scholarly journals Assessment of utilization of anticancer drugs in cancer centre at tertiary care hospitals in Telangana region

2020 ◽  
Vol 11 (2) ◽  
pp. 1562-1570
Author(s):  
Praveen Kumar T ◽  
Nadeem Ahmed ◽  
Sravan Kumar B ◽  
Chinna Eswaraiah M
Keyword(s):  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Kinase Inhibitors ◽  
Tertiary Care ◽  
Cost Effective ◽  
Prescribing Patterns ◽  
Female Patients ◽  
Rational Drug ◽  
Cost Effective Treatment ◽  
Life Threatening

Cancer is a life-threatening disease and is a major economic burden to families in India. Assessment of the utilization of anticancerdrugs promotes rational in using drugs.The main objective of the study was to identify theprevalence of various types of cancers, analyzing the prescribing patterns of anticancer drugs in cancer centers atthe tertiary care government hospital of Telangana. It was aProspective and observational study carried out in hospitals ofTelangana for a period of six months, which includes 300 patients. All the patients with respective to age, sex, diagnosis, and treatment, who were on anticancer prescription and were willing to give consent, were included in the study.Among 300 patients selected in our study, 111 (37 %) were males, and 189 (63 %) were female patients.170 (56.66 %) cancer cases were evident between 71 to 80 years of age. Hypertension is the major comorbidity observed in 68 cancer patients.54 drugs were prescribed for different cancers patients in our study.  The most commonly used class of anticancer agents wastyrosine kinase inhibitors (10drugs), monoclonal antibodies (10 drugs). 33 female patients were suffering from breast cancer, and Lungs cancer was found in 44 patients. Carboplatin was given to 30 (10%) patients, followed by Chlorambucil to 27 patients (9%).Assessment of utilization of Anticancer Drugs promotes education to a physician for rational drug use and can give better health care and also cost-effective treatment.

scholarly journals Drug Utilization and Cost Analysis Review of Anticancer Drugs Used in a Tertiary Care Teaching Hospital in South India

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 73s-73s
Author(s):  
S.K. Babasahib ◽  
S. Maria ◽  
S. Chillakunnel Hussain Rawther
Keyword(s):  
Anticancer Drugs ◽  
Care Delivery ◽  
Case Reports ◽  
Tertiary Care ◽  
Palliative Therapy ◽  
Cost Effective ◽  
Noncommunicable Diseases ◽  
Prescribing Practices ◽  
Cost Effective Treatment ◽  
Cost Distribution

Background: Cancer is ranked high among noncommunicable diseases and millions of people in India receive treatment of cancer every year. Aim: The current study aims to evaluate the trends and pattern of prescribing of anticancer drugs. The objectives of the study were to assess the rational use of anticancer drugs, to identify various types of cancer and to analyze the cost distribution of anticancer drugs. Methods: An observational, prospective study was conducted in 200 prescriptions in oncology department. Data were collected from case reports, prescriptions and medication charts in specially designed forms. Results: Out of 200 patients enrolled, majority were female (59.5%) and in the age group of 40-60 years (52%). Gastrointestinal tract cancers (25%) were most commonly observed, followed by breast cancer (18.5%) and genitourinary cancers (16.5%). Cisplatin (35%) was the most commonly prescribed anticancer drug, followed by paclitaxel (18.5%), carboplatin (14%), 5-fluorouracil (12.5%) and oxaliplatin (7.5%). Ranitidine, dexamethasone and ondansetron were used as palliative therapy either to prevent or manage the adverse reactions of the anticancer drugs. Trastuzumab contribute to the major cost (Rs. 450,000) in the drug therapy. The average cost of drug per prescription was Rs. 11,135. The overall prescribing indicators, point that the average number of total drugs, anticancer drugs and antibiotics were 12.22, 1.73 and 0.43 respectively. Conclusion: The usage of drugs was found to be rational and about 99.38% of the drugs used were from the hospital formulary. The prescribing habits are appropriate and are in accordance with WHO guidelines. The current study may support best prescribing practices to promote cost effective treatment and better health care delivery.

scholarly journals Drug utilization patterns of antidepressants in Federal Neuro-Psychiatric Hospital Lagos, Nigeria

