Therapeutic effect of the Indigenous drug modality in the management of Adenocarcinoma of colon – A case report based on cytokines expressions

A clinical study was conducted from May to July 2017 in the outpatient department of Bandaranaike Memorial Ayurvedic Research Institute (BMARI), Navinna, Sri Lanka to test the antitumor activity of the indigenous drug modality which is used to manage the colon cancer. A forty year old colon cancer patient volunteered to the study. Ethical approval has been taken from the Institute of Indigenous Medicine, University of Colombo Sri Lanka. Detailed history, clinical examinations and relevant investigations were conducted at BMARI and the Department of Zoology, Faculty of Science, University of Ruhuna. Three herbal formulations namely SG powder- 5g/day, KY powder -10g/day and A1 powder -10g/day were given for the patient throughout 90 days of study. Serum Interleukin-2 (IL-2), Interleukin-5 (IL-5), Interleukin 17 (IL-17), Interferon (IFN)-ɣ and p53 Upregulated Modulator of Apoptosis (PUMA) were quantified using Enzyme-Linked Immunosorbent Assay (ELISA) before and after the treatments (after 45 and 90 days) as these cytokines play a significant role in tumor growth control. Tumor marker expression and stool samples were tested before and after treatments (after 45 and 90 days). Symptoms of colon cancer were significantly decreased during the treatment along with changes in tumor markers. According to the results of the ELISA, IL-2, IFN-ɣ and IL-17 concentrations were increased significantly after the treatment and expression level increased in all three cytokines over time indicating the possible control of colon cancer growth by the drug modality. Further investigations are required to evaluate the mechanism of effectiveness of this indigenous drug modality in controlling carcinoma of colon.

Ayurveda management in premature ovarian insufficiency- A case study

Premature ovarian insufficiency (POI) is defined as a cessation of ovarian function before the age of 40 years. It is associated with hypoestrogenism and loss of residual follicles, both of which lead to menstrual abnormalities, pregnancy failures, and decreased health-related quality of life. The prevalence of POI is estimated at 1% in the general population. The risk of premature ovarian insufficiency (POI) before the age of 40 years is 1 %. The aetiopathology of premature ovarian insufficiency in the majority of cases is unknown and is termed as spontaneous or idiopathic POI. This is a case with signs and symptoms of POI which was developed after the administration of GnRH agonist drugs as a part of treatment of endometriosis. In this single case study, a female of 33 years having complaints of absence of periods since 6 months treated with Ayurveda treatment with pre and post evaluation. The symptoms of secondary amenorrhoea, hot flashes, vaginal dryness and mood swings were relieved after Ayurveda medications and procedures.

Management of Non-Healing Ulcer with topical application of Marham-i-‘Asal - A case study

The wounds which fail to progress through a timely sequence of repair or that proceed through the wound healing process without restoring anatomic and functional integrity are referred as chronic non-healing wounds. This study was conducted on a 50-year old male patient with a painful non-healing ulcer on the medial malleolus of the left lower limb caused by the use of hot water bag during harsh winter in Srinagar. The size of the wound was 2x2 cm on assessing the wound profile. The wound was treated with the application of an ointment made with the combination of powder of Astragalus sarcocolla and Honey in equal amounts. The ointment was applied twice a day on the wound for 20 days. After 7 days of daily application, there was a considerable reduction in the size of wound and significant improvement in other symptoms like pain and tenderness. The ulcer was completely healed in a time period of 21 days. The present case reports that, the ointment prepared with Astragalus sarcocolla and Honey is a cost effective treatment for chronic non-healing wound.

Effects of Herbal formulations in management of Uterine Fibroid (Sul’ah-E-Rehm) – A Case Report

Uterine fibroid is the commonest benign and solid tumor in female during reproductive life. Approximately 15-25 million of Indian women have affected from fibroid uterus. Histologically itis composed of smooth muscle and fibrous connective tissue of varying proportional. It is considered as Sul’ah (tumor) in Unani classic litretures, as Ali Ibn-e-Abbas Majusi (930-994 AD) defined it under the topic of Warm-e-Balghami; as it is a swelling filled with viscid phlegm (Balgham-e-Ghaleez).Present paper deals with a reports of a 30 years old female having uterine fibroids measuring 2.6 cm× 3.1 cm, 2.6 cm× 3.6 cm, with left ovarian cyst of 3.1 cm × 4 cm. Patient was treated with herbal formulations; Majun Dabeedul Ward ( 5 gm paste), Kanchanar Guggul (2 tablet) and Niswani (10 ml syrup) twice a day for 8 consecutive weeks as oral administration. The patient was clinically assessed fortnightly, and radiologically just after treatment. Patient has shown encouraging result in post treatment investigation of Ultrasonography and finally patients got free from uterine fibroids without operation. The drugs were found to be safe and effective in this case.

