 06 (02) ◽  
pp. 137-145
Author(s):  
Pratima Jaiswal ◽  
Lakshmi Verma ◽  
Tuhin Ghulyani
Keyword(s):  
Negative Correlation ◽  
Clinical Importance ◽  
Regression Equations ◽  
Strong Positive Correlation ◽  
Neck Length ◽  
Femoral Offset ◽  
Strong Negative Correlation ◽  
Mean Values ◽  
Positive Correlation ◽  
Neck Shaft Angle

Abstract Background and aims: Surgeries involving the femur are quite common. The clinical importance of femur in sports biomechanics and rehabilitation is well known. Therefore, its morphometries has orthopedic implications. The present study aims at establishing interrelationship among various external parameters in adult dried femora including femoral offset (FO), neck shaft angle [NSA], femoral anteversion angle [FNA], Neck width [NW], Anterior Neck length [ANL], Posterior Neck length [PNL], Oblique length [OL] and trochanteric oblique length [TOL], Materials and Methods: A total of 100 [50 right and 50 left] intact, dried adult human femora from department of Anatomy, Government Medical College, Kota were included in this study. The FO, NSA and FNA were measured by digital image analysis in ‘IMAGEJ’ software. OL and TOL were measured using osteometric board. ANL, PNL and NW were recorded using sliding caliper. Statistical analysis was done using SPSS and Microsoft Excel software. The mean values were calculated, relationship between parameters was measured by Pearson's correlation coefficient ‘r’. Multiple regression equations were derived in order to calculate FO by other variables. Results: FO showed strong negative correlation with NSA; strong positive correlation with ANL, PNL, NW; moderate positive correlation with OL, TOL; but no relationship with FNA. NSA had moderate negative correlation with NW and weak negative correlation with PNL. NW & ANL had positive correlation with OL, TOL. Conclusion: In our method we used dried, intact bone and digital photographs with standardised method. Therefore it should provide accurate results; in addition it is cost effective. However studies on larger scale are warranted to design implants for Indian population.

scholarly journals The Presence, Trends, and Causes of Security Vulnerabilities in Operating Systems of IoT’s Low-End Devices

Sensors ◽  
2021 ◽  
Vol 21 (7) ◽  
pp. 2329
Author(s):  
Abdullah Al-Boghdady ◽  
Khaled Wassif ◽  
Mohammad El-Ramly
Keyword(s):  
Operating Systems ◽  
Negative Correlation ◽  
Source Code ◽  
Strong Positive Correlation ◽  
Strong Negative Correlation ◽  
Security Vulnerabilities ◽  
Positive Correlation ◽  
Security Breaches ◽  
Error Density ◽  
Code Complexity

Internet of Things Operating Systems (IoT OSs) run, manage and control IoT devices. Therefore, it is important to secure the source code for IoT OSs, especially if they are deployed on devices used for human care and safety. In this paper, we report the results of our investigations of the security status and the presence of security vulnerabilities in the source code of the most popular open source IoT OSs. Through this research, three Static Analysis Tools (Cppcheck, Flawfinder and RATS) were used to examine the code of sixteen different releases of four different C/C++ IoT OSs, with 48 examinations, regarding the presence of vulnerabilities from the Common Weakness Enumeration (CWE). The examination reveals that IoT OS code still suffers from errors that lead to security vulnerabilities and increase the opportunity of security breaches. The total number of errors in IoT OSs is increasing from version to the next, while error density, i.e., errors per 1K of physical Source Lines of Code (SLOC) is decreasing chronologically for all IoT Oss, with few exceptions. The most prevalent vulnerabilities in IoT OS source code were CWE-561, CWE-398 and CWE-563 according to Cppcheck, (CWE-119!/CWE-120), CWE-120 and CWE-126 according to Flawfinder, and CWE-119, CWE-120 and CWE-134 according to RATS. Additionally, the CodeScene tool was used to investigate the development of the evolutionary properties of IoT OSs and the relationship between them and the presence of IoT OS vulnerabilities. CodeScene reveals strong positive correlation between the total number of security errors within IoT OSs and SLOC, as well as strong negative correlation between the total number of security errors and Code Health. CodeScene also indicates strong positive correlation between security error density (errors per 1K SLOC) and the presence of hotspots (frequency of code changes and code complexity), as well as strong negative correlation between security error density and the Qualitative Team Experience, which is a measure of the experience of the IoT OS developers.