2017 ◽  
Vol 6 (5) ◽  
pp. 12 ◽  
Author(s):  
Oyinlade A. Kehinde ◽  
Emmanuel N. Anyika ◽  
Isaac Abah
Keyword(s):  
Average Cost ◽  
Treatment Guidelines ◽  
Tertiary Care ◽  
Essential Medicine ◽  
Prescribing Patterns ◽  
World Health ◽  
Rational Drug ◽  
Generic Prescribing ◽  
Cost Of Drugs ◽  
Health Organization

Backgroud: The paucity of information on prescribing patterns and use of antidepressants in accordance with practice guidelines necessitated this study in Nigeria.Objective: To assess the prescribing patterns of antidepressants, average cost of prescriptions and the index of rational drug prescribing (IRDP) in a Nigerian tertiary care hospital.Methods: A retrospective study which involved the assessment of 683 prescriptions and case records of patients who received antidepressants from 1st January 2013 to 31st December 2014 was conducted. Information on diagnosis, patients’ demographics, prescribing patterns and cost of medications was obtained therefrom. Compliance to the World Health Organization (WHO) prescribing indicators and Nigerian Standard Treatment Guidelines (STG) was assessed. The IRDP for antdepressants was determined using a validated mathematical model. The statistical analysis was performed using SPSS version 20.Results: Tricyclic antidepressants (TCAs) were the most commonly prescribed drug group (61.3%), followed by selective serotonin re-uptake inhibitors (SSRIs) with a total of 38.7%. On the average, three drugs were prescribed per prescription, while 60.3% and 38.3% of the drugs were prescribed from National Essential Medicine List (NEML) and STG respectively. The IRDP was 3.96 over 5 points. The average cost of drugs per prescription was 4.2 USD. The cost of drugs in the prescriptions written according to STG was lower compared to that in prescriptions not compliant with the STG (p < .001).Conclusions: TCAs are the most commonly prescribed antidepressants due to their affordability. The generic prescribing, medicines prescribed from the NEML and in compliance with the STG were less than the WHO standard. The rational drug use is suboptimal. Better prescribing habits, affordability and use of newer antidepressants should be encouraged by the hospital management.

scholarly journals Study the Effect of Ipomea carnea Jacq. Patra swarasa (Leaves Juice) in Treatment of Indralupta (Alopecia Areata): A Pilot Study

2021 ◽  
pp. 1-6
Author(s):  
Prashant R. Umate ◽  
Pramod D. Khobragade ◽  
Saurabh Deshmukh ◽  
Sonali Wairagade ◽  
Minal Kalambe ◽  
...  
Keyword(s):  
Alopecia Areata ◽  
Negative Impact ◽  
Cost Effective ◽  
Treatment Modalities ◽  
Rank Test ◽  
Signed Rank ◽  
Cost Effective Treatment ◽  
Signed Rank Test ◽  
Life Threatening ◽  
Leaf Juice

Introduction: Hair and skin disease create negative impact on individuals. Although such diseases doesn’t have any life threatening effects like systemic diseases still have much more importance as the cosmetic issue concern. Indralupta is a rare entity found in both male, and female at any age which can be correlated with Alopecia areata. There are many treatment modalities are available for the Indralupta (Alopecia areata) but application of leaf juice of Ipomoea carnia is simple and cost effective treatment. Aim &Objective: Study the effect of Ipomea carnea Jacq. patra swarasa (leaves juice) in management of Indralupta (Alopecia Areata). To study the adverse effects of Ipomea carnia leaf juice local application if noted during study. Methodology: Fresh leaf juice will be extracted from clean leaf of Ipomea carnia and apply over the spot where hairs are lost for 15 days at morning before bath. 10 objects will be selected from kaychikitsa OPD randomly and consider for study after their willingness and consent. Outcomes will be assessed with the help of different criteria according to hair texture, Hair fall and scalp area examination. Result: Result will be observed according to criteria and Wilcoxon signed rank test will be a applied. Conclusion: Ipomea carnea will be effective in Indralupta(Alopecia areata).

scholarly journals Cost of Hemodialysis in a Tertiary Care Hospital in North India

JMS SKIMS ◽  
2012 ◽  
Vol 15 (1) ◽  
pp. 47-50
Author(s):  
Mushtaq Ahmad ◽  
Ajaz Mustafa ◽  
M Saleem Najar ◽  
Farooq Ahmad Jan ◽  
Anil Manhas ◽  
...  
Keyword(s):  
Average Cost ◽  
Tertiary Care ◽  
Public Health Problem ◽  
Cost Effective ◽  
Chronic Hemodialysis ◽  
North India ◽  
Care Hospital ◽  
Effective Treatment Option ◽  
Cost Effective Treatment ◽  
Cost Efficient

