scholarly journals Drug Utilization and Cost Analysis Review of Anticancer Drugs Used in a Tertiary Care Teaching Hospital in South India

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 73s-73s
Author(s):  
S.K. Babasahib ◽  
S. Maria ◽  
S. Chillakunnel Hussain Rawther
Keyword(s):  
Anticancer Drugs ◽  
Care Delivery ◽  
Case Reports ◽  
Tertiary Care ◽  
Palliative Therapy ◽  
Cost Effective ◽  
Noncommunicable Diseases ◽  
Prescribing Practices ◽  
Cost Effective Treatment ◽  
Cost Distribution

Background: Cancer is ranked high among noncommunicable diseases and millions of people in India receive treatment of cancer every year. Aim: The current study aims to evaluate the trends and pattern of prescribing of anticancer drugs. The objectives of the study were to assess the rational use of anticancer drugs, to identify various types of cancer and to analyze the cost distribution of anticancer drugs. Methods: An observational, prospective study was conducted in 200 prescriptions in oncology department. Data were collected from case reports, prescriptions and medication charts in specially designed forms. Results: Out of 200 patients enrolled, majority were female (59.5%) and in the age group of 40-60 years (52%). Gastrointestinal tract cancers (25%) were most commonly observed, followed by breast cancer (18.5%) and genitourinary cancers (16.5%). Cisplatin (35%) was the most commonly prescribed anticancer drug, followed by paclitaxel (18.5%), carboplatin (14%), 5-fluorouracil (12.5%) and oxaliplatin (7.5%). Ranitidine, dexamethasone and ondansetron were used as palliative therapy either to prevent or manage the adverse reactions of the anticancer drugs. Trastuzumab contribute to the major cost (Rs. 450,000) in the drug therapy. The average cost of drug per prescription was Rs. 11,135. The overall prescribing indicators, point that the average number of total drugs, anticancer drugs and antibiotics were 12.22, 1.73 and 0.43 respectively. Conclusion: The usage of drugs was found to be rational and about 99.38% of the drugs used were from the hospital formulary. The prescribing habits are appropriate and are in accordance with WHO guidelines. The current study may support best prescribing practices to promote cost effective treatment and better health care delivery.

scholarly journals Assessment of utilization of anticancer drugs in cancer centre at tertiary care hospitals in Telangana region

2020 ◽  
Vol 11 (2) ◽  
pp. 1562-1570
Author(s):  
Praveen Kumar T ◽  
Nadeem Ahmed ◽  
Sravan Kumar B ◽  
Chinna Eswaraiah M
Keyword(s):  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Kinase Inhibitors ◽  
Tertiary Care ◽  
Cost Effective ◽  
Prescribing Patterns ◽  
Female Patients ◽  
Rational Drug ◽  
Cost Effective Treatment ◽  
Life Threatening

Cancer is a life-threatening disease and is a major economic burden to families in India. Assessment of the utilization of anticancerdrugs promotes rational in using drugs.The main objective of the study was to identify theprevalence of various types of cancers, analyzing the prescribing patterns of anticancer drugs in cancer centers atthe tertiary care government hospital of Telangana. It was aProspective and observational study carried out in hospitals ofTelangana for a period of six months, which includes 300 patients. All the patients with respective to age, sex, diagnosis, and treatment, who were on anticancer prescription and were willing to give consent, were included in the study.Among 300 patients selected in our study, 111 (37 %) were males, and 189 (63 %) were female patients.170 (56.66 %) cancer cases were evident between 71 to 80 years of age. Hypertension is the major comorbidity observed in 68 cancer patients.54 drugs were prescribed for different cancers patients in our study.  The most commonly used class of anticancer agents wastyrosine kinase inhibitors (10drugs), monoclonal antibodies (10 drugs). 33 female patients were suffering from breast cancer, and Lungs cancer was found in 44 patients. Carboplatin was given to 30 (10%) patients, followed by Chlorambucil to 27 patients (9%).Assessment of utilization of Anticancer Drugs promotes education to a physician for rational drug use and can give better health care and also cost-effective treatment.

scholarly journals Recommending form of anticancer drugs in oncology unit of a tertiary care teaching hospital

2021 ◽  
Vol 12 (2) ◽  
pp. 1201-1207
Author(s):  
Pandiamunian Jayabal ◽  
Nithiya Dhanasekaran ◽  
Shanmugasundaram S
Keyword(s):  
Anticancer Drugs ◽  
Care Delivery ◽  
Demographic Data ◽  
Tertiary Care ◽  
Dose Intensity ◽  
World Health ◽  
Tertiary Care Centre ◽  
Cost Effective Treatment ◽  
The World ◽  
Oncology Unit