Management of Covid-19 patients with indigenous formulations in home settings- Case reports of two patients

This is to report 2 cases experiencing action of indigenous medicine in controlling Covid-19 symptoms in the home setting, without any requirement of hospitalization. Covid-19 (SARS-CoV-2), a viral disease by novel coronavirus, impacted 220 countries. Although, numerous attempts have been made for the management and treatment of Covid-19 with various drugs, traditional Ayurveda and Siddha has been widely reported to be effective in treating viral diseases through altering innate adaptive immune response and inhibition of virus attachment to body cells. It is found to inhibit attachment of virus to human cell, hence reducing viral load induced cytokine storm, inflammatory over reactions in the body of patients and inhibition of community spread. The experience of 2 cases reported here showed how senior citizens with various co-morbidities recovered from covid 19 and remained healthy without sequelae or side effects even after 6 months of follow-up. These observations are vital clues for a large population-based study and ongoing clinical trials. Mechanism of action of Sidha and Ayurvedic medicines like Kabasura Kudineer, Sitopladi, Triphala are well published and highly recommended for affecting viral entry and immune regulatory pathways. With no side effects, secondary infections and action, these regimens pave the ways for safe and effective cure for Covid-19.

Ayurveda Management of Kampavata with special reference to Parkinson’s Disease- A Single Case Study

Parkinson’s disease is a progressive degenerative neurological disorder which mainly affects the motor system of body and it is characterized by resting tremors, slowness of movements, rigidity, gait disturbances/postural instability. It is correlated with Kampa Vata [Disease associated with tremors in body] in Ayurveda, [Indian ancient science for healthy life] as it is characterized by Sarvanga Kampa / Shiro Kampa [tremors all over body or tremors in head]. It is a Vata Vyadhi [principal element of body which caused diseases] which occurs due to pathological increase of Chala Guna [Moving property] of Vata. [Principal element of body] Treatment consists of both internal and external administration of different forms aimed to reverse pathology of Vata imbalance. Here, a case of 57 years male patient presented with tremors in both hands and neck, unable to walk without support since 12 years. Patient was treated with Panchakarma therapies; like Sarvanga Abhyanga, [External oil massage] Nadi Sweda, [sudation theorapy] Shiro Abhyanga [Head massage], Shiro Pichu [Oil soaked cotton pad putting on head] and Shiro Basti [Retension of oil on head] and Shamana Aushadhis like Tab Vatachintamani Rasa, Kapikachu Beeja Choorna [Mucuna pruriens], Ashwagandha Choorna, [Withamnia somnifera] Cap Ksheerabala 101, Avipatikara Choorna for 1 month. The patient got remarkable relief in symptoms with above Panchakarma and Ayurveda medicines.

An Evidence Based Case of Planter Psoriasis Treated by Individualized Homoeopathic Medicine

Psoriasis is a non-contagious, inflammatory disease of the skin that results in itchy, scaly patches on different parts of the body. This disorder causes skin cells to multiply at an abnormally faster rate. The patients depict an unpredictable course of remission and relapse; winter aggravation is common. Conventional treatment involves application of topical ointments, steroids, anti-inflammatory and immunosuppressive drugs. Homoeopathy is a popular alternative from of treatment in this type of skin conditions. The person is treated as a whole and a suitable constitutional remedy is prescribed, so that there is very less chance of relapse of symptoms. The patient’s general condition, mental status along with the symptoms of psoriasis is considered during finding the similimum remedy. In this case of chronic planter psoriasis an individualised homoeopathic medicine has been prescribed. A female patient suffered from painful cracks, exfoliating scales and slight itching of the soles. This condition is termed as “Planter Psoriasis”. The case came to the surgery OPD of MBHMC&H. We constructed a totality of the patient and based on that a similimum was selected after Repertorization and consultation with the Homoeopathic Materia Medica. The case was well managed with Homoeopathic medicine “Graphites”and there was no remission of symptoms in the following winter.