BACKGROUND: Chronic kidney disease (CKD) is a worldwide public health problem with significant health consequences and involvement of high cost on treatment worldwide. Although renal transplant is a cost effective treatment option for ESRD, use of hemodialysis in patients with ESRD patients remains one of the most resource intensive and expensive therapeutic intervention. OBJECTIVE: To estimate cost of hemodialysis treatment for patients with ESRD that would help in making policy decisions and enable cost efficient utilization of ESRD programme and hemodialysis. METHODS: 58 patients with ESRD on chronic hemodialysis were incorporated in the present study at a tertiary care teaching hospital between January 2010 to December 2010. Patients who survived less than 3 months after commencement of treatment were excluded. RESULTS: Mean age of the study patients was 46.4±8 in yrs. Among the 54 patients studied 51 % were male. 86% of patients received three sessions of hemodialysis weekly, with duration per session varying between 2 - 4 hours. Average cost was Rs. 2001.84 per session. Estimated total annual burden was Rs. 209449.10 per patient. Average cost borne by hospital was Rs. 951.84 per session/patient (47.55 % of cost bone by the patient); cost born by hospital per patient per year was Rs. 123647.70. Principal expenses (% wise) were: staff salary cost 20.84 %, instrument cost (purchased locally from market) 32.50%, salary cost 20.84%, and rental cost 18.20 %. CONCLUSION: The costs estimated in this study comparable with national average cost of hemodialysis in India but lower as compared to that in other SARC countries; approaches to reduce cost further are needed. JMS 2012;15(1):47-50.

scholarly journals Recommending form of anticancer drugs in oncology unit of a tertiary care teaching hospital

2021 ◽  
Vol 12 (2) ◽  
pp. 1201-1207
Author(s):  
Pandiamunian Jayabal ◽  
Nithiya Dhanasekaran ◽  
Shanmugasundaram S
Keyword(s):  
Anticancer Drugs ◽  
Care Delivery ◽  
Demographic Data ◽  
Tertiary Care ◽  
Dose Intensity ◽  
World Health ◽  
Tertiary Care Centre ◽  
Cost Effective Treatment ◽  
The World ◽  
Oncology Unit

Cancer has become a chief ailment and danger to the global society. It is one of the foremost reasons for demise in the world. A survey by the World Health Organization (WHO) indicates that 8.2 million people died from cancer in 2012 and it may rise to 19 million by 2025. Drug interactions connected through anticancer drugs are a global concern and should not be ignored. Nausea, vomiting or some other mild response to extreme myelosuppression may vary from adverse drug reactions. Analysis of prescription trend is a possible method in ascertaining the position of drugs in culture and it has to be taken out at every hospital regularly. The research is developed to examine the prescription pattern of anticancer drugs in the clinical oncology unit of a tertiary care centre in India. The patient's demographic data, medication name, type, dose, intensity and duration etc., have been analyzed in each prescription  Commonly utilized anticancer narcotics and different forms of cancer were identified and the national essential drug list percentage of the medicines used was analysed. The current study intended to assess the tendencies and pattern of prescribing anticancer drugs. The prescribing practises were apposite and were in agreement with WHO strategies. The present study seemed to sustenance best proposing performs in order to endorse cost effective treatment and improved health care delivery.

scholarly journals THE PHARMACOECONOMIC IMPACT OF GASTRO-PROTECTIVE AGENTS AT A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 92-96
Author(s):  
NIRUPAMA KULKARNI ◽  
MOPIDEVI RASI ◽  
NAZARIYA NIZAR ◽  
NISHOJA DAVID ◽  
PRASAD N BALI ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Cost Benefit Analysis ◽  
Tertiary Care ◽  
Medical Science ◽  
Cost Effective ◽  
Care Hospital ◽  
Statistical Tool ◽  
Protective Agents ◽  
Cost Effective Treatment ◽  
Study Results