scholarly journals The Relationship Between Water Quality and Phytoplankton Abundance at The Eastern Part of Segara Anakan Cilacap, Central Java

2019 ◽  
Vol 1 (2) ◽  
pp. 1
Author(s):  
Hasby Ghoni Asiddiqi ◽  
Agatha Sih Piranti ◽  
Erwin Ardli Riyanto
Keyword(s):  
Water Quality ◽  
Negative Correlation ◽  
Physical Factor ◽  
Phytoplankton Abundance ◽  
Chemical Factor ◽  
Strong Negative Correlation ◽  
Positive Correlation ◽  
Central Java ◽  
Primary Producer ◽  
The Relationship

Phytoplankton is the primary producer whose existence depends not only on the nutrient. The eastern part of Segara Anakan waters experienced changes where the decline in quality which received input from organic and inorganic wastes and residential, industrial and factory wastes of Holcim and Pertamina factories. The purpose of this research is to study the water quality and to study the relationship between water quality and abundance of phytoplankton at the eastern part of Segara Anakan. The result showed that Water quality in Segara Anakan waters in the eastern part of Cilacap consists of several parameters that beyond the quality standards according to the Keputusan Menteri Lingkungan Hidup No. 51 of 2004 such as pH, Nitrate, Ammonia, Phosphate, and TSS. Water temperature is a physical factor which has a strong negative correlation with the abundance of phytoplankton, followed by TSS as a physical factor which has a positive correlation. The chemical factor which has a positive correlation with abundance are TDS, Nitrite and pH, followed by Phosphate, Salinity, Ammonia, and Nitrate which has a negative correlation with the abundance of phytoplankton. Key Words: Environmental factor, phytoplankton, Segara Anakan, Spatial variation, temporal variation.

Correlations of the Droplet Size-Velocity of the Two-Phase, Air/Liquid Spray Using a Particle-Dynamic-Analyzer

2008 ◽  
Author(s):  
Mohammad A. Rahman ◽  
Johana Gomez ◽  
Ted Heidrick ◽  
Brian A. Fleck ◽  
Jennifer McMillan
Keyword(s):  
Void Fraction ◽  
Heavy Oil ◽  
Droplet Diameter ◽  
Liquid Product ◽  
Process Industry ◽  
Particle Dynamic ◽  
Strong Positive Correlation ◽  
Two Phase ◽  
Strong Negative Correlation ◽  
Positive Correlation

In the heavy oil process industry preheated bitumen and steam are mixed upstream of the feed nozzle and subsequently injected into fluid bed coker reactors via feed nozzles. To achieve high liquid product yields, the bitumen should contact a large number of fluidized coke particles quickly and uniformly. One of the drawbacks of the spray issuing from the nozzle is the potential pulsation within the spray and in the feeding conduit, which is highly undesirable to yield high productivity. These pulsations result in poor atomization and in most instances, a slug of liquid is ejected out of the nozzle. It would be valuable to investigate under which two-phase fluid conditions this pulsation aggravates. It would also be beneficial to examine the detailed spray map with changing air-to-liquid ratio (ALR) by mass and void fraction (α). The average void fraction in the feeding conduit was measured by a pneumatic controlled quick-closing-valve (QCV). The length and diameter of the feeding conduit was 36.8 cm and 6.35 mm, respectively. The experiments were performed using mixtures of air with water at water flow rates of 1.50 to 7.50 kg / min and air-to-liquid (ALR) mass ratios of 0.30 to 9.3%. This study indicates that there exists a strong positive correlation between the droplet diameter and axial velocity at the center of the spray. A positive correlation also exists in between the spray center and periphery. However, a strong negative correlation exists at the periphery of the spray. Knowledge from this study would help the heavy oil process industry to upgrade their heavy oil upgrading process and increase the product yield.

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