Comparison of mortality trends in geriatric and nongeriatric patients with salivary gland tumors.

e23026 Background: The treatment of salivary gland tumors has not changed significantly in the past two decades. However, its increased incidence in the geriatric population poses new challenges for their management. This study explores the incidence-based mortality (IBM) trends in the geriatric and non-geriatric population for the time period of 2000 to 2014 and compares the trends between races. Methods: Mortality data was extracted from the Surveillance, Epidemiology, and End Results (SEER) Database for the years 2000 to 2014. IBM for all stages of salivary gland tumors was queried and the results were grouped by age (geriatric vs. non-geriatric) and race (Caucasian/White, African American (AA)/Black, American Indian/Alaskan native and Asian/Pacific Islander). All stages and both genders were included in the analysis. T-test was used to determine statistically significance difference between various subgroups. Linearized trend lines were used to visualize the mortality trends between various subgroups (Geriatric vs. Non- geriatric and Caucasian vs. African American). Results: IBM for salivary gland tumors has worsened since 2000 to 2014 for both geriatric and non-geriatric patients (P < 0.05), There was a statistically significant difference between these two groups in both Caucasian/White and AA/Black patients. Notably, the worst IBM rates were noted in non-geriatric AA/Black patients followed by non-geriatric Caucasian/White patients. However, there was no statistical difference in IBM between geriatric patients of Caucasian/White and AA/Black descent. Conclusions: The similarity in IBM for geriatric patients with salivary gland tumors in both Caucasian/White and AA/Black groups suggest that the effects of race may not be pronounced in the elderly population. The high rate of IBM in non-geriatric AA/Black patients may suggest environmental influence and warrants further study.

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Comparison of mortality trends in patients with non-salivary gland and salivary gland adenoid cystic carcinoma in the United States population.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.e17584 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. e17584-e17584

Author(s):

Girindra Ghanshyam Raval ◽

Germame Hailegiorgis Ajebo ◽

Locke Johnson Bryan ◽

Achuta Kumar Guddati

Keyword(s):

African American ◽

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Neck Region ◽

Mortality Trends ◽

Adenoid Cystic ◽

Black Patients ◽

Significant Difference ◽

American Black ◽

White Patients

e17584 Background: Adenoid cystic carcinoma is the most common histological subtype of malignancy seen in major and minor salivary glands. Although indolent they tend to recur and progress. Adenoid cystic carcinoma also arises from other structures such as lacrimal glands and trachea. This study compares the incidence-based mortality between patients who have salivary and no-salivary origin adenoid cystic carcinomas of the head and neck region over the period of 2000 to 2014. Methods: A nation-wide analysis was conducted utilizing the Surveillance, Epidemiology, and End Results (SEER) Database from the years 2000 to 2014. Incidence-based mortality for all stages of adenoid cystic carcinoma was queried and the results were grouped by race (Caucasian/White, African American/Black, American Indian/Alaskan native and Asian/Pacific Islander) and gender. All stages were included in the analysis. T-test was used to determine statistically significance difference between various subgroups. Linearized trend lines were used to visualize the mortality trends of all sub groups. Results: Incidence-based mortality for salivary gland adenoid cystic carcinomas in African American/Black patients is comparable to Caucasian/White patients despite a higher incidence in Caucasian/White patients (no statistically significant difference was noted). Also, the incidence-based mortality for non-salivary gland adenoid cystic carcinomas of the head and neck region in African American/Black patients was similar to Caucasian/White patients. Essentially no racial difference in mortality was noted between salivary and non-salivary gland tumors. Comparison of mortality between genders in both races in salivary and non-salivary gland tumors also did not show any statistically significant difference. Conclusions: This study showed that adenoid cystic carcinoma of non-salivary gland origin have the same mortality trends as that from salivary gland origin in both Caucasian/White and American/Black patients and in both genders. Given such uniformity, genetic and environmental factors may not play significant role in the progression and outcomes of this disease. Hence, adenoid cystic carcinoma may be treated with similar therapeutic approaches regardless of the origin, gender and race of the patient.