Objectives: The study aimed to evaluate the pharmacoeconomic impact of gastro-protective agents (GPA) by carrying out cost-benefit analysis (CBA) and cost-effective analysis (CEA). Methods: This prospective observational study was carried out by simple randomization technique at Karnataka Institute of Medical Science, Hubballi. Data used were socio-economic details based on modified B. G Prasad scale. Current Index of Medical Specialists updated version March 2021 was used for CBA and CEA. Regression analysis was the statistical tool used in the study. Results: A total of 120 participants were included in the study. 57.5% were male and 42.5% were female. 3.33% were pediatrics, 32.5% were young adults, 37.5% were elder adults and 26.67% were geriatrics. Out of 120 samples, 94 participants were prescribed with pantoprazole, other drugs prescribed include domperidone and pantoprazole, rabeprazole, and ranitidine. The CBA revealed ratio of benefits over costs for pantoprazole was 3.86, ranitidine was 9.31, pantoprazole and domperidone was 0.84 and rabeprazole was 0.84. Additional cost of 138.30 Indian Rupee must be spent on pantoprazole over ranitidine to get cost-effective treatment without disease for one whole year. Conclusion: The CBA revealed that maximum patients received benefits for pantoprazole. CEA gives an idea on best effective treatment over two drugs of different class. Our study concludes that pantoprazole is deemed to be superior over other drugs of GPA prescribed among study participants.

scholarly journals The Assessment of Drug Utilization Study of Anticancer Drugs Using WHO Prescribing Indicators in a Government Tertiary Care Hospital of the Hyderabad - Karnataka Region of India

2019 ◽  
Vol 7 (7) ◽  
pp. 1203-1208 ◽  
Author(s):  
Asmatanzeem Bepari ◽  
Nayana Sakre ◽  
Ishrat Rahman ◽  
Shaik Kalimulla Niazi ◽  
Asmabi M. Dervesh
Keyword(s):  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Tertiary Care ◽  
Inappropriate Drug ◽  
Care Hospital ◽  
Essential Drug ◽  
Prescribing Indicators ◽  
Rational Use ◽  
Essential Drug List ◽  
Drug List

BACKGROUND: Cancer is a major burden and threat to global society. A wide range of chemotherapeutic agents is extensively used to treat cancer at different stages. Inappropriate drug use may also lead to the raised cost of medical care, adverse drug effects, and patient mortality. Hence, in recent years, drug utilisation studies have become a potential tool to be used in the evaluation of different health care systems including cancer. AIMS: The objectives of the study were to identify the various types of cancer, the commonly prescribed drugs, rational use of anticancer drugs, and analyse the prescribing indicators in a tertiary care government hospital of India. MATERIAL AND METHODS: Newly diagnosed cancer and/or known case of carcinoma of either sex which required treatment/on treatment with chemotherapy aged > 18 yrs admitted in Radiotherapy Department from April 2016 to September 2016 were included in the study and analysed for prescribing indicators. RESULTS: The head & neck cancers were the prevalent cancers observed with more preponderance among males. Most of the patients were prescribed with a single anticancer drug. Cisplatin was the most commonly used cytotoxic drug followed by carboplatin, and antimetabolites. The most commonly used adjuvant drugs in our study were anti-emetics and anti-peptic ulcer drugs. Over 82% of anticancer agents were taken from the essential drug list and were prescribed in generic names, indicating rational use. CONCLUSION: Over 82% of anticancer agents were taken from the essential drug list and were prescribed in generic names, indicating rational use.

scholarly journals STEROIDS IN THE TREATMENT OF CHRONIC DISEASES

2019 ◽  
pp. 91-97
Author(s):  
SHARMA P ◽  
IMAM S ◽  
MEHTA DK
Keyword(s):  
Skin Diseases ◽  
Tertiary Care ◽  
Educational Interventions ◽  
The Body ◽  
Teaching Hospitals ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Disease States ◽  
Rational Drug ◽  
Life Threatening

Since their identification, which was almost 80 years ago, steroids have played a prominent role in the treatment of many disease states such as chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, and inflammatory bowel disease. Many of the clinical roles of steroids are related to their potent anti-inflammatory and immune-modulating properties. Numerous skin diseases are successfully treated with systemic steroids. Corticosteroids, though they are lifesaving drugs, produce adverse reactions which may be mild or life threatening. Steroids have diverse effects on various systems of the body. Therefore, educational interventions among physician, patients, as well as students should be carried out to further enhance rational drug use. The purpose of this review was to identify the most commonly prescribed steroids and their side effects, basic pharmacology, complications, as well as the assessment of patient knowledge about the use of steroids in tertiary care teaching hospitals.