Cancer has become a chief ailment and danger to the global society. It is one of the foremost reasons for demise in the world. A survey by the World Health Organization (WHO) indicates that 8.2 million people died from cancer in 2012 and it may rise to 19 million by 2025. Drug interactions connected through anticancer drugs are a global concern and should not be ignored. Nausea, vomiting or some other mild response to extreme myelosuppression may vary from adverse drug reactions. Analysis of prescription trend is a possible method in ascertaining the position of drugs in culture and it has to be taken out at every hospital regularly. The research is developed to examine the prescription pattern of anticancer drugs in the clinical oncology unit of a tertiary care centre in India. The patient's demographic data, medication name, type, dose, intensity and duration etc., have been analyzed in each prescription  Commonly utilized anticancer narcotics and different forms of cancer were identified and the national essential drug list percentage of the medicines used was analysed. The current study intended to assess the tendencies and pattern of prescribing anticancer drugs. The prescribing practises were apposite and were in agreement with WHO strategies. The present study seemed to sustenance best proposing performs in order to endorse cost effective treatment and improved health care delivery.

scholarly journals Cost of Hemodialysis in a Tertiary Care Hospital in North India

JMS SKIMS ◽  
2012 ◽  
Vol 15 (1) ◽  
pp. 47-50
Author(s):  
Mushtaq Ahmad ◽  
Ajaz Mustafa ◽  
M Saleem Najar ◽  
Farooq Ahmad Jan ◽  
Anil Manhas ◽  
...  
Keyword(s):  
Average Cost ◽  
Tertiary Care ◽  
Public Health Problem ◽  
Cost Effective ◽  
Chronic Hemodialysis ◽  
North India ◽  
Care Hospital ◽  
Effective Treatment Option ◽  
Cost Effective Treatment ◽  
Cost Efficient

BACKGROUND: Chronic kidney disease (CKD) is a worldwide public health problem with significant health consequences and involvement of high cost on treatment worldwide. Although renal transplant is a cost effective treatment option for ESRD, use of hemodialysis in patients with ESRD patients remains one of the most resource intensive and expensive therapeutic intervention. OBJECTIVE: To estimate cost of hemodialysis treatment for patients with ESRD that would help in making policy decisions and enable cost efficient utilization of ESRD programme and hemodialysis. METHODS: 58 patients with ESRD on chronic hemodialysis were incorporated in the present study at a tertiary care teaching hospital between January 2010 to December 2010. Patients who survived less than 3 months after commencement of treatment were excluded. RESULTS: Mean age of the study patients was 46.4±8 in yrs. Among the 54 patients studied 51 % were male. 86% of patients received three sessions of hemodialysis weekly, with duration per session varying between 2 - 4 hours. Average cost was Rs. 2001.84 per session. Estimated total annual burden was Rs. 209449.10 per patient. Average cost borne by hospital was Rs. 951.84 per session/patient (47.55 % of cost bone by the patient); cost born by hospital per patient per year was Rs. 123647.70. Principal expenses (% wise) were: staff salary cost 20.84 %, instrument cost (purchased locally from market) 32.50%, salary cost 20.84%, and rental cost 18.20 %. CONCLUSION: The costs estimated in this study comparable with national average cost of hemodialysis in India but lower as compared to that in other SARC countries; approaches to reduce cost further are needed. JMS 2012;15(1):47-50.

scholarly journals Management of Non-Healing Ulcer with topical application of Marham-i-‘Asal - A case study

2021 ◽  
Vol 5 (2) ◽  
pp. 78-83
Author(s):  
Afsahul Kalam ◽  
Mohd Tauseef Alam ◽  
Fouzia Farooq
Keyword(s):  
Case Reports ◽  
Healing Process ◽  
Cost Effective ◽  
Hot Water ◽  
Wound Healing Process ◽  
Medial Malleolus ◽  
Healing Ulcer ◽  
Time Period ◽  
Cost Effective Treatment ◽  
Healing Wound