Therapeutic Management of Covid-19 Pneumonia with Ayurveda – Case Series Report

Infection of Severe Acute Respiratory Syndrome Corona virus 2 (SARS-CoV- 2) which causes novel corona virus disease (COVID-19) has put the world in a medical disaster. Scientists are taking vast efforts to contain the disease by finding a vaccine or clinically proven medicine. Despite the efforts there is no proven medication in any stream of medicine. Covid19 affects respiratory tract and causes pneumonia. Here we are presenting a case series report of patients who had developed Covid19 with subsequent pneumonia and approached for Ayurvedic treatment. All these patients were primarily diagnosed with Covid-19 by RT PCR and SAARS Covid-19 Antigen test. They had subsequently developed viral pneumonia. As per Ayurveda, patients had developed symptoms of vitiation of Vata and Kapha Doshas which affected Rasavaha Srotasa and Pranavaha Srotasa. Patients were treated uniformly with internal Ayurvedic medicines which were prescribed for median duration of 30days and had been analyzed clinically with pre and post chest X-rays. All the symptoms were relieved as well as haziness in chest was also cleared in all patients, which was confirmed with pre and post chest x-rays. This study will be an evidence-based example that Ayurveda can contribute in fight against Covid-19 successfully.

Effect of coded Unani formulation Unim-401 and Soranil with NB-UV-B therapy in a case of chronic palmo-plantar plaque psoriasis- A Case Study.

Da’ al-Sadaf (Plaque psoriasis) is the most common form of the psoriasis in which raised, red patches covered with a silvery white buildup of dead skin cells. These patches or plaques most often show up on the scalp, knees, elbows and lower back. Sometimes it is itchy and painful and, may cracked and bleed. Unani oral and topical medicines along with Narrow Band Ultra-Violet (NB-UV-B) therapy is used here for treatment. Unani coded formulation UNIM-401 containing Barg Shahtra (Fumaria parviflora Linn.), Chiraita Talkh (Swertia chirata Buch.), Babchi (Psoralea corylifolia Linn.) and Haleela Siyah (Terminalia chebula Retz.) in the ratio of 5:5:5:2, in a dose of 2 capsules (500 mg each) orally with lukewarm water twice a day in empty stomach for a period of three months are given and Soranil ointment mixed with clarified butter in 1:1 ratio was applied on the affected part and exposed to the NB-UVB light for 10 minutes. Plaques of psoriasis getting shade off after one month of treatment and almost disappeared from the site of lesion after three months. The skin of patient almost become normal. It may be concluded that Unani drugs (oral & topical) along with NB-UVB therapy is beneficial for controlling and treating plaque psoriasis.

Effect of Ksheera Vaitarana Vasti, Janu Vasti along with Adjuvant Ayurveda Drugs in the management of Sandhigatavata (Osteoarthritis in knee joint)- A case study

Sandhigatavata is a disease with Shoola (pain), Shotha (swelling) and Hanti Sandhi Gatah Sandhi (impairment of the functions of joints). This can be correlated with osteoarthritis. Osteoarthritis is a degenerative arthritis. While any joint can be affected in osteoarthritis, knee joint is most commonly affected. Vangasena Samhitha mentions Ksheera Vaitarana Vasti as a treatment for Janu Sankocha (stiffness of joint), Kati Prushta Shoola Shotha (swelling and pain in waist, knee and back). Prasarana Akunchanayoh Pravrutthishca Savedana (pain during contraction and extension of limbs) is described as a symptom of Sandhigatavata and stiffness in joint is a symptom of osteoarthritis. Sri Lankan traditional physician family ‘Weerasinghe’ treat Sandhigatavata with Belimul Thippilimul Amu Inguru Kashaya with effective results. Gugguladi Thaila is described in Sri Lankan Ayurveda Pharmacopeia in treatment of Vata Roga. Susruta advises to conduct Snehana in treatment of Vata Roga. Janu Vasti is one method of administering Bhahya Snehana to Janu Sandhi (knee joint). A 65 years old female with an 8 years history of Sandhigatavata Ayurveda treatments for 21 days. Ksheera Vaitarana Vasti was conducted for seven days and from Day 8 to 21, with oral administration of Belimul Thippilimul Amu Inguru Kashaya along with Janu Vasti using Gugguladi Thaila. After completion of treatment, it was observed that swelling, tenderness and pain during contraction and extension of limbs were completely relived. It is concluded that above treatment regimen is effective in treatment of Sandhigatavata (osteoarthritis).