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A Nationwide analysis of mortality trends in geriatric and non-geriatric patients with oral cavity tumors.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.e17510 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. e17510-e17510

Author(s):

Bushra Waseem ◽

Germame Hailegiorgis Ajebo ◽

Allan N. Krutchik ◽

Achuta Kumar Guddati

Keyword(s):

African American ◽

Oral Cavity ◽

Geriatric Patients ◽

Linear Trend ◽

Significant Risk ◽

Significant Risk Factor ◽

Mortality Trends ◽

Alaskan Native ◽

Significant Difference ◽

American Black

e17510 Background: Squamous cell carcinoma is the most common histological-subtype of oral cavity tumors and no major advances in its treatment have occurred recently. However, p16 positive tumors have been noted to have a better prognosis than p16 negative tumors. Older patients have increasingly been found to have p16 positive oral cavity cancers. This study explores the incidence based mortality of geriatric patients irrespective of p16 status. Methods: Data from Surveillance, Epidemiology, and End Results (SEER) Database was extracted to study the incidence-based mortality for the years 2000 to 2014. Incidence-based mortality for all stages of oral cavity tumors was queried and the results were grouped by age (geriatric vs. non-geriatric) and race (Caucasian/White, African American/Black, American Indian/Alaskan native and Asian/Pacific Islander). All stages and both genders were included in the analysis. T-test was used to determine statistically significant difference between various subgroups. Linear trend lines were used to visualize the mortality trends between various subgroups (Geriatric vs. Non- geriatric and Caucasian vs. African American). Results: Incidence-based mortality for oral cavity tumors has worsened since 2000 to 2014 for geriatric patients (p < 0.05) when compared to non-geriatric patients in both Caucasian/White patients and African American/Black patients. The results are summarized in the table below. Conclusions: The similarity in incidence-based mortality for geriatric patients with oral cavity tumors is high in all races and may imply age as a significant risk factor in these patients. A stage-specific, gender-specific and age-binned analysis may help differentiate these concerning trends. [Table: see text]

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Pattern of salivary gland tumors in Manipur, India: A 10 year study

South Asian Journal of Cancer ◽

10.4103/2278-330x.119886 ◽

2013 ◽

Vol 02 (04) ◽

pp. 250-253 ◽

Cited By ~ 2

Author(s):

Rajesh Singh Laishram ◽

Arun Kumar K. ◽

Gayatri Devi Pukhrambam ◽

Sharmila Laishram ◽

Kaushik Debnath

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Salivary Gland Tumors ◽

Neoplastic Lesion ◽

Chronic Sialadenitis ◽

Significant Difference ◽

North Eastern ◽

Neoplastic Lesions ◽

Malignant Group ◽

Malignant Lesions

Abstract Background: Salivary gland lesions, especially the neoplastic lesions constitute a highly heterogeneous histopathologic group. Several studies have reported a significant difference in the global distribution of salivary gland tumors, but no formal study has been carried out in this part of the globe. Objectives: To document the pattern of various salivary gland tumors in Manipur, a state in North Eastern India. Materials and Methods: This is a 10 years (2002-2011) retrospective study of all salivary gland specimens received at our referral teaching hospital in Manipur, India. All the histopathology slides of salivary gland specimens during the study period were reviewed and clinical details were obtained from the archives. Restaining of slides and fresh sections of tissue blocks were performed whenever required. Data thus collected were analyzed. Results: A total of 104 cases of salivary gland lesions were studied during the study period. Age ranged from 5 years to 78 years with an overall slight female preponderance (M:F = 1:1.08). Parotid (56.65%) was the commonest gland involved followed by submandibular gland (31.73%). Neoplastic lesions comprised of 78 (75%) cases and non-neoplastic lesions constituted 25% (26 cases). Among the neoplastic lesions, benign lesions (53.85%) predominated over malignant lesions (21.15%). Pleomorphic adenoma was the commonest benign neoplastic lesion and mucoepidermoid carcinoma was the commonest malignant tumor. Chronic sialadenitis was the predominant lesion in the non-neoplastic group. Conclusion: The principal site for salivary gland tumors was the parotid gland and pleomorphic adenoma outnumbered all the other tumors. Females are more affected in the malignant group.

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Clinicopathological study of salivary gland tumors: an assessment of 303 patients

Cadernos de Saúde Pública ◽

10.1590/s0102-311x2011000500020 ◽

2011 ◽

Vol 27 (5) ◽

pp. 1035-1040 ◽

Cited By ~ 9

Author(s):

Maria de Lourdes Silva de Arruda Morais ◽

Paulo Roberto Azevedo ◽

Cyntia Helena Carvalho ◽

Lélia Medeiros ◽

Tirzah Lajus ◽

...