The wounds which fail to progress through a timely sequence of repair or that proceed through the wound healing process without restoring anatomic and functional integrity are referred as chronic non-healing wounds. This study was conducted on a 50-year old male patient with a painful non-healing ulcer on the medial malleolus of the left lower limb caused by the use of hot water bag during harsh winter in Srinagar. The size of the wound was 2x2 cm on assessing the wound profile. The wound was treated with the application of an ointment made with the combination of powder of Astragalus sarcocolla and Honey in equal amounts. The ointment was applied twice a day on the wound for 20 days. After 7 days of daily application, there was a considerable reduction in the size of wound and significant improvement in other symptoms like pain and tenderness. The ulcer was completely healed in a time period of 21 days. The present case reports that, the ointment prepared with Astragalus sarcocolla and Honey is a cost effective treatment for chronic non-healing wound.

scholarly journals THE PHARMACOECONOMIC IMPACT OF GASTRO-PROTECTIVE AGENTS AT A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 92-96
Author(s):  
NIRUPAMA KULKARNI ◽  
MOPIDEVI RASI ◽  
NAZARIYA NIZAR ◽  
NISHOJA DAVID ◽  
PRASAD N BALI ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Cost Benefit Analysis ◽  
Tertiary Care ◽  
Medical Science ◽  
Cost Effective ◽  
Care Hospital ◽  
Statistical Tool ◽  
Protective Agents ◽  
Cost Effective Treatment ◽  
Study Results

Objectives: The study aimed to evaluate the pharmacoeconomic impact of gastro-protective agents (GPA) by carrying out cost-benefit analysis (CBA) and cost-effective analysis (CEA). Methods: This prospective observational study was carried out by simple randomization technique at Karnataka Institute of Medical Science, Hubballi. Data used were socio-economic details based on modified B. G Prasad scale. Current Index of Medical Specialists updated version March 2021 was used for CBA and CEA. Regression analysis was the statistical tool used in the study. Results: A total of 120 participants were included in the study. 57.5% were male and 42.5% were female. 3.33% were pediatrics, 32.5% were young adults, 37.5% were elder adults and 26.67% were geriatrics. Out of 120 samples, 94 participants were prescribed with pantoprazole, other drugs prescribed include domperidone and pantoprazole, rabeprazole, and ranitidine. The CBA revealed ratio of benefits over costs for pantoprazole was 3.86, ranitidine was 9.31, pantoprazole and domperidone was 0.84 and rabeprazole was 0.84. Additional cost of 138.30 Indian Rupee must be spent on pantoprazole over ranitidine to get cost-effective treatment without disease for one whole year. Conclusion: The CBA revealed that maximum patients received benefits for pantoprazole. CEA gives an idea on best effective treatment over two drugs of different class. Our study concludes that pantoprazole is deemed to be superior over other drugs of GPA prescribed among study participants.

scholarly journals Targeting phytoprotection in the COVID-19-induced lung damage and associated systemic effects—the evidence-based 3PM proposition to mitigate individual risks

2021 ◽  
Author(s):  
Alena Liskova ◽  
Lenka Koklesova ◽  
Marek Samec ◽  
Basma Abdellatif ◽  
Kevin Zhai ◽  
...  
Keyword(s):  
Health Risks ◽  
Vascular Dysfunction ◽  
Scientific Evidence ◽  
Tertiary Care ◽  
Cost Effective ◽  
Lung Damage ◽  
Noncommunicable Diseases ◽  
Social Risks ◽  
Effective Manner ◽  
Preventive And Personalized Medicine

AbstractThe risks related to the COVID-19 are multi-faceted including but by far not restricted to the following: direct health risks by poorly understood effects of COVID-19 infection, overloaded capacities of healthcare units, restricted and slowed down care of patients with non-communicable disorders such as cancer, neurologic and cardiovascular pathologies, among others; social risks—restricted and broken social contacts, isolation, professional disruption, explosion of aggression in the society, violence in the familial environment; mental risks—loneliness, helplessness, defenceless, depressions; and economic risks—slowed down industrial productivity, broken delivery chains, unemployment, bankrupted SMEs, inflation, decreased capacity of the state to perform socially important programs and to support socio-economically weak subgroups in the population. Directly or indirectly, the above listed risks will get reflected in a healthcare occupation and workload which is a tremendous long-term challenge for the healthcare capacity and robustness. The article does not pretend to provide solutions for all kind of health risks. However, it aims to present the scientific evidence of great clinical utility for primary, secondary, and tertiary care to protect affected individuals in a cost-effective manner. To this end, due to pronounced antimicrobial, antioxidant, anti-inflammatory, and antiviral properties, naturally occurring plant substances are capable to protect affected individuals against COVID-19-associated life-threatening complications such as lung damage. Furthermore, they can be highly effective, if being applied to secondary and tertiary care of noncommunicable diseases under pandemic condition. Thus, the stratification of patients evaluating specific health conditions such as sleep quality, periodontitis, smoking, chronic inflammation and diseases, metabolic disorders and obesity, vascular dysfunction, and cancers would enable effective managemenet of COVID-19-associated complications in primary, secondary, and tertiary care in the context of predictive, preventive, and personalized medicine (3PM).