scholarly journals Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a “Black Box” Warning: A Canadian Tertiary Care Center Study

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Nauzer Forbes ◽  
Mohan Cooray ◽  
Raed Al-Dabbagh ◽  
Yuhong Yuan ◽  
Frances Tse ◽  
...  
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Cardiac Risk ◽  
Left Ventricular ◽  
Prescribing Patterns ◽  
Prescribing Practices ◽  
Ensure Patient Safety ◽  
Dosing Regimens ◽  
Life Threatening ◽  
Health Canada

Background.In 2012, Health Canada released a warning regarding domperidone use, based on associations with life-threatening arrhythmias and death.Objective.This study aimed to compare the appropriateness of domperidone prescribing patterns before the advisory to those afterward.Methods.Two retrospective reviews were conducted for patients prescribed domperidone during quarters in 2005 and 2012. Outcomes included appropriateness of indication, dosing regimens, monitoring of electrolytes, baseline electrocardiogram performance and characteristics, presence of left ventricular dysfunction, and coprescription of QT-prolonging medications. Univariable and multivariable logistic regression analyses were performed.pvalues < 0.05 were considered significant.Results.290 and 287 patients were analyzed in 2005 and 2012, respectively. Domperidone initiation in hospital decreased from 2005 to 2012 (71.4% versus 39.4%,p<0.0001) as did prescriptions for nonapproved indications (84.8% versus 58.2%,p<0.0001). In-hospital initiation predicted prescription for nonapproved indications (OR = 7.01, 95% CI 4.52–10.87,p<0.0001). Use of domperidone as the sole GI drug predicted nonapproved indications (OR = 2.51, 95% CI 1.38–4.55,p=0.002).Conclusions.The advisory was associated with more appropriate domperidone initiation and compliance with recommended dosages. Our study suggests the need for increased awareness of the dosing and monitoring of domperidone to ensure patient safety.

scholarly journals Study of the effect of pharmacotherapeutic audit meetings on prescription writing in a tertiary care center-an interventional study

2020 ◽  
Vol 8 (1) ◽  
pp. 113
Author(s):  
Vinod Kumar ◽  
Minakshi Dhar ◽  
Shailendra Handu ◽  
Vikas Kumar ◽  
Puneet Dhamija
Keyword(s):  
Care Center ◽  
Drug Prescription ◽  
Tertiary Care ◽  
Prescribing Patterns ◽  
World Health ◽  
Antibiotic Prescribing ◽  
Prescribing Practices ◽  
Rational Drug ◽  
Significant Change ◽  
Prescription Writing

Background: Rational drug prescription is a practice when an appropriate drug with correct dosage, formulation, frequency and duration is prescribed. Prescription audit with the help of regular Pharmaco-therapeutic audit meetings (PTAM) is a continuous cycle, involving observing practice, setting standards, comparing practice with standards, implementing changes and observing new practice. World health organization (WHO) and international network for rational use of drugs (INRUD) jointly provided a few prescription and drug use indicators to guide rational prescription writing practice. Aim of the study was to assess the effect of pharmaco-therapeutic audit meetings on prescription writing and its rationality.Methods: This was a single center cross-sectional, prospective study conducted over a period of 14 months (December 2018-February 2020). Prescriptions from outpatient departments of general medicine, pulmonary medicine, physical medicine and rehabilitation (PMR), community and family medicine (CFM), pediatrics and psychiatry were collected. All the collected prescriptions were screened for rationality using WHO/INRUD core indicators and the index of rational drug prescribing was calculated. Prescriptions beyond acceptable limit were discussed in PTAM and same process was repeated over next 2 months to assess change in prescribing patterns after PTAM. Chi-square and student’s t-test was used for statistical analysis.Results: Statistically significant change in proportions for antibiotic prescribing was 3.4% [95% CI (-1.7%-9.4%), p=0.20] and prescriptions with generic name drugs was 10.5% [95% CI (6.1-14.6%) p<0.0001 was seen while no significant change was seen in injectable preparation use 0.6% [95% CI (-0.6%-1.5%); p=0.26)] and prescriptions from essential drug list (EDL) 0.5% [95% CI (-4.2%-5.4%) p=0.83].Conclusions: Our study showed that PTAM is an effective way to improve rationality of prescriptions and must be done regularly for improving prescribing practices.

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