Keyword(s):

Salivary Gland ◽

Disease Duration ◽

Malignant Tumors ◽

Salivary Gland Tumors ◽

Clinical Aspects ◽

Malignant Neoplasms ◽

Common Mean ◽

Significant Difference ◽

Case Files ◽

Tumor Consistency

Salivary gland neoplasms are remarkable for their histological diversity and several studies point to their varied occurrence in the population. Clinical aspects were histologically assessed to determine possible associations and define parameters to differentiate benign and malignant neoplasms. The case files of patients diagnosed with epithelial salivary gland tumors between 1989 and 2005 were reviewed. A majority (71%) of the 303 salivary gland tumors studied were benign and pleomorphic adenoma were found to be most common. Mean ages for patients with benign and malignant tumors were 49.2 and 58.5 years, respectively. A statistically significant difference between these tumors was observed for the following variables: mean age, tumor size and disease duration. A correlation was found between histological diagnosis and tumor consistency. The data presented here corroborate a number of previous studies and are therefore relevant in understanding the diverse characteristics exhibited by these tumors.

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Proliferation PET/CT Imaging of Salivary Gland Tumor

Diagnostics ◽

10.3390/diagnostics11112065 ◽

2021 ◽

Vol 11 (11) ◽

pp. 2065

Author(s):

Ryogo Minamimoto

Keyword(s):

Salivary Gland ◽

Salivary Gland Tumor ◽

Standardized Uptake Value ◽

Ct Imaging ◽

Salivary Gland Tumors ◽

Parotid Carcinoma ◽

Positron Emission ◽

Pet Ct ◽

Significant Difference ◽

Malignant Salivary Gland Tumors

Salivary gland tumors are rare neoplasms which vary in terms of origin and malignant potential. 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET) has limited ability to differentiate between different types of salivary gland tumors because both Warthin’s tumors and pleomorphic adenomas usually show increased FDG uptake, with no statistically significant difference in standardized uptake value (SUV) compared with malignant salivary gland tumors. Here, we discuss 4′-[methyl-11C]-thiothymidine (4DST) PET, which provides cell proliferation imaging capable of demonstrating intense uptake in parotid carcinoma and Warthin’s tumor, but no uptake in parotid pleomorphic adenoma. This is the first report of the potential of proliferation PET/ computed tomography (CT) imaging for characterizing salivary gland tumors based on the molecular pathogenesis of the tumor.

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Comparison of continuous ambulatory peritoneal dialysis and hemodialysis patient survival with evaluation of trends during the 1980s.

Journal of the American Society of Nephrology ◽

10.1681/asn.v351147 ◽

1992 ◽

Vol 3 (5) ◽

pp. 1147-1155 ◽

Cited By ~ 2

Author(s):

C B Nelson ◽

F K Port ◽

R A Wolfe ◽

K E Guire

Keyword(s):

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Proportional Hazards ◽

Mortality Rates ◽

Cox Proportional Hazards ◽

Diabetic Patients ◽

Mortality Trends ◽

Black Patients ◽

Significant Difference ◽

Intent To Treat

To evaluate the mortality of continuous ambulatory peritoneal dialysis (CAPD) patients relative to hemodialysis (HD) patients, all Michigan residents 20 to 59 yr of age who initiated therapy for ESRD during the 1980s (N = 4,288) were studied. The study population was stratified by primary renal diagnosis (glomerulonephritis, hypertension, diabetes, other), and analyses were conducted within each group by Cox proportional hazards methods controlling for age, race, sex, and year in which chronic dialysis was initiated. Intent-to-treat (ITT) and treatment history (RxHx) censoring criteria were used. For patients with hypertension or other reported causes of ESRD, there was no significant difference in CAPD and HD patient mortality (relative risk (RR) = 0.99 and 1.05, respectively). In the ITT analysis, both glomerulonephritic (RR = 0.73; P = 0.10) and diabetic patients using CAPD experienced mortality rates lower than their HD counterparts. Among diabetics, this difference ranged from a RR of 0.40 to 0.70, being lowest for younger diabetics and statistically significant (P < or = 0.05) for ages 20 to 52 yr. Evaluation of mortality trends showed a significant (P < 0.01) decrease in diabetic CAPD mortality rates during the decade, whereas diabetic HD mortality rates increased (P = 0.06). Among diabetics, men had higher mortality rates than women (ITT--RxHx; RR = 1.22 to 1.27; P < 0.001) and white patients had higher mortality rates than black patients (ITT--RxHx, RR = 1.34 to 1.44; P < 0.001). Differences in mortality by sex and race were not found among nondiabetics, but mortality did increase significantly with age in all groups.(ABSTRACT TRUNCATED AT 250 WORDS)

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Differentiation of salivary gland tumor using diffusion-weighted imaging with a fractional order calculus model

British Journal of Radiology ◽

10.1259/bjr.20200052 ◽

2020 ◽

Vol 93 (1113) ◽

pp. 20200052

Author(s):

Wei Chen ◽

Liu-Ning Zhu ◽

Yong-Ming Dai ◽

Jia-Suo Jiang ◽

Shou-Shan Bu ◽

...

Keyword(s):

Salivary Gland ◽

Diffusion Model ◽

Fractional Order ◽

Diffusion Weighted Imaging ◽

Diagnostic Performance ◽

Salivary Gland Tumors ◽

Characteristic Analysis ◽

Fractional Order Calculus ◽

Diffusion Weighted ◽

Significant Difference

Objective: To evaluate the feasibility of using imaging parameters (D, β and μ) obtained from fractional order calculus (FROC) diffusion model to differentiate salivary gland tumors. Methods: 15 b-value (0–2000 s/mm2) diffusion-weighted imaging (DWI) was scanned in 62 patients with salivary gland tumors (47 benign and 15 malignant). Diffusion coefficient D, fractional order parameter β (which correlates with tissue heterogeneity) and a microstructural quantity μ of the solid portion within the tumor were calculated, and compared between benign and malignant groups, or among pleomorphic adenoma (PA), Warthin’s tumor (WT), and malignant tumor (MT) groups. Performance of FROC parameters for differentiation was assessed using receiver operating characteristic analysis. Results: None of the FROC parameters exhibited significant differences between benign and malignant group (D, p = 0.150; β, p = 0.967; μ, p = 0.693). WT showed significantly lower D (p < 0.001) and β (p < 0.001), while higher μ (p = 0.001) than PA. Combination of D, β and μ showed optimal diagnostic performance (area under the curve, AUC, 0.998). MT showed significantly lower D (p = 0.001) and β (p = 0.025) than PA, while no significant difference was found on μ (p = 0.064). Combination of D and β showed optimal diagnostic performance (AUC, 0.933). Significant difference was found on β (p = 0.027) between MT and WT, while not on D (p = 0.806) and μ (p = 0.789). Setting a βof 0.615 as the cut-off value, optimal diagnostic performance could be obtained (AUC = 0.806). Conclusion: A non-Gaussian FROC diffusion model can serve as a noninvasive and quantitative imaging technique for differentiating salivary gland tumors. Advances in knowledge: (1) PA showed higher D and β and lower μ than WT. (2) PA had higher D and β than MT. (3) WT demonstrated lower β than MT. (4) β, as a new FROC parameter, could offer an added value to the differentiation.

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Evaluation of the Serum Level of High Mobility Group Box 1 Protein in Benign and Malignant Salivary Gland Tumors

ACTA MEDICA IRANICA ◽

10.18502/acta.v59i9.7553 ◽

2021 ◽

Author(s):

Maryam Mardani ◽

Azadeh Andisheh Tadbir ◽

Sadaf Pourshahian ◽

Bijan Khademi ◽

Mahyar Malekzadeh

Keyword(s):

Salivary Gland ◽

Serum Level ◽

Malignant Tumors ◽

Clinical Stage ◽

High Mobility ◽

Salivary Gland Tumors ◽

High Mobility Group ◽

Enzyme Linked Immunosorbent Assay ◽

Clinical Value ◽

Significant Difference

Despite a low prevalence, salivary gland tumors (SGTs) represent a diverse set of tumors with a broad range of biological behaviors. Implementation of early detection programs has significantly improved the outcome of treatment and patients' survival. High mobility group box one protein (HMGB1) may likely be a candidate for the detection of SGTs due to its background in other human tumors. This study, for the first time, aimed to investigate the clinical value of HMGB1 in patients with benign and malignant SGTs and analyze its correlation with clinicopathologic outcomes. Using an enzyme-linked immunosorbent assay (ELISA), the serum level of HMGB1 was measured in 85 patients with SGTs (30 benign and 55 malignant cases) and 85 age- and sex-matched healthy individuals. HMGB1 levels had a significant difference between patients with SGTs and healthy controls (2041.4±787.1 pg/ml versus 536.3±374.6 pg/ml, P<0.0001) as well as those with benign and malignant tumors (1680.1±429.7 pg/ml versus 2238.6±867.2 pg/ml, P<0.0001). The serum level of HMGB1 was associated with some clinicopathologic factors, such as the size of the main tumor, clinical stage, and the lymph node metastasis, but not with patients' gender, age as well as the site of the lesions. These results suggest that the serum level of HMGB1 has the potential to be a supportive diagnostic marker for SGTs and can provide a precise assessment of the tumor status. There is no published report regarding the serum level of HMGB1 in SGTs; therefore, further studies are warranted.

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