Partners In Health Generalist/Specialist Twinning: A Health Delivery Model Used in Treating Childhood Lymphoma in Rural Rwanda,

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4222-4222
Author(s):  
Sara Stulac ◽  
Merab Nyishime ◽  
Jean Bosco Bigirimana ◽  
Alain N Uwumugambi ◽  
Sara Chaffee ◽  
...  
Keyword(s):  
Conflicts Of Interest ◽  
Care Delivery ◽  
Treatment Plan ◽  
Tertiary Care ◽  
Developed Countries ◽  
Noncommunicable Diseases ◽  
Curative Intent ◽  
Complete Surgical Excision ◽  
Resource Poor ◽  
Pediatric Oncologist

Abstract Abstract 4222 In the developed world approximately 80% of children with lymphoma can be cured. As global health initiatives have broadened to address noncommunicable diseases the approach to cancer care for children in resource poor settings becomes of increasing concern. Traditional models of tertiary care provision will not be applicable as there is not an adequate number of existing pediatricians subspecializing in oncology to provide for the world's children. At Rwinkwavu, a Partners In Health (PIH) supported government district hospital in rural Rwanda, a small cohort of children with lymphoma have received therapy over the past 4 years using a unique approach to care delivery. Each case is managed by a team consisting of a Rwandan physician with no specialty training, a Rwandan nurse coordinator focused on oncology patients, a Rwanda-based US trained pediatrician and a US- based pediatric oncologist. Biopsies and radiologic staging studies were obtained in Rwanda but all pathologic diagnoses were made at Brigham and Women's Hospital, a Harvard teaching hospital, through a formal arrangement. A treatment plan for each patient was formulated with the consulting pediatric oncologist and a road map was generated. Chemotherapy was administered by nurses in the Rwinkwavu pediatric ward under the daily supervision of the local generalist and with the support of the pediatrician. Blood counts and broad spectrum antibiotics were available but blood cultures could not be performed. If radiation therapy was required patients were transported to Uganda for the treatments. Ten patients aged 3–15 (median age 9.5 years) have been treated using this approach. 5 (50%) have completed therapy - Hodgkin's Disease (HD) n =2, HIV-associated large cell lymphoma (HIV LCL) n =2, Burkitt's Lymphoma (BL) n=1. They received either CHOP (cyclophosphamide, adriamycin, vincristine, prednisone), n=3 or ABVD (adriamycin, bleomycin, vincristine, dacarbazine), n=1; 1 patient with Stage 1 Lymphocyte Predominant HD is being observed without adjuvant therapy after complete surgical excision. All 5 have no evidence of disease recurrence 4 months - 4 years following completion of therapy (median = 14 months). 2 patients are currently on therapy (recurrent HD, HIV LCL) and are in remission. 2 patients succumbed to treatment complications (HD- died from cardiomyopathy, BL- died from transverse myelopathy) and 1 patient (BL) died of progressive disease while receiving chemotherapy. We can not determine the number of pediatric patients with lymphoma who died before a diagnosis was made or before receiving appropriate therapy. In the developing world lymphoma is one of the most common oncologic diseases in children. These data suggest that chemotherapy can be administered with curative intent to a subset of these patients in the setting of a confirmed pathological diagnosis. This approach provides a platform for models of care that rely on local physicians acting in concert with trained consultants from the developed countries to deliver subspeciality care in resource poor settings. Disclosures: No relevant conflicts of interest to declare.

Imaginal Desensitization: A Cost-Effective Treatment in Two Shop-Lifters and a Binge-Eater Resistant to Previous Therapy

1988 ◽  
Vol 22 (1) ◽  
pp. 78-82 ◽  
Author(s):  
Nathaniel McConaghy ◽  
Alex Blaszczynski
Keyword(s):  
Binge Eating ◽  
Effective Treatment ◽  
Case Reports ◽  
Cost Effective ◽  
Previous Therapy ◽  
Cost Effective Treatment ◽  
Cost Efficacy

Case reports are given of three patients, two suffering from compulsive shop-lifting and one from binge-eating, who responded to a week's treatment with imaginal desensitization after having failed to respond to prolonged interpretative psychotherapy. Expectancy of improvement did not appear to play a major role in their response, but it appears impossible to disprove that expectancy determines the response to this or any form of psychotherapy. Whether or not imaginal desensitization acted specifically in the present study, in view of its cost-efficacy it is suggested it is worthy of trial in impulse disorders which have persisted despite treatment.

scholarly journals Assessment of drug utilization pattern in patients undergoing chemotherapy for various types of metastatic cancers in a tertiary care government hospital

2020 ◽  
Vol 9 (9) ◽  
pp. 1331
Author(s):  
D. Vijayalakshmi ◽  
Srinivas Rao Bendi ◽  
Motakatla Usharani ◽  
K. Swarna Latha
Keyword(s):  
Anticancer Drugs ◽  
Drug Utilization ◽  
Case Reports ◽  
Drug Prescription ◽  
Tertiary Care ◽  
Developed Countries ◽  
World Health ◽  
International Agency ◽  
Antibiotic Prescribing ◽  
Utilization Pattern

Background: Cancer is one among main causes of morbidity and mortality in developing and developed countries. The World Cancer Report 2014 of World Health Organization’s (WHO’s) International Agency for Research on Cancer (IARC), states that in 2012 the global incidence of cancer increased to a 14 million new cases, the figure expected to rise to an annual 19.3 million by 2025. The prescription pattern of anticancer drugs has evolved considerably in recent years because of better understanding of underlying pathophysiology of carcinomas as well as introduction of newer drugs. Methods: It was a hospital-based prospective, cross-sectional study conducted in Department of Oncology, GGH, Kakinada for a period of twelve months from February 2017 to January 2018. A total of 100 patients were enrolled using convenience sampling technique. Patient demographics like age, gender, educational level, employment status, marital status, smoking category, alcohol consumption, stage of cancer was collected. Drug utilization pattern was obtained from inpatient case reports, prescriptions and medication charts used during a chemotherapy cycle.Results: Among all anticancer drugs, cisplatin and 5-flurouracil were most commonly prescribed followed by Adriamycin. The most commonly used adjuvant drugs were B-complex, diclofenac, granisetron, ranitidine, dexamethasone. Antibiotic use was found to be very limited.Conclusions: Various anticancer drug prescription patterns are being used for treatment of patient with metastatic cancers. In this study, cisplatin and 5-flurouracil were commonly used. Injudicious antibiotic prescribing was not observed.  

scholarly journals HOW COST EFFECTIVE IS THE TREATMENT? ARE PRESCRIBERS CONCERNED ?

2003 ◽  
Vol 42 (146) ◽  
pp. 86-88
Author(s):  
B P Das ◽  
M A Naga Rani ◽  
G P Rauniar ◽  
H Sangraula
Keyword(s):  
Effective Treatment ◽  
Antimicrobial Agents ◽  
Tertiary Care ◽  
Cost Effective ◽  
Undergraduate Curriculum ◽  
Primary Concern ◽  
Care Hospital ◽  
Poor Countries ◽  
Cost Effective Treatment ◽  
Competitive Prices

ABSTRACTCost-effective treatment should be of primary concern to prescribers in poor countries like Nepal. Thepresent study was carried out at a tertiary care hospital in Nepal to find out the perception of prices ofcommonly prescribed drugs among prescribers. The participants selected randomly were directed to writein 10 minutes on a proforma, the generic name(s) and price of the brand preparation of 18 most commonlyused drugs listed under their brand name.The price of the drug was considered correct if the price mentioned was within a range of 20% above orbelow the brand price. Results indicated that the participants were aware of the composition of majority(80%) of the drugs, but were not aware of the prices of 81.80% of the drugs. No single participant mentionedthe correct prices of all the drugs. Among the drug groups studied, the most accurate data was providedabout composition (90.43%) and price (24.47%) of non steroidal anti-inflammatory drugs (NSAIDs). Onlyin 9.22% of brand preparations of antimicrobial agents (AMA), the prices were mentioned correctly. Hence,sensitisation of physicians about cost-effective treatment is of immense importance and to facilitate this,hospital authorities could provide prescribers with regularly updated price lists of commonly prescribeddrugs and competitive prices of various brand preparations. Pharmacoeconomics may be introduced in the undergraduate curriculum which can be reinforced by continuing medical education.Key Words: Cost-effective, Pharmacoeconomics